PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1997401-0 1991 Regulation of interleukin-1 and tumour necrosis factor gene expression in myelomonocytic cell lines by 1,25-dihydroxyvitamin D3. Calcitriol 103-127 interleukin 1 alpha Homo sapiens 14-54 7566325-13 1995 This excess of calcitriol synthesis may be secondary either to monocyte increased synthesis of IL-1 which stimulates the renal 1 alpha-hydroxylase by the mean of an increased PGE2 synthesis or to the relative hypophosphatemia of the calcium stone formers comparatively to healthy controls. Calcitriol 15-25 interleukin 1 alpha Homo sapiens 95-99 7786524-8 1995 HC (5 micrograms/ml), 1,25(OH)2D3 (10(-6) M) and MC903 (10(-6) M), but not CsA (5 micrograms/ml), inhibited IL-1 alpha production by HSC-1 cells stimulated with 100 U/ml of rIFN-gamma. Calcitriol 22-33 interleukin 1 alpha Homo sapiens 108-118 8193081-5 1994 In the present study, we investigated the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and its analogue MC903 on IL-1 alpha and IL-8 secretion by human keratinocytes in vitro. Calcitriol 79-90 interleukin 1 alpha Homo sapiens 118-128 8193081-11 1994 Addition of 1,25(OH)2D3 or MC903 inhibited the increased secretion of IL-8 but restored decreased secretion of IL-1 alpha from stimulated NHKs dose dependently. Calcitriol 12-23 interleukin 1 alpha Homo sapiens 111-121 8289985-4 1993 Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively). Calcitriol 0-10 interleukin 1 alpha Homo sapiens 113-117 1478705-7 1992 Although pretreatment of monocytes for 2 h with 1,25-(OH)2D3 caused significant reduction in the release of IL-1 alpha and TNF alpha, reconstitution of monocyte-depleted cultures with similarly treated monocytes had no inhibitory effect on the proliferative response. Calcitriol 48-60 interleukin 1 alpha Homo sapiens 108-118 1880018-9 1991 This is consistent with the finding that 1,25-(OH)2D3 also inhibited IL-1 alpha, TNF alpha and LT production in these cultures. Calcitriol 41-53 interleukin 1 alpha Homo sapiens 69-79 8891757-3 1996 In the human osteoblastic cell line MG-63, IL-1 alpha (10-1000 pg/ml), IL-1 beta (3-300 pg/ml) and TNF-alpha (1-30 ng/ml) stimulated prostaglandin E2 (PGE2) formation and inhibited 1,25(OH)2-vitamin D3-induced osteocalcin biosynthesis as well as basal production of type I collagen. Calcitriol 181-201 interleukin 1 alpha Homo sapiens 43-53 1576016-0 1992 Effect of calcitriol on the secretion of prostaglandin E2, interleukin 1, and tumor necrosis factor alpha by human monocytes. Calcitriol 10-20 interleukin 1 alpha Homo sapiens 41-105 2039486-0 1991 1,25(OH)2-D3 is a potent regulator of interleukin-1 induced interleukin-8 expression and production. Calcitriol 0-12 interleukin 1 alpha Homo sapiens 38-51 2039486-3 1991 We studied the possible effect of an endogenous immune modulator 1,25(OH)2-cholecalciferol (1,25(OH)2-D3) on the IL-1-induced IL-8-production by several types of cells. Calcitriol 92-104 interleukin 1 alpha Homo sapiens 113-117 2039486-4 1991 1,25(OH)2-D3 inhibited the IL-1-alpha induced IL-8 production and mRNA expression in keratinocytes, fibroblasts and PBMC, but not in endothelial cells. Calcitriol 0-12 interleukin 1 alpha Homo sapiens 27-37 1783465-8 1991 Blood mononuclear cells from individuals treated with 1,25-(OH)2D3 showed a significantly reduced production of both interleukin-1 alpha (45%) and tumor necrosis factor-alpha (58%) (both measured by ELISA). Calcitriol 54-66 interleukin 1 alpha Homo sapiens 117-136 34872043-0 2021 1,25-Dihydroxyvitamin D3 attenuates IL-1beta secretion by suppressing NLRP1 inflammasome activation by upregulating the NRF2-HO-1 pathway in epidermal keratinocytes. Calcitriol 0-24 interleukin 1 alpha Homo sapiens 36-44 34502510-5 2021 1,25(OH)2D3 was administered to the cells with or without interleukin 1 beta (IL-1beta). Calcitriol 0-11 interleukin 1 alpha Homo sapiens 78-86 3259542-0 1988 1 alpha,25-Dihydroxyvitamin D3 and a novel vitamin D analogue MC 903 are potent inhibitors of human interleukin 1 in vitro. Calcitriol 0-30 interleukin 1 alpha Homo sapiens 100-113 2783896-8 1989 Thus, these experiments clearly demonstrate that the suppression of Con A-driven T cell proliferation by calcitriol is Mo mediated and works by a non-IL-1 mechanism. Calcitriol 105-115 interleukin 1 alpha Homo sapiens 150-154 2832052-0 1988 Requirement of differentiative signals of both interferon-gamma and 1,25-dihydroxyvitamin D3 for induction and secretion of interleukin-1 by HL-60 cells. Calcitriol 68-92 interleukin 1 alpha Homo sapiens 124-137 3259542-5 1988 1,25(OH)2D3 may play a physiological immunomodulatory role as a selective inhibitor of the function of IL-1, and MC 903 may prove clinically useful in this regard because of its limited calcium metabolic activity. Calcitriol 0-11 interleukin 1 alpha Homo sapiens 103-107 3117462-8 1987 Addition of in vitro purified IL-1 to nonadherent cells enhanced 1,25-dihydroxyvitamin D3-induced inhibition of Ig production. Calcitriol 65-89 interleukin 1 alpha Homo sapiens 30-34 3331847-10 1987 At local sites of chronic inflammation concentrations of 1,25-(OH)2D3 may be elevated and may act in an autocrine or paracrine fashion to alter the immune response, for example, by increasing IL 1 production and antigen presentation by tissue monocyte/macrophages. Calcitriol 57-69 interleukin 1 alpha Homo sapiens 192-196 24244740-0 2013 A role for interleukin-1 alpha in the 1,25 dihydroxyvitamin D3 response in mammary epithelial cells. Calcitriol 38-62 interleukin 1 alpha Homo sapiens 11-30 3877692-4 1985 The cultured cells generally produce less IL-1 than do monocytes, but considerably more IL-1 is induced from cells that have undergone a terminal differentiation as a result of exposure to 1 alpha,25-dihydroxyvitamin D3. Calcitriol 189-219 interleukin 1 alpha Homo sapiens 88-92 3879241-3 1985 Furthermore, 1,25(OH)2D3 suppressed interleukin 1 (IL 1) production of monocytes (Mo), and the agent-treated Mo were unable to promote IL 2 production of non-adherent cells (NAC). Calcitriol 13-24 interleukin 1 alpha Homo sapiens 36-55 32982316-4 2020 Our aim was to investigate the anti-fibrogenic effect of 1,25(OH)2D3 in TGF-beta1 or TNF-alpha-IL-1beta-stimulated human bronchial fibroblast cells (HBFCs) from severe asthmatic compared with non-asthmatic subjects. Calcitriol 57-68 interleukin 1 alpha Homo sapiens 95-103 32982316-11 2020 Additionally, we observed decreased mRNA expression of FN 1, LUM, BGN, MMP2, COL5A1, TIMP1 and CC-chemokines (CCL2, CCL5, CCL11) in response to 1,25(OH)2D3 addition to the TGF-beta1 or TNF-alpha-IL-1beta-stimulated HBFCs. Calcitriol 144-155 interleukin 1 alpha Homo sapiens 195-203 3489547-0 1986 Differential effects of 1,25-dihydroxyvitamin D3 on human lymphocytes and monocyte/macrophages: inhibition of interleukin-2 and augmentation of interleukin-1 production. Calcitriol 24-48 interleukin 1 alpha Homo sapiens 144-157 3489547-7 1986 In contrast to its effects on IL-2 production, 1,25-(OH)2D3 caused a dose-dependent increase in the production of interleukin-1 (IL-1) by monocyte/macrophages. Calcitriol 47-59 interleukin 1 alpha Homo sapiens 114-133 30180922-0 2019 1,25(OH)2D3 Attenuates IL-1beta-Induced Epithelial-to-Mesenchymal Transition Through Inhibiting the Expression of lncTCF7. Calcitriol 0-11 interleukin 1 alpha Homo sapiens 23-31 27779898-7 2016 The active form of VD is 1,25(OH)2D3 that produces biological effects via the nuclear hormone receptor named VD receptor (VDR), which may interfere with the immune cells and macrophages leading to the suppression of the inflammatory process by decreasing the release of TNF-alpha, IL-1, IL-6, and IL-8, IL-12, and IL-23. Calcitriol 25-36 interleukin 1 alpha Homo sapiens 281-285 24244740-7 2013 Furthermore, 1,25(OH)2D3 increased the intracellular expression of IL1alpha, which was necessary for the anti-proliferative effects of 1,25(OH)2D3 in mammary cells. Calcitriol 13-24 interleukin 1 alpha Homo sapiens 67-75 24244740-7 2013 Furthermore, 1,25(OH)2D3 increased the intracellular expression of IL1alpha, which was necessary for the anti-proliferative effects of 1,25(OH)2D3 in mammary cells. Calcitriol 135-146 interleukin 1 alpha Homo sapiens 67-75 11774448-0 1998 [1,25(OH)2 vitamin D3 induces IL-1 alpha mRNA expression from osteoblastic-like and bone marrow co-culture cells]. Calcitriol 1-21 interleukin 1 alpha Homo sapiens 30-40 21653679-0 2011 Interleukin-1alpha mediates the antiproliferative effects of 1,25-dihydroxyvitamin D3 in prostate progenitor/stem cells. Calcitriol 61-85 interleukin 1 alpha Homo sapiens 0-18 17112620-8 2007 1,25-Dihydroxyvitamin D(3) was able to down-regulate the expression of TNF-alpha, IL-6, IL-1, and IL-8, confirming its immunomodulatory properties. Calcitriol 0-26 interleukin 1 alpha Homo sapiens 88-92 16517748-0 2006 Regulation of IL-1 family cytokines IL-1alpha, IL-1 receptor antagonist, and IL-18 by 1,25-dihydroxyvitamin D3 in primary keratinocytes. Calcitriol 86-110 interleukin 1 alpha Homo sapiens 36-45 12899535-1 2003 Calcitriol, the hormonal form of vitamin D, enhances the anticancer activity of the immune cytokine tumor necrosis factor, interleukin 1 and interleukin 6 in human breast and renal cell carcinoma cells without affecting the cytotoxic action of interferon-alpha or killer lymphocytes. Calcitriol 0-10 interleukin 1 alpha Homo sapiens 123-136 11340307-0 2001 1,25-dihydroxyvitamin D3 differentially regulates IL-1alpha-stimulated IL-8 and MCP-1 mRNA expression and chemokine secretion by human primary proximal tubular epithelial cells. Calcitriol 0-24 interleukin 1 alpha Homo sapiens 50-59 15587751-4 2004 Calcitriol treatment for 6 months significantly increased BMD and reduced serum IL-1 and TNF-alpha concentrations compared with no significant changes in patients treated with calcium alone. Calcitriol 0-10 interleukin 1 alpha Homo sapiens 80-84 15587751-8 2004 Significant reductions in serum IL-1 and TNF-alpha concentrations suggest that, in addition to increasing the absorption of calcium, calcitriol may directly affect bone metabolism via cytokines. Calcitriol 133-143 interleukin 1 alpha Homo sapiens 32-36 14708413-5 2003 The intravenous calcitriol treatment group showed significant decreases in levels of iPTH, TNF-alpha, IL-1 and IL-6 and a significant increase in total calcium level after 3 and 6 months. Calcitriol 16-26 interleukin 1 alpha Homo sapiens 102-106 12037399-9 2002 The effect of calcitriol was maximal at 10(-7) to 10(-9) and noneffective at 10(-11) M. Calcitriol diminished the secretion of IL-1, TNF-alpha, and MG-CSF in PBMC. Calcitriol 14-24 interleukin 1 alpha Homo sapiens 127-131 12037399-9 2002 The effect of calcitriol was maximal at 10(-7) to 10(-9) and noneffective at 10(-11) M. Calcitriol diminished the secretion of IL-1, TNF-alpha, and MG-CSF in PBMC. Calcitriol 88-98 interleukin 1 alpha Homo sapiens 127-131 11007863-0 2000 Changing relationships between serum IL-1, IL-6, and TNF-alpha and dynamic tests of parathyroid gland function in haemodialysis patients with severe hyperparathyroidism in response to calcitriol therapy. Calcitriol 184-194 interleukin 1 alpha Homo sapiens 37-41 10769429-10 2000 D-hormone preparations (alfacalcidol, calcitriol) possess immunoregulatory effects in vitro and in vivo by inhibiting the cytokines IL-1, IL-6, TNF-alpha and particularly IL-12. Calcitriol 38-48 interleukin 1 alpha Homo sapiens 132-136 11774448-5 1998 CONCLUSION: These results demonstrate that IL-1 alpha involves in osteoclast formation induced by 1,25(OH)2D3. Calcitriol 98-109 interleukin 1 alpha Homo sapiens 43-53