PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20797388-1 2010 OATP1A2 and OATP2B1 are uptake transporters of the human organic anion transporting polypeptide (OATP) family with a broad substrate spectrum including several endogenous compounds as well as drugs such as the antihistaminic drug fexofenadine and HMG-CoA reductase inhibitors. fexofenadine 230-242 solute carrier organic anion transporter family member 2B1 Homo sapiens 12-19 21780830-5 2011 Studies with cellular models expressing single transporters showed that OATP2B1 expression stimulated uptake of fexofenadine at pH 6.0. fexofenadine 112-124 solute carrier organic anion transporter family member 2B1 Homo sapiens 72-79 21780830-6 2011 Apical uptake of fexofenadine into Caco-2 cells was decreased by 45% by pretreatment with estrone 3-sulfate, an OATP inhibitor, at pH 6.0 but not at pH 7.4, indicating that OATP2B1 mediates apical uptake of fexofenadine into these cells. fexofenadine 17-29 solute carrier organic anion transporter family member 2B1 Homo sapiens 173-180 21780830-6 2011 Apical uptake of fexofenadine into Caco-2 cells was decreased by 45% by pretreatment with estrone 3-sulfate, an OATP inhibitor, at pH 6.0 but not at pH 7.4, indicating that OATP2B1 mediates apical uptake of fexofenadine into these cells. fexofenadine 207-219 solute carrier organic anion transporter family member 2B1 Homo sapiens 173-180 21780830-11 2011 The results provide a novel insight into a vectorial transport system mainly consisting of apical OATP2B1 and basolateral MRP3 that may play an important role in delivering hydrophilic anionic and zwitterionic drugs such as pravastatin and fexofenadine into systemic circulation upon oral administration. fexofenadine 240-252 solute carrier organic anion transporter family member 2B1 Homo sapiens 98-105 25759055-7 2015 The findings suggested that a combination of multiple transporters involving organic anion transporting polypeptide (OATP) 2B1, P-glycoprotein (P-gp), and multidrug resistance-associated protein 2 (MRP2) react to stereoselective fexofenadine exposure. fexofenadine 229-241 solute carrier organic anion transporter family member 2B1 Homo sapiens 77-126 25759055-11 2015 Moreover, in in vitro studies, the uptake of both fexofenadine enantiomers into OATP2B1 cRNA-injected oocytes was significantly higher than that into water-injected oocytes, and this effect was greater for (R)-fexofenadine. fexofenadine 50-62 solute carrier organic anion transporter family member 2B1 Homo sapiens 80-87 25759055-13 2015 Furthermore, OATP2B1 is a key determinant of the stereoselective pharmacokinetics of fexofenadine, and drug transporters may have chiral discrimination ability. fexofenadine 85-97 solute carrier organic anion transporter family member 2B1 Homo sapiens 13-20 33825113-10 2021 CONCLUSIONS: Our study showed a low extent, slow rate of non-enantioselective placental transfer of fexofenadine enantiomers, indicating a limited fetal fexofenadine exposure mediated by placental P-gp and/or OATP2B1. fexofenadine 100-112 solute carrier organic anion transporter family member 2B1 Homo sapiens 209-216 20839930-2 2010 The area under the plasma concentration-time curve (AUC(0-24)) of S-fexofenadine, but not R-fexofenadine, was significantly lower in subjects with a SLCO2B1*1/*1 allele as compared to subjects with a *3 allele (p = 0.031). fexofenadine 66-80 solute carrier organic anion transporter family member 2B1 Homo sapiens 149-156 20839930-4 2010 The pharmacokinetic properties of S-fexofenadine are affected by a single polymorphism of SLCO2B1 in combination with several polymorphisms of ABCB1 C1236T, C3435T, and ABCC2 C-24T. fexofenadine 34-48 solute carrier organic anion transporter family member 2B1 Homo sapiens 90-97 14610227-5 2004 Dehydroepiandrosterone-sulfate, estrone-3-sulfate, and fexofenadine were transported by OATP-B at both neutral and acidic pH, whereas estradiol-17beta-glucuronide, acetic acid, and lactic acid were not transported at all. fexofenadine 55-67 solute carrier organic anion transporter family member 2B1 Homo sapiens 88-94 32571913-6 2020 40, a common azo dye excipient and a potent inhibitor of OATP2B1, decreased the plasma level of the OATP2B1 substrate fexofenadine, suggesting that FD&C Red No. fexofenadine 118-130 solute carrier organic anion transporter family member 2B1 Homo sapiens 57-64 28712300-14 2017 As proof of concept, incorporating OATP2B1 and P-gp markedly improved the EOC and predicted Cmax and Tmax for fexofenadine. fexofenadine 110-122 solute carrier organic anion transporter family member 2B1 Homo sapiens 35-42 32571913-6 2020 40, a common azo dye excipient and a potent inhibitor of OATP2B1, decreased the plasma level of the OATP2B1 substrate fexofenadine, suggesting that FD&C Red No. fexofenadine 118-130 solute carrier organic anion transporter family member 2B1 Homo sapiens 100-107 29635947-5 2018 Expert opinion: Differences in pharmacokinetics between fexofenadine enantiomers were caused by organic anion transporting polypeptide (OATP) 2B1, with a minor contribution from P-glycoprotein (P-gp). fexofenadine 56-68 solute carrier organic anion transporter family member 2B1 Homo sapiens 96-145 30652318-5 2019 In contrast, atorvastatin, bosentan, etoposide, fexofenadine, fluvastatin, glibenclamide and simeprevir were broadly transported by recombinant monkey OATP1B1, OATP1B3 and OATP2B1. fexofenadine 48-60 solute carrier organic anion transporter family member 2B1 Homo sapiens 172-179 29635947-8 2018 Apple juice and grape fruit juice, OATP2B1 inhibitors, significantly decrease the exposure of both fexofenadine enantiomers, particularly the (S)-enantiomer, but do not change the t1/2. fexofenadine 99-111 solute carrier organic anion transporter family member 2B1 Homo sapiens 35-42 29635947-10 2018 Combinations of multiple transporters such as OATP2B1 and P-gp facilitate enantioselective disposition of fexofenadine. fexofenadine 106-118 solute carrier organic anion transporter family member 2B1 Homo sapiens 46-53