PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10679076-3 2000 1,25(OH)2D3 prevents the differentiation in immature DCs of human monocytes cultured with GM-CSF and IL-4. Calcitriol 0-11 colony stimulating factor 2 Homo sapiens 90-96 8136311-2 1994 Monocytic maturation may be induced in acute myeloid leukaemia (AML) blasts and the U937 leukaemic cell line by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], an effect which is augmented by both gamma interferon (IFN) or granulocyte-macrophage colony stimulating factor (GM-CSF). Calcitriol 112-136 colony stimulating factor 2 Homo sapiens 215-263 10022520-8 1999 On the other hand, 1,25(OH)2D3 dose-dependently inhibited both GM-CSF- and 5637 CM-driven myeloid colony formation by as much as 90% at 100 nM. Calcitriol 19-30 colony stimulating factor 2 Homo sapiens 63-69 10022520-9 1999 Addition of IL-1beta to GM-CSF-stimulated cultures dampened the inhibitory effect of 1,25(OH)2D3. Calcitriol 85-96 colony stimulating factor 2 Homo sapiens 24-30 9553089-5 1998 We report here that GMCSF transcription in Jurkat T cells is also directly repressed by 1, 25-(OH)2D3 and VDR. Calcitriol 88-101 colony stimulating factor 2 Homo sapiens 20-25 10330159-1 1999 We previously described a control element in the granulocyte-macrophage colony-stimulating factor (GM-CSF) enhancer that is necessary and sufficient to mediate both transcriptional activation in response to T-cell stimuli and transcriptional repression by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] through the vitamin D3 receptor (VDR). Calcitriol 256-280 colony stimulating factor 2 Homo sapiens 49-97 10330159-1 1999 We previously described a control element in the granulocyte-macrophage colony-stimulating factor (GM-CSF) enhancer that is necessary and sufficient to mediate both transcriptional activation in response to T-cell stimuli and transcriptional repression by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] through the vitamin D3 receptor (VDR). Calcitriol 256-280 colony stimulating factor 2 Homo sapiens 99-105 9808170-1 1998 1Alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] exerts several effects on the immune system, by regulating lymphocyte proliferation, differentiation of monocytes and secretion of cytokines as IL-2, granulocyte-macrophage colony-stimulating factor and IFN-gamma in T cells. Calcitriol 0-29 colony stimulating factor 2 Homo sapiens 195-257 9808170-1 1998 1Alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] exerts several effects on the immune system, by regulating lymphocyte proliferation, differentiation of monocytes and secretion of cytokines as IL-2, granulocyte-macrophage colony-stimulating factor and IFN-gamma in T cells. Calcitriol 31-43 colony stimulating factor 2 Homo sapiens 195-257 7643018-2 1995 On both monocyte-derived macrophages and the myelomonocytic cell lines, Fc alpha R/CD89 expression was induced by calcitriol alone and additively in combination with tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and granulocyte-macrophage colony-stimulating factor. Calcitriol 114-124 colony stimulating factor 2 Homo sapiens 241-289 8018933-3 1994 Similarly, HL-60 cells pretreated with retinoic acid or 1,25 dihydroxyvitamin D3 were also capable of responding to GM-CSF. Calcitriol 56-80 colony stimulating factor 2 Homo sapiens 116-122 8136311-2 1994 Monocytic maturation may be induced in acute myeloid leukaemia (AML) blasts and the U937 leukaemic cell line by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], an effect which is augmented by both gamma interferon (IFN) or granulocyte-macrophage colony stimulating factor (GM-CSF). Calcitriol 112-136 colony stimulating factor 2 Homo sapiens 265-271 8121721-14 1993 Secondary signals involve the production of cytokines such as TNF alpha, IL2 and GM-CSF being transduced by bacterial cell wall products (such as lipopolysaccharide, teichoic acid, or lipoarabinomanan) or by the calcitriol pathway recently described during mycobacterial infection. Calcitriol 212-222 colony stimulating factor 2 Homo sapiens 81-87 7681783-8 1993 When calcitriol was added, the following increases in day-20 TRAP-positive colonies occurred: with M-CSF, 189%; with IL-3, 109%; with the combination of M-CSF and IL-3, 52%; and with GM-CSF there was no change. Calcitriol 5-15 colony stimulating factor 2 Homo sapiens 183-189 1378159-3 1992 In addition, the effective concentration of 1,25(OH)2D3 was reduced by up to 100 times in the presence of GM-CSF. Calcitriol 44-55 colony stimulating factor 2 Homo sapiens 106-112 1994545-1 1991 It is known that 1,25(OH)2D3 inhibits IL-2, IFN-gamma, and GM-CSF mRNA accumulation in activated T cells. Calcitriol 17-28 colony stimulating factor 2 Homo sapiens 59-65 2183943-0 1990 1,25 Dihydroxyvitamin D3-dependent inhibition of growth or killing of Mycobacterium avium complex in human macrophages is mediated by TNF and GM-CSF. Calcitriol 0-24 colony stimulating factor 2 Homo sapiens 142-148 2323362-7 1990 GM-CSF caused an increase (193%, p less than 0.0004) in total colony numbers that was only partially inhibited by calcitriol. Calcitriol 114-124 colony stimulating factor 2 Homo sapiens 0-6 2323362-11 1990 When GM-CSF was present, calcitriol caused a maximum number of TRAP-positive colonies to appear at 1 nM, and it caused a drastic decrease in TRAP-positive colonies at higher doses. Calcitriol 25-35 colony stimulating factor 2 Homo sapiens 5-11 2323362-12 1990 Calcitriol at 10 nM caused TRAP-negative colonies to increase in number and proportion when GM-CSF was present, but in the presence of M-CSF, the same dose of calcitriol caused a decline in numbers of TRAP-negative colonies. Calcitriol 0-10 colony stimulating factor 2 Homo sapiens 92-98 3290254-0 1988 1,25-Dihydroxyvitamin D3 modulates the expression of a lymphokine (granulocyte-macrophage colony-stimulating factor) posttranscriptionally. Calcitriol 0-24 colony stimulating factor 2 Homo sapiens 67-115 3290254-1 1988 We recently showed that 1,25(OH)2D3 sensitively inhibited the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in normal human mitogen-activated peripheral blood lymphocytes and in the human T lymphotropic virus I immortalized T cell line known as S-LB1 at the levels of both mRNA and protein. Calcitriol 24-35 colony stimulating factor 2 Homo sapiens 76-124 3290254-1 1988 We recently showed that 1,25(OH)2D3 sensitively inhibited the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in normal human mitogen-activated peripheral blood lymphocytes and in the human T lymphotropic virus I immortalized T cell line known as S-LB1 at the levels of both mRNA and protein. Calcitriol 24-35 colony stimulating factor 2 Homo sapiens 126-132 3290254-2 1988 Using S-LB1 cells as a model system the present paper identifies at least in part the mechanisms by which 1,25(OH)2D3 regulates the expression of GM-CSF. Calcitriol 106-117 colony stimulating factor 2 Homo sapiens 146-152 3290254-4 1988 Studies using cycloheximide as a protein synthesis inhibitor showed that the inhibitory action of 1,25(OH)2D3 on GM-CSF expression was dependent on new protein synthesis. Calcitriol 98-109 colony stimulating factor 2 Homo sapiens 113-119 3290254-7 1988 Taken together, these results demonstrate that 1,25(OH)2D3 regulates expression of the lymphokine GM-CSF posttranscriptionally by influencing the stability of GM-CSF mRNA. Calcitriol 47-58 colony stimulating factor 2 Homo sapiens 98-104 3290254-7 1988 Taken together, these results demonstrate that 1,25(OH)2D3 regulates expression of the lymphokine GM-CSF posttranscriptionally by influencing the stability of GM-CSF mRNA. Calcitriol 47-58 colony stimulating factor 2 Homo sapiens 159-165 30610965-0 2019 Calcitriol, but not FGF23, increases in CSF and serum of MS patients. Calcitriol 0-10 colony stimulating factor 2 Homo sapiens 40-43 30610965-3 2019 The probable changes of FGF23 and calcitriol concentrations in the CSF and serum of patients with MS were evaluated. Calcitriol 34-44 colony stimulating factor 2 Homo sapiens 67-70 30610965-4 2019 Calcitriol concentration in the CSF and serum of MS patients was significantly higher than that in non-MS patients, while FGF23 concentration in MS patients was comparable to controls. Calcitriol 0-10 colony stimulating factor 2 Homo sapiens 32-35 30610965-5 2019 We concluded that calcitriol concentration increases in the CSF and serum of MS patients independent of FGF23 status. Calcitriol 18-28 colony stimulating factor 2 Homo sapiens 60-63 25458313-7 2015 Moreover, addition of the immune modulator calcitriol to the former condition resulted in reduced frequencies of Th17 and GM-CSF+Th17 cells, and also of IL-10+ Th cells. Calcitriol 43-53 colony stimulating factor 2 Homo sapiens 122-128 1505451-8 1992 In the presence of 1,25-dihydroxyvitamin D3, IGF-I, like granulocyte-macrophage colony-stimulating factor (GM-CSF), dose-dependently increased the number of TRAP-positive MNCs. Calcitriol 19-43 colony stimulating factor 2 Homo sapiens 57-105 1505451-8 1992 In the presence of 1,25-dihydroxyvitamin D3, IGF-I, like granulocyte-macrophage colony-stimulating factor (GM-CSF), dose-dependently increased the number of TRAP-positive MNCs. Calcitriol 19-43 colony stimulating factor 2 Homo sapiens 107-113 1708292-0 1991 Dexamethasone and 1,25-dihydroxyvitamin D3, but not cyclosporine A, inhibit production of granulocyte-macrophage colony-stimulating factor in human fibroblasts. Calcitriol 18-42 colony stimulating factor 2 Homo sapiens 90-138 1708292-5 1991 Similarly, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], a hormone with possible physiologic immunoregulatory significance, reduced GM-CSF expression in a concentration- and time-dependent manner. Calcitriol 11-35 colony stimulating factor 2 Homo sapiens 126-132 1708292-5 1991 Similarly, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], a hormone with possible physiologic immunoregulatory significance, reduced GM-CSF expression in a concentration- and time-dependent manner. Calcitriol 37-48 colony stimulating factor 2 Homo sapiens 126-132 2323362-0 1990 Modulation of tartrate-resistant acid phosphatase expression by calcitriol in CSF-induced macrophage colonies. Calcitriol 64-74 colony stimulating factor 2 Homo sapiens 78-81 2323362-3 1990 In addition, the effect of 1,25-dihydroxyvitamin D3 (calcitriol) on CSF-induced colony growth and TRAP expression was also determined. Calcitriol 27-51 colony stimulating factor 2 Homo sapiens 68-71 2323362-3 1990 In addition, the effect of 1,25-dihydroxyvitamin D3 (calcitriol) on CSF-induced colony growth and TRAP expression was also determined. Calcitriol 53-63 colony stimulating factor 2 Homo sapiens 68-71 2594016-1 1989 1,25-Dihydroxyvitamin-D3 (1,25-D3) is known to inhibit DNA synthesis, immunoglobulin and lymphokine production [interleukin-2 (IL-2), gamma interferon (G-IFN), and granulocyte-monocyte colony-stimulating factor (GM-CSF)] by mitogen-stimulated human peripheral blood mononuclear cells (PBMCs). Calcitriol 0-24 colony stimulating factor 2 Homo sapiens 164-210 2594016-1 1989 1,25-Dihydroxyvitamin-D3 (1,25-D3) is known to inhibit DNA synthesis, immunoglobulin and lymphokine production [interleukin-2 (IL-2), gamma interferon (G-IFN), and granulocyte-monocyte colony-stimulating factor (GM-CSF)] by mitogen-stimulated human peripheral blood mononuclear cells (PBMCs). Calcitriol 0-24 colony stimulating factor 2 Homo sapiens 212-218 2594016-1 1989 1,25-Dihydroxyvitamin-D3 (1,25-D3) is known to inhibit DNA synthesis, immunoglobulin and lymphokine production [interleukin-2 (IL-2), gamma interferon (G-IFN), and granulocyte-monocyte colony-stimulating factor (GM-CSF)] by mitogen-stimulated human peripheral blood mononuclear cells (PBMCs). Calcitriol 26-33 colony stimulating factor 2 Homo sapiens 164-210 2594016-1 1989 1,25-Dihydroxyvitamin-D3 (1,25-D3) is known to inhibit DNA synthesis, immunoglobulin and lymphokine production [interleukin-2 (IL-2), gamma interferon (G-IFN), and granulocyte-monocyte colony-stimulating factor (GM-CSF)] by mitogen-stimulated human peripheral blood mononuclear cells (PBMCs). Calcitriol 26-33 colony stimulating factor 2 Homo sapiens 212-218 3034980-2 1987 We show that 1,25-dihydroxyvitamin D3 (1,25[OH]2D3), the most hormonally active metabolite of vitamin D3, modulates sensitively and specifically both the protein and messenger RNA accumulation of the multilineage growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF). Calcitriol 13-37 colony stimulating factor 2 Homo sapiens 227-275 3034980-2 1987 We show that 1,25-dihydroxyvitamin D3 (1,25[OH]2D3), the most hormonally active metabolite of vitamin D3, modulates sensitively and specifically both the protein and messenger RNA accumulation of the multilineage growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF). Calcitriol 13-37 colony stimulating factor 2 Homo sapiens 277-283 3034980-2 1987 We show that 1,25-dihydroxyvitamin D3 (1,25[OH]2D3), the most hormonally active metabolite of vitamin D3, modulates sensitively and specifically both the protein and messenger RNA accumulation of the multilineage growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF). Calcitriol 39-50 colony stimulating factor 2 Homo sapiens 227-275 3034980-2 1987 We show that 1,25-dihydroxyvitamin D3 (1,25[OH]2D3), the most hormonally active metabolite of vitamin D3, modulates sensitively and specifically both the protein and messenger RNA accumulation of the multilineage growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF). Calcitriol 39-50 colony stimulating factor 2 Homo sapiens 277-283 3034980-5 1987 Inhibition of GM-CSF expression by 1,25(OH)2D3 can occur independently of interleukin 2 regulation and is probably mediated through cellular 1,25(OH)2D3 receptors. Calcitriol 35-46 colony stimulating factor 2 Homo sapiens 14-20 3332553-5 1986 The subsequent addition of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) to cultures initially treated with CSF-GM or CSF-1 further increased multinucleated cell formation. Calcitriol 27-51 colony stimulating factor 2 Homo sapiens 102-105 3332553-5 1986 The subsequent addition of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) to cultures initially treated with CSF-GM or CSF-1 further increased multinucleated cell formation. Calcitriol 53-65 colony stimulating factor 2 Homo sapiens 102-105