PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19554262-0	2010	Nelfinavir induces mitochondria protection by ERK1/2-mediated mcl-1 stabilization that can be overcome by sorafenib.	Nelfinavir	0-10	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	62-67	
19554262-3	2010	In contrast to the pro-apoptotic effect of nelfinavir on human cancer cells, we noticed a significant upregulation of the anti-apoptotic mitochondrial membrane protein mcl-1 by nelfinavir, resulting in a mitochondria-independent induction of apoptosis.	Nelfinavir	177-187	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	168-173	
19554262-6	2010	The combination of nelfinavir with sorafenib, a clinically applied inhibitor of the RAS/RAF/ERK1/2 pathway, inhibited nelfinavir-induced ERK1/2 activation and mcl-1 protein upregulation.	Nelfinavir	19-29	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	159-164	
15078991-2	2004	In this study, we found that protease inhibitors, including ritonavir, saquinavir, and nelfinavir, but not indinavir, induced growth arrest and apoptosis of U266, RPMI8226, and ARH77 human multiple myeloma (MM) cells in association with down-regulation of antiapoptotic protein Mcl-1.	Nelfinavir	87-97	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	278-283	
20105315-7	2010	Despite caspase activation, the upregulation of the anti-apoptotic bcl-2 family member protein mcl-1 that resulted from nelfinavir treatment stabilized the mitochondrial membrane potential, resulting in primarily mitochondria-independent cell death.	Nelfinavir	120-130	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	95-100	
20105315-8	2010	Pharmacological downregulation of mcl-1 expression by treatment with sorafenib (2 microg/ml) significantly enhanced nelfinavir-induced apoptosis even at lower nelfinavir concentrations (5 microg/ml), but did not have additional detrimental effects on non-malignant bone marrow cells.	Nelfinavir	116-126	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	34-39	
20105315-8	2010	Pharmacological downregulation of mcl-1 expression by treatment with sorafenib (2 microg/ml) significantly enhanced nelfinavir-induced apoptosis even at lower nelfinavir concentrations (5 microg/ml), but did not have additional detrimental effects on non-malignant bone marrow cells.	Nelfinavir	159-169	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	34-39	
20105315-0	2010	The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization.	Nelfinavir	49-59	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	116-121