PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9892033-0	1998	Terfenadine and fexofenadine reduce in vitro ICAM-1 expression on human continuous cell lines.	fexofenadine	16-28	intercellular adhesion molecule 1	Homo sapiens	45-51	
16270723-0	2005	The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils.	fexofenadine	14-26	intercellular adhesion molecule 1	Homo sapiens	44-77	
16270723-3	2005	To assess the possible anti-inflammatory activity of fexofenadine, a selective H1-receptor antagonist, we evaluated its capacity to modulate the expression of adhesion molecules leukocyte function-associated antigen (LFA) 1 and intracellular adhesion molecule (ICAM) 1 on eosinophil surface and to induce apoptosis of eosinophils.	fexofenadine	53-65	intercellular adhesion molecule 1	Homo sapiens	228-268	
16270723-7	2005	In this study, fexofenadine did not cause any significant changes in the expression of LFA-1 but was shown to be able to inhibit the expression of ICAM-1 at concentrations between 10(-3) and 10(-4) M. Moreover, concentrations of fexofenadine from 10(-3) to 6 x 10(-4) M induced a significant increment in the percentage of apoptotic cells.	fexofenadine	15-27	intercellular adhesion molecule 1	Homo sapiens	147-153	
16270723-7	2005	In this study, fexofenadine did not cause any significant changes in the expression of LFA-1 but was shown to be able to inhibit the expression of ICAM-1 at concentrations between 10(-3) and 10(-4) M. Moreover, concentrations of fexofenadine from 10(-3) to 6 x 10(-4) M induced a significant increment in the percentage of apoptotic cells.	fexofenadine	229-241	intercellular adhesion molecule 1	Homo sapiens	147-153	
16270723-8	2005	Our findings indicate the possibility of obtaining relevant anti-inflammatory pharmacologic effects, other than antihistamine activity, by fexofenadine, such as inhibition of ICAM-1 expression and induction of eosinophil apoptosis.	fexofenadine	139-151	intercellular adhesion molecule 1	Homo sapiens	175-181	
14530792-7	2003	In addition, fexofenadine has proven anti-inflammatory activity and has been shown to inhibit a number of mediators at clinically relevant concentrations, including in vitro inhibition of ICAM-1 expression on conjunctival and nasal epithelial cells.	fexofenadine	13-25	intercellular adhesion molecule 1	Homo sapiens	188-194	
9892033-3	1998	OBJECTIVE: The aim of the study was to evaluate the effect exerted by terfenadine and fexofenadine on adhesion molecules expression (CD54/ICAM-1 and CD29) of a human continuously cultured conjunctival epithelial cell line (WK) and a fibroblast cell line (HEL).	fexofenadine	86-98	intercellular adhesion molecule 1	Homo sapiens	133-137	
9892033-6	1998	RESULTS: Terfenadine and fexofenadine significantly reduced ICAM-1 basal expression on WK cells at the concentration of 1 microg/mL and 50 microg/mL, respectively.	fexofenadine	25-37	intercellular adhesion molecule 1	Homo sapiens	60-66	
9892033-7	1998	In addition, both terfenadine and fexofenadine were able to decrease soluble ICAM-1 levels in IFN gamma-stimulated WK cells.	fexofenadine	34-46	intercellular adhesion molecule 1	Homo sapiens	77-83	
9892033-8	1998	On HEL fibroblasts, fexofenadine only was able to inhibit ICAM-1 upregulation induced by IFN gamma.	fexofenadine	20-32	intercellular adhesion molecule 1	Homo sapiens	58-64	
9892033-10	1998	CONCLUSION: This study shows that terfenadine and fexofenadine exert a biologic effect directly on epithelial cells and fibroblasts reducing ICAM-1 expression and partially reducing soluble ICAM-1 release.	fexofenadine	50-62	intercellular adhesion molecule 1	Homo sapiens	141-147	
9892033-10	1998	CONCLUSION: This study shows that terfenadine and fexofenadine exert a biologic effect directly on epithelial cells and fibroblasts reducing ICAM-1 expression and partially reducing soluble ICAM-1 release.	fexofenadine	50-62	intercellular adhesion molecule 1	Homo sapiens	190-196