PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32721806-5	2020	Current data shows that spironolactone may concurrently mitigate abnormal ACE2 expression, correct the balances membrane-attached and free circulating ACE2 and between angiotensin II and Angiotensin-(1-7) (Ang-(1-7)), suppress androgen-mediated TMPRSS2 activity, and inhibit obesity-related RAAS dysfunctions, with consequent decrease of viral priming.	Spironolactone	24-38	transmembrane serine protease 2	Homo sapiens	245-252	
33708781-1	2021	Purpose: On the basis that spironolactone is involved in ACE2 expression and TMPRSS2 activity, previous studies have suggested that spironolactone may influence the infectivity of COVID-19.	Spironolactone	27-41	transmembrane serine protease 2	Homo sapiens	77-84	
33708781-1	2021	Purpose: On the basis that spironolactone is involved in ACE2 expression and TMPRSS2 activity, previous studies have suggested that spironolactone may influence the infectivity of COVID-19.	Spironolactone	132-146	transmembrane serine protease 2	Homo sapiens	77-84	
33477294-10	2021	It has been proposed that spironolactone may prevent acute lung injury in COVID-19 infection due to its pleiotropic effects with favorable renin-angiotensin-aldosterone system (RAAS) and ACE2 expression, reduction in transmembrane serine protease 2 (TMPRSS2) activity and antiandrogenic action, and therefore it may prove to act as additional protection for patients at highest risk of severe pneumonia.	Spironolactone	26-40	transmembrane serine protease 2	Homo sapiens	217-248	
33477294-10	2021	It has been proposed that spironolactone may prevent acute lung injury in COVID-19 infection due to its pleiotropic effects with favorable renin-angiotensin-aldosterone system (RAAS) and ACE2 expression, reduction in transmembrane serine protease 2 (TMPRSS2) activity and antiandrogenic action, and therefore it may prove to act as additional protection for patients at highest risk of severe pneumonia.	Spironolactone	26-40	transmembrane serine protease 2	Homo sapiens	250-257	
33278189-5	2020	Since TMPRSS2 contains an androgen promoter, it may be downregulated by the antiandrogenic actions of spironolactone.	Spironolactone	102-116	transmembrane serine protease 2	Homo sapiens	6-13	
33278189-11	2020	We review the evidence that spironolactone may be the preferred RASSi to increase PN1 and decrease TMPRSS2, furin and plasmin activities and thereby to reduce viral cell binding, entry, infectivity and bad outcomes.	Spironolactone	28-42	transmembrane serine protease 2	Homo sapiens	99-106	
35455823-3	2022	Furthermore, spironolactone, a type of MRA, has been suggested to have a beneficial effect on SARS-CoV-2 outcomes through its dual action as an MRA and antiandrogen, resulting in reduced transmembrane protease receptor serine type 2 (TMPRSS2)-related viral entry to host cells.	Spironolactone	13-27	transmembrane serine protease 2	Homo sapiens	234-241	
34983356-10	2022	However, the combination of dipeptidyl peptidase-4 (DDP4) inhibitors and spironolactone/eplerenone seems to be more effective by reducing soluble ACE2 level, antagonizing TMPRSS2, maintaining ACE2 on cell membrane and reducing risk of viral entry into the cells.	Spironolactone	73-87	transmembrane serine protease 2	Homo sapiens	171-178