PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27324897-7 2017 The synaptic-related protein expression increased via activation of the cyclic AMP response element binding (CREB) protein/brain-derived neurotrophic factor (BDNF) signaling pathway induced by fluoxetine exposure. Fluoxetine 193-203 cAMP responsive element binding protein 1 Mus musculus 72-107 34280458-9 2021 The protein ratios of p-ERK/ERK, p-CREB/CREB and ERK mRNA, and CREB mRNA expression decreased in the CUMS group (p < 0.01) and markedly increased in the FLU and BA groups (p < 0.05, p < 0.01). Fluoxetine 154-157 cAMP responsive element binding protein 1 Mus musculus 35-39 34280458-9 2021 The protein ratios of p-ERK/ERK, p-CREB/CREB and ERK mRNA, and CREB mRNA expression decreased in the CUMS group (p < 0.01) and markedly increased in the FLU and BA groups (p < 0.05, p < 0.01). Fluoxetine 154-157 cAMP responsive element binding protein 1 Mus musculus 40-44 34280458-9 2021 The protein ratios of p-ERK/ERK, p-CREB/CREB and ERK mRNA, and CREB mRNA expression decreased in the CUMS group (p < 0.01) and markedly increased in the FLU and BA groups (p < 0.05, p < 0.01). Fluoxetine 154-157 cAMP responsive element binding protein 1 Mus musculus 63-67 34280458-10 2021 The IOD value of the p-ERK and p-CREB in the CUMS group was decreased versus the CON group (p < 0.01), and these changes were improved via BA and FLU treatment (p < 0.05, p < 0.01). Fluoxetine 147-150 cAMP responsive element binding protein 1 Mus musculus 33-37 33241493-8 2021 Our results show that FLX treatment results in long-term dysregulation of mRNA levels across numerous genes from the ERK, PI3K/AKT, and Wnt intracellular signaling pathways, along with increases of the transcription factors CREB, DeltaFosB, and Zif268. Fluoxetine 22-25 cAMP responsive element binding protein 1 Mus musculus 224-228 31351316-2 2019 Our previously published results from transgenic mice functionally lacking CREB in chosen neural populations have shown that BDNF upregulation evoked by chronic treatment with fluoxetine seems to be dependent on CREB residing exclusively in serotonergic neurons. Fluoxetine 176-186 cAMP responsive element binding protein 1 Mus musculus 75-79 30294251-4 2018 In our previous study using mice lacking CREB in serotonergic neurons (Creb1TPH2CreERT2 mice), we showed that selective CREB ablation in these particular neuronal populations is crucial for drug-resistant phenotypes in the tail suspension test observed after fluoxetine administration in Creb1TPH2CreERT2 mice. Fluoxetine 259-269 cAMP responsive element binding protein 1 Mus musculus 41-45 30294251-4 2018 In our previous study using mice lacking CREB in serotonergic neurons (Creb1TPH2CreERT2 mice), we showed that selective CREB ablation in these particular neuronal populations is crucial for drug-resistant phenotypes in the tail suspension test observed after fluoxetine administration in Creb1TPH2CreERT2 mice. Fluoxetine 259-269 cAMP responsive element binding protein 1 Mus musculus 120-124 30294251-6 2018 Here, we show for the first time that BDNF upregulation observed after fluoxetine in the hippocampus or PFC might be dependent on the transcription factor CREB residing, not within these particular structures targeted by serotonergic projections, but exclusively in serotonergic neurons. Fluoxetine 71-81 cAMP responsive element binding protein 1 Mus musculus 155-159 33833356-6 2021 Interestingly, FLX re-exposure in adulthood reversed the enduring FLX-induced anxiety-related responses across all behavioral tasks, while restoring ERK2-CREB-proBDNF markers to control levels and increasing mBDNF within the prefrontal cortex, but not the hippocampus. Fluoxetine 15-18 cAMP responsive element binding protein 1 Mus musculus 154-158 33528752-10 2021 Fluoxetine 10 mg/kg increased CREB phosphorylation and BDNF expression in the prefrontal cortex and hippocampus. Fluoxetine 0-10 cAMP responsive element binding protein 1 Mus musculus 30-34 31351316-2 2019 Our previously published results from transgenic mice functionally lacking CREB in chosen neural populations have shown that BDNF upregulation evoked by chronic treatment with fluoxetine seems to be dependent on CREB residing exclusively in serotonergic neurons. Fluoxetine 176-186 cAMP responsive element binding protein 1 Mus musculus 212-216 30294251-0 2018 Selective Depletion of CREB in Serotonergic Neurons Affects the Upregulation of Brain-Derived Neurotrophic Factor Evoked by Chronic Fluoxetine Treatment. Fluoxetine 132-142 cAMP responsive element binding protein 1 Mus musculus 23-27 27324897-7 2017 The synaptic-related protein expression increased via activation of the cyclic AMP response element binding (CREB) protein/brain-derived neurotrophic factor (BDNF) signaling pathway induced by fluoxetine exposure. Fluoxetine 193-203 cAMP responsive element binding protein 1 Mus musculus 109-113 27598965-2 2016 Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA). Fluoxetine 0-10 cAMP responsive element binding protein 1 Mus musculus 143-180 27598965-2 2016 Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA). Fluoxetine 0-10 cAMP responsive element binding protein 1 Mus musculus 182-186 27598965-2 2016 Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA). Fluoxetine 74-80 cAMP responsive element binding protein 1 Mus musculus 143-180 27598965-2 2016 Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA). Fluoxetine 74-80 cAMP responsive element binding protein 1 Mus musculus 182-186 23473877-0 2013 Oxcarbazepine and fluoxetine protect against mouse models of obsessive compulsive disorder through modulation of cortical serotonin and CREB pathway. Fluoxetine 18-28 cAMP responsive element binding protein 1 Mus musculus 136-140 24452697-8 2014 RESULTS: MPH + FLX, or cocaine exposure in juvenile mice increased mRNA expression of ERK2 and its downstream targets (CREB, cFos, and Zif268), and increased protein phosphorylation of ERK2 and CREB 2 months after drug exposure. Fluoxetine 15-18 cAMP responsive element binding protein 1 Mus musculus 119-123 23473877-10 2013 Chronic treatment with FLX and OXC effectively mitigated the lowering effects of 8-OHDPAT on cortical 5-HT, and enabled an efficient recovery in basal CREB levels. Fluoxetine 23-26 cAMP responsive element binding protein 1 Mus musculus 151-155 23085336-5 2013 In the present work we studied by Western blot analysis the modulation of CREB expression and activation in the mouse superior colliculus in three models of neuronal plasticity: (1) developmental plasticity; (2) lesion-induced plasticity; (3) and fluoxetine-induced restored plasticity. Fluoxetine 247-257 cAMP responsive element binding protein 1 Mus musculus 74-78 22695008-1 2013 Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that has been suggested to participate in fluoxetine (FLX)-induced phosphorylation of cyclic AMP-response element binding protein (CREB). Fluoxetine 118-128 cAMP responsive element binding protein 1 Mus musculus 162-205 22695008-1 2013 Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that has been suggested to participate in fluoxetine (FLX)-induced phosphorylation of cyclic AMP-response element binding protein (CREB). Fluoxetine 118-128 cAMP responsive element binding protein 1 Mus musculus 207-211 22695008-1 2013 Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that has been suggested to participate in fluoxetine (FLX)-induced phosphorylation of cyclic AMP-response element binding protein (CREB). Fluoxetine 130-133 cAMP responsive element binding protein 1 Mus musculus 162-205 22695008-1 2013 Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that has been suggested to participate in fluoxetine (FLX)-induced phosphorylation of cyclic AMP-response element binding protein (CREB). Fluoxetine 130-133 cAMP responsive element binding protein 1 Mus musculus 207-211 22695008-9 2013 Phosphorylation of CaMKIV was up-regulated in WT mice and phosphorylation of CREB was impaired in CaMKIV KO mice after FLX treatment. Fluoxetine 119-122 cAMP responsive element binding protein 1 Mus musculus 77-81 23085336-7 2013 The results showed that: (1) the expression and activation of CREB increase during the development of the superior colliculus in temporal correlation with the plastic process of refinement of retino-collicular projections; (2) the activation of CREB is induced by a monocular lesion performed during the critical period for plasticity in young animals but not when performed in less plastic juvenile mice; (3) the expression and activation of CREB increase in adult animals treated with fluoxetine, known to restore high levels of plasticity in adult animals. Fluoxetine 487-497 cAMP responsive element binding protein 1 Mus musculus 62-66 23085336-7 2013 The results showed that: (1) the expression and activation of CREB increase during the development of the superior colliculus in temporal correlation with the plastic process of refinement of retino-collicular projections; (2) the activation of CREB is induced by a monocular lesion performed during the critical period for plasticity in young animals but not when performed in less plastic juvenile mice; (3) the expression and activation of CREB increase in adult animals treated with fluoxetine, known to restore high levels of plasticity in adult animals. Fluoxetine 487-497 cAMP responsive element binding protein 1 Mus musculus 245-249 23085336-7 2013 The results showed that: (1) the expression and activation of CREB increase during the development of the superior colliculus in temporal correlation with the plastic process of refinement of retino-collicular projections; (2) the activation of CREB is induced by a monocular lesion performed during the critical period for plasticity in young animals but not when performed in less plastic juvenile mice; (3) the expression and activation of CREB increase in adult animals treated with fluoxetine, known to restore high levels of plasticity in adult animals. Fluoxetine 487-497 cAMP responsive element binding protein 1 Mus musculus 245-249 23018126-4 2013 OB caused significant increases in ERK1 and CREB (Ser(133)) phosphorylation and in the expression of BDNF immunocontent, all of which were prevented by fluoxetine administration. Fluoxetine 152-162 cAMP responsive element binding protein 1 Mus musculus 44-48 23018126-8 2013 Conversely, fluoxetine prevented these OB-induced behavioral changes and avoided the activation of ERK1/CREB/BDNF in the hippocampus. Fluoxetine 12-22 cAMP responsive element binding protein 1 Mus musculus 104-108 22742873-9 2012 Moreover, Ipt and Flx enhanced the phosphorylation of Akt and CREB in the hippocampus of Kir6.1(+/+) mice. Fluoxetine 18-21 cAMP responsive element binding protein 1 Mus musculus 62-66 22449479-7 2012 Further studies are needed to examine the effect of chronic fluoxetine treatment on the ERK-CREB system, and to determine whether there is a causal relationship between the disruption of the ERK-CREB system and the effect of this antidepressant on memory performance. Fluoxetine 60-70 cAMP responsive element binding protein 1 Mus musculus 92-96 18923397-5 2009 Meanwhile, AQP4 knockout abolished fluoxetine-induced enhancement of hippocampal cyclic AMP-responsive element binding protein (CREB) phosphorylation. Fluoxetine 35-45 cAMP responsive element binding protein 1 Mus musculus 81-126 18923397-5 2009 Meanwhile, AQP4 knockout abolished fluoxetine-induced enhancement of hippocampal cyclic AMP-responsive element binding protein (CREB) phosphorylation. Fluoxetine 35-45 cAMP responsive element binding protein 1 Mus musculus 128-132 16519925-6 2006 Repeated treatment with antidepressant drugs, imipramine (Imi) and fluoxetine (Flu), significantly reduced the plasma corticosterone concentration and enhanced the BDNF and CREB levels. Fluoxetine 67-77 cAMP responsive element binding protein 1 Mus musculus 173-177 16519925-6 2006 Repeated treatment with antidepressant drugs, imipramine (Imi) and fluoxetine (Flu), significantly reduced the plasma corticosterone concentration and enhanced the BDNF and CREB levels. Fluoxetine 79-82 cAMP responsive element binding protein 1 Mus musculus 173-177 20122921-0 2010 A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice. Fluoxetine 91-101 cAMP responsive element binding protein 1 Mus musculus 167-171 20122921-8 2010 However, both citalopram and fluoxetine treatment completely abolished the increase in CRE/CREB-directed transcription induced by chronic psychosocial stress. Fluoxetine 29-39 cAMP responsive element binding protein 1 Mus musculus 91-95 17913473-14 2008 While papaverine treatment reduced CREB protein levels in the hippocampus and striatum, fluoxetine increased CREB in the hippocampus. Fluoxetine 88-98 cAMP responsive element binding protein 1 Mus musculus 109-113 17913473-15 2008 These data suggest that papaverine and fluoxetine may produce quite different effects on behavior; these behaviors may be linked to CREB expression in brain regions associated with motor and cognitive functions. Fluoxetine 39-49 cAMP responsive element binding protein 1 Mus musculus 132-136