PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25759055-7	2015	The findings suggested that a combination of multiple transporters involving organic anion transporting polypeptide (OATP) 2B1, P-glycoprotein (P-gp), and multidrug resistance-associated protein 2 (MRP2) react to stereoselective fexofenadine exposure.	fexofenadine	229-241	solute carrier organic anion transporter family member 2B1	Homo sapiens	77-126	
25759055-11	2015	Moreover, in in vitro studies, the uptake of both fexofenadine enantiomers into OATP2B1 cRNA-injected oocytes was significantly higher than that into water-injected oocytes, and this effect was greater for (R)-fexofenadine.	fexofenadine	50-62	solute carrier organic anion transporter family member 2B1	Homo sapiens	80-87	
25759055-13	2015	Furthermore, OATP2B1 is a key determinant of the stereoselective pharmacokinetics of fexofenadine, and drug transporters may have chiral discrimination ability.	fexofenadine	85-97	solute carrier organic anion transporter family member 2B1	Homo sapiens	13-20	
21780830-5	2011	Studies with cellular models expressing single transporters showed that OATP2B1 expression stimulated uptake of fexofenadine at pH 6.0.	fexofenadine	112-124	solute carrier organic anion transporter family member 2B1	Homo sapiens	72-79	
21780830-6	2011	Apical uptake of fexofenadine into Caco-2 cells was decreased by 45% by pretreatment with estrone 3-sulfate, an OATP inhibitor, at pH 6.0 but not at pH 7.4, indicating that OATP2B1 mediates apical uptake of fexofenadine into these cells.	fexofenadine	17-29	solute carrier organic anion transporter family member 2B1	Homo sapiens	173-180	
21780830-6	2011	Apical uptake of fexofenadine into Caco-2 cells was decreased by 45% by pretreatment with estrone 3-sulfate, an OATP inhibitor, at pH 6.0 but not at pH 7.4, indicating that OATP2B1 mediates apical uptake of fexofenadine into these cells.	fexofenadine	207-219	solute carrier organic anion transporter family member 2B1	Homo sapiens	173-180	
21780830-11	2011	The results provide a novel insight into a vectorial transport system mainly consisting of apical OATP2B1 and basolateral MRP3 that may play an important role in delivering hydrophilic anionic and zwitterionic drugs such as pravastatin and fexofenadine into systemic circulation upon oral administration.	fexofenadine	240-252	solute carrier organic anion transporter family member 2B1	Homo sapiens	98-105	
14610227-5	2004	Dehydroepiandrosterone-sulfate, estrone-3-sulfate, and fexofenadine were transported by OATP-B at both neutral and acidic pH, whereas estradiol-17beta-glucuronide, acetic acid, and lactic acid were not transported at all.	fexofenadine	55-67	solute carrier organic anion transporter family member 2B1	Homo sapiens	88-94	
20839930-2	2010	The area under the plasma concentration-time curve (AUC(0-24)) of S-fexofenadine, but not R-fexofenadine, was significantly lower in subjects with a SLCO2B1*1/*1 allele as compared to subjects with a *3 allele (p = 0.031).	fexofenadine	66-80	solute carrier organic anion transporter family member 2B1	Homo sapiens	149-156	
20839930-4	2010	The pharmacokinetic properties of S-fexofenadine are affected by a single polymorphism of SLCO2B1 in combination with several polymorphisms of ABCB1 C1236T, C3435T, and ABCC2 C-24T.	fexofenadine	34-48	solute carrier organic anion transporter family member 2B1	Homo sapiens	90-97	
20797388-1	2010	OATP1A2 and OATP2B1 are uptake transporters of the human organic anion transporting polypeptide (OATP) family with a broad substrate spectrum including several endogenous compounds as well as drugs such as the antihistaminic drug fexofenadine and HMG-CoA reductase inhibitors.	fexofenadine	230-242	solute carrier organic anion transporter family member 2B1	Homo sapiens	12-19	
33825113-10	2021	CONCLUSIONS: Our study showed a low extent, slow rate of non-enantioselective placental transfer of fexofenadine enantiomers, indicating a limited fetal fexofenadine exposure mediated by placental P-gp and/or OATP2B1.	fexofenadine	100-112	solute carrier organic anion transporter family member 2B1	Homo sapiens	209-216	
32571913-6	2020	40, a common azo dye excipient and a potent inhibitor of OATP2B1, decreased the plasma level of the OATP2B1 substrate fexofenadine, suggesting that FD&C Red No.	fexofenadine	118-130	solute carrier organic anion transporter family member 2B1	Homo sapiens	100-107	
28712300-14	2017	As proof of concept, incorporating OATP2B1 and P-gp markedly improved the EOC and predicted Cmax and Tmax for fexofenadine.	fexofenadine	110-122	solute carrier organic anion transporter family member 2B1	Homo sapiens	35-42	
32571913-6	2020	40, a common azo dye excipient and a potent inhibitor of OATP2B1, decreased the plasma level of the OATP2B1 substrate fexofenadine, suggesting that FD&C Red No.	fexofenadine	118-130	solute carrier organic anion transporter family member 2B1	Homo sapiens	57-64	
30652318-5	2019	In contrast, atorvastatin, bosentan, etoposide, fexofenadine, fluvastatin, glibenclamide and simeprevir were broadly transported by recombinant monkey OATP1B1, OATP1B3 and OATP2B1.	fexofenadine	48-60	solute carrier organic anion transporter family member 2B1	Homo sapiens	172-179	
29635947-5	2018	Expert opinion: Differences in pharmacokinetics between fexofenadine enantiomers were caused by organic anion transporting polypeptide (OATP) 2B1, with a minor contribution from P-glycoprotein (P-gp).	fexofenadine	56-68	solute carrier organic anion transporter family member 2B1	Homo sapiens	96-145	
29635947-8	2018	Apple juice and grape fruit juice, OATP2B1 inhibitors, significantly decrease the exposure of both fexofenadine enantiomers, particularly the (S)-enantiomer, but do not change the t1/2.	fexofenadine	99-111	solute carrier organic anion transporter family member 2B1	Homo sapiens	35-42	
29635947-10	2018	Combinations of multiple transporters such as OATP2B1 and P-gp facilitate enantioselective disposition of fexofenadine.	fexofenadine	106-118	solute carrier organic anion transporter family member 2B1	Homo sapiens	46-53