PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23690781-1 2013 Insulin-like growth factor I (IGF-I) is implicated in breast cancer development and 1, 25-dihydroxyvitamin D3 (1, 25-D3) has been shown to attenuate prosurvival effects of IGF-I on breast cancer cells. Calcitriol 84-109 insulin like growth factor 1 Homo sapiens 172-177 9069158-0 1997 Effect of 1,25(OH)2 vitamin D3 on circulating insulin-like growth factor-I and beta 2 microglobulin in patients with osteoporosis. Calcitriol 10-30 insulin like growth factor 1 Homo sapiens 46-74 11524241-6 2001 Furthermore, 1,25-(OH)2D3 inhibited IGF-induced proliferation, but this was partially reversed by high concentrations of IGF-I. Calcitriol 13-25 insulin like growth factor 1 Homo sapiens 121-126 10674019-3 1999 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and its analogues inhibit IGF-I-stimulated growth of MCF-7 human breast cancer cells. Calcitriol 0-24 insulin like growth factor 1 Homo sapiens 65-70 10674019-3 1999 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and its analogues inhibit IGF-I-stimulated growth of MCF-7 human breast cancer cells. Calcitriol 26-37 insulin like growth factor 1 Homo sapiens 65-70 10421806-0 1999 Effects of IGF-I on 1,25-dihydroxyvitamin D(3) synthesis by human placenta in culture. Calcitriol 20-46 insulin like growth factor 1 Homo sapiens 11-16 9578515-2 1998 Both IGF-I and vitamin K2 stimulated 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-induced osteocalcin containing Gla secretion in a concentration-dependent manner. Calcitriol 37-61 insulin like growth factor 1 Homo sapiens 5-10 9578515-2 1998 Both IGF-I and vitamin K2 stimulated 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-induced osteocalcin containing Gla secretion in a concentration-dependent manner. Calcitriol 63-74 insulin like growth factor 1 Homo sapiens 5-10 22496496-9 2012 CONCLUSION: The IGF-I-mediated and PTH-independent increase in calcitriol synthesis in acromegaly is responsible for both absorptive hypercalciuria and increased fasting plasma calcium linked to enhanced distal tubular calcium reabsorption, as shown by the selectively diminished calciuric response to furosemide. Calcitriol 63-73 insulin like growth factor 1 Homo sapiens 16-21 19918113-4 2008 Data analysis demonstrated significant calcitriol modulation of gene expression toward inhibition of the adipocyte apoptosis (e.g., VEGF and STC-2) and promotion of adipocyte proliferation (e.g., IGF-1 and IGF-1R). Calcitriol 39-49 insulin like growth factor 1 Homo sapiens 196-201 9202240-11 1997 In summary, we demonstrated that 1,25-(OH)2D3 exerts an anabolic effect on osteoblasts by enhancing their production of VEGF, which stimulates its receptors on endothelial cells, followed by increased production of osteotropic growth factors, such as insulin-like growth factor I and ET-1. Calcitriol 33-45 insulin like growth factor 1 Homo sapiens 251-279 9069158-4 1997 The authors conclude that exogenous 1,25(OH)2D3 promotes the production of IGF-I and beta 2 microglobulin in osteoporotic patients in parallel to the marker of osteoblastic function, osteocalcin, which supports the tested hypothesis. Calcitriol 36-47 insulin like growth factor 1 Homo sapiens 75-80 8992878-9 1996 We have demonstrated that PTH, IGF-I, and most potently 1,25-(OH)2D3 stimulate the mRNA expression and secretion of VEGF in human osteoblast-like cells, suggesting that one of the anabolic effects of 1,25-(OH)2D3 on skeletal tissue may be mediated by VEGF produced by osteoblasts. Calcitriol 200-212 insulin like growth factor 1 Homo sapiens 31-36 9077371-15 1997 (iii) IGF-I increases free calcitriol index in face of unchanged serum levels of calcium, phosphate and PTH, consistent with a direct stimulatory effect on 25-OHD-1a-hydroxylase. Calcitriol 27-37 insulin like growth factor 1 Homo sapiens 6-11 9081364-2 1996 The purpose of the present study was to investigate a possible interaction of 1,25-(OH)2D3 and the vitamin D3 analogue EB1089 with the insulin-IGF-I regulatory system. Calcitriol 78-90 insulin like growth factor 1 Homo sapiens 143-148 9081364-5 1996 The growth stimulation by insulin and by long R3 IGF-I was completely inhibited by 1,25-(OH)2D3 and EB1089. Calcitriol 83-95 insulin like growth factor 1 Homo sapiens 49-54 7592714-6 1995 Human recombinant IGF-I (10-100 ng/ml) stimulated both sodium-dependent phosphate uptake and 1,25-(OH)2D3 synthesis by these cells, in a time- and dose-dependent manner. Calcitriol 93-105 insulin like growth factor 1 Homo sapiens 18-23 7684391-2 1993 Treatment of U-2 cells with IGF-I markedly increased medium levels of IGFBP-5 in a concentration- and time-dependent manner; other skeletal regulatory factors (GH, insulin, PTH, dexamethasone, beta-estradiol, 1,25-dihydroxyvitamin D3, transforming growth factor-beta) had no effect. Calcitriol 209-233 insulin like growth factor 1 Homo sapiens 28-33 8281940-1 1993 The 1,25-dihydroxyvitamin-D3-(calcitriol)-induced medium osteocalcin and cellular osteocalcin mRNA concentrations are increased in a dose-dependent and time-dependent manner by prior treatment of the human MG-63 osteosarcoma cells with insulin-like growth factor-I (IGF-I). Calcitriol 4-28 insulin like growth factor 1 Homo sapiens 236-264 8281940-1 1993 The 1,25-dihydroxyvitamin-D3-(calcitriol)-induced medium osteocalcin and cellular osteocalcin mRNA concentrations are increased in a dose-dependent and time-dependent manner by prior treatment of the human MG-63 osteosarcoma cells with insulin-like growth factor-I (IGF-I). Calcitriol 4-28 insulin like growth factor 1 Homo sapiens 266-271 8281940-1 1993 The 1,25-dihydroxyvitamin-D3-(calcitriol)-induced medium osteocalcin and cellular osteocalcin mRNA concentrations are increased in a dose-dependent and time-dependent manner by prior treatment of the human MG-63 osteosarcoma cells with insulin-like growth factor-I (IGF-I). Calcitriol 30-40 insulin like growth factor 1 Homo sapiens 236-264 8281940-1 1993 The 1,25-dihydroxyvitamin-D3-(calcitriol)-induced medium osteocalcin and cellular osteocalcin mRNA concentrations are increased in a dose-dependent and time-dependent manner by prior treatment of the human MG-63 osteosarcoma cells with insulin-like growth factor-I (IGF-I). Calcitriol 30-40 insulin like growth factor 1 Homo sapiens 266-271 8281940-5 1993 In contrast to its effects on osteocalcin synthesis, both baseline and calcitriol-stimulated alkaline phosphatase activities are decreased by IGF-I treatment. Calcitriol 71-81 insulin like growth factor 1 Homo sapiens 142-147 1505451-8 1992 In the presence of 1,25-dihydroxyvitamin D3, IGF-I, like granulocyte-macrophage colony-stimulating factor (GM-CSF), dose-dependently increased the number of TRAP-positive MNCs. Calcitriol 19-43 insulin like growth factor 1 Homo sapiens 45-50 1641052-2 1992 IGF-1, a growth hormone dependent factor, enhances at the kidney level both the tubular reabsorption of inorganic phosphate (Pi) and the production of 1,25-dihydroxyvitamin D3. Calcitriol 151-175 insulin like growth factor 1 Homo sapiens 0-5 1370789-11 1992 These data suggests that the synergistic effects of 1,25-(OH)2D3 on the action of IGF-I on osteoblastic cells, which we reported previously, may be modulated by locally produced IGFBP-3. Calcitriol 52-64 insulin like growth factor 1 Homo sapiens 82-87 1924097-4 1991 Proliferation and differentiation of cartilage cells (i.e., chondrocytes) as studied mostly in culture, is regulated by various endocrine, paracrine, and autocrine agents such as growth hormone, insulin-like growth factor-I (IGF-I), transforming growth factor (TGE-beta), and vitamin D metabolites (1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol). Calcitriol 299-328 insulin like growth factor 1 Homo sapiens 195-223 32379895-11 2020 VDR is a transcription factor for the IGFBP-3 gene, and IGF-1 can increases calcitriol synthesis. Calcitriol 76-86 insulin like growth factor 1 Homo sapiens 56-61 2059879-0 1991 Dexamethasone and 1,25(OH)2 vitamin D3 modulate the synthesis of insulin-like growth factor-I in osteoblast-like cells. Calcitriol 18-38 insulin like growth factor 1 Homo sapiens 65-93 2059879-4 1991 The active vitamin D metabolite 1,25-dihydroxycholecalciferol [1,25(OH)2D3] slightly increased the IGF-I level, but the increase was not statistically significant. Calcitriol 32-61 insulin like growth factor 1 Homo sapiens 99-104 2059879-4 1991 The active vitamin D metabolite 1,25-dihydroxycholecalciferol [1,25(OH)2D3] slightly increased the IGF-I level, but the increase was not statistically significant. Calcitriol 63-74 insulin like growth factor 1 Homo sapiens 99-104 2180972-16 1990 Regression analysis demonstrated a correlation between the change in calcitriol during PD and the IGF-I level (r = 0.83). Calcitriol 69-79 insulin like growth factor 1 Homo sapiens 98-103 2357426-8 1990 At the same concentrations, GH also increased by 140% endogenous IGF-1 levels in cell culture supernatants, 1,25(OH)2D3 (10 nM) also increased time- and dose-dependently, IGF-1 levels in human bone cell supernatants, and stimulated dose-dependently alkaline phosphatase activity and osteocalcin secretion. Calcitriol 108-119 insulin like growth factor 1 Homo sapiens 65-70 2357426-8 1990 At the same concentrations, GH also increased by 140% endogenous IGF-1 levels in cell culture supernatants, 1,25(OH)2D3 (10 nM) also increased time- and dose-dependently, IGF-1 levels in human bone cell supernatants, and stimulated dose-dependently alkaline phosphatase activity and osteocalcin secretion. Calcitriol 108-119 insulin like growth factor 1 Homo sapiens 171-176 24373797-2 2014 It has been reported that insulin-like growth factor I (IGF-I) stimulates placental calcitriol synthesis and that circulating levels of both hormones are low in preeclampsia. Calcitriol 84-94 insulin like growth factor 1 Homo sapiens 26-54 24373797-2 2014 It has been reported that insulin-like growth factor I (IGF-I) stimulates placental calcitriol synthesis and that circulating levels of both hormones are low in preeclampsia. Calcitriol 84-94 insulin like growth factor 1 Homo sapiens 56-61