PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23214203-4 2012 FGF-23 with a coreceptor (Klotho protein) inhibits renal phosphate reabsorption and synthesis of calcitriol by reducing 1alpha-hydroxylase (CYP27B1) activity, reducing vitamin D-dependent phosphate intestinal absorption. Calcitriol 97-107 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 140-147 23642201-1 2013 Our understanding of the mechanism of action of vitamin D has been broadened by the discovery of the extrarenal 1alpha-hydroxylase (CYP27B1) in various vitamin D target tissues around the body and the implications of this for the putative paracrine actions of 1alpha,25-dihydroxyvitamin D3. Calcitriol 260-289 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 132-139 23909735-2 2013 In the kidney, this mechanism regulates serum 25D3 levels and production of 1,25-dihydroxycholecalciferol (1,25D3) by CYP27B1 for systemic use. Calcitriol 76-105 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 118-125 22862690-1 2012 CYP27B1 is a mitochondrial cytochrome P450 that catalyses the hydroxylation of 25-hydroxyvitamin D3 at the C1alpha-position to give the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3. Calcitriol 174-203 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-7 24247665-1 2013 BACKGROUND: Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney, is required for the suppression of 1,25(OH)2D3-generating 25-hydroxyvitamin D3 1-alpha-hydroxylase (Cyp27b1) by FGF23. Calcitriol 129-140 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 152-192 24247665-1 2013 BACKGROUND: Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney, is required for the suppression of 1,25(OH)2D3-generating 25-hydroxyvitamin D3 1-alpha-hydroxylase (Cyp27b1) by FGF23. Calcitriol 129-140 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 194-201 22801352-8 2012 We hypothesize that dietary vitamin D would exhibit similar anticancer activity due to the presence of the enzyme 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) in breast cells ensuring conversion of circulating 25-hydroxyvitamin D to calcitriol locally within the breast micro-environment where it can act in a paracrine manner to inhibit BCa growth. Calcitriol 237-247 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 154-161 21792935-6 2012 The expression of CYP27B1, the enzyme responsible for calcitriol production, was marginally increased by poly(I:C) and markedly by TNFalpha treatment. Calcitriol 54-64 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 18-25 21793032-4 2011 These cells express CYP27B1, the gene encoding for the enzyme responsible for the synthesis of the vitamin D hormonally active metabolite, calcitriol. Calcitriol 139-149 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 20-27 21664249-6 2011 Metabolism of vitamin D in target tissues is mediated by two key enzymes: 1alpha-hydroxylase (CYP27B1), which catalyzes the synthesis of calcitriol from 25(OH)D and 24-hydroxylase (CYP24), which catalyzes the initial step in the conversion of calcitriol to less active metabolites. Calcitriol 137-147 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 94-101 21664249-6 2011 Metabolism of vitamin D in target tissues is mediated by two key enzymes: 1alpha-hydroxylase (CYP27B1), which catalyzes the synthesis of calcitriol from 25(OH)D and 24-hydroxylase (CYP24), which catalyzes the initial step in the conversion of calcitriol to less active metabolites. Calcitriol 243-253 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 94-101 17254777-7 2007 Our results indicate that in JEG-3 cells calcitriol production is diminished due to CYP27B1 dysregulation and low protein content, and suggest that hyperproliferation could be a consequence of these alterations. Calcitriol 41-51 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 84-91 18936726-3 2008 25(OH)D3 is metabolized by a renal 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) into the vitamin D hormone 1,25 dihydroxycholecalciferol (calcitriol), which generates a wide range of biological responses via both the regulation of gene transcription and nongenomic pathways. Calcitriol 142-152 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 75-82 18535110-2 2008 Although endocrine synthesis of 1,25(OH)2D3 takes place in the kidney, the enzyme that catalyzes this, 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27b1 in humans, Cyp27b1 in mice), is expressed at many extra-renal sites including the colon. Calcitriol 32-43 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 143-150 18535110-2 2008 Although endocrine synthesis of 1,25(OH)2D3 takes place in the kidney, the enzyme that catalyzes this, 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27b1 in humans, Cyp27b1 in mice), is expressed at many extra-renal sites including the colon. Calcitriol 32-43 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 162-169 17236759-2 2007 The enzyme responsible for calcitriol synthesis 25 hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-OHase) has been reported in many human tissues. Calcitriol 27-37 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 91-103 17236759-8 2007 We postulate that the expression of 1alpha-OHase gene variants may contribute to the antiproliferative effects of calcitriol. Calcitriol 114-124 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 36-48 17254772-0 2007 RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells. Calcitriol 45-56 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 27-34 20926527-0 2011 Short- and long-term outcome of patients with pseudo-vitamin D deficiency rickets treated with calcitriol. Calcitriol 95-105 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 46-81 20926527-1 2011 BACKGROUND: Pseudo-vitamin D deficiency rickets (PDDR; OMIM 264700) is a rare autosomal recessive disorder caused by mutations in the CYP27B1 gene, leading to an inability to synthesize 1alpha,25-dihydroxyvitamin D(3) (calcitriol). Calcitriol 186-217 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 12-47 20926527-1 2011 BACKGROUND: Pseudo-vitamin D deficiency rickets (PDDR; OMIM 264700) is a rare autosomal recessive disorder caused by mutations in the CYP27B1 gene, leading to an inability to synthesize 1alpha,25-dihydroxyvitamin D(3) (calcitriol). Calcitriol 186-217 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 49-53 20926527-1 2011 BACKGROUND: Pseudo-vitamin D deficiency rickets (PDDR; OMIM 264700) is a rare autosomal recessive disorder caused by mutations in the CYP27B1 gene, leading to an inability to synthesize 1alpha,25-dihydroxyvitamin D(3) (calcitriol). Calcitriol 186-217 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 134-141 20926527-1 2011 BACKGROUND: Pseudo-vitamin D deficiency rickets (PDDR; OMIM 264700) is a rare autosomal recessive disorder caused by mutations in the CYP27B1 gene, leading to an inability to synthesize 1alpha,25-dihydroxyvitamin D(3) (calcitriol). Calcitriol 219-229 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 12-47 20926527-1 2011 BACKGROUND: Pseudo-vitamin D deficiency rickets (PDDR; OMIM 264700) is a rare autosomal recessive disorder caused by mutations in the CYP27B1 gene, leading to an inability to synthesize 1alpha,25-dihydroxyvitamin D(3) (calcitriol). Calcitriol 219-229 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 49-53 20926527-1 2011 BACKGROUND: Pseudo-vitamin D deficiency rickets (PDDR; OMIM 264700) is a rare autosomal recessive disorder caused by mutations in the CYP27B1 gene, leading to an inability to synthesize 1alpha,25-dihydroxyvitamin D(3) (calcitriol). Calcitriol 219-229 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 134-141 20926527-3 2011 MATERIALS AND METHODS: Thirty-nine patients (20 females) with PDDR received calcitriol for periods of 2.0-26 yr. Calcitriol 76-86 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 62-66 20926527-12 2011 CONCLUSION: Treatment with calcitriol started in infancy results in short- and long-term correction of all clinical, biochemical, and radiological abnormalities related to PDDR. Calcitriol 27-37 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 172-176 22145480-2 2011 Vitamin D dependent rickets type 1 (VDDR-I) is caused by an inborn error of vitamin D metabolism, which interferes with renal conversion of calcidiol (25OHD) to calcitriol (1,25(OH)2D) by the enzyme 1alpha-hydroxylase. Calcitriol 161-171 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 36-40 20682996-7 2010 Calcitriol-synthesising enzyme CYP27B1 or vitamin D receptor (VDR), were transfected in cervical cancer SiHa cells. Calcitriol 0-10 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 31-38 20682996-11 2010 CYP27B1-transfected cells produced more calcitriol and less EAG1 mRNA. Calcitriol 40-50 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-7 19667162-5 2009 It has been speculated that the extrarenal CYP27B1-mediated local synthesis of 1,25(OH)2D3 represents a key regulator of important cellular functions including growth and differentiation in various cell types and tissues by autocrine or paracrine signalling pathways. Calcitriol 79-90 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 43-50 19667166-5 2009 Studies on tissue-specific expression of the CYP27B1-encoded 25-hdroxyvitamin D-1alpha-hydroxylase and of the extracellular calcium-sensing receptor (CaR) have led to an understanding how locally produced 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and extracellular Ca2+ act jointly as key regulators of cellular proliferation, differentiation and function. Calcitriol 205-229 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 45-52 17395703-0 2007 Splice variants of the CYP27b1 gene and the regulation of 1,25-dihydroxyvitamin D3 production. Calcitriol 58-82 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 23-30 17395703-1 2007 The cytochrome P450 25-hydroxyvitamin D3-1alpha-hydroxylase (CYP27b1) plays a pivotal role in vitamin D physiology by catalyzing synthesis of active 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Calcitriol 149-173 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 61-68 17395703-4 2007 Regulation of 1,25(OH)2D3 synthesis in these cell lines by calciotropic and noncalciotropic factors was associated with altered expression of the CYP27b1 splice variants. Calcitriol 14-25 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 146-153 17395703-9 2007 These data indicate that noncoding splice variants of CYP27b1 are functionally active and may play a significant role in the regulation of 1,25(OH)2D3 synthesis during normal physiology. Calcitriol 139-150 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 54-61 17287116-3 2007 25-Hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase, CYP27B1) is one of the key enzymes in the formation of calcitriol. Calcitriol 118-128 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-41 17287116-3 2007 25-Hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase, CYP27B1) is one of the key enzymes in the formation of calcitriol. Calcitriol 118-128 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 63-70 17257826-2 2007 The placenta synthesizes calcitriol through the expression of CYP27B1, but little is known about local actions of this hormone in the fetoplacental unit. Calcitriol 25-35 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 62-69 16902422-2 2007 In the research presented here, we have investigated the influence of UVB-triggered calcitriol production on gene expression of the vitamin D3 hydroxylating enzymes catabolic 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), active vitamin-D3-25-hydroxylase (CYP27A1), and 25-hydroxyvitamin-D3-1alpha-hydroxylase (CYP27B1) using real-time PCR. Calcitriol 84-94 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 270-309 17029768-0 2007 1alpha,25-dihydroxyvitamin D3 downregulates CYP27B1 and induces CYP24A1 in colon cells. Calcitriol 0-29 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 44-51 17079137-5 2007 The use of a selective inhibitor of PKA (H-89) prevented the effects of calcitriol on CYP27B1 gene and hCG secretion, but not on CYP24A1 transcription. Calcitriol 72-82 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 86-93 17079137-8 2007 The overall data suggest that calcitriol downregulates CYP27B1 expression via a cAMP-dependent signaling pathway, whereas upregulates 24-hydroxylase gene expression through a VDR-dependent mechanism. Calcitriol 30-40 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 55-62 17426122-1 2007 The human 25-hydroxyvitamin D3 (25(OH)D3) 1alpha-hydroxylase, which is encoded by the CYP27B1 gene, catalyzes the metabolic activation of the 25(OH)D3 into 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3), the most biologically potent vitamin D3 metabolite. Calcitriol 156-185 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 86-93 17507873-3 2007 Another enzyme, CYP27B1, involved in the synthesis of 1,25-dihydroxyvitamin D(3) , is stimulated by isoflavonoids, and this may result in a similar effect of increasing in the serum level of 1,25-dihydroxyvitamin D3. Calcitriol 54-80 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 16-23 17507873-3 2007 Another enzyme, CYP27B1, involved in the synthesis of 1,25-dihydroxyvitamin D(3) , is stimulated by isoflavonoids, and this may result in a similar effect of increasing in the serum level of 1,25-dihydroxyvitamin D3. Calcitriol 191-215 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 16-23 16902422-2 2007 In the research presented here, we have investigated the influence of UVB-triggered calcitriol production on gene expression of the vitamin D3 hydroxylating enzymes catabolic 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), active vitamin-D3-25-hydroxylase (CYP27A1), and 25-hydroxyvitamin-D3-1alpha-hydroxylase (CYP27B1) using real-time PCR. Calcitriol 84-94 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 311-318 12899526-2 2003 There are two principal enzymes involved in the formation of circulating 1,25(OH)2D3 from vitamin D, the vitamin D 25-hydroxylase (25-OHase) and the 1alpha-hydroxylase (1alpha-OHase). Calcitriol 73-84 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 169-181 16886667-1 2006 Extensive research on the CYP27B1-encoded 25-(OH)D-1alpha-hydroxylase has contributed much to our understanding about how locally produced 1,25-(OH)2D3 exerts tissue-specific control of cellular growth, differentiation and function. Calcitriol 139-151 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 26-33 16886667-1 2006 Extensive research on the CYP27B1-encoded 25-(OH)D-1alpha-hydroxylase has contributed much to our understanding about how locally produced 1,25-(OH)2D3 exerts tissue-specific control of cellular growth, differentiation and function. Calcitriol 139-151 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 42-69 16549446-2 2006 CYP27B1 is a cytochrome P450-containing hydroxylase expressed in kidney and other tissues that generates 1alpha,25(OH)2D3 from an inactive vitamin D precursor 25-hydroxycholecalciferol [25(OH)D3]. Calcitriol 105-121 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-7 16555680-1 2006 Vitamin D3 is modified by vitamin D3 25-hydroxylase in the liver, and by 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1) in the kidney, to form the active metabolite 1alpha,25-dihydroxyvitamin D3. Calcitriol 168-197 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 73-112 16555680-1 2006 Vitamin D3 is modified by vitamin D3 25-hydroxylase in the liver, and by 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1) in the kidney, to form the active metabolite 1alpha,25-dihydroxyvitamin D3. Calcitriol 168-197 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 114-121 16061850-11 2005 The administration of calcitriol led to an elevated expression of CYP27B1 and CYP24 but left the expression of the VDR unaltered. Calcitriol 22-32 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 66-73 15816500-1 2005 Vitamin D3 is modified by vitamin D3-25-hydroxylase in the liver, and 25-hydroxyvitamin D3-1alpha-hydroxylase in the kidney, to form the active metabolite, 1,25-dihydroxyvitamin D3. Calcitriol 156-180 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 70-109 15083599-1 2004 Vitamin D3 is modified by vitamin D3-25-hydroxylase in the liver and 25-hydroxyvitamin D3-1 alpha-hydroxylase in the kidney to form the active metabolite 1 alpha,25-dihydroxyvitamin D3. Calcitriol 154-184 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 69-109 14657005-1 2004 According to the present paradigm, 1alpha,25-dihydroxyvitamin D3 [1alpha,25-(OH)2D3] is a biologically active hormone; whereas 25-hydroxyvitamin D3 (25OHD3) is regarded as a prohormone activated through the action of 25-hydroxyvitamin D3 1alpha-hydroxylase (1alpha-hydroxylase). Calcitriol 35-64 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 217-256 17156732-2 2006 Conversion into the active metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) from the precursor is effected by cytochrome P450 enzymes in the liver (CYP27A1 and CYP2R1) and the kidney (CYP27B1). Calcitriol 38-62 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 185-192 17156732-2 2006 Conversion into the active metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) from the precursor is effected by cytochrome P450 enzymes in the liver (CYP27A1 and CYP2R1) and the kidney (CYP27B1). Calcitriol 64-75 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 185-192 17156732-4 2006 CYP27B1 is tightly regulated by the plasma levels of calcium, phosphate, parathyroid hormone (PTH) and 1,25(OH)2D3 itself. Calcitriol 103-114 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-7 15208365-3 2004 Evaluation of 1,25-dihydroxyvitamin D(3)-synthesizing CYP27B1 hydroxylase mRNA (real-time PCR) and protein (immunoblotting, immunofluorescence) showed enhanced expression in high- to medium-differentiated human colon tumors compared with tumor-adjacent normal mucosa or with colon mucosa from non-cancer patients. Calcitriol 14-40 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 54-61 12485911-7 2002 CYP27B1 is the cytochrome enzyme that synthesizes 1,25-D3. Calcitriol 50-57 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-7 12027461-2 2002 Expression of VDR, CYP27B1, and CYP24 determines the efficacy of the antimitotic action of 1,25-D3 and is distinctly related to the degree of differentiation of cancerous lesions. Calcitriol 91-98 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 19-26 11338230-3 2001 In view of non response to calcium and vitamin D3, a possible diagnosis of VDDR I (Vitamin D-dependent rickets) was made and he was treated with calcium and calcitriol. Calcitriol 157-167 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 75-81 11576342-8 2001 Conversely, treatment with 1,25(OH)2D3 itself decreased 1alpha-OHase activity. Calcitriol 27-38 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 56-68 11686044-9 2001 The coexpression system with CYP27B1 might be useful as a bioreactor to produce 1 alpha,25-dihydroxyvitamin D3. Calcitriol 80-110 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 29-36 10902806-10 2000 The overall results of this study provide evidence for the presence of 1alpha-(OH)ase in the human placenta, suggesting that conversion of 25OHD(3) to 1,25-dihydroxyvitamin D3 in the trophoblast is most probably attributed to an enzymatic 1alpha-hydroxylation reaction. Calcitriol 151-175 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 71-85 11013342-2 2000 Synthesis of 1, 25(OH)(2)D(3) from the major circulating metabolite, 25-hydroxyvitamin D(3) (25(OH)D(3)), is catalysed by a mitochondrial cytochrome P450 enzyme, 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase). Calcitriol 13-29 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 202-214 11019830-0 2000 Regulation of 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxyvitamin D3. Calcitriol 97-121 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 14-53 7608289-1 1995 Pseudo-Vitamin D Deficiency Rickets (PDDR), an heritable defect in renal 25-hydroxyvitamin D 1 alpha-hydroxylase activity, leads to insufficient synthesis of 1 alpha, 25-dihydroxyvitamin D (calcitriol) and the early onset of severe rickets which can only be offset by replacement therapy with calcitriol. Calcitriol 190-200 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-35 10654820-2 2000 Production of 1,25(OH)2D3 is catalyzed by the mitchondrial cytochrome P450, 25-hydroxyvitamin D3-1alpha-hydroxylase (1alpha-HYD). Calcitriol 14-25 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 76-115 9486994-1 1998 BACKGROUND: Pseudovitamin D-deficiency rickets is characterized by the early onset of rickets with hypocalcemia and is thought to be caused by a deficit in renal 25-hydroxyvitamin D3 1alpha-hydroxylase, the key enzyme for the synthesis of 1alpha,25-dihydroxyvitamin D3. Calcitriol 239-268 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 162-201 7608289-1 1995 Pseudo-Vitamin D Deficiency Rickets (PDDR), an heritable defect in renal 25-hydroxyvitamin D 1 alpha-hydroxylase activity, leads to insufficient synthesis of 1 alpha, 25-dihydroxyvitamin D (calcitriol) and the early onset of severe rickets which can only be offset by replacement therapy with calcitriol. Calcitriol 293-303 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 37-41 7608289-1 1995 Pseudo-Vitamin D Deficiency Rickets (PDDR), an heritable defect in renal 25-hydroxyvitamin D 1 alpha-hydroxylase activity, leads to insufficient synthesis of 1 alpha, 25-dihydroxyvitamin D (calcitriol) and the early onset of severe rickets which can only be offset by replacement therapy with calcitriol. Calcitriol 190-200 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 37-41 7608289-1 1995 Pseudo-Vitamin D Deficiency Rickets (PDDR), an heritable defect in renal 25-hydroxyvitamin D 1 alpha-hydroxylase activity, leads to insufficient synthesis of 1 alpha, 25-dihydroxyvitamin D (calcitriol) and the early onset of severe rickets which can only be offset by replacement therapy with calcitriol. Calcitriol 293-303 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-35 8092975-6 1994 VDDR I is caused by decreased production of the active form of vitamin D, 1,25-dihydroxycholecalciferol, with the proposed defect being in the gene encoding the enzyme 1 alpha-hydroxylase. Calcitriol 74-103 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-6 7938037-2 1994 1 alpha,25(OH)2D3 can be produced in keratinocytes from 25-hydroxyvitamin D3 by the enzyme 25-hydroxyvitamin D3-1 alpha-hydroxylase (1-OHase). Calcitriol 0-17 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 91-131 8092975-7 1994 VDDR II results from mutations in the gene for the intracellular receptor for 1,25-dihydroxycholecalciferol (vitamin D receptor), resulting in changes in hormone or DNA binding, depending on the mutation. Calcitriol 78-107 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-4 34621269-6 2021 In the present study, we show that pro-inflammatory, monocyte-derived M1 macrophages express very high levels of the 25(OH)D-1alpha-hydroxylase CYP27B1 that enables them to convert 25(OH)D3 into 1,25(OH)2D3 even in the presence of physiological concentrations of DBP. Calcitriol 195-206 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 117-143 2157942-1 1990 Use of 1,25(OH)2D3 (calcitriol) can be of benefit in the treatment of two hereditary types of rickets and osteomalacia, vitamin D dependency type I (VDD1) and X-linked hypophosphatemic vitamin D-resistant rickets (HPDR). Calcitriol 7-18 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 149-153 2157942-1 1990 Use of 1,25(OH)2D3 (calcitriol) can be of benefit in the treatment of two hereditary types of rickets and osteomalacia, vitamin D dependency type I (VDD1) and X-linked hypophosphatemic vitamin D-resistant rickets (HPDR). Calcitriol 20-30 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 149-153 2157942-3 1990 In VDD1, replacement therapy with calcitriol results in complete correction of the abnormal phenotype. Calcitriol 34-44 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 3-7 34250710-1 2021 1alpha,25-Dihydroxyvitamin D 3 (abbreviated here as 1,25D 3 ; other hydroxylated compounds are designated similarly) is a hormonally active form of vitamin D 3 (D 3 ), and is produced from D 3 by CYP27A1-mediated hydroxylation at C25, followed by CYP27B1-mediated hydroxylation at C1. Calcitriol 0-30 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 250-257 34621269-6 2021 In the present study, we show that pro-inflammatory, monocyte-derived M1 macrophages express very high levels of the 25(OH)D-1alpha-hydroxylase CYP27B1 that enables them to convert 25(OH)D3 into 1,25(OH)2D3 even in the presence of physiological concentrations of DBP. Calcitriol 195-206 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 144-151 34272637-1 2021 CYP27B1, a cytochrome P450-containing hydroxylase enzyme, converts vitamin D precursor calcidiol (25-hydroxycholecalciferol) to its active form calcitriol (1alpha,25(OH)2D3). Calcitriol 144-154 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-7 34522373-12 2021 The hypercalcemia is thought to be calcitriol mediated, where overexpression of CYP27B1 in the macrophages forming the granulomas leads to pathological extrarenal calcitriol production. Calcitriol 35-45 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 80-87 34522373-12 2021 The hypercalcemia is thought to be calcitriol mediated, where overexpression of CYP27B1 in the macrophages forming the granulomas leads to pathological extrarenal calcitriol production. Calcitriol 163-173 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 80-87 34578991-8 2021 UTI-female placentas showed higher expression of cathelicidin and CYP27B1, the calcitriol activating-enzyme, compared to male and NP samples. Calcitriol 79-89 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 66-73 34272637-1 2021 CYP27B1, a cytochrome P450-containing hydroxylase enzyme, converts vitamin D precursor calcidiol (25-hydroxycholecalciferol) to its active form calcitriol (1alpha,25(OH)2D3). Calcitriol 156-172 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-7 34272637-4 2021 Within this framework, the current study focuses on identifying other possible kinase inhibitors that may affect the calcitriol level in the body by inhibiting CYP27B1. Calcitriol 117-127 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 160-167 34590047-3 2021 Histologically, the tumor itself and tumor-adjacent macrophages were positive for the CYP27B1 protein, a key enzyme that generates 1,25-dihydroxyvitamin D3. Calcitriol 131-155 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 86-93 35482362-8 2022 The next hydroxylation step occurs in the renal proximal tubule via the 1-alphahydroxylase enzyme (encoded by CYP27B1) thereby generating 1,25-dihydroxyvitamin D, that is, calcitriol. Calcitriol 172-182 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 110-117 34337274-1 2021 25-hydroxyvitamin D 1alpha-hydroxylase (encoded by CYP27B1), which catalyzes the synthesis of 1,25-dihydroxyvitamin D3, is subject to negative or positive modulation by extracellular Ca2+ (Ca2+ o) depending on the tissue. Calcitriol 94-118 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 51-58 35482362-10 2022 Plasma calcitriol levels are primarily determined by the regulated expression of CYP27B1 and CYP24A1. Calcitriol 7-17 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 81-88 35482362-11 2022 This occurs in response to parathyroid hormone (increases CYP27B1), calcitriol itself (decreases CYP27B1 and increases CYP24A1), calcitonin (increases or decreases CYP24A1 and increases CYP27B1), FGF23 (decreases CYP27B1 and increases CYP24A1) and potentially plasma calcium and phosphate levels themselves (mixed effects). Calcitriol 68-78 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 97-104 35482362-11 2022 This occurs in response to parathyroid hormone (increases CYP27B1), calcitriol itself (decreases CYP27B1 and increases CYP24A1), calcitonin (increases or decreases CYP24A1 and increases CYP27B1), FGF23 (decreases CYP27B1 and increases CYP24A1) and potentially plasma calcium and phosphate levels themselves (mixed effects). Calcitriol 68-78 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 213-220 33386952-13 2021 We found a clear genotype-phenotype correlation in VDDR-IA, notably CYP27B1 intronic c.195 + 2T > G mutation causes a more severe phenotype with lower height SDS at presentation and, higher calcitriol requirement, while less severe phenotype occurs in p.K192E mutation. Calcitriol 190-200 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 51-55 35058935-7 2021 ATG increased gene expression of CYP27B1, the enzyme responsible for the conversion of 25-hydroxyvitamin D3 into 1,25-dihydroxyvitamin D3, which was accompanied by higher 1,25-dihydroxyvitamin D3 levels in ATG-treated DC culture supernatants. Calcitriol 113-137 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 33-40 35058935-7 2021 ATG increased gene expression of CYP27B1, the enzyme responsible for the conversion of 25-hydroxyvitamin D3 into 1,25-dihydroxyvitamin D3, which was accompanied by higher 1,25-dihydroxyvitamin D3 levels in ATG-treated DC culture supernatants. Calcitriol 171-195 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 33-40 33386952-13 2021 We found a clear genotype-phenotype correlation in VDDR-IA, notably CYP27B1 intronic c.195 + 2T > G mutation causes a more severe phenotype with lower height SDS at presentation and, higher calcitriol requirement, while less severe phenotype occurs in p.K192E mutation. Calcitriol 190-200 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 68-75 31734492-5 2020 Ocular localization of the 1,25-dihydroxyvitamin D3-generating (CYP27B1) and deactivating (CYP24A1) hydroxylases was performed by immunohistochemistry. Calcitriol 27-51 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 64-71 33058307-2 2021 These enzymes contribute to the formation of 1,25-dihydroxyvitamin D3, which starts with a 25-hydroxylation by CYP2R1 and CYP27A1 and a subsequent 1alpha-hydroxylation via CYP27B1. Calcitriol 45-69 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 172-179 33244402-3 2020 Vitamin D metabolism includes 25-hydroxyvitamin D3 (25(OH)D3) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), as the inactive and active form, with the help of 1alpha-hydroxylase (CYP27B1) enzyme. Calcitriol 66-90 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 176-183 32540991-2 2020 The major circulating metabolite of vitamin D (25-hydroxyvitamin D) is converted to the active form (calcitriol) by the hydroxylase enzyme CYP27B1 In multiple sclerosis lesions, the tyrosine kinase MerTK expressed by myeloid cells regulates phagocytosis of myelin debris and apoptotic cells that can accumulate and inhibit tissue repair and remyelination. Calcitriol 101-111 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 139-146 28938443-0 2017 Microbiota-Dependent Induction of Colonic Cyp27b1 Is Associated With Colonic Inflammation: Implications of Locally Produced 1,25-Dihydroxyvitamin D3 in Inflammatory Regulation in the Colon. Calcitriol 124-148 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 42-49 31867158-3 2019 VD3 is converted to the active form, 1alpha,25-dihydroxyvitamin D3 (1,25-D3), by cytochrome P450 2R1 (CYP2R1)/CYP27A1 and CYP27B1 sequentially, and deactivated by multiple enzymes including CYP3A4. Calcitriol 37-66 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 122-129 31867158-3 2019 VD3 is converted to the active form, 1alpha,25-dihydroxyvitamin D3 (1,25-D3), by cytochrome P450 2R1 (CYP2R1)/CYP27A1 and CYP27B1 sequentially, and deactivated by multiple enzymes including CYP3A4. Calcitriol 68-75 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 122-129 29080636-2 2017 Mutations of the activating enzymes CYP2R1 and CYP27B1 cause lack of normal 1,25-(OH)2D3 synthesis and result in rickets whereas mutations of the inactivating enzyme CYP24A1 cause build-up of excess 1,25-(OH)2D3 and result in hypercalcemia, nephrolithiasis, and nephrocalcinosis. Calcitriol 76-88 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 47-54 29080636-2 2017 Mutations of the activating enzymes CYP2R1 and CYP27B1 cause lack of normal 1,25-(OH)2D3 synthesis and result in rickets whereas mutations of the inactivating enzyme CYP24A1 cause build-up of excess 1,25-(OH)2D3 and result in hypercalcemia, nephrolithiasis, and nephrocalcinosis. Calcitriol 199-211 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 47-54 30382318-3 2019 In addition, we observed the response to long-term treatment of calcitriol in 15 Chinese patients with PDDR, which showed that the biochemical abnormalities had been corrected satisfactorily after 1-year treatment. Calcitriol 64-74 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 103-107 30382318-5 2019 The purpose of this study was to identify the CYP27B1 mutations and investigate the response to long-term treatment of calcitriol in Chinese patients with PDDR. Calcitriol 119-129 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 155-159 30382318-7 2019 To investigate the response to long-term (13 years) treatment with calcitriol in PDDR patients, we additionally collected clinical data of eight families from our previous report and analyzed their biochemical parameter and radiographic changes during the treatment. Calcitriol 67-77 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 81-85 30504710-2 2018 In cooperation with the transmembrane protein Klotho, FGF23 is a powerful inhibitor of 1alpha 25OH Vitamin D Hydroxylase (Cyp27b1) and thus of the formation of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Calcitriol 160-184 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 122-129 28938443-3 2017 Here we showed that cytochrome P450 27b1 (Cyp27b1), a cytochrome P450 enzyme necessary for 1,25(OH)2D3 biosynthesis, is highly induced in colonic mucosa in inflammatory response. Calcitriol 91-102 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 20-40 28938443-3 2017 Here we showed that cytochrome P450 27b1 (Cyp27b1), a cytochrome P450 enzyme necessary for 1,25(OH)2D3 biosynthesis, is highly induced in colonic mucosa in inflammatory response. Calcitriol 91-102 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 42-49 28938443-9 2017 Collectively these data suggest that induction of colonic epithelial Cyp27b1, which is expected to increase local production of 1,25(OH)2D3, is a protective mechanism that partially compensates for the downregulation of epithelial VDR during colonic inflammation. Calcitriol 128-139 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 69-76 27364341-1 2016 Pseudovitamin D deficiency is the consequence of a genetic defect in the CYP27B1 gene resulting in diminished or absent conversion of 25-hydroxyvitamin D3 (25-(OH)D3) into 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and leads to growth retardation and rickets, usually in the first 2 years of life. Calcitriol 172-196 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 73-80 28054069-4 2017 Human keratinocytes contain the enzymatic machinery (CYP27B1) for the synthesis of the biologically most active natural vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), representing an autonomous vitamin D3 pathway. Calcitriol 141-165 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 53-60 28054069-4 2017 Human keratinocytes contain the enzymatic machinery (CYP27B1) for the synthesis of the biologically most active natural vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), representing an autonomous vitamin D3 pathway. Calcitriol 167-178 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 53-60 27889974-9 2016 CONCLUSIONS: The presence of CYP24A1 mRNA and the reduced expression of VDR and CYP27B1 mRNA in human hepatocellular carcinoma samples indicate decreased bioavailability of 1,25-Dihydroxy vitamin D3, providing an escape mechanism from the anti-tumor effect. Calcitriol 173-198 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 80-87 29179169-4 2017 FGF23 inhibits Cyp27b1, an enzyme to produce an active vitamin D3, 1,25(OH)2D3, through FGF receptor/Klotho complex. Calcitriol 67-78 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 15-22 28078042-7 2016 We observed that Cca cells express CD23; ligation of CD23 with IgE on Cca cells increased the expression of cyp27b1 in Cca, which promoted the conversion of VD3 to calcitriol, the latter increased the expression of FasL by Cca cells, and induced apoptosis of Cca cells. Calcitriol 164-174 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 108-115 27210415-3 2016 Calcitriol availability depends on CYP27B1 and CYP24A1 expression, the cytochromes involved in its synthesis and degradation, respectively. Calcitriol 0-10 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 35-42 27364341-1 2016 Pseudovitamin D deficiency is the consequence of a genetic defect in the CYP27B1 gene resulting in diminished or absent conversion of 25-hydroxyvitamin D3 (25-(OH)D3) into 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and leads to growth retardation and rickets, usually in the first 2 years of life. Calcitriol 198-210 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 73-80 26654942-8 2016 CYP27B1 encodes the 1alpha-hydroxylase (1alphaOHase) that converts 25D3 to the active metabolite, 1,25-dihydroxyvitamin D3 (1,25D3). Calcitriol 98-122 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-7 27399352-1 2016 CONTEXT: CYP27B1 converts 25-hydroxyvitamin D3 to active 1,25-dihydroxyvitamin D3, playing a vital role in calcium homeostasis and bone growth. Calcitriol 57-81 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 9-16 27530414-9 2016 A significant increase (p <0.01) in the mRNA expression of CYP24A1, CYP27B1, and VDR was observed after stimulation of ADMSCs with calcitriol (10 nM). Calcitriol 134-144 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 71-78 27403416-4 2016 The active form of vitamin D, 1,25-dihydroxyvitamin D (calcitriol), is biosynthesised in the kidney through the hydroxylation of 25-hydroxycholecalciferol by the CYP27B1 enzyme. Calcitriol 55-65 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 162-169 26982175-2 2016 Mutations in CYP27B1 disrupt or lead to a total loss of the 1-alpha-hydroxylase activity and require treatment with physiological doses of calcitriol. Calcitriol 139-149 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 13-20 25501638-1 2015 CYP27B1 hydroxylates 25-hydroxyvitamin D3 in position C1alpha into biologically active 1,25-dihydroxyvitamin D3, calcitriol. Calcitriol 87-111 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-7 25730676-1 2015 1,25 Dihydroxyvitamin D3 (1,25D) is a hormone produced from vitamin D through two hydroxylating steps catalyzed successively in the liver by the vitamin D 25-hydroxylase Cyp2R1 and in the kidney by the 25-hydroxyvitamin D3 1alpha-hydroxylase Cyp27B1. Calcitriol 0-24 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 202-241 25730676-1 2015 1,25 Dihydroxyvitamin D3 (1,25D) is a hormone produced from vitamin D through two hydroxylating steps catalyzed successively in the liver by the vitamin D 25-hydroxylase Cyp2R1 and in the kidney by the 25-hydroxyvitamin D3 1alpha-hydroxylase Cyp27B1. Calcitriol 0-24 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 242-249 25501638-1 2015 CYP27B1 hydroxylates 25-hydroxyvitamin D3 in position C1alpha into biologically active 1,25-dihydroxyvitamin D3, calcitriol. Calcitriol 113-123 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-7 23713873-1 2014 The synthesis of 1alpha,25-dihydroxyvitamin D3 (Calcitriol) takes place mostly in the kidneys through the action of 1alpha-hydroxylase (CYP27B1) which converts 25(OH)D into 1,25(OH)2D3. Calcitriol 17-46 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 136-143 24361583-2 2014 During pregnancy, calcitriol, the active metabolite of vitamin D, is also metabolized by decidua and placental tissue by means of CYP27B1 and CYP24A1 for synthesis and inactivation of calcitriol respectively. Calcitriol 18-28 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 130-137 24361583-2 2014 During pregnancy, calcitriol, the active metabolite of vitamin D, is also metabolized by decidua and placental tissue by means of CYP27B1 and CYP24A1 for synthesis and inactivation of calcitriol respectively. Calcitriol 184-194 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 130-137 25230725-9 2014 CONCLUSIONS: Activated T cells express CYP27B1 and can convert 25(OH)D3 to 1,25(OH)2D3 in sufficiently high concentrations to affect vitamin D-responsive genes when cultured in serum-free medium. Calcitriol 75-86 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 39-46 24471562-1 2014 CONTEXT: Placental CYP27B1 may contribute to circulating maternal calcitriol concentrations across gestation, but determinants of CYP27B1 and CYP24A1 expression in term human placental tissue are not well established. Calcitriol 66-76 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 19-26 24471562-2 2014 OBJECTIVE: We hypothesized that higher CYP27B1 protein expression would be associated with increased maternal calcitriol during gestation and that CYP27B1 expression would be impacted by substrate availability. Calcitriol 110-120 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 39-46 24471562-13 2014 CONCLUSIONS: Higher maternal 25(OH)D during pregnancy was associated with significantly higher placental protein expression of CYP27B1 at term supportive of a link between substrate availability and placental production of calcitriol. Calcitriol 223-233 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 127-134 25584965-6 2015 Calcitriol synthesis and degradation depend on the expression and activity of CYP27B1 and CYP24A1 cytochromes, respectively, for which regulation is tissue specific. Calcitriol 0-10 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 78-85 24535953-1 2014 The potency of 25-hydroxyvitamin D3 (25(OH)D3) is increased by several fold through its metabolism into 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3) by cytochrome P450 27B1 (CYP27B1). Calcitriol 104-133 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 156-176 24535953-1 2014 The potency of 25-hydroxyvitamin D3 (25(OH)D3) is increased by several fold through its metabolism into 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3) by cytochrome P450 27B1 (CYP27B1). Calcitriol 104-133 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 178-185 23713873-1 2014 The synthesis of 1alpha,25-dihydroxyvitamin D3 (Calcitriol) takes place mostly in the kidneys through the action of 1alpha-hydroxylase (CYP27B1) which converts 25(OH)D into 1,25(OH)2D3. Calcitriol 48-58 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 136-143 23020803-1 2013 Vitamin D is a fat-soluble precursor of the circulating 25-hydroxyvitamin D3 (25(OH)D3)which can be converted by the 1alpha-hydroxylase (1alpha(OH)ase) enzyme into the bioactive hormonal metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), generally known to promote bone mineralization through its ability to enhance calcium absorption from the gut. Calcitriol 198-222 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 137-150 22982627-3 2013 Osteoblastogenesis is also stimulated by 25-hydroxyvitamin D [25(OH)D], an effect that requires conversion to 1alpha,25(OH)2D3 by 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1). Calcitriol 110-126 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 130-169 22982627-3 2013 Osteoblastogenesis is also stimulated by 25-hydroxyvitamin D [25(OH)D], an effect that requires conversion to 1alpha,25(OH)2D3 by 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1). Calcitriol 110-126 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 171-178 24910833-2 2013 VDDR type 1 (VDDR-I) is caused by an inborn error of vitamin D metabolism, which interferes with renal conversion of calcidiol (25OHD) to calcitriol (1,25(OH)2D) by the enzyme 1-alpha-hydroxylase. Calcitriol 138-148 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 0-4 24910833-2 2013 VDDR type 1 (VDDR-I) is caused by an inborn error of vitamin D metabolism, which interferes with renal conversion of calcidiol (25OHD) to calcitriol (1,25(OH)2D) by the enzyme 1-alpha-hydroxylase. Calcitriol 138-148 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 13-17 23020803-1 2013 Vitamin D is a fat-soluble precursor of the circulating 25-hydroxyvitamin D3 (25(OH)D3)which can be converted by the 1alpha-hydroxylase (1alpha(OH)ase) enzyme into the bioactive hormonal metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), generally known to promote bone mineralization through its ability to enhance calcium absorption from the gut. Calcitriol 224-235 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 137-150