PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28968471-4 2017 The effects and mechanisms of epirubicin treatment on the expressions of upstream survival signals (e.g., beta-catenin) and downstream MDR transporters (e.g., P-gp) and anti-apoptotic pathways (e.g., Bcl-2) were assessed with or without HuR knockdown (siHuR) or overexpression (overHuR; ectopic HuR or pcDNA3/HA-HuR). Epirubicin 30-40 catenin beta 1 Homo sapiens 106-118 32811806-8 2020 Finally, DNER protects BC cells from epirubicin-induced growth inhibition and apoptosis via the Wnt/beta-catenin pathway. Epirubicin 37-47 catenin beta 1 Homo sapiens 100-112 28968471-12 2017 Our findings provide insight into the mechanisms by which siHuR potentiated epirubicin-induced cytotoxicity via inhibiting galectin-3/beta-catenin signaling, suppressing MDR transporters and provoking apoptosis. Epirubicin 76-86 catenin beta 1 Homo sapiens 134-146 28968471-5 2017 Our results showed that siHuR decreased transcriptional expressions of galectin-3, beta-catenin, cyclin D1, Bcl-2, P-gp, MRP1, and MRP2 in epirubicin-treated colon cancer cells. Epirubicin 139-149 catenin beta 1 Homo sapiens 83-95 24303084-10 2013 We show for the first time that the silencing of galectin-3 sensitizes MDR cells to epirubicin by inhibiting ABC transporters and activating the mitochondrial pathway of apoptosis through modulation of the beta-catenin/GSK-3beta pathway in human colon cancer cells. Epirubicin 84-94 catenin beta 1 Homo sapiens 206-218 22529978-5 2012 Epirubicin-treated GRP78 knockdown cells resulted in more inactivated Akt pathway members, such as phosphorylated Akt and GSK-3beta, as well as downstream targets of beta-catenin expression. Epirubicin 0-10 catenin beta 1 Homo sapiens 166-178