PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18379402-0	2008	1,25(OH)2-vitamin D3 inhibits proliferation and decreases production of monocyte chemoattractant protein-1, thrombopoietin, VEGF, and angiogenin by human annulus cells in vitro.	Calcitriol	0-20	C-C motif chemokine ligand 2	Homo sapiens	72-106	
17869082-4	2008	Similar results were also found in cultured 3T3-L1 adipocytes; in addition, calcitriol also up-regulated macrophage colony-stimulating factor, macrophage inflammatory protein, interleukin-6 (IL-6) as well as monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes and stimulated tumor necrosis factor as well as IL-6 expression in RAW 264 macrophages.	Calcitriol	76-86	C-C motif chemokine ligand 2	Homo sapiens	208-242	
11340307-0	2001	1,25-dihydroxyvitamin D3 differentially regulates IL-1alpha-stimulated IL-8 and MCP-1 mRNA expression and chemokine secretion by human primary proximal tubular epithelial cells.	Calcitriol	0-24	C-C motif chemokine ligand 2	Homo sapiens	80-85	
33365026-6	2020	In vitro treatment with 1,25(OH)2D3 reduced proinflammatory cytokines (IL-6, CCL-2, IL-23A, IL-15) whereas anti-inflammatory cytokines (IL-10 and PD-L1) rose both in APS-type 1 diabetes and APS-Addison s disease.	Calcitriol	24-35	C-C motif chemokine ligand 2	Homo sapiens	77-82	
32982316-11	2020	Additionally, we observed decreased mRNA expression of FN 1, LUM, BGN, MMP2, COL5A1, TIMP1 and CC-chemokines (CCL2, CCL5, CCL11) in response to 1,25(OH)2D3 addition to the TGF-beta1 or TNF-alpha-IL-1beta-stimulated HBFCs.	Calcitriol	144-155	C-C motif chemokine ligand 2	Homo sapiens	110-114	
31114197-8	2019	Encapsulated calcitriol diminished mRNA gene levels of TNF-, NF-B, MCP-1 and IL-6, while upregulating IL-10.	Calcitriol	13-23	C-C motif chemokine ligand 2	Homo sapiens	67-72	
24184699-0	2014	CCL2 induction by 1,25(OH)2D3 in dendritic cells from healthy donors and multiple sclerosis patients.	Calcitriol	18-29	C-C motif chemokine ligand 2	Homo sapiens	0-4	
26949104-9	2016	This suggests that 1,25(OH)2D3 inhibits ROS, MCP-1, ICAM-1, and adherence of monocytes mediated by the upregulation of GCLC and GSH.	Calcitriol	19-30	C-C motif chemokine ligand 2	Homo sapiens	45-50	
24184699-4	2014	In this study we analyzed the role of 1,25(OH)2D3, the bioactive vitamin D metabolite, in the regulation of CCL2 expression by dendritic cells (DC) obtained from healthy donors and relapsing-remitting MS patients.	Calcitriol	38-49	C-C motif chemokine ligand 2	Homo sapiens	108-112	
24184699-5	2014	We report that 1,25(OH)2D3, as well as 25OHD3, its main blood precursor, induce the secretion of high levels of CCL2.	Calcitriol	15-26	C-C motif chemokine ligand 2	Homo sapiens	112-116	
24184699-7	2014	Moreover, we observed that 1,25(OH)2D3 is able to induce a significant CCL2 secretion in DC obtained from relapsing-remitting MS patients, although CCL2 levels in these latter are lower with respect to healthy controls.	Calcitriol	27-38	C-C motif chemokine ligand 2	Homo sapiens	71-75	
24184699-9	2014	However, we propose CCL2 as a molecular player contributing to the immunomodulatory activity of 1,25(OH)2D3 on DC, and hypothesize a role for this chemokine in the response of MS patients to vitamin D therapy.	Calcitriol	96-107	C-C motif chemokine ligand 2	Homo sapiens	20-24	
24587317-9	2014	In primary hPdLCs, both 25(OH)D3 and 1,25(OH)2D3 inhibited the production of IL-8 and MCP-1 but have no significant effect on the IL-6 production.	Calcitriol	37-48	C-C motif chemokine ligand 2	Homo sapiens	86-91	
22508334-0	2013	1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes.	Calcitriol	0-24	C-C motif chemokine ligand 2	Homo sapiens	68-73	
23361158-9	2013	In vitro, LPS- and Pseudomonas-activated monocytes treated with 1,25(OH)2D3 had significantly less MCP-1 secretion compared with untreated cells.	Calcitriol	64-75	C-C motif chemokine ligand 2	Homo sapiens	99-104	
22508334-10	2013	Pretreatment with 1,25(OH)2D3 (10 nM and 100 nM) significantly decreased the stimulatory effects of MC medium, TNFalpha and IL-1beta on MCP-1 expression and protein release, although the effect on stimulated release of IL-6 was less potent.	Calcitriol	18-29	C-C motif chemokine ligand 2	Homo sapiens	136-141	
22508334-11	2013	CONCLUSIONS: These results demonstrate that 1,25(OH)2D3 decreases the production of MCP-1 and other proinflammatory mediators by preadipocytes and reduces monocyte migration.	Calcitriol	44-55	C-C motif chemokine ligand 2	Homo sapiens	84-89	
21701898-9	2012	DHCC attenuated TNFalpha-induced CCL2 mRNA expression in both pre-incubation (~15%, p < 0.05) and concomitant (~60%, p < 0.01) treatments.	Calcitriol	0-4	C-C motif chemokine ligand 2	Homo sapiens	33-37	
21701898-0	2012	Differential effects of 1alpha,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes.	Calcitriol	24-58	C-C motif chemokine ligand 2	Homo sapiens	62-67	
21701898-13	2012	CONCLUSIONS: DHCC attenuates MCP-1 and adiponectin production in human adipocytes, thereby reducing the expression of both pro- and anti-inflammatory factors.	Calcitriol	13-17	C-C motif chemokine ligand 2	Homo sapiens	29-34	
22169009-8	2012	Immunohistochemistry showed that calcitriol and paricalcitol reduced MCP-1 and IL-6 in podocytes and tubular cells as well as glomerular infiltration by macrophages, glomerular cell NF-kappaB activation, apoptosis, and extracellular matrix deposition.	Calcitriol	33-43	C-C motif chemokine ligand 2	Homo sapiens	69-74	
22169009-9	2012	In cultured podocytes, paricalcitol and calcitriol at concentrations in the physiological and clinically significant range prevented the increase in MCP-1, IL-6, renin, and fibronectin mRNA expression and the secretion of MCP-1 to the culture media induced by high glucose.	Calcitriol	40-50	C-C motif chemokine ligand 2	Homo sapiens	149-154	
22169009-9	2012	In cultured podocytes, paricalcitol and calcitriol at concentrations in the physiological and clinically significant range prevented the increase in MCP-1, IL-6, renin, and fibronectin mRNA expression and the secretion of MCP-1 to the culture media induced by high glucose.	Calcitriol	40-50	C-C motif chemokine ligand 2	Homo sapiens	222-227