PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32982316-11 2020 Additionally, we observed decreased mRNA expression of FN 1, LUM, BGN, MMP2, COL5A1, TIMP1 and CC-chemokines (CCL2, CCL5, CCL11) in response to 1,25(OH)2D3 addition to the TGF-beta1 or TNF-alpha-IL-1beta-stimulated HBFCs. Calcitriol 144-155 C-C motif chemokine ligand 2 Homo sapiens 110-114 21701898-0 2012 Differential effects of 1alpha,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes. Calcitriol 24-58 C-C motif chemokine ligand 2 Homo sapiens 62-67 22169009-8 2012 Immunohistochemistry showed that calcitriol and paricalcitol reduced MCP-1 and IL-6 in podocytes and tubular cells as well as glomerular infiltration by macrophages, glomerular cell NF-kappaB activation, apoptosis, and extracellular matrix deposition. Calcitriol 33-43 C-C motif chemokine ligand 2 Homo sapiens 69-74 22169009-9 2012 In cultured podocytes, paricalcitol and calcitriol at concentrations in the physiological and clinically significant range prevented the increase in MCP-1, IL-6, renin, and fibronectin mRNA expression and the secretion of MCP-1 to the culture media induced by high glucose. Calcitriol 40-50 C-C motif chemokine ligand 2 Homo sapiens 149-154 22169009-9 2012 In cultured podocytes, paricalcitol and calcitriol at concentrations in the physiological and clinically significant range prevented the increase in MCP-1, IL-6, renin, and fibronectin mRNA expression and the secretion of MCP-1 to the culture media induced by high glucose. Calcitriol 40-50 C-C motif chemokine ligand 2 Homo sapiens 222-227 17869082-4 2008 Similar results were also found in cultured 3T3-L1 adipocytes; in addition, calcitriol also up-regulated macrophage colony-stimulating factor, macrophage inflammatory protein, interleukin-6 (IL-6) as well as monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes and stimulated tumor necrosis factor as well as IL-6 expression in RAW 264 macrophages. Calcitriol 76-86 C-C motif chemokine ligand 2 Homo sapiens 208-242 18379402-0 2008 1,25(OH)2-vitamin D3 inhibits proliferation and decreases production of monocyte chemoattractant protein-1, thrombopoietin, VEGF, and angiogenin by human annulus cells in vitro. Calcitriol 0-20 C-C motif chemokine ligand 2 Homo sapiens 72-106 11340307-0 2001 1,25-dihydroxyvitamin D3 differentially regulates IL-1alpha-stimulated IL-8 and MCP-1 mRNA expression and chemokine secretion by human primary proximal tubular epithelial cells. Calcitriol 0-24 C-C motif chemokine ligand 2 Homo sapiens 80-85 21701898-9 2012 DHCC attenuated TNFalpha-induced CCL2 mRNA expression in both pre-incubation (~15%, p < 0.05) and concomitant (~60%, p < 0.01) treatments. Calcitriol 0-4 C-C motif chemokine ligand 2 Homo sapiens 33-37 21701898-13 2012 CONCLUSIONS: DHCC attenuates MCP-1 and adiponectin production in human adipocytes, thereby reducing the expression of both pro- and anti-inflammatory factors. Calcitriol 13-17 C-C motif chemokine ligand 2 Homo sapiens 29-34 33365026-6 2020 In vitro treatment with 1,25(OH)2D3 reduced proinflammatory cytokines (IL-6, CCL-2, IL-23A, IL-15) whereas anti-inflammatory cytokines (IL-10 and PD-L1) rose both in APS-type 1 diabetes and APS-Addison s disease. Calcitriol 24-35 C-C motif chemokine ligand 2 Homo sapiens 77-82 31114197-8 2019 Encapsulated calcitriol diminished mRNA gene levels of TNF-, NF-B, MCP-1 and IL-6, while upregulating IL-10. Calcitriol 13-23 C-C motif chemokine ligand 2 Homo sapiens 67-72 24587317-9 2014 In primary hPdLCs, both 25(OH)D3 and 1,25(OH)2D3 inhibited the production of IL-8 and MCP-1 but have no significant effect on the IL-6 production. Calcitriol 37-48 C-C motif chemokine ligand 2 Homo sapiens 86-91 22508334-0 2013 1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes. Calcitriol 0-24 C-C motif chemokine ligand 2 Homo sapiens 68-73 22508334-10 2013 Pretreatment with 1,25(OH)2D3 (10 nM and 100 nM) significantly decreased the stimulatory effects of MC medium, TNFalpha and IL-1beta on MCP-1 expression and protein release, although the effect on stimulated release of IL-6 was less potent. Calcitriol 18-29 C-C motif chemokine ligand 2 Homo sapiens 136-141 22508334-11 2013 CONCLUSIONS: These results demonstrate that 1,25(OH)2D3 decreases the production of MCP-1 and other proinflammatory mediators by preadipocytes and reduces monocyte migration. Calcitriol 44-55 C-C motif chemokine ligand 2 Homo sapiens 84-89 26949104-9 2016 This suggests that 1,25(OH)2D3 inhibits ROS, MCP-1, ICAM-1, and adherence of monocytes mediated by the upregulation of GCLC and GSH. Calcitriol 19-30 C-C motif chemokine ligand 2 Homo sapiens 45-50 24184699-0 2014 CCL2 induction by 1,25(OH)2D3 in dendritic cells from healthy donors and multiple sclerosis patients. Calcitriol 18-29 C-C motif chemokine ligand 2 Homo sapiens 0-4 24184699-4 2014 In this study we analyzed the role of 1,25(OH)2D3, the bioactive vitamin D metabolite, in the regulation of CCL2 expression by dendritic cells (DC) obtained from healthy donors and relapsing-remitting MS patients. Calcitriol 38-49 C-C motif chemokine ligand 2 Homo sapiens 108-112 24184699-5 2014 We report that 1,25(OH)2D3, as well as 25OHD3, its main blood precursor, induce the secretion of high levels of CCL2. Calcitriol 15-26 C-C motif chemokine ligand 2 Homo sapiens 112-116 24184699-7 2014 Moreover, we observed that 1,25(OH)2D3 is able to induce a significant CCL2 secretion in DC obtained from relapsing-remitting MS patients, although CCL2 levels in these latter are lower with respect to healthy controls. Calcitriol 27-38 C-C motif chemokine ligand 2 Homo sapiens 71-75 24184699-9 2014 However, we propose CCL2 as a molecular player contributing to the immunomodulatory activity of 1,25(OH)2D3 on DC, and hypothesize a role for this chemokine in the response of MS patients to vitamin D therapy. Calcitriol 96-107 C-C motif chemokine ligand 2 Homo sapiens 20-24 23361158-9 2013 In vitro, LPS- and Pseudomonas-activated monocytes treated with 1,25(OH)2D3 had significantly less MCP-1 secretion compared with untreated cells. Calcitriol 64-75 C-C motif chemokine ligand 2 Homo sapiens 99-104