PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19114463-1	2009	P-glycoprotein (P-gp) plays an important role in determining net brain uptake of fexofenadine.	fexofenadine	81-93	phosphoglycolate phosphatase	Mus musculus	0-14	
19114463-1	2009	P-glycoprotein (P-gp) plays an important role in determining net brain uptake of fexofenadine.	fexofenadine	81-93	phosphoglycolate phosphatase	Mus musculus	16-20	
19114463-3	2009	In contrast, the P-gp efflux ratio at the blood-brain barrier (BBB) for fexofenadine was only approximately 4 using an in situ brain perfusion technique.	fexofenadine	72-84	phosphoglycolate phosphatase	Mus musculus	17-21	
19114463-4	2009	Pharmacokinetic modeling based on the experimental results indicated that the apparent fexofenadine P-gp efflux ratio is time-dependent due to low passive permeability at the BBB.	fexofenadine	87-99	phosphoglycolate phosphatase	Mus musculus	100-104	
19114463-9	2009	Taken together, these results indicate that the fexofenadine BBB P-gp efflux ratio has been underestimated previously due to the lack of complete equilibration of fexofenadine across the blood-brain interface under typical experimental paradigms.	fexofenadine	48-60	phosphoglycolate phosphatase	Mus musculus	65-69	
19114463-9	2009	Taken together, these results indicate that the fexofenadine BBB P-gp efflux ratio has been underestimated previously due to the lack of complete equilibration of fexofenadine across the blood-brain interface under typical experimental paradigms.	fexofenadine	163-175	phosphoglycolate phosphatase	Mus musculus	65-69	
16455807-11	2006	Such intestinal absorption property of bepotastine is distinctly different from the low membrane-permeable P-gp substrate fexofenadine.	fexofenadine	122-134	phosphoglycolate phosphatase	Mus musculus	107-111	
17913796-1	2008	Previous studies implicated P-glycoprotein (P-gp) as the major transport protein responsible for the biliary excretion of fexofenadine (FEX).	fexofenadine	122-134	phosphoglycolate phosphatase	Mus musculus	28-42	
17913796-1	2008	Previous studies implicated P-glycoprotein (P-gp) as the major transport protein responsible for the biliary excretion of fexofenadine (FEX).	fexofenadine	122-134	phosphoglycolate phosphatase	Mus musculus	44-48	
17913796-1	2008	Previous studies implicated P-glycoprotein (P-gp) as the major transport protein responsible for the biliary excretion of fexofenadine (FEX).	fexofenadine	136-139	phosphoglycolate phosphatase	Mus musculus	28-42	
17913796-1	2008	Previous studies implicated P-glycoprotein (P-gp) as the major transport protein responsible for the biliary excretion of fexofenadine (FEX).	fexofenadine	136-139	phosphoglycolate phosphatase	Mus musculus	44-48	
10421612-7	1999	administration of [(14)C]fexofenadine to mice lacking mdr1a-encoded P-gp resulted in 5- and 9-fold increases in the drug"s plasma and brain levels, respectively, compared with wild-type mice.	fexofenadine	25-37	phosphoglycolate phosphatase	Mus musculus	68-72	
15821041-0	2005	P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion.	fexofenadine	51-63	phosphoglycolate phosphatase	Mus musculus	0-14	
15821041-6	2005	In addition, the steady-state brain-to-plasma concentration ratio of fexofenadine was approximately 3-fold higher in Mdr1a/1b P-gp knockout mice than in wild-type mice.	fexofenadine	69-81	phosphoglycolate phosphatase	Mus musculus	126-130