PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16270723-0 2005 The effect of fexofenadine on expression of intercellular adhesion molecule 1 and induction of apoptosis on peripheral eosinophils. fexofenadine 14-26 intercellular adhesion molecule 1 Homo sapiens 44-77 16270723-3 2005 To assess the possible anti-inflammatory activity of fexofenadine, a selective H1-receptor antagonist, we evaluated its capacity to modulate the expression of adhesion molecules leukocyte function-associated antigen (LFA) 1 and intracellular adhesion molecule (ICAM) 1 on eosinophil surface and to induce apoptosis of eosinophils. fexofenadine 53-65 intercellular adhesion molecule 1 Homo sapiens 228-268 16270723-7 2005 In this study, fexofenadine did not cause any significant changes in the expression of LFA-1 but was shown to be able to inhibit the expression of ICAM-1 at concentrations between 10(-3) and 10(-4) M. Moreover, concentrations of fexofenadine from 10(-3) to 6 x 10(-4) M induced a significant increment in the percentage of apoptotic cells. fexofenadine 15-27 intercellular adhesion molecule 1 Homo sapiens 147-153 16270723-7 2005 In this study, fexofenadine did not cause any significant changes in the expression of LFA-1 but was shown to be able to inhibit the expression of ICAM-1 at concentrations between 10(-3) and 10(-4) M. Moreover, concentrations of fexofenadine from 10(-3) to 6 x 10(-4) M induced a significant increment in the percentage of apoptotic cells. fexofenadine 229-241 intercellular adhesion molecule 1 Homo sapiens 147-153 16270723-8 2005 Our findings indicate the possibility of obtaining relevant anti-inflammatory pharmacologic effects, other than antihistamine activity, by fexofenadine, such as inhibition of ICAM-1 expression and induction of eosinophil apoptosis. fexofenadine 139-151 intercellular adhesion molecule 1 Homo sapiens 175-181 9892033-0 1998 Terfenadine and fexofenadine reduce in vitro ICAM-1 expression on human continuous cell lines. fexofenadine 16-28 intercellular adhesion molecule 1 Homo sapiens 45-51 9892033-3 1998 OBJECTIVE: The aim of the study was to evaluate the effect exerted by terfenadine and fexofenadine on adhesion molecules expression (CD54/ICAM-1 and CD29) of a human continuously cultured conjunctival epithelial cell line (WK) and a fibroblast cell line (HEL). fexofenadine 86-98 intercellular adhesion molecule 1 Homo sapiens 133-137 9892033-6 1998 RESULTS: Terfenadine and fexofenadine significantly reduced ICAM-1 basal expression on WK cells at the concentration of 1 microg/mL and 50 microg/mL, respectively. fexofenadine 25-37 intercellular adhesion molecule 1 Homo sapiens 60-66 9892033-7 1998 In addition, both terfenadine and fexofenadine were able to decrease soluble ICAM-1 levels in IFN gamma-stimulated WK cells. fexofenadine 34-46 intercellular adhesion molecule 1 Homo sapiens 77-83 9892033-8 1998 On HEL fibroblasts, fexofenadine only was able to inhibit ICAM-1 upregulation induced by IFN gamma. fexofenadine 20-32 intercellular adhesion molecule 1 Homo sapiens 58-64 9892033-10 1998 CONCLUSION: This study shows that terfenadine and fexofenadine exert a biologic effect directly on epithelial cells and fibroblasts reducing ICAM-1 expression and partially reducing soluble ICAM-1 release. fexofenadine 50-62 intercellular adhesion molecule 1 Homo sapiens 141-147 9892033-10 1998 CONCLUSION: This study shows that terfenadine and fexofenadine exert a biologic effect directly on epithelial cells and fibroblasts reducing ICAM-1 expression and partially reducing soluble ICAM-1 release. fexofenadine 50-62 intercellular adhesion molecule 1 Homo sapiens 190-196 14530792-7 2003 In addition, fexofenadine has proven anti-inflammatory activity and has been shown to inhibit a number of mediators at clinically relevant concentrations, including in vitro inhibition of ICAM-1 expression on conjunctival and nasal epithelial cells. fexofenadine 13-25 intercellular adhesion molecule 1 Homo sapiens 188-194