PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30148498-6 2018 Based on this method, we identified quantitative lipid-binding preferences and phosphatidyl-inositol phosphates (PIPs) as critical binders of MLKL that are required for plasma membrane targeting and permeabilization in necroptosis. Phosphatidylinositol Phosphates 79-111 mixed lineage kinase domain like pseudokinase Homo sapiens 142-146 30148498-6 2018 Based on this method, we identified quantitative lipid-binding preferences and phosphatidyl-inositol phosphates (PIPs) as critical binders of MLKL that are required for plasma membrane targeting and permeabilization in necroptosis. Phosphatidylinositol Phosphates 113-117 mixed lineage kinase domain like pseudokinase Homo sapiens 142-146 26853145-4 2016 The MLKL brace, proximal to the N-terminal helix bundle (NB), is involved in oligomerization to facilitate plasma membrane targeting through the low-affinity binding of NB to phosphorylated inositol polar head groups of phosphatidylinositol phosphate (PIP) phospholipids. Phosphatidylinositol Phosphates 220-250 mixed lineage kinase domain like pseudokinase Homo sapiens 4-8 26853145-4 2016 The MLKL brace, proximal to the N-terminal helix bundle (NB), is involved in oligomerization to facilitate plasma membrane targeting through the low-affinity binding of NB to phosphorylated inositol polar head groups of phosphatidylinositol phosphate (PIP) phospholipids. Phosphatidylinositol Phosphates 252-255 mixed lineage kinase domain like pseudokinase Homo sapiens 4-8 24813885-0 2014 MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. Phosphatidylinositol Phosphates 57-88 mixed lineage kinase domain like pseudokinase Homo sapiens 0-4 24813885-3 2014 Moreover, we found that a patch of positively charged amino acids on the surface of the 4HBD binds to phosphatidylinositol phosphates (PIPs) and allows recruitment of MLKL to the plasma membrane. Phosphatidylinositol Phosphates 102-133 mixed lineage kinase domain like pseudokinase Homo sapiens 167-171 24813885-3 2014 Moreover, we found that a patch of positively charged amino acids on the surface of the 4HBD binds to phosphatidylinositol phosphates (PIPs) and allows recruitment of MLKL to the plasma membrane. Phosphatidylinositol Phosphates 135-139 mixed lineage kinase domain like pseudokinase Homo sapiens 167-171