PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23401542-5	2013	Administration of fluoxetine also increased AChE activity throughout the brain, with the greatest change in the hippocampus.	Fluoxetine	18-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-48	
12009429-1	2002	This study examines the effect of the antidepressants fluoxetine, sertraline and amitriptyline on cholinesterase (acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)) activities in human serum and erythrocyte membrane (ghost).	Fluoxetine	54-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	114-134	
12034133-8	2002	Finally, tianeptine-fluoxetine coadministration had no effect on learning consolidation; nevertheless, administration of an acetylcholinesterase inhibitor, phenserine, potentiated subeffective tianeptine or fluoxetine doses.	Fluoxetine	207-217	acetylcholinesterase (Cartwright blood group)	Homo sapiens	124-144	
26420918-9	2015	From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report p-cholorophenyl substituted rivastigmine and fluoxetine hybrid (26d) to be a potential candidate for AcHE inhibition which in addition can overcome narrow therapeutic window of present AChE inhibitors in clinical treatment of Alzheimer s disease.	Fluoxetine	179-189	acetylcholinesterase (Cartwright blood group)	Homo sapiens	235-239	
26420918-9	2015	From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report p-cholorophenyl substituted rivastigmine and fluoxetine hybrid (26d) to be a potential candidate for AcHE inhibition which in addition can overcome narrow therapeutic window of present AChE inhibitors in clinical treatment of Alzheimer s disease.	Fluoxetine	179-189	acetylcholinesterase (Cartwright blood group)	Homo sapiens	319-323	
24258317-0	2014	AChE and RACK1 promote the anti-inflammatory properties of fluoxetine.	Fluoxetine	59-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4	
24258317-4	2014	Furthermore, we show that fluoxetine intercepts the LPS-induced decreases in intracellular acetylcholinesterase (AChE-S) and that AChE-S interacts with the nuclear factor kappa B (NFkappaB)-activating intracellular receptor for activated C kinase 1 (RACK1).	Fluoxetine	26-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-111	
24258317-4	2014	Furthermore, we show that fluoxetine intercepts the LPS-induced decreases in intracellular acetylcholinesterase (AChE-S) and that AChE-S interacts with the nuclear factor kappa B (NFkappaB)-activating intracellular receptor for activated C kinase 1 (RACK1).	Fluoxetine	26-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-119	
23401542-8	2013	The behavioral changes due to shRNA-mediated knockdown of AChE were rescued by coinfusion of an shRNA-resistant AChE transgene into the hippocampus and reversed by systemic administration of fluoxetine.	Fluoxetine	191-201	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-62	
23401542-10	2013	The sensitivity of these effects to fluoxetine suggests that shRNA-mediated knockdown of hippocampal AChE represents a model for anxiety- and depression-like phenotypes.	Fluoxetine	36-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105	
22697296-7	2012	That fluoxetine induces vasodilatation of cerebral arterioles suggests co-promotion of endothelial muscarinic and nitric oxide signalling, facilitated by albumin-dependent inhibition of serum AChE.	Fluoxetine	5-15	acetylcholinesterase (Cartwright blood group)	Homo sapiens	192-196	
20190429-4	2010	Such dual inhibitors were designed by the hybridization of rivastigmine and fluoxetine based on a hypothetical model of the AChE active site.	Fluoxetine	76-86	acetylcholinesterase (Cartwright blood group)	Homo sapiens	124-128