PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30061216-0 2018 Nelfinavir Induces Endoplasmic Reticulum Stress and Sensitizes Renal Cancer Cells to TRAIL. Nelfinavir 0-10 TNF superfamily member 10 Homo sapiens 85-90 30061216-3 2018 MATERIALS AND METHODS: Using renal cancer cells (769-P, 786-O, Caki-2), the ability of nelfinavir to induce ER stress and sensitize them to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) was tested. Nelfinavir 87-97 TNF superfamily member 10 Homo sapiens 140-195 30061216-3 2018 MATERIALS AND METHODS: Using renal cancer cells (769-P, 786-O, Caki-2), the ability of nelfinavir to induce ER stress and sensitize them to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) was tested. Nelfinavir 87-97 TNF superfamily member 10 Homo sapiens 197-202 30061216-6 2018 Nelfinavir induced ER stress and increased the expression of TRAIL death receptor (DR) 4 and DR5, sensitizing the cancer cells to TRAIL. Nelfinavir 0-10 TNF superfamily member 10 Homo sapiens 61-66 30061216-6 2018 Nelfinavir induced ER stress and increased the expression of TRAIL death receptor (DR) 4 and DR5, sensitizing the cancer cells to TRAIL. Nelfinavir 0-10 TNF superfamily member 10 Homo sapiens 130-135 30061216-8 2018 CONCLUSION: Nelfinavir induces ER stress in renal cancer cells and sensitizes them to TRAIL. Nelfinavir 12-22 TNF superfamily member 10 Homo sapiens 86-91 21697087-10 2011 We provide evidence that Nelfinavir-induced ER stress modulates DR5 expression in human glioblastoma multiforme cells and can enhance TRAIL efficacy. Nelfinavir 25-35 TNF superfamily member 10 Homo sapiens 134-139 19000651-0 2008 Nelfinavir induces TRAIL receptor upregulation in ovarian cancer cells. Nelfinavir 0-10 TNF superfamily member 10 Homo sapiens 19-24 19000651-4 2008 Nelfinavir sensitized ovarian cancer cells to treatment with an apoptosis-inducing TRAIL receptor antibody due to upregulation of the TRAIL receptor DR5 as shown by RT-PCR and FACScan analysis. Nelfinavir 0-10 TNF superfamily member 10 Homo sapiens 83-88 19000651-4 2008 Nelfinavir sensitized ovarian cancer cells to treatment with an apoptosis-inducing TRAIL receptor antibody due to upregulation of the TRAIL receptor DR5 as shown by RT-PCR and FACScan analysis. Nelfinavir 0-10 TNF superfamily member 10 Homo sapiens 134-139 19000651-5 2008 We conclude that nelfinavir, an already approved drug, is a highly efficient agent against ovarian cancer cells and could sensitize ovarian cancer cells to TRAIL treatment, either therapeutically applied or endogenously produced by cells of the immune system. Nelfinavir 17-27 TNF superfamily member 10 Homo sapiens 156-161 21697087-0 2011 Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Nelfinavir 99-109 TNF superfamily member 10 Homo sapiens 154-209 21697087-0 2011 Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Nelfinavir 99-109 TNF superfamily member 10 Homo sapiens 211-216