PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17133272-1 2006 HIV-1 protease inhibitor (PI), nelfinavir (NFV) induced growth arrest and apoptosis of NCI-H460 and -H520, A549, EBC-1 and ABC-1 non-small-cell lung cancer (NSCLC) cells in association with upregulation of p21waf1, p27kip1 and p53, and downregulation of Bcl-2 and matrix metalloproteinase (MMP)-2 proteins. Nelfinavir 31-41 matrix metallopeptidase 2 Homo sapiens 264-296 22564423-0 2012 Matrix metalloproteinase-2 and -9 in glioblastoma: a trio of old drugs-captopril, disulfiram and nelfinavir-are inhibitors with potential as adjunctive treatments in glioblastoma. Nelfinavir 97-107 matrix metallopeptidase 2 Homo sapiens 0-33 18302767-8 2008 On the other hand, only Nelfinavir increased significantly Notch 4 processing, Notch4 intracellular domain nuclear localization and the expression of notch intracellular domain targets NFkappaB and matrix metalloproteinase 2. Nelfinavir 24-34 matrix metallopeptidase 2 Homo sapiens 198-224 18302767-11 2008 CONCLUSION: Nelfinavir affects Notch 4 processing that results in induction of expression of the pro-angiogenic genes NFkappaB and matrix metalloproteinase 2 in cerebral endothelial cells. Nelfinavir 12-22 matrix metallopeptidase 2 Homo sapiens 131-157