PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18281521-2 2008 In the present study, we have analyzed the effects of calcitriol treatment on the expression and activity of the UDP-glucuronosyltransferase (UGT) 2B15 and 2B17 in prostate cancer LNCaP and 22Rv1 cells. Calcitriol 54-64 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 113-160 18281521-7 2008 By contrast, transient transfection and site-directed mutagenesis experiments revealed that calcitriol down-regulates UGT2B15 promoter activity through a responsive region between positions -171 and -113 bp. Calcitriol 92-102 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 118-125 18281521-8 2008 In conclusion, the present study identifies the vitamin D receptor activator calcitriol as a negative regulator of the UGT2B15- and UGT2B17-dependent inactivation of androgens in prostate cancer LNCaP cells. Calcitriol 77-87 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 119-126 9307296-5 1997 Androgens and 1,25-dihydroxyvitamin D3 were able to down-regulate UGT2B15 mRNA in LNCaP-LNO cells. Calcitriol 14-38 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 66-73