PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33540416-13 2021 In contrast, 1,25 (OH)2 D3 pretreatment increased the production of IL-8 by LPS- and LTA-stimulated endometrial cells. Calcitriol 13-26 C-X-C motif chemokine ligand 8 Homo sapiens 68-72 26396142-6 2015 Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1. Calcitriol 36-46 C-X-C motif chemokine ligand 8 Homo sapiens 260-263 27779898-7 2016 The active form of VD is 1,25(OH)2D3 that produces biological effects via the nuclear hormone receptor named VD receptor (VDR), which may interfere with the immune cells and macrophages leading to the suppression of the inflammatory process by decreasing the release of TNF-alpha, IL-1, IL-6, and IL-8, IL-12, and IL-23. Calcitriol 25-36 C-X-C motif chemokine ligand 8 Homo sapiens 297-301 27035829-11 2016 RESULTS: In vitro studies showed that 1,25(OH)2D3 significantly reduced IL-1beta- or TNF-alpha-induced inflammatory responses, such as IL-8 expression and prostaglandin activity. Calcitriol 38-49 C-X-C motif chemokine ligand 8 Homo sapiens 135-139 26990648-0 2016 The differential effects of 1,25-dihydroxyvitamin D3 on Salmonella-induced interleukin-8 and human beta-defensin-2 in intestinal epithelial cells. Calcitriol 28-52 C-X-C motif chemokine ligand 8 Homo sapiens 75-88 26893158-7 2016 However, 1,25-dihydroxyvitamin D3 exhibited superior anti-inflammatory effects as it furthermore reduced cytokine-induced NF-kappaB nuclear translocation and interleukin-8 mRNA stability and secretion. Calcitriol 9-33 C-X-C motif chemokine ligand 8 Homo sapiens 158-171 25610950-5 2016 RESULTS: We found that BP IgG-induced IL-6 and IL-8 release from HaCaT cells was reduced in the presence of non-toxic doses of calcitriol. Calcitriol 127-137 C-X-C motif chemokine ligand 8 Homo sapiens 47-51 26156812-5 2015 Calcitriol inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 20, CXC chemokine ligand (CXCL) 10, and matrix metalloproteinase (MMP)-3 release from IL-1beta-stimulated HPDLC. Calcitriol 0-10 C-X-C motif chemokine ligand 8 Homo sapiens 41-45 26156812-7 2015 Moreover, we found c-jun N-terminal kinase (JNK) phosphorylation and IkappaB-alpha degradation in IL-1beta-stimulated HPDLC were inhibited by calcitriol, and JNK and nuclear factor (NF)-kappaB inhibitors could decrease IL-6, IL-8, CCL20, CXCL10, and MMP-3 productions in IL-1beta-treated HPDLC. Calcitriol 142-152 C-X-C motif chemokine ligand 8 Homo sapiens 225-229 24700927-8 2014 Moreover, in an in vitro model of psoriasis (RHE), Calcitriol significantly inhibited relevant gene expression of chemokines (Interleukin-8, Regulated upon Activation Normal T-cell Expressed and Secreted [RANTES]) and psoriasin (S100A7). Calcitriol 51-61 C-X-C motif chemokine ligand 8 Homo sapiens 126-139 25749775-13 2015 Dexamethasone, calcitriol, anti-MD2/anti-TLR2 antibodies, and signalling inhibitors significantly reduced LPS+Der p2-induced IL-6/IL-8 secretion. Calcitriol 15-25 C-X-C motif chemokine ligand 8 Homo sapiens 130-134 24587317-9 2014 In primary hPdLCs, both 25(OH)D3 and 1,25(OH)2D3 inhibited the production of IL-8 and MCP-1 but have no significant effect on the IL-6 production. Calcitriol 37-48 C-X-C motif chemokine ligand 8 Homo sapiens 77-81 24250750-0 2013 Primary 1,25-dihydroxyvitamin D3 response of the interleukin 8 gene cluster in human monocyte- and macrophage-like cells. Calcitriol 8-32 C-X-C motif chemokine ligand 8 Homo sapiens 49-62 12753408-0 2003 Regulation of 1-alpha, 25-dihydroxyvitamin D3 on interleukin-6 and interleukin-8 induced by sulfur mustard (HD) on human skin cells. Calcitriol 14-45 C-X-C motif chemokine ligand 8 Homo sapiens 67-80 22841897-0 2012 1alpha,25-Dihydroxyvitamin D(3) inhibits vascular cellular adhesion molecule-1 expression and interleukin-8 production in human coronary arterial endothelial cells. Calcitriol 0-31 C-X-C motif chemokine ligand 8 Homo sapiens 94-107 20439185-0 2010 Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures. Calcitriol 23-33 C-X-C motif chemokine ligand 8 Homo sapiens 76-89 20439185-3 2010 The purpose of this study was to investigate the influence of 1alpha,25-dihydroxyvitamin D3 (calcitriol) and 1alpha,24(R)-dihydroxyvitamin D3 (tacalcitol) on the secretion of IL-6 and IL-8 by fibroblasts derived from NP. Calcitriol 62-91 C-X-C motif chemokine ligand 8 Homo sapiens 184-188 20439185-8 2010 RESULTS: Treatment with calcitriol or tacalcitol inhibits the synthesis of both IL-6 and IL-8 compared to the control group. Calcitriol 24-34 C-X-C motif chemokine ligand 8 Homo sapiens 89-93 20439185-12 2010 CONCLUSIONS: The present study demonstrates that calcitriol and tacalcitol are capable of affecting pro-inflammatory cytokine (IL-6 and IL-8) levels in NP cultures. Calcitriol 49-59 C-X-C motif chemokine ligand 8 Homo sapiens 136-140 23083515-2 2013 The present study aimed to discover the effects of 1a,25-dihydroxyvitamin D3 (1,25D) on the expressions of interleukin (IL)-6 and IL-8 in human periodontal ligament cells (hPDLCs) stimulated with Porphyromonas gingivalis (P. gingivalis) W83. Calcitriol 51-76 C-X-C motif chemokine ligand 8 Homo sapiens 130-134 22526597-8 2012 The decreased activation of RelA by calcitriol was confirmed by decreased release of RelA-inducible molecules, including IL-5, IL-6 and IL-8, by HBSMCs upon calcitriol treatment. Calcitriol 36-46 C-X-C motif chemokine ligand 8 Homo sapiens 136-140 22526597-8 2012 The decreased activation of RelA by calcitriol was confirmed by decreased release of RelA-inducible molecules, including IL-5, IL-6 and IL-8, by HBSMCs upon calcitriol treatment. Calcitriol 157-167 C-X-C motif chemokine ligand 8 Homo sapiens 136-140 17112620-8 2007 1,25-Dihydroxyvitamin D(3) was able to down-regulate the expression of TNF-alpha, IL-6, IL-1, and IL-8, confirming its immunomodulatory properties. Calcitriol 0-26 C-X-C motif chemokine ligand 8 Homo sapiens 98-102 16624828-0 2006 1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis. Calcitriol 0-30 C-X-C motif chemokine ligand 8 Homo sapiens 42-55 12022438-3 2002 1,25(OH)2D3 inhibited only the late phase of the biphasic IL-8 production in lipopolysaccharide-stimulated human whole blood. Calcitriol 0-11 C-X-C motif chemokine ligand 8 Homo sapiens 58-62 12022438-0 2002 1 alpha,25-dihydroxyvitamin D3 suppresses interleukin-1beta-induced interleukin-8 production in human whole blood: an involvement of erythrocytes in the inhibition. Calcitriol 0-30 C-X-C motif chemokine ligand 8 Homo sapiens 68-81 12022438-6 2002 Although monocytes were found to be mainly responsible for IL-1beta-induced IL-8 production in whole blood, 1,25(OH)2D3 inhibited IL-8 production by isolated mononuclear cells only marginally. Calcitriol 108-119 C-X-C motif chemokine ligand 8 Homo sapiens 130-134 12022438-8 2002 These results suggest that erythrocytes play a role in mediating the inhibitory effects of 1,25(OH)2D3 on IL-8 production in IL-1beta-stimulated whole blood. Calcitriol 91-102 C-X-C motif chemokine ligand 8 Homo sapiens 106-110 9431991-0 1997 1alpha,25-dihydroxyvitamin D3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-kappaB-mediated interleukin-8 gene expression. Calcitriol 0-29 C-X-C motif chemokine ligand 8 Homo sapiens 128-141 11340307-0 2001 1,25-dihydroxyvitamin D3 differentially regulates IL-1alpha-stimulated IL-8 and MCP-1 mRNA expression and chemokine secretion by human primary proximal tubular epithelial cells. Calcitriol 0-24 C-X-C motif chemokine ligand 8 Homo sapiens 71-75 9723955-11 1998 Three active vitamin D3 compounds, tacalcitol, 1alpha,25-dihydroxyvitamin D3 and MC903 (calcipotriol), inhibited the production of RANTES and IL-8, with very similar potencies. Calcitriol 47-76 C-X-C motif chemokine ligand 8 Homo sapiens 142-146 9431991-3 1997 1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha-induced IL-8 release and IL-8 mRNA levels. Calcitriol 0-29 C-X-C motif chemokine ligand 8 Homo sapiens 53-57 9431991-3 1997 1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha-induced IL-8 release and IL-8 mRNA levels. Calcitriol 0-29 C-X-C motif chemokine ligand 8 Homo sapiens 241-245 9431991-3 1997 1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha-induced IL-8 release and IL-8 mRNA levels. Calcitriol 0-29 C-X-C motif chemokine ligand 8 Homo sapiens 241-245 9431991-3 1997 1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha-induced IL-8 release and IL-8 mRNA levels. Calcitriol 31-41 C-X-C motif chemokine ligand 8 Homo sapiens 53-57 9431991-3 1997 1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha-induced IL-8 release and IL-8 mRNA levels. Calcitriol 31-41 C-X-C motif chemokine ligand 8 Homo sapiens 241-245 9431991-3 1997 1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha-induced IL-8 release and IL-8 mRNA levels. Calcitriol 31-41 C-X-C motif chemokine ligand 8 Homo sapiens 241-245 9431991-6 1997 Furthermore, overexpression of VDR in the parental G-361 cell line enhanced the repressive effect of calcitriol on activation of the IL-8 promoter by either TNF-alpha stimulation or overexpression of the NF-kappaB subunit p65. Calcitriol 101-111 C-X-C motif chemokine ligand 8 Homo sapiens 133-137 9431991-7 1997 Electrophoretic mobility shift assays using nuclear extracts from A3 cells showed that calcitriol decreased the abundance of nuclear factors bound to the NF-kappaB binding site of the IL-8 promoter and this reduced binding of NF-kappaB proteins presumably contributes to its inhibitory action. Calcitriol 87-97 C-X-C motif chemokine ligand 8 Homo sapiens 184-188 8915775-3 1996 NaF increased cellular reduction of nitroblue tetrazolium (NBT), and this effect was strongly augmented by 1,25(OH)2D3. Calcitriol 107-118 C-X-C motif chemokine ligand 8 Homo sapiens 0-3 9302649-0 1997 1,25-Dihydroxyvitamin D3 and a new analogue, 22-oxacalcitriol, modulate proliferation and interleukin-8 secretion of normal human keratinocytes. Calcitriol 0-24 C-X-C motif chemokine ligand 8 Homo sapiens 90-103 9302649-6 1997 Proliferation of cultured normal human epidermal keratinocytes was inhibited in the presence of 1,25-dihydroxyvitamin D3 at the concentrations of 1 x 10(-8) to 1 x 10(-6) M and 22-oxacalcitriol at concentrations of more than 1 x 10(-9) M at 48 h. IL-8 secretion from normal human epidermal keratinocytes was augmented by TNF-alpha, or synergistically by TNF-alpha and IFN-gamma. Calcitriol 96-120 C-X-C motif chemokine ligand 8 Homo sapiens 247-251 9302649-7 1997 1,25-Dihydroxyvitamin D3 and 22-oxacalcitriol inhibited cytokine-stimulated IL-8 production dose dependently after 24 h incubation without inhibition of cell proliferation. Calcitriol 0-24 C-X-C motif chemokine ligand 8 Homo sapiens 76-80 9302649-8 1997 1,25-Dihydroxyvitamin D3 and 22-oxacalcitriol are considered to inhibit the proliferation of keratinocytes directly and indirectly with inhibition of the secretion of IL-8 from keratinocytes. Calcitriol 0-24 C-X-C motif chemokine ligand 8 Homo sapiens 167-171 9228216-6 1997 The immunoreactivity of markers for epidermal proliferation and differentiation, as well as of CD1a and NAP-1/IL-8, changed after 8 weeks of calcitriol treatment almost completely to the pattern characteristic for non-lesional psoriatic skin, while a large number of 55 kDa TNF-receptor positive cells could be found in the dermal compartment. Calcitriol 141-151 C-X-C motif chemokine ligand 8 Homo sapiens 104-109 9228216-6 1997 The immunoreactivity of markers for epidermal proliferation and differentiation, as well as of CD1a and NAP-1/IL-8, changed after 8 weeks of calcitriol treatment almost completely to the pattern characteristic for non-lesional psoriatic skin, while a large number of 55 kDa TNF-receptor positive cells could be found in the dermal compartment. Calcitriol 141-151 C-X-C motif chemokine ligand 8 Homo sapiens 110-114 8915775-5 1996 Furthermore, NaF increased expression of CD11b and CD66b, and this stimulation was enhanced by adding 1,25(OH)2D3. Calcitriol 102-113 C-X-C motif chemokine ligand 8 Homo sapiens 13-16 8915775-9 1996 Similarly, NaF stimulated the production of interleukin 1 alpha (IL-1 alpha), IL-6, and tumor necrosis factor-alpha, and 1,25(OH)2D3 again strongly enhanced these effects. Calcitriol 121-132 C-X-C motif chemokine ligand 8 Homo sapiens 11-14 8915775-11 1996 These additional findings together with the observed slow onset (24-48 h) of NaF and 1,25(OH)2D3 interaction strongly suggest that 1,25(OH)2D3 acts as a cofactor with NaF primarily through interaction with an endogenous NaF-induced cyclo-oxygenase product(s), quite possibly PGE2 itself. Calcitriol 85-96 C-X-C motif chemokine ligand 8 Homo sapiens 167-170 8915775-11 1996 These additional findings together with the observed slow onset (24-48 h) of NaF and 1,25(OH)2D3 interaction strongly suggest that 1,25(OH)2D3 acts as a cofactor with NaF primarily through interaction with an endogenous NaF-induced cyclo-oxygenase product(s), quite possibly PGE2 itself. Calcitriol 85-96 C-X-C motif chemokine ligand 8 Homo sapiens 167-170 8915775-11 1996 These additional findings together with the observed slow onset (24-48 h) of NaF and 1,25(OH)2D3 interaction strongly suggest that 1,25(OH)2D3 acts as a cofactor with NaF primarily through interaction with an endogenous NaF-induced cyclo-oxygenase product(s), quite possibly PGE2 itself. Calcitriol 131-142 C-X-C motif chemokine ligand 8 Homo sapiens 77-80 8915775-11 1996 These additional findings together with the observed slow onset (24-48 h) of NaF and 1,25(OH)2D3 interaction strongly suggest that 1,25(OH)2D3 acts as a cofactor with NaF primarily through interaction with an endogenous NaF-induced cyclo-oxygenase product(s), quite possibly PGE2 itself. Calcitriol 131-142 C-X-C motif chemokine ligand 8 Homo sapiens 167-170 8915775-11 1996 These additional findings together with the observed slow onset (24-48 h) of NaF and 1,25(OH)2D3 interaction strongly suggest that 1,25(OH)2D3 acts as a cofactor with NaF primarily through interaction with an endogenous NaF-induced cyclo-oxygenase product(s), quite possibly PGE2 itself. Calcitriol 131-142 C-X-C motif chemokine ligand 8 Homo sapiens 167-170 8915775-12 1996 Such a mechanism for NaF and 1,25(OH)2D3 interaction would be strongly analogous to the interaction we have recently demonstrated between 1,25(OH)2D3 and PGE1 on the differentiation of HL-60 cells. Calcitriol 138-149 C-X-C motif chemokine ligand 8 Homo sapiens 21-24 8202627-0 1994 Inhibition of IL-6 and IL-8 production in human fibroblast cell lines by 1,25 (OH)2 vitamin D3 and two of its analogs with lower calcemic activity. Calcitriol 73-94 C-X-C motif chemokine ligand 8 Homo sapiens 23-27 8726037-0 1996 Inhibitory effect of erythromycin on interleukin 8 production by 1 alpha,25-dihydroxyvitamin D3-stimulated THP-1 cells. Calcitriol 65-95 C-X-C motif chemokine ligand 8 Homo sapiens 37-50 7670094-4 1995 Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA). Calcitriol 0-10 C-X-C motif chemokine ligand 8 Homo sapiens 51-64 7670094-4 1995 Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA). Calcitriol 0-10 C-X-C motif chemokine ligand 8 Homo sapiens 66-70 7670094-4 1995 Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA). Calcitriol 0-10 C-X-C motif chemokine ligand 8 Homo sapiens 161-165 7571853-19 1995 1 alpha, 25-dihydroxy vitamin D3 also inhibited neutrophil-derived IL-8. Calcitriol 0-32 C-X-C motif chemokine ligand 8 Homo sapiens 67-71 8088360-3 1994 Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected. Calcitriol 14-24 C-X-C motif chemokine ligand 8 Homo sapiens 88-101 8088360-3 1994 Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected. Calcitriol 14-24 C-X-C motif chemokine ligand 8 Homo sapiens 149-162 8162169-7 1994 In the presence of 1,25-dihydroxycholecalciferol (10(-9) mol/l), NaF enhanced alkaline phosphatase (p < 0.05, N = 8), procollagen type I propeptide (p < 0.05, N = 7) and osteocalcin (p < 0.05, N = 7) production by hMS(OB) cells but not by hOB cells. Calcitriol 19-48 C-X-C motif chemokine ligand 8 Homo sapiens 65-68 8193081-5 1994 In the present study, we investigated the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and its analogue MC903 on IL-1 alpha and IL-8 secretion by human keratinocytes in vitro. Calcitriol 53-79 C-X-C motif chemokine ligand 8 Homo sapiens 133-137 8193081-5 1994 In the present study, we investigated the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and its analogue MC903 on IL-1 alpha and IL-8 secretion by human keratinocytes in vitro. Calcitriol 79-90 C-X-C motif chemokine ligand 8 Homo sapiens 133-137 8193081-11 1994 Addition of 1,25(OH)2D3 or MC903 inhibited the increased secretion of IL-8 but restored decreased secretion of IL-1 alpha from stimulated NHKs dose dependently. Calcitriol 12-23 C-X-C motif chemokine ligand 8 Homo sapiens 70-74 2039486-0 1991 1,25(OH)2-D3 is a potent regulator of interleukin-1 induced interleukin-8 expression and production. Calcitriol 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 60-73 8304046-3 1993 NaF alone did not increase type I collagen production, but in the presence of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] (10(-9) M), NaF enhanced type I collagen production in a dose-dependent way to 300% of 1,25-(OH)2D3-treated control cultures. Calcitriol 104-116 C-X-C motif chemokine ligand 8 Homo sapiens 130-133 7681085-4 1993 Calcitriol was used to induce a high level of CD14 expression in the human monocyte-like cell line THP-1, resulting in enhanced responses of these cells to LPS-LBP complexes manifested by enhanced binding of LPS and a decrease in the amount of LPS needed to induce IL-8 release. Calcitriol 0-10 C-X-C motif chemokine ligand 8 Homo sapiens 265-269 2039486-3 1991 We studied the possible effect of an endogenous immune modulator 1,25(OH)2-cholecalciferol (1,25(OH)2-D3) on the IL-1-induced IL-8-production by several types of cells. Calcitriol 92-104 C-X-C motif chemokine ligand 8 Homo sapiens 126-130 2039486-4 1991 1,25(OH)2-D3 inhibited the IL-1-alpha induced IL-8 production and mRNA expression in keratinocytes, fibroblasts and PBMC, but not in endothelial cells. Calcitriol 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 46-50