PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32820157-8 2020 Further, we found that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) reduced obviously the expression of IRX4 and NANOG by inhibiting the activation of TGF-beta1/Smad3 signaling pathway; moreover, combination of 1,25(OH)2D3 and gefitinib decreased cell viability and proliferation or tumor progression and the expression of IRX4 and NANOG compared with single treatment alone both in PC-9/GR cells and in a PC-9/GR xenograft tumor model. Calcitriol 23-47 transforming growth factor beta 1 Homo sapiens 145-154 32820157-8 2020 Further, we found that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) reduced obviously the expression of IRX4 and NANOG by inhibiting the activation of TGF-beta1/Smad3 signaling pathway; moreover, combination of 1,25(OH)2D3 and gefitinib decreased cell viability and proliferation or tumor progression and the expression of IRX4 and NANOG compared with single treatment alone both in PC-9/GR cells and in a PC-9/GR xenograft tumor model. Calcitriol 49-60 transforming growth factor beta 1 Homo sapiens 145-154 32820157-8 2020 Further, we found that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) reduced obviously the expression of IRX4 and NANOG by inhibiting the activation of TGF-beta1/Smad3 signaling pathway; moreover, combination of 1,25(OH)2D3 and gefitinib decreased cell viability and proliferation or tumor progression and the expression of IRX4 and NANOG compared with single treatment alone both in PC-9/GR cells and in a PC-9/GR xenograft tumor model. Calcitriol 205-216 transforming growth factor beta 1 Homo sapiens 145-154 31729097-7 2020 Calcitriol inhibited migration and invasion not only in TGF-beta1-stimulated but also in TGF-beta1-unstimulated RCC cells. Calcitriol 0-10 transforming growth factor beta 1 Homo sapiens 56-65 32982316-2 2020 1,25 Dihydroxy vitamin D3 (1,25(OH)2D3) is an important therapeutic agent that blocks many features of airway remodeling induced by profibrogenic mediators, such as transforming growth factor beta 1 (TGF-beta1) or T helper type 1 inflammatory cytokines. Calcitriol 0-25 transforming growth factor beta 1 Homo sapiens 165-198 32982316-2 2020 1,25 Dihydroxy vitamin D3 (1,25(OH)2D3) is an important therapeutic agent that blocks many features of airway remodeling induced by profibrogenic mediators, such as transforming growth factor beta 1 (TGF-beta1) or T helper type 1 inflammatory cytokines. Calcitriol 0-25 transforming growth factor beta 1 Homo sapiens 200-209 32982316-2 2020 1,25 Dihydroxy vitamin D3 (1,25(OH)2D3) is an important therapeutic agent that blocks many features of airway remodeling induced by profibrogenic mediators, such as transforming growth factor beta 1 (TGF-beta1) or T helper type 1 inflammatory cytokines. Calcitriol 27-38 transforming growth factor beta 1 Homo sapiens 165-198 32982316-2 2020 1,25 Dihydroxy vitamin D3 (1,25(OH)2D3) is an important therapeutic agent that blocks many features of airway remodeling induced by profibrogenic mediators, such as transforming growth factor beta 1 (TGF-beta1) or T helper type 1 inflammatory cytokines. Calcitriol 27-38 transforming growth factor beta 1 Homo sapiens 200-209 32982316-4 2020 Our aim was to investigate the anti-fibrogenic effect of 1,25(OH)2D3 in TGF-beta1 or TNF-alpha-IL-1beta-stimulated human bronchial fibroblast cells (HBFCs) from severe asthmatic compared with non-asthmatic subjects. Calcitriol 57-68 transforming growth factor beta 1 Homo sapiens 72-81 32982316-11 2020 Additionally, we observed decreased mRNA expression of FN 1, LUM, BGN, MMP2, COL5A1, TIMP1 and CC-chemokines (CCL2, CCL5, CCL11) in response to 1,25(OH)2D3 addition to the TGF-beta1 or TNF-alpha-IL-1beta-stimulated HBFCs. Calcitriol 144-155 transforming growth factor beta 1 Homo sapiens 172-181 32982316-13 2020 1,25(OH)2D3 inhibited proliferation in TGF-beta1-stimulated HBFCs through G0/G1 cell cycle arrest and these effects were not correlated with the induction of apoptosis. Calcitriol 0-11 transforming growth factor beta 1 Homo sapiens 39-48 32452895-0 2020 1alpha, 25-dihydroxyvitamin D3 inhibits transforming growth factor beta1-induced epithelial-mesenchymal transition via beta-catenin pathway. Calcitriol 0-30 transforming growth factor beta 1 Homo sapiens 40-72 32452895-2 2020 Recent studies have shown that 1alpha, 25-dihydroxyvitamin D3(1alpha, 25(OH)2D3) inhibits TGF-beta1-induced EMT, although the underlying mechanism have not yet been fully elucidated. Calcitriol 31-61 transforming growth factor beta 1 Homo sapiens 90-99 32452895-2 2020 Recent studies have shown that 1alpha, 25-dihydroxyvitamin D3(1alpha, 25(OH)2D3) inhibits TGF-beta1-induced EMT, although the underlying mechanism have not yet been fully elucidated. Calcitriol 62-79 transforming growth factor beta 1 Homo sapiens 90-99 32452895-9 2020 CONCLUSION: 1alpha, 25(OH)2D3 synergizes with ICG-001 and inhibits TGF-beta1-induced EMT in alveolar epithelial cells by negatively regulating the Wnt/beta-catenin signaling pathway. Calcitriol 12-29 transforming growth factor beta 1 Homo sapiens 67-76 31729097-7 2020 Calcitriol inhibited migration and invasion not only in TGF-beta1-stimulated but also in TGF-beta1-unstimulated RCC cells. Calcitriol 0-10 transforming growth factor beta 1 Homo sapiens 89-98 31729097-8 2020 Moreover, calcitriol suppressed E-cadherin downregulation and vimentin upregulation not only in TGF-beta1-stimulated but also in TGF-beta1-unstimulated ACHN and CAKI-2 cells. Calcitriol 10-20 transforming growth factor beta 1 Homo sapiens 96-105 31729097-8 2020 Moreover, calcitriol suppressed E-cadherin downregulation and vimentin upregulation not only in TGF-beta1-stimulated but also in TGF-beta1-unstimulated ACHN and CAKI-2 cells. Calcitriol 10-20 transforming growth factor beta 1 Homo sapiens 129-138 31729097-10 2020 In addition, calcitriol blocked TGF-beta1-induced nuclear translocation of ZEB1, Snail and Twist1 in ACHN and CAKI-2 cells. Calcitriol 13-23 transforming growth factor beta 1 Homo sapiens 32-41 31204163-3 2019 In this study, the effect of calcitriol on the TGFbeta/Smad signaling pathway and miR-21 expression in human bronchial fibroblasts was investigated to explore the mechanism of action of calcitriol and the inhaled glucocorticoid, budesonide, in airway remodeling. Calcitriol 29-39 transforming growth factor beta 1 Homo sapiens 47-54 31196627-0 2019 1alpha,25-dihydroxyvitamin D3 attenuates oxidative stress-induced damage in human trabecular meshwork cells by inhibiting TGFbeta-SMAD3-VDR pathway. Calcitriol 0-29 transforming growth factor beta 1 Homo sapiens 122-129 31196627-5 2019 Overall, these findings define a mechanism by which 1, 25-(OH)2D3 reduces ECM accumulation and suppresses the TGF-beta-SMAD3-VDR pathway in HTMCs, thus protecting the cells from oxidative stress, suggesting 1, 25-(OH)2D3 might be a potential therapeutic for glaucoma. Calcitriol 52-65 transforming growth factor beta 1 Homo sapiens 110-118 30465855-6 2019 In fact we showed that 1,25(OH)2D3 repressed the transcriptional induction of respiratory complex, limited the enhanced mitochondrial membrane potential and restrained the increased levels of mitochondrial ATP; 1,25(OH)2D3 also decreased the production of reactive oxygen species promoted by TGF-beta. Calcitriol 23-34 transforming growth factor beta 1 Homo sapiens 292-300 30465855-6 2019 In fact we showed that 1,25(OH)2D3 repressed the transcriptional induction of respiratory complex, limited the enhanced mitochondrial membrane potential and restrained the increased levels of mitochondrial ATP; 1,25(OH)2D3 also decreased the production of reactive oxygen species promoted by TGF-beta. Calcitriol 211-222 transforming growth factor beta 1 Homo sapiens 292-300 31204163-8 2019 Both budesonide and calcitriol up-regulated the low expression of VDR induced by TGFbeta1 in human bronchial fibroblasts. Calcitriol 20-30 transforming growth factor beta 1 Homo sapiens 81-89 28259913-7 2017 1,25(OH)2D3 pretreatment inhibited the expression of inflammatory cytokines in HPMCs and attenuated HG-induced EMT, possibly through inhibition of the TGFbeta/Smad pathway by binding to its receptor VDR. Calcitriol 0-11 transforming growth factor beta 1 Homo sapiens 151-158 28926770-0 2017 1,25(OH)2D3 induces regulatory T cell differentiation by influencing the VDR/PLC-gamma1/TGF-beta1/pathway. Calcitriol 0-11 transforming growth factor beta 1 Homo sapiens 88-97 28926770-6 2017 In addition, 1,25(OH)2D3 promoted secretion of the anti-inflammatory cytokine, transforming Growth Factor beta1 (TGF-beta1) but suppressed pro-inflammatory cytokines such as interleukin-17 (IL-17). Calcitriol 13-24 transforming growth factor beta 1 Homo sapiens 79-111 28926770-6 2017 In addition, 1,25(OH)2D3 promoted secretion of the anti-inflammatory cytokine, transforming Growth Factor beta1 (TGF-beta1) but suppressed pro-inflammatory cytokines such as interleukin-17 (IL-17). Calcitriol 13-24 transforming growth factor beta 1 Homo sapiens 113-122 28779150-7 2017 Treatment with 1,25(OH)2D3 also significantly suppressed TGF-beta1-enhanced contractility and motility in a contraction assay and Transwell migration assay. Calcitriol 15-26 transforming growth factor beta 1 Homo sapiens 57-66 28779150-9 2017 Taken together, our results suggest that 1,25(OH)2D3 might be an effective therapy for nasal polyps by reducing myofibroblast differentiation and ECM production mediated by Smad2/3-dependent TGF-beta1 signaling pathways in NPDFs. Calcitriol 41-52 transforming growth factor beta 1 Homo sapiens 191-200 26396142-6 2015 Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1. Calcitriol 36-46 transforming growth factor beta 1 Homo sapiens 275-283 26523511-3 2015 In this study, the effect of 1,25(OH)2D3 on TGF-beta1/beta2-induced epithelial-mesenchymal transition (EMT) is tested in colon cancer cells. Calcitriol 29-40 transforming growth factor beta 1 Homo sapiens 44-53 26523511-4 2015 The results suggest that 1,25(OH)2D3 inhibited TGF-beta1/beta2-induced increased invasion and migration of in SW-480 and HT-29 cells. Calcitriol 25-36 transforming growth factor beta 1 Homo sapiens 47-56 26523511-7 2015 1,25(OH)2D3 also inhibited the secretion of MMP-2 and MMP-9 and increased expression of F-actin induced by TGF-beta1/beta2 in SW-480 cells. Calcitriol 0-11 transforming growth factor beta 1 Homo sapiens 107-116 26061181-0 2015 1,25 Dihydroxyvitamin D3 Inhibits TGFbeta1-Mediated Primary Human Cardiac Myofibroblast Activation. Calcitriol 0-24 transforming growth factor beta 1 Homo sapiens 34-42 26311239-6 2015 1,25(OH)2D3 inhibited differentiation and downregulated miR-27b expression in human lung fibroblasts induced by TGF-beta1. Calcitriol 0-11 transforming growth factor beta 1 Homo sapiens 112-121 26061181-7 2015 1,25(OH)2D3 treatment significantly inhibited TGFbeta1-mediated cell contraction, and confocal imaging demonstrated reduced stress fiber formation in the presence of 1,25(OH)2D3. Calcitriol 0-11 transforming growth factor beta 1 Homo sapiens 46-54 25204635-7 2015 Additionally, calcitriol attenuated TNFalpha and TGFbeta-induced collagen III expression and deposition, and separately, inhibited proliferation of fetal ASM cells induced by either inflammatory mediator. Calcitriol 14-24 transforming growth factor beta 1 Homo sapiens 49-56 25204635-9 2015 Overall, our data demonstrate that calcitriol can blunt multiple effects of TNFalpha and TGFbeta in developing airway, and point to a potentially novel approach to alleviating structural changes in inflammatory airway diseases of childhood. Calcitriol 35-45 transforming growth factor beta 1 Homo sapiens 89-96 24356557-8 2013 It turns out that calcitriol effectively blocks myofibroblast activation from interstitial fibroblasts, as evidenced by suppression of TGF-beta1-mediated alpha-SMA expression. Calcitriol 18-28 transforming growth factor beta 1 Homo sapiens 135-144 26495304-9 2015 Meanwhile, 1alpha,25(OH)2D3 also ameliorated TGF-beta1-induced decrease in E-cadherin expression, increase in Snai1 and alpha-SMA expression, intracellular F-actin redistribution, and migration activity in vitro. Calcitriol 11-27 transforming growth factor beta 1 Homo sapiens 45-54 25413472-9 2014 Calcitriol attenuated TGF-beta1- and TGF-beta2-induced cell motility. Calcitriol 0-10 transforming growth factor beta 1 Homo sapiens 22-31 25413472-10 2014 Also, calcitriol inhibited the expression of EMT markers in TGF-beta1-treated epithelial cells with less effect on TGF-beta2. Calcitriol 6-16 transforming growth factor beta 1 Homo sapiens 60-69 25413472-11 2014 CONCLUSIONS: These data suggest that calcitriol inhibits both migration and invasion induced by TGF-beta1 and TGF-beta2 in human airway epithelial cells. Calcitriol 37-47 transforming growth factor beta 1 Homo sapiens 96-105 12562365-9 2003 In response to stimulation by 1,25-(OH)2D3 cellular production of TGF-beta1, was also significantly greater (P < 0.05) on the blasted surfaces than on the turned one. Calcitriol 30-42 transforming growth factor beta 1 Homo sapiens 66-75 20504837-9 2011 Vitamin D receptor activation with paricalcitol or calcitriol prevented the increase in TGF-beta1, CD74 and extracellular matrix induced by lyso-Gb3. Calcitriol 51-61 transforming growth factor beta 1 Homo sapiens 88-97 15042604-0 2004 1alpha,25-dihydroxyvitamin D3 induced growth inhibition of PC-3 prostate cancer cells requires an active transforming growth factor beta signaling pathway. Calcitriol 0-29 transforming growth factor beta 1 Homo sapiens 105-136 15042604-8 2004 We show that 1,25(OH)2D3 treatment elevates TGFbeta production and signaling, as well as receptor levels, in PC-3 cells. Calcitriol 13-24 transforming growth factor beta 1 Homo sapiens 44-51 11246968-2 2001 MG63 cells exhibit decreased proliferation and increased differentiation when cultured on rough Ti surfaces (Ra > 2 microm) and response to 1,25-(OH)2D3 is enhanced, resulting in synergistic increases in TGF-beta1 and PGE2. Calcitriol 143-155 transforming growth factor beta 1 Homo sapiens 207-216 11925111-7 2002 Our results suggest that 1,25(OH)2-vitamin D3 modulates in opposite ways the effects of BMP7 and TGFbeta1 on osteoblast differentiation. Calcitriol 25-45 transforming growth factor beta 1 Homo sapiens 97-105 11597027-3 2001 In this study, we examined the effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the expressions of osteocalcin and osteonectin/secreted protein, acidic and rich in cysteine (SPARC), by human pulp cells in the presence or absence of transforming growth factor-beta1 (TGF-beta1) or basic fibroblast growth factor (bFGF). Calcitriol 42-66 transforming growth factor beta 1 Homo sapiens 236-268 11597027-3 2001 In this study, we examined the effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the expressions of osteocalcin and osteonectin/secreted protein, acidic and rich in cysteine (SPARC), by human pulp cells in the presence or absence of transforming growth factor-beta1 (TGF-beta1) or basic fibroblast growth factor (bFGF). Calcitriol 42-66 transforming growth factor beta 1 Homo sapiens 270-279 12223346-4 2002 We observed that 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] sensitized Caco-2 and SW480 cells to TGF-beta 1 growth inhibitory effects. Calcitriol 17-43 transforming growth factor beta 1 Homo sapiens 99-109 11820800-0 2002 1 alpha,25-dihydroxyvitamin D3 increases TGF beta 1 binding to human osteoblasts. Calcitriol 0-30 transforming growth factor beta 1 Homo sapiens 41-51 11597027-5 2001 The osteocalcin level induced by 1,25(OH)2D3 was decreased and increased by TGF-beta1 and bFGF, respectively. Calcitriol 33-44 transforming growth factor beta 1 Homo sapiens 76-85 11246968-13 2001 The effect of 1,25-(OH)2D3 on TGF-beta1 production is not via PKC. Calcitriol 14-26 transforming growth factor beta 1 Homo sapiens 30-39 10547074-1 1999 Transforming growth factor beta (TGF-beta) enhanced the growth-inhibitory activities of dexamethasone (Dex) and 1alpha,25-dihydroxyvitamin D3 (VD3) on human monocytoid leukemia U937 cells. Calcitriol 112-141 transforming growth factor beta 1 Homo sapiens 0-31 10809903-0 2000 Production and action of transforming growth factor-beta in human osteoblast cultures: dependence on cell differentiation and modulation by calcitriol. Calcitriol 140-150 transforming growth factor beta 1 Homo sapiens 25-56 10809903-12 2000 TGF-beta1 inhibited collagen type I production in hMS(OB) cells and these effects were abolished in presence of calcitriol. Calcitriol 112-122 transforming growth factor beta 1 Homo sapiens 0-9 10809903-13 2000 In presence of calcitriol, TGF-beta1 increased collagen type I production in hOB cells. Calcitriol 15-25 transforming growth factor beta 1 Homo sapiens 27-36 11122013-3 2000 Objectives Here we report the response of the TGF-beta regulation system to 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], an active vitamin D3 analogue Patients/methods We studied two types of fibroblasts derived from normal and psoriatic lesional skin, using an enzyme-linked immunosorbent assay and Northern blotting techniques. Calcitriol 76-105 transforming growth factor beta 1 Homo sapiens 46-54 10547074-1 1999 Transforming growth factor beta (TGF-beta) enhanced the growth-inhibitory activities of dexamethasone (Dex) and 1alpha,25-dihydroxyvitamin D3 (VD3) on human monocytoid leukemia U937 cells. Calcitriol 112-141 transforming growth factor beta 1 Homo sapiens 33-41 9823454-0 1998 Treatment of resting zone chondrocytes with transforming growth factor-beta 1 induces differentiation into a phenotype characteristic of growth zone chondrocytes by downregulating responsiveness to 24,25-(OH)2D3 and upregulating responsiveness to 1,25-(OH)2D3. Calcitriol 247-259 transforming growth factor beta 1 Homo sapiens 44-77 9823454-5 1998 When RC cells were pretreated for 120 h with TGF-beta 1, treatment with 1,25-(OH)2D3 caused a dose-dependent increase in ALPase-specific activity and collagen synthesis, with no effect on proteoglycan production. Calcitriol 72-84 transforming growth factor beta 1 Homo sapiens 45-55 9071474-2 1997 However, we previously found an inverse relationship between the TGF beta-induced VDR up-regulation and subsequent 1,25-(OH)2D3-induced biological responses. Calcitriol 115-127 transforming growth factor beta 1 Homo sapiens 65-73 9502167-7 1998 In normal or transformed epithelial cells, it has been demonstrated that the inhibitory effect of calcitriol on cell growth could be related to an induction of TGF-beta synthesis, and of a paracrine/autocrine loop. Calcitriol 98-108 transforming growth factor beta 1 Homo sapiens 160-168 9202299-4 1997 Calcitriol had an additive effect when applied together with IL-1beta and a synergistic effect when applied with TGF-beta1. Calcitriol 0-10 transforming growth factor beta 1 Homo sapiens 113-122 9202299-5 1997 Moreover, calcitriol not only counteracted the inhibitory effect of corticosterone on NGF secretion stimulated by TGF-beta1 but even augmented it to a level more than threefold higher than that reached with TGF-beta1 alone. Calcitriol 10-20 transforming growth factor beta 1 Homo sapiens 114-123 9660180-7 1998 Addition of cycloheximide together with the second inducer inhibited only the TGFbeta but not the calcitriol effects, which indicated that there is a direct stimulation of 5-LO transcription by calcitriol in the presence of TGFbeta-induced proteins. Calcitriol 194-204 transforming growth factor beta 1 Homo sapiens 78-85 9225067-10 1997 Cell lines sensitive to TGF beta 1 each expressed PKC delta endogenously, or expression was up-regulated with 1,25-dihydroxyvitamin D3. Calcitriol 110-134 transforming growth factor beta 1 Homo sapiens 24-34 9135559-5 1997 The basal as well as IL-4, IL-6, IFN-gamma, TNF-alpha and TGF-beta-driven levels of HLA-ABC Ag were significantly diminished by calcitriol. Calcitriol 128-138 transforming growth factor beta 1 Homo sapiens 58-66 8954158-8 1996 Also, 5-lipoxygenase activity in homogenates or 100,000 x g supernatants of 1,25-dihydroxyvitamin D3/TGF beta differentiated HL-60 cells and of human granulocytes was not inhibited by dithiothreitol or GSH. Calcitriol 76-100 transforming growth factor beta 1 Homo sapiens 101-109 7882362-0 1995 1,25-Dihydroxyvitamin D3 enhances the expression of transforming growth factor beta 1 and its latent form binding protein in cultured breast carcinoma cells. Calcitriol 0-24 transforming growth factor beta 1 Homo sapiens 52-85 8687506-6 1996 This study shows that TGF-beta is involved in the growth response to calcitriol and KH1060 in MCF-7 cells. Calcitriol 69-79 transforming growth factor beta 1 Homo sapiens 22-30 8852947-0 1996 1,25-dihydroxyvitamin D3-mediated transforming growth factor-beta release is impaired in cultured osteoblasts from patients with multiple pituitary hormone deficiencies. Calcitriol 0-24 transforming growth factor beta 1 Homo sapiens 34-65 1572278-13 1992 Recombinant human transforming growth factor-beta 1 increased the percent production of 1,25-(OH)2D3 after 1 h in resting zone cells and, after 24 h, the production of 24,25-(OH)2D3 in growth zone cells. Calcitriol 88-100 transforming growth factor beta 1 Homo sapiens 18-51 7817811-2 1994 In addition, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]-induced osteocalcin synthesis was greatly influenced by TGF-beta 1. Calcitriol 13-37 transforming growth factor beta 1 Homo sapiens 108-118 7817811-2 1994 In addition, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]-induced osteocalcin synthesis was greatly influenced by TGF-beta 1. Calcitriol 39-50 transforming growth factor beta 1 Homo sapiens 108-118 1295905-0 1992 1,25-Dihydroxy-vitamin-D3 enhances antiproliferative effect and transcription of TGF-beta1 on human keratinocytes in culture. Calcitriol 0-25 transforming growth factor beta 1 Homo sapiens 81-90 1295905-11 1992 When keratinocyte cultures were treated with 1,25(OH)2D3 and neutralizing antibodies to TGF-beta, the induced-antiproliferative activity was blocked by more than 50%. Calcitriol 45-56 transforming growth factor beta 1 Homo sapiens 88-96 1577731-1 1992 Transforming growth factor beta (TGF beta) and 1,25-dihydroxyvitamin D3 (1,25D3), when added simultaneously to a human osteosarcoma cell line, MG-63, induce alkaline phosphatase activity 40-70-fold over basal levels, 6-7-fold over 1,25D3 treatment alone, and 15-20-fold over TGF beta treatment alone. Calcitriol 47-71 transforming growth factor beta 1 Homo sapiens 275-283 1611299-8 1992 When TGF beta was combined with 1,25(OH)2D3, 1,25(OH)2D3 had no effect on phospholipase A2 and did not interfere with TGF beta stimulation of phospholipase A2 activity. Calcitriol 45-56 transforming growth factor beta 1 Homo sapiens 5-13 1611299-10 1992 Therefore, TGF beta not only plays an important role in matrix formation and differentiation, but works in conjunction with 1,25(OH)2D3 to greatly potentiate the effects seen with 1,25(OH)2D3 alone. Calcitriol 124-135 transforming growth factor beta 1 Homo sapiens 11-19 1611299-10 1992 Therefore, TGF beta not only plays an important role in matrix formation and differentiation, but works in conjunction with 1,25(OH)2D3 to greatly potentiate the effects seen with 1,25(OH)2D3 alone. Calcitriol 180-191 transforming growth factor beta 1 Homo sapiens 11-19 7961777-0 1994 Latent transforming growth factor-beta is produced by chondrocytes and activated by extracellular matrix vesicles upon exposure to 1,25-(OH)2D3. Calcitriol 131-143 transforming growth factor beta 1 Homo sapiens 7-38 7961777-3 1994 However, when 1,25-(OH)2D3 is added, a dose-dependent inhibition of latent TGF-beta release is found. Calcitriol 14-26 transforming growth factor beta 1 Homo sapiens 75-83 7980561-0 1994 Modulation of responses to TGF-beta by 1, 25 dihydroxyvitamin D3 in MG-63 osteoblastic cells: possible involvement of regulation of TGF-beta type II receptor. Calcitriol 39-64 transforming growth factor beta 1 Homo sapiens 27-35 1324244-0 1992 Transforming growth factor-beta enhances calcitonin-induced cyclic AMP production and the number of calcitonin receptors in long-term cultures of human umbilical cord blood monocytes in the presence of 1,25-dihydroxycholecalciferol. Calcitriol 202-231 transforming growth factor beta 1 Homo sapiens 0-31 1498252-4 1992 Treatment of the cells with the systemic hormones 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] (10(-8) M) and parathyroid hormone (10(-7) M) induced an increase in TGF-beta mRNA but failed to stimulate the production of IL-1-beta mRNA. Calcitriol 50-76 transforming growth factor beta 1 Homo sapiens 159-167 1498252-4 1992 Treatment of the cells with the systemic hormones 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] (10(-8) M) and parathyroid hormone (10(-7) M) induced an increase in TGF-beta mRNA but failed to stimulate the production of IL-1-beta mRNA. Calcitriol 76-88 transforming growth factor beta 1 Homo sapiens 159-167 1498252-10 1992 However, when the stimulating agent 1,25-(OH)2D3 was added in conjunction with hydrocortisone the mRNA expression of TGF-beta mRNA returned to 70% of the stimulated level. Calcitriol 36-48 transforming growth factor beta 1 Homo sapiens 117-125 2384446-0 1990 Transforming growth factor-beta 1 modulates the effect of 1 alpha, 25-dihydroxyvitamin D3 on leukemic cells. Calcitriol 58-89 transforming growth factor beta 1 Homo sapiens 0-33 35025148-0 2022 1,25-(OH)2D3 participates and modulates airway remodeling by reducing MGP and TGF-beta1 expression in TNF-alpha-induced airway smooth muscle cells. Calcitriol 0-12 transforming growth factor beta 1 Homo sapiens 78-87 35025148-10 2022 The 1,25-(OH)2D3 treatment significantly reduced TGF-beta1 expression (0.69 +-0.17), compared to that of the TNF-alpha group (1.6 +-0.18) (p < 0.05). Calcitriol 4-16 transforming growth factor beta 1 Homo sapiens 49-58 35025148-11 2022 CONCLUSIONS: The 1,25-(OH)2D3 could participate and modulate airway remodeling by reducing MGP and TGF-beta1 expression in TNF-alpha-induced ASMCs. Calcitriol 17-29 transforming growth factor beta 1 Homo sapiens 99-108 34894920-5 2021 Furthermore, 1alpha,25(OH)2D3 dramatically decreased the secretion of TGF-beta1 and MMP-9 in M2 macrophages. Calcitriol 13-29 transforming growth factor beta 1 Homo sapiens 70-79