PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15858856-4	2005	Intravenous administration with the P-gp inhibitor GF120918 to mdr1a/1b (+/+) mice increased nelfinavir concentrations over a range of 2.3- to 27-fold, whereas nelfinavir distribution in mdr1a/1b (-/-) mice was 2- to 16-fold higher than that in their wild counterparts.	Nelfinavir	160-170	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	187-192	
15858856-6	2005	In contrast, mdr1a/1b knockout mice exhibited higher nelfinavir levels in the brain (16.1-fold vs. 8.9-fold increase) and spleen (4.1-fold vs. 2.3-fold increase) compared to pharmacological inhibition with GF120918 in wild mice.	Nelfinavir	53-63	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	13-18	
15858856-8	2005	Our results suggest mdr1a/1b-independant mechanisms may also contribute to nelfinavir tissue distribution in mice.	Nelfinavir	75-85	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	20-25