PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17397830-0 2007 1,25-dihydroxyvitamin D3 induces biphasic NF-kappaB responses during HL-60 leukemia cells differentiation through protein induction and PI3K/Akt-dependent phosphorylation/degradation of IkappaB. Calcitriol 0-24 nuclear factor kappa B subunit 1 Homo sapiens 42-51 18717824-0 2008 Calcitriol blunts pro-atherosclerotic parameters through NFkappaB and p38 in vitro. Calcitriol 0-10 nuclear factor kappa B subunit 1 Homo sapiens 57-65 18717824-8 2008 Furthermore, the LPS induced nuclear factor kappaB (NFkappaB)-p65 DNA-binding activity was also decreased by calcitriol. Calcitriol 109-119 nuclear factor kappa B subunit 1 Homo sapiens 52-60 18717824-11 2008 CONCLUSIONS: The decreased NFkappaB and p38 activities followed by calcitriol treatment may explain the anti-inflammatory/atherosclerotic properties of calcitriol that were observed previously and were emphasized in this study, demonstrating the inhibitory effect of calcitriol on the pro-inflammatory parameters: adhesion molecules, RAGE and IL-6. Calcitriol 152-162 nuclear factor kappa B subunit 1 Homo sapiens 27-35 18717824-11 2008 CONCLUSIONS: The decreased NFkappaB and p38 activities followed by calcitriol treatment may explain the anti-inflammatory/atherosclerotic properties of calcitriol that were observed previously and were emphasized in this study, demonstrating the inhibitory effect of calcitriol on the pro-inflammatory parameters: adhesion molecules, RAGE and IL-6. Calcitriol 152-162 nuclear factor kappa B subunit 1 Homo sapiens 27-35 9431991-0 1997 1alpha,25-dihydroxyvitamin D3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-kappaB-mediated interleukin-8 gene expression. Calcitriol 0-29 nuclear factor kappa B subunit 1 Homo sapiens 112-118 12234604-8 2002 These results indicate that PKC, PI3-K, ERK and NF-kappaB may be involved in 1,25-(OH)(2)D(3)-mediated cell differentiation enhanced by costunolide. Calcitriol 77-93 nuclear factor kappa B subunit 1 Homo sapiens 48-57 11777342-0 2002 1alpha,25-dihydroxyvitamin D3 stimulates phosphorylation of IkappaBalpha and synergizes with TPA to induce nuclear translocation of NFkappaB during monocytic differentiation of NB4 leukemia cells. Calcitriol 0-29 nuclear factor kappa B subunit 1 Homo sapiens 132-140 11877332-0 2002 Enhancement of 1 alpha,25-dihydroxyvitamin D(3)-induced differentiation of human leukaemia HL-60 cells into monocytes by parthenolide via inhibition of NF-kappa B activity. Calcitriol 15-47 nuclear factor kappa B subunit 1 Homo sapiens 152-162 11877332-13 2002 Furthermore, PT restored 1,25-(OH)(2)D(3)-induced VDRE-dependent promoter activity inhibited by TNF-alpha, an activator of NF-kappa B signalling pathway. Calcitriol 25-41 nuclear factor kappa B subunit 1 Homo sapiens 123-133 11877332-15 2002 These results indicate that PT strongly potentiates the 1,25-(OH)(2)D(3)-induced HL-60 cell differentiation into monocytes via the inhibition of NF-kappa B activity and provide evidence that inhibition of NF-kappa B activation can be a pre-requisite to the efficient entry of promyelocytic leukaemia cells into a differentiation pathway. Calcitriol 56-72 nuclear factor kappa B subunit 1 Homo sapiens 145-155 11281654-6 2001 In U87 cells that were stably transfected with BAG-1 p50, binding of the VDR to its response element in electrophoretic mobility shift assays was blocked, enhancement of transcriptional activation was inhibited, cell growth rate was enhanced, cell growth inhibition induced by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] was blocked, and 1,25(OH)2D3-mediated VDR induction was inhibited. Calcitriol 277-301 nuclear factor kappa B subunit 1 Homo sapiens 53-56 11281654-6 2001 In U87 cells that were stably transfected with BAG-1 p50, binding of the VDR to its response element in electrophoretic mobility shift assays was blocked, enhancement of transcriptional activation was inhibited, cell growth rate was enhanced, cell growth inhibition induced by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] was blocked, and 1,25(OH)2D3-mediated VDR induction was inhibited. Calcitriol 303-314 nuclear factor kappa B subunit 1 Homo sapiens 53-56 11281654-6 2001 In U87 cells that were stably transfected with BAG-1 p50, binding of the VDR to its response element in electrophoretic mobility shift assays was blocked, enhancement of transcriptional activation was inhibited, cell growth rate was enhanced, cell growth inhibition induced by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] was blocked, and 1,25(OH)2D3-mediated VDR induction was inhibited. Calcitriol 333-344 nuclear factor kappa B subunit 1 Homo sapiens 53-56 11281654-7 2001 These results suggest that BAG-1 p50 is a novel regulator of the vitamin D signaling pathway, and its overexpression may lead to cellular resistance to 1,25(OH)2D3 therapy. Calcitriol 152-163 nuclear factor kappa B subunit 1 Homo sapiens 33-36 9566710-2 1998 We have also shown that a variety of agents which inhibit NF-kappaB, including vitamin E and related antioxidants, curcumin and several non-steroidal anti-inflammatory agents, significantly enhanced the differentiation of HL-60 leukemia cells when combined with low levels of 1,25-dihydroxyvitamin D3 (vitamin D3). Calcitriol 276-300 nuclear factor kappa B subunit 1 Homo sapiens 58-67 9431991-6 1997 Furthermore, overexpression of VDR in the parental G-361 cell line enhanced the repressive effect of calcitriol on activation of the IL-8 promoter by either TNF-alpha stimulation or overexpression of the NF-kappaB subunit p65. Calcitriol 101-111 nuclear factor kappa B subunit 1 Homo sapiens 204-213 9431991-7 1997 Electrophoretic mobility shift assays using nuclear extracts from A3 cells showed that calcitriol decreased the abundance of nuclear factors bound to the NF-kappaB binding site of the IL-8 promoter and this reduced binding of NF-kappaB proteins presumably contributes to its inhibitory action. Calcitriol 87-97 nuclear factor kappa B subunit 1 Homo sapiens 157-163 9431991-7 1997 Electrophoretic mobility shift assays using nuclear extracts from A3 cells showed that calcitriol decreased the abundance of nuclear factors bound to the NF-kappaB binding site of the IL-8 promoter and this reduced binding of NF-kappaB proteins presumably contributes to its inhibitory action. Calcitriol 87-97 nuclear factor kappa B subunit 1 Homo sapiens 154-163 31288897-6 2019 1,25(OH)2D3 inhibited LPS-stimulated phosphorylation of Akt at S473 and T308, IkappaBalpha phosphorylation, and nuclear accumulation of NF-kappaB. Calcitriol 0-11 nuclear factor kappa B subunit 1 Homo sapiens 136-145 31684930-7 2019 Additionally, 1,25D3 increased VDR expression and AhR activation, and repressed NF-kappaB phosphorylation. Calcitriol 14-20 nuclear factor kappa B subunit 1 Homo sapiens 80-89 31684930-8 2019 Furthermore, 1,25D3 suppressed IL-6 expression and enhanced VDR expression and regulated AhR/NF-kappaB signaling activation in a dose-dependent manner after 48 h treatment. Calcitriol 13-19 nuclear factor kappa B subunit 1 Homo sapiens 93-102 31684930-9 2019 CONCLUSIONS: These results suggest that 1,25D3 may inhibit LPS-induced IL-6 overexpression in human oral epithelial cells through AhR/NF-kappaB signaling. Calcitriol 40-46 nuclear factor kappa B subunit 1 Homo sapiens 134-143 7479923-0 1995 Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3. Calcitriol 79-103 nuclear factor kappa B subunit 1 Homo sapiens 19-29 7479923-1 1995 The effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2)D3], a steroid hormone with immunomodulating properties, on nuclear factor kappa B (NF-kappa B) proteins was examined in in vitro activated normal human lymphocytes by Western blot analysis. Calcitriol 14-38 nuclear factor kappa B subunit 1 Homo sapiens 110-132 7479923-1 1995 The effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2)D3], a steroid hormone with immunomodulating properties, on nuclear factor kappa B (NF-kappa B) proteins was examined in in vitro activated normal human lymphocytes by Western blot analysis. Calcitriol 14-38 nuclear factor kappa B subunit 1 Homo sapiens 134-144 7479923-1 1995 The effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2)D3], a steroid hormone with immunomodulating properties, on nuclear factor kappa B (NF-kappa B) proteins was examined in in vitro activated normal human lymphocytes by Western blot analysis. Calcitriol 40-52 nuclear factor kappa B subunit 1 Homo sapiens 110-132 7479923-1 1995 The effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2)D3], a steroid hormone with immunomodulating properties, on nuclear factor kappa B (NF-kappa B) proteins was examined in in vitro activated normal human lymphocytes by Western blot analysis. Calcitriol 40-52 nuclear factor kappa B subunit 1 Homo sapiens 134-144 7479923-5 1995 Besides p50, 1,25(OH)2D3 decreased the levels of another NF-kappa B protein, namely c-rel. Calcitriol 13-24 nuclear factor kappa B subunit 1 Homo sapiens 57-67 7479923-7 1995 Further, 1,25(OH)2D3 inhibited the transcriptional activity of NF-kappa B in Jurkat cells transiently transfected with a construct containing four tandem repeats of the NF-kappa B binding sequence of the immunoglobulin kappa light chain gene linked to the chloramphenicol acetyltransferase reporter gene. Calcitriol 9-20 nuclear factor kappa B subunit 1 Homo sapiens 63-73 7479923-7 1995 Further, 1,25(OH)2D3 inhibited the transcriptional activity of NF-kappa B in Jurkat cells transiently transfected with a construct containing four tandem repeats of the NF-kappa B binding sequence of the immunoglobulin kappa light chain gene linked to the chloramphenicol acetyltransferase reporter gene. Calcitriol 9-20 nuclear factor kappa B subunit 1 Homo sapiens 169-179 31288897-8 2019 Blocking NF-kappaB signaling blunted the suppression effect of 1,25(OH)2D3 on IkappaBalpha phosphorylation, NF-kappaB accumulation in the nucleus and COX-2 expression. Calcitriol 63-74 nuclear factor kappa B subunit 1 Homo sapiens 9-18 31288897-8 2019 Blocking NF-kappaB signaling blunted the suppression effect of 1,25(OH)2D3 on IkappaBalpha phosphorylation, NF-kappaB accumulation in the nucleus and COX-2 expression. Calcitriol 63-74 nuclear factor kappa B subunit 1 Homo sapiens 108-117 31288897-9 2019 These results indicate that 1,25(OH)2D3 suppresses inflammatory response in LPS-induced HUVECs through PI3K/Akt/NF-kappaB signaling pathway. Calcitriol 28-39 nuclear factor kappa B subunit 1 Homo sapiens 112-121 30928409-15 2019 In conclusion, 1,25-(OH)2D3 could protect Schwann cell against AGE-induced apoptosis through PKA/NF-kappaB pathway. Calcitriol 15-27 nuclear factor kappa B subunit 1 Homo sapiens 97-106 30928409-0 2019 1,25-(OH)2D3 protects Schwann cells against advanced glycation end products-induced apoptosis through PKA-NF-kappaB pathway. Calcitriol 0-12 nuclear factor kappa B subunit 1 Homo sapiens 106-115 29039981-10 2019 In vitro studies showed that calcitriol significantly decreased the expression of pro-inflammatory mediators in iHCECs under hyperosmotic stress, probably through inhibiting NF-kappaB activation. Calcitriol 29-39 nuclear factor kappa B subunit 1 Homo sapiens 174-183 30430362-0 2019 1,25-Dihydroxy Vitamin D3 Attenuates the Oxidative Stress-Mediated Inflammation Induced by PM2.5via the p38/NF-kappaB/NLRP3 Pathway. Calcitriol 0-25 nuclear factor kappa B subunit 1 Homo sapiens 108-117 30430362-7 2019 Furthermore, 1,25-(OH)2D3 also reduced transcriptional activation of NF-kappaB induced by PM2.5 as indicated by a significant decrease in luciferase activity in HBE cells stably transfected with the NF-kappaB response element (RE)-driven luciferase reporter. Calcitriol 13-25 nuclear factor kappa B subunit 1 Homo sapiens 69-78 30430362-7 2019 Furthermore, 1,25-(OH)2D3 also reduced transcriptional activation of NF-kappaB induced by PM2.5 as indicated by a significant decrease in luciferase activity in HBE cells stably transfected with the NF-kappaB response element (RE)-driven luciferase reporter. Calcitriol 13-25 nuclear factor kappa B subunit 1 Homo sapiens 199-208 28722189-8 2017 Moreover, control and NF-kappaB inhibitor-treated HL-1 cells had similar RAGE and sRAGE expression, suggesting that calcitriol-mediated RAGE modulation was independent of NF-kappaB signalling. Calcitriol 116-126 nuclear factor kappa B subunit 1 Homo sapiens 22-31 26700731-5 2016 However, addition of calcitriol or paricalcitol blunted the TNF-alpha-induced TF expression and activity (2.01 +- 0.24 and 1.32 +- 0.14 vs. 3.02 +- 0.39 pmol/mg protein, P < 0.05), which was associated with down-regulation of NF-kappaB signaling and PAR-2 expression, as well as with restored levels of vitamin D receptor and enhanced expression of TF pathway inhibitor. Calcitriol 21-31 nuclear factor kappa B subunit 1 Homo sapiens 229-238 27856242-6 2017 Further studies revealed that 1, 25(OH)2D3-induced interaction of VDR with p50 decreases LPS-induced interaction of KLF5 with p50. Calcitriol 30-42 nuclear factor kappa B subunit 1 Homo sapiens 75-78 27856242-6 2017 Further studies revealed that 1, 25(OH)2D3-induced interaction of VDR with p50 decreases LPS-induced interaction of KLF5 with p50. Calcitriol 30-42 nuclear factor kappa B subunit 1 Homo sapiens 126-129 27856242-7 2017 Collectively, we identify a novel regulatory pathway in which 1, 25(OH)2D3 induces VDR expression and promotes VDR interaction with p50 subunit of NF-kappaB, which in turn attenuates the association of KLF5 with p50 subunit of NF-kappaB and thus exerts anti-inflammatory and anti-proliferative effects on macrophages. Calcitriol 62-74 nuclear factor kappa B subunit 1 Homo sapiens 132-135 27856242-7 2017 Collectively, we identify a novel regulatory pathway in which 1, 25(OH)2D3 induces VDR expression and promotes VDR interaction with p50 subunit of NF-kappaB, which in turn attenuates the association of KLF5 with p50 subunit of NF-kappaB and thus exerts anti-inflammatory and anti-proliferative effects on macrophages. Calcitriol 62-74 nuclear factor kappa B subunit 1 Homo sapiens 150-156 27856242-7 2017 Collectively, we identify a novel regulatory pathway in which 1, 25(OH)2D3 induces VDR expression and promotes VDR interaction with p50 subunit of NF-kappaB, which in turn attenuates the association of KLF5 with p50 subunit of NF-kappaB and thus exerts anti-inflammatory and anti-proliferative effects on macrophages. Calcitriol 62-74 nuclear factor kappa B subunit 1 Homo sapiens 212-215 27856242-7 2017 Collectively, we identify a novel regulatory pathway in which 1, 25(OH)2D3 induces VDR expression and promotes VDR interaction with p50 subunit of NF-kappaB, which in turn attenuates the association of KLF5 with p50 subunit of NF-kappaB and thus exerts anti-inflammatory and anti-proliferative effects on macrophages. Calcitriol 62-74 nuclear factor kappa B subunit 1 Homo sapiens 230-236 26782341-0 2016 1,25-Dihydroxyvitamin D3 alleviates salivary adenoid cystic carcinoma progression by suppressing GPX1 expression through the NF-kappaB pathway. Calcitriol 0-24 nuclear factor kappa B subunit 1 Homo sapiens 125-134 24747771-6 2014 We found that 1alpha,25-dihydroxyvitamin D3 stimulates the gene expression of IkB, an NFkappaB-inhibiting protein, and that cells pretreated with 1alpha,25-dihydroxyvitamin D3 have a decreased sensitivity to TNFalpha stimulation. Calcitriol 14-43 nuclear factor kappa B subunit 1 Homo sapiens 86-94 25610950-6 2016 Additionally, calcitriol blunted BP IgG-mediated STAT3 phosphorylation and NFkappaB activity, whereas Hsp70 and VDR expression were not affected. Calcitriol 14-24 nuclear factor kappa B subunit 1 Homo sapiens 75-83 24747771-0 2014 1alpha,25-dihydroxyvitamin D3 inhibits cell growth and NFkappaB signaling in tamoxifen-resistant breast cancer cells. Calcitriol 0-29 nuclear factor kappa B subunit 1 Homo sapiens 55-63 24747771-5 2014 We found that 1alpha,25-dihydroxyvitamin D3 is able to strongly decrease the growth of both tamoxifen-sensitive and -resistant breast cancer cells and that this antiproliferative effect of 1alpha,25-dihydroxyvitamin D3 might be mediated via inhibition of the NFkappaB pathway. Calcitriol 14-43 nuclear factor kappa B subunit 1 Homo sapiens 259-267 24747771-8 2014 This manuscript reports novel findings regarding the effects of 1alpha,25-dihydroxyvitamin D3 on NFkappaB signaling in tamoxifen-resistant breast cancer cells and suggests that vitamin D might be interesting for further evaluation as a new strategy to treat antiestrogen-resistant breast cancers. Calcitriol 64-93 nuclear factor kappa B subunit 1 Homo sapiens 97-105 23637889-0 2013 1,25-dihydroxyvitamin D3 protects against macrophage-induced activation of NFkappaB and MAPK signalling and chemokine release in human adipocytes. Calcitriol 0-24 nuclear factor kappa B subunit 1 Homo sapiens 75-83 23637889-5 2013 Treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) abolished macrophage-induced activation of NFkappaB signalling by increasing IkappaBalpha expression (2.7-fold, P = 0.005) and reducing NFkappaB p65 phosphorylation (68%; P<0.001). Calcitriol 15-39 nuclear factor kappa B subunit 1 Homo sapiens 97-105 23637889-5 2013 Treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) abolished macrophage-induced activation of NFkappaB signalling by increasing IkappaBalpha expression (2.7-fold, P = 0.005) and reducing NFkappaB p65 phosphorylation (68%; P<0.001). Calcitriol 15-39 nuclear factor kappa B subunit 1 Homo sapiens 190-198 22508334-7 2013 The involvement of NFkappaB signalling was shown by the upregulation of IkappaBalpha protein abundance by 1,25(OH)2D3 in preadipocytes. Calcitriol 106-117 nuclear factor kappa B subunit 1 Homo sapiens 19-27 20371119-0 2010 1alpha,25-Dihydroxyvitamin D3 inhibits transcriptional potential of nuclear factor kappa B in breast cancer cells. Calcitriol 0-29 nuclear factor kappa B subunit 1 Homo sapiens 68-90 22615136-12 2012 Overall, our results indicate that progesterone and calcitriol inhibit IkappaBalpha phosphorylation, NFkappaB activation, and the expression of NFkappaB regulated metastasis promoting genes. Calcitriol 52-62 nuclear factor kappa B subunit 1 Homo sapiens 101-109 22615136-12 2012 Overall, our results indicate that progesterone and calcitriol inhibit IkappaBalpha phosphorylation, NFkappaB activation, and the expression of NFkappaB regulated metastasis promoting genes. Calcitriol 52-62 nuclear factor kappa B subunit 1 Homo sapiens 144-152 23152895-0 2012 1,25-Dihydroxyvitamin D3 promotes a sustained LPS-induced NF-kappaB-dependent expression of CD55 in human monocytic THP-1 cells. Calcitriol 0-24 nuclear factor kappa B subunit 1 Homo sapiens 58-67 22798425-0 2012 Inhibition of cytokine secretion from adipocytes by 1,25-dihydroxyvitamin D3 via the NF-kappaB pathway. Calcitriol 52-76 nuclear factor kappa B subunit 1 Homo sapiens 85-94 22798425-2 2012 We hypothesized that 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] inhibits cytokine secretion from adipocytes via direct inhibition of transcription factor nuclear factor-kappaB (NF-kappaB). Calcitriol 21-47 nuclear factor kappa B subunit 1 Homo sapiens 179-188 22615136-7 2012 Knockdown of NFkappaB resulted in a reduced expression of CXCL1 and CXCL2 and the inhibitory effect of progesterone and calcitriol on the expression of chemokines was abrogated in NFkappaB-silenced cancer cells. Calcitriol 120-130 nuclear factor kappa B subunit 1 Homo sapiens 13-21 22615136-7 2012 Knockdown of NFkappaB resulted in a reduced expression of CXCL1 and CXCL2 and the inhibitory effect of progesterone and calcitriol on the expression of chemokines was abrogated in NFkappaB-silenced cancer cells. Calcitriol 120-130 nuclear factor kappa B subunit 1 Homo sapiens 180-188 20020446-11 2010 The effect of calcitriol was associated with inhibition of JNK activation and reduction of DNA-binding activities of the transcription factors activator protein-1 (AP-1) and NFkappaB following treatment with TNFalpha. Calcitriol 14-24 nuclear factor kappa B subunit 1 Homo sapiens 174-182