PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34780781-6	2022	In vitro, disulfide bond reducing agents affect the RBD secondary structure, lower its melting temperature from 52 C to 36-39 C and decrease its binding affinity to ACE2 by two orders of magnitude at 37 C. Consistent with these in vitro findings, the reducing agents tris(2-carboxyethyl)phosphine (TCEP) and dithiothreitol (DTT) were able to inhibit viral replication at low millimolar levels in cell-based assays.	tris(2-carboxyethyl)phosphine	267-296	angiotensin converting enzyme 2	Homo sapiens	165-169	
34780781-6	2022	In vitro, disulfide bond reducing agents affect the RBD secondary structure, lower its melting temperature from 52 C to 36-39 C and decrease its binding affinity to ACE2 by two orders of magnitude at 37 C. Consistent with these in vitro findings, the reducing agents tris(2-carboxyethyl)phosphine (TCEP) and dithiothreitol (DTT) were able to inhibit viral replication at low millimolar levels in cell-based assays.	tris(2-carboxyethyl)phosphine	298-302	angiotensin converting enzyme 2	Homo sapiens	165-169