PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9077482-1 1997 We have examined the mechanism by which endogenous retinoid X receptor (RXR), vitamin D3 receptor (VDR), and cognate ligands regulate nuclear 1,25-dihydroxyvitamin D3 (D3) signaling in epidermal keratinocytes from skin, a physiologic D3 target. Calcitriol 142-166 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 78-97 9165006-9 1997 Pretreatment of mice with cycloheximide (400 microg/g), an inhibitor of protein synthesis, potentiated the increase in 24-OHase mRNA abundance, but blocked the increase in 24-OHase activity, induced by 1,25-(OH)2D3 in kidney and duodenum, suggesting that 24-OHase gene expression may be regulated not only by the vitamin D receptor but also by a short-lived repressor protein. Calcitriol 202-214 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 313-331 9077482-1 1997 We have examined the mechanism by which endogenous retinoid X receptor (RXR), vitamin D3 receptor (VDR), and cognate ligands regulate nuclear 1,25-dihydroxyvitamin D3 (D3) signaling in epidermal keratinocytes from skin, a physiologic D3 target. Calcitriol 142-166 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 99-102 8977379-6 1997 Scatchard analysis of [3H]1,25-(OH)2D3 binding showed the VDR concentration to be 173 fmol/mg protein and the affinity to be 0.12 nM. Calcitriol 26-38 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 58-61 8977379-11 1997 VDR up-regulation by FSK pretreatment augmented the NGF response to 1,25-(OH)2D3 2-fold compared to that in vehicle-pretreated cells for a total 6-fold increase compared to basal NGF levels. Calcitriol 68-80 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 8977379-14 1997 In conclusion, we have characterized the VDR in L929 cells and shown that 1,25-(OH)2D3 and its less calcemic analogs induce NGF. Calcitriol 74-86 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 41-44 8977379-16 1997 These effects of 1,25-(OH)2D3 and its analogs via VDR to regulate NGF synthesis may have significance for the eventual treatment of neurodegenerative diseases that are caused by decreased NGF production. Calcitriol 17-29 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 50-53 7878015-1 1995 The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], regulates gene transcription through binding to the vitamin D receptor (VDR), a member of the nuclear hormone receptor superfamily. Calcitriol 36-60 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 128-146 9627702-1 1996 Vitamin D3 derivative 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) exerts various biological effects in cells that possess vitamin D3 receptor (VDR), including enhancement of cell differentiation and inhibition of cell proliferation. Calcitriol 22-46 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 117-136 9627702-1 1996 Vitamin D3 derivative 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) exerts various biological effects in cells that possess vitamin D3 receptor (VDR), including enhancement of cell differentiation and inhibition of cell proliferation. Calcitriol 22-46 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 138-141 9627702-1 1996 Vitamin D3 derivative 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) exerts various biological effects in cells that possess vitamin D3 receptor (VDR), including enhancement of cell differentiation and inhibition of cell proliferation. Calcitriol 48-59 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 117-136 9627702-1 1996 Vitamin D3 derivative 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) exerts various biological effects in cells that possess vitamin D3 receptor (VDR), including enhancement of cell differentiation and inhibition of cell proliferation. Calcitriol 48-59 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 138-141 8828486-3 1996 Here, we report that calcitriol (VD), which activates a nuclear receptor (VDR) closely related to the T3R and retinoid receptors, also markedly affects nuclear T3 binding and T3-induced differentiation of Ob 17 cells. Calcitriol 21-31 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 74-77 8967346-6 1996 Conversely, the presence of VDR mRNA in other parts of the nephron suggests that calcitriol has genomically mediated actions within the kidney in addition to stimulation of CaBP-D28k synthesis. Calcitriol 81-91 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 28-31 8574944-1 1995 The effects of retinoic acid (RA), and calcitriol are mediated by specific nuclear receptors (RARs and VDR, respectively). Calcitriol 39-49 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 103-106 7878015-1 1995 The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], regulates gene transcription through binding to the vitamin D receptor (VDR), a member of the nuclear hormone receptor superfamily. Calcitriol 36-60 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 148-151 7878015-1 1995 The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], regulates gene transcription through binding to the vitamin D receptor (VDR), a member of the nuclear hormone receptor superfamily. Calcitriol 62-73 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 128-146 7878015-1 1995 The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], regulates gene transcription through binding to the vitamin D receptor (VDR), a member of the nuclear hormone receptor superfamily. Calcitriol 62-73 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 148-151 7878015-7 1995 In contrast, transfection of NIH 3T3 cells generated strong reporter activation by 1,25(OH)2D3 in the presence of VDR alone, and cotransfection of TFIIB led to specific dose-dependent repression of reporter activity. Calcitriol 83-94 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 114-117 7686756-0 1993 Vitamin D receptor gene expression is up-regulated by 1, 25-dihydroxyvitamin D3 in 3T3-L1 preadipocytes. Calcitriol 54-79 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-18 7954451-4 1994 While 1,25-(OH)2D3 treatment increased the level of expression of vitamin D receptor mRNA 20-fold in parental cells, the E1A-transformed cells failed to express vitamin D receptor mRNA even after treatment with 1,25-(OH)2D3. Calcitriol 6-18 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 66-84 7954451-5 1994 Transfection of the E1A-transformed cell line with an expression construct encoding the vitamin D receptor restored receptor expression as well as the inhibition of growth by 1,25-(OH)2D3. Calcitriol 175-187 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 88-106 7954451-6 1994 These results suggest that one of the mechanisms for acquisition of 1,25-(OH)2D3 resistance induced by E1A may involve loss of vitamin D receptor inducibility by 1,25-(OH)2D3. Calcitriol 68-80 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 127-145 7954451-6 1994 These results suggest that one of the mechanisms for acquisition of 1,25-(OH)2D3 resistance induced by E1A may involve loss of vitamin D receptor inducibility by 1,25-(OH)2D3. Calcitriol 162-174 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 127-145 7947199-2 1994 It has been shown previously that the potent steroid hormone 1,25-dihydroxyvitamin D3 (1,25-D3) modulates growth and differentiation of keratinocytes via binding to a high-affinity nuclear vitamin D receptor (VDR). Calcitriol 61-85 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 189-207 7947199-2 1994 It has been shown previously that the potent steroid hormone 1,25-dihydroxyvitamin D3 (1,25-D3) modulates growth and differentiation of keratinocytes via binding to a high-affinity nuclear vitamin D receptor (VDR). Calcitriol 61-85 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 209-212 7947199-2 1994 It has been shown previously that the potent steroid hormone 1,25-dihydroxyvitamin D3 (1,25-D3) modulates growth and differentiation of keratinocytes via binding to a high-affinity nuclear vitamin D receptor (VDR). Calcitriol 87-94 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 189-207 7947199-2 1994 It has been shown previously that the potent steroid hormone 1,25-dihydroxyvitamin D3 (1,25-D3) modulates growth and differentiation of keratinocytes via binding to a high-affinity nuclear vitamin D receptor (VDR). Calcitriol 87-94 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 209-212 8187933-4 1994 10 nM 1,25-(OH)2D3 stimulated 1,25-(OH)2D3 receptor (VDR) synthesis in both non-transformed C3H/10T1/2 Cl 8 and in chemically transformed C3H/10T1/2 Cl 16 cells within 4 hr of treatment. Calcitriol 6-18 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 53-56 8187933-20 1994 Our data suggest that 1,25-(OH)2D3 mediated induction of VDR does not require prior c-myc protein synthesis in the C3H/10T1/2 cells. Calcitriol 22-34 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 57-60 34950826-5 2021 The requirement for a vitamin D receptor for the photoprotective actions of 1,25(OH)2D3 and of naturally occurring CYP11A1-derived vitamin D-related compounds may explain why mice lacking the vitamin D receptor in skin are more susceptible to UV-induced skin cancers, whereas mice lacking the 1alpha-hydroxylase and thus unable to make 1,25(OH)2D3 are not more susceptible. Calcitriol 76-87 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 22-40 34956480-11 2021 VDR (Vit D receptor), which mediates the cellular actions of active 1,25(OH)2D3, was also rescued by Vit D supplementation, especially in dentate gyrus (DG) region of hippocampus. Calcitriol 68-79 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 34956480-11 2021 VDR (Vit D receptor), which mediates the cellular actions of active 1,25(OH)2D3, was also rescued by Vit D supplementation, especially in dentate gyrus (DG) region of hippocampus. Calcitriol 68-79 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 5-19 1373930-5 1992 Similar to peripheral blood mononuclear cells incubated with mitogen, the T cell clone evaluated in this study expressed a high-affinity specific receptor for 1,25-(OH)2D3 (VDR; K(in) = 0.03 nM) upon exposure to MBP. Calcitriol 159-171 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 173-176 1373930-7 1992 The DTH response in the recipient was completely blocked when the clone was preincubated with greater than or equal to 10(-8) M 1,25-(OH)2D3 before transfer; the half-maximal inhibitory concentration of hormone (EC50) was 5 x 10(-9) M. These data indicate that exposure of antigen-reactive T helper lymphocytes to a VDR saturating concentration of 1,25-(OH)2D3 can dramatically lessen the expression of immunoreactivity in vivo. Calcitriol 128-140 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 316-319 34986435-3 2022 The actions of 1,25(OH)2D3 are mediated by the vitamin D receptor (VDR), a transcription regulator crucial for skin homeostasis. Calcitriol 15-26 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 47-65 34986435-3 2022 The actions of 1,25(OH)2D3 are mediated by the vitamin D receptor (VDR), a transcription regulator crucial for skin homeostasis. Calcitriol 15-26 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 67-70 34950832-1 2021 1,25(OH)2D3, the biologically active form of vitamin D3, is a major regulator of mineral and bone homeostasis and exerts its actions through binding to the vitamin D receptor (VDR), a ligand-activated transcription factor that can directly modulate gene expression in vitamin D-target tissues such as the intestine, kidney, and bone. Calcitriol 0-11 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 156-174 34950832-1 2021 1,25(OH)2D3, the biologically active form of vitamin D3, is a major regulator of mineral and bone homeostasis and exerts its actions through binding to the vitamin D receptor (VDR), a ligand-activated transcription factor that can directly modulate gene expression in vitamin D-target tissues such as the intestine, kidney, and bone. Calcitriol 0-11 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 176-179 34950832-2 2021 Inactivating VDR mutations or vitamin D deficiency during development results in rickets, hypocalcemia, secondary hyperparathyroidism, and hypophosphatemia, pointing to the critical role of 1,25(OH)2D3-induced signaling in the maintenance of mineral homeostasis and skeletal health. Calcitriol 190-201 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 13-16 34950826-5 2021 The requirement for a vitamin D receptor for the photoprotective actions of 1,25(OH)2D3 and of naturally occurring CYP11A1-derived vitamin D-related compounds may explain why mice lacking the vitamin D receptor in skin are more susceptible to UV-induced skin cancers, whereas mice lacking the 1alpha-hydroxylase and thus unable to make 1,25(OH)2D3 are not more susceptible. Calcitriol 76-87 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 192-210 35620386-10 2022 Interestingly, the PVH neurons of both sexes were activated by exogenous vitamin D (1,25-dihydroxyvitamin D3), an effect dependent upon the VDR. Calcitriol 84-108 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 140-143 34219248-2 2021 The relative changes accompanying aging, high cholesterol, and/or treatment of calcitriol, active vitamin D receptor (VDR) ligand, under normal physiology are unknown. Calcitriol 79-89 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 98-116 34219248-2 2021 The relative changes accompanying aging, high cholesterol, and/or treatment of calcitriol, active vitamin D receptor (VDR) ligand, under normal physiology are unknown. Calcitriol 79-89 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 118-121 34199743-8 2021 The mechanistic elucidations indicate that tumor inhibition by the aPPD and calcitriol combination was accompanied by elevated vitamin D receptor (VDR) protein expression. Calcitriol 76-86 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 127-145 34199743-8 2021 The mechanistic elucidations indicate that tumor inhibition by the aPPD and calcitriol combination was accompanied by elevated vitamin D receptor (VDR) protein expression. Calcitriol 76-86 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 147-150 34199743-10 2021 Interestingly, the combination of aPPD and calcitriol activated VDR at a significantly higher level than calcitriol alone and this indicates that aPPD may be an allosteric activator of VDR. Calcitriol 43-53 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 64-67 34199743-10 2021 Interestingly, the combination of aPPD and calcitriol activated VDR at a significantly higher level than calcitriol alone and this indicates that aPPD may be an allosteric activator of VDR. Calcitriol 43-53 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 185-188 34199743-10 2021 Interestingly, the combination of aPPD and calcitriol activated VDR at a significantly higher level than calcitriol alone and this indicates that aPPD may be an allosteric activator of VDR. Calcitriol 105-115 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 64-67 34199743-10 2021 Interestingly, the combination of aPPD and calcitriol activated VDR at a significantly higher level than calcitriol alone and this indicates that aPPD may be an allosteric activator of VDR. Calcitriol 105-115 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 185-188 33647520-1 2021 Mature osteoclasts express the vitamin D receptor (VDR) and are able to respond to active vitamin D (1alpha, 25-dihydroxyvitamin D3; 1,25(OH)2D3) by regulating cell maturation and activity. Calcitriol 133-144 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 31-49 35369317-9 2022 The VDR antagonist pyridoxal-5-phosphate (P5P) partially reversed the neuroprotective effects of 1,25-D3 described above. Calcitriol 97-104 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-7 33647520-1 2021 Mature osteoclasts express the vitamin D receptor (VDR) and are able to respond to active vitamin D (1alpha, 25-dihydroxyvitamin D3; 1,25(OH)2D3) by regulating cell maturation and activity. Calcitriol 133-144 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 51-54 34013750-3 2021 Skeletal muscle expresses the vitamin D receptor (VDR), which responds to the active form of vitamin D, 1,25-dihydroxyvitamin D3 by altering gene expression in target cells. Calcitriol 104-128 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 30-48 34013750-3 2021 Skeletal muscle expresses the vitamin D receptor (VDR), which responds to the active form of vitamin D, 1,25-dihydroxyvitamin D3 by altering gene expression in target cells. Calcitriol 104-128 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 50-53 32427932-6 2020 In primary cell culture, nuclear VDR protein was expressed in undifferentiated skeletal muscle stem cells (SMSC) after 1alpha,25(OH)2D3 treatment. Calcitriol 119-135 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 33-36 33965570-8 2021 Given that the biological effects of D3 rely on its activation, and the binding of 1, 25(OH)2D3 to VDR in specific tissues, our findings provide novel insights into the possible role of vitamin D in the development and progression of influenza. Calcitriol 83-95 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 99-102 32882254-5 2021 Compared to MCAO alone, subsequent CUMS aggravated motor dysfunction and depression-like behaviors, whereas injection of calcitriol (VitD3) enhanced expression levels of VDR and BDNF in the hippocampus as well as ameliorated both motor dysfunction and depression-like behaviors of PSD model mice, with optimal efficacy at 25 microg/kg. Calcitriol 121-131 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 170-173 32848720-9 2020 In addition, knockdown of the vitamin D receptor (VDR) abolished the radiosensitization of 1alpha,25(OH)2D3, which confirmed that 1alpha,25(OH)2D3 radiosensitized tumor cells that depend on VDR. Calcitriol 91-107 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 30-48 32848720-9 2020 In addition, knockdown of the vitamin D receptor (VDR) abolished the radiosensitization of 1alpha,25(OH)2D3, which confirmed that 1alpha,25(OH)2D3 radiosensitized tumor cells that depend on VDR. Calcitriol 91-107 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 50-53 32848720-9 2020 In addition, knockdown of the vitamin D receptor (VDR) abolished the radiosensitization of 1alpha,25(OH)2D3, which confirmed that 1alpha,25(OH)2D3 radiosensitized tumor cells that depend on VDR. Calcitriol 91-107 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 190-193 32848720-11 2020 In summary, these results demonstrate that 1alpha,25(OH)2D3 enhances the radiosensitivity depending on VDR and activates the NADPH oxidase-ROS-apoptosis axis. Calcitriol 43-59 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 103-106 32582667-6 2020 The bioactive form of vitamin D (aVD; 1, 25-Dihydroxyvitamin D3), which inhibits pro-inflammatory transcription factor NF-kappaB via the intracellular nuclear hormone receptor vitamin D receptor (VDR), was stably loaded into poly(ethylene glycol)-block-poly(propylene sulfide) (PEG-b-PPS) filomicelles. Calcitriol 38-63 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 176-194 32582667-6 2020 The bioactive form of vitamin D (aVD; 1, 25-Dihydroxyvitamin D3), which inhibits pro-inflammatory transcription factor NF-kappaB via the intracellular nuclear hormone receptor vitamin D receptor (VDR), was stably loaded into poly(ethylene glycol)-block-poly(propylene sulfide) (PEG-b-PPS) filomicelles. Calcitriol 38-63 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 196-199 33553990-4 2021 Genetic studies in older mice have also shed light on the molecular mechanisms underlying the important role of the calcitriol/VDR pathway in diseases of aging such as osteoporosis and cancer. Calcitriol 116-126 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 127-130 33198348-4 2020 The 6-OHDA-induced transcriptional repression of these genes were recovered after the VDR ligand-1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) treatment. Calcitriol 97-126 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 86-89 33198348-4 2020 The 6-OHDA-induced transcriptional repression of these genes were recovered after the VDR ligand-1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) treatment. Calcitriol 128-139 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 86-89 32987399-0 2020 The vitamin D receptor in osteoblast-lineage cells is essential for the proresorptive activity of 1alpha,25(OH)2D3 in vivo (118 characters including spaces). Calcitriol 98-114 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-22 32987399-10 2020 Taken together, this study demonstrated that the proresorptive, hypercalcemic, and toxic actions of high-dose 1alpha,25(OH)2D3 are mediated by VDR in osteoblast-lineage cells. Calcitriol 110-126 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 143-146 32918222-4 2020 The hormone derived from vitamin D, calcitriol (1,25-dihydroxyvitamin D3) and other related compounds, working via the vitamin D receptor and at least in part through endoplasmic reticulum protein 57 (ERp57), reduce cyclobutane pyrimidine dimers and oxidative DNA damage in keratinocytes and other skin cell types after UV. Calcitriol 36-46 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 119-137 31940280-1 2020 The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3) exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes. Calcitriol 49-73 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 152-170 31940280-1 2020 The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3) exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes. Calcitriol 49-73 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 172-175 31881310-2 2020 Transepithelial intestinal Ca absorption is mediated by 1,25-dihydroxyvitamin D (1,25(OH)2D, calcitriol) through the vitamin D receptor (VDR). Calcitriol 93-103 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 137-140 32918222-4 2020 The hormone derived from vitamin D, calcitriol (1,25-dihydroxyvitamin D3) and other related compounds, working via the vitamin D receptor and at least in part through endoplasmic reticulum protein 57 (ERp57), reduce cyclobutane pyrimidine dimers and oxidative DNA damage in keratinocytes and other skin cell types after UV. Calcitriol 48-72 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 119-137 30508318-1 2019 Vitamin D receptor (VDR) null fetuses have normal serum minerals, parathyroid hormone (PTH), skeletal morphology, and mineralization but increased serum calcitriol, placental calcium transport, and placental expression of Pthrp, Trpv6, and (as reported in this study) Pdia3. Calcitriol 153-163 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-18 31034649-1 2019 The vitamin D receptor (VDR) is a nuclear receptor for the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 , and regulates various physiologic processes, such as bone and calcium metabolism, cellular proliferation and differentiation, and immunity. Calcitriol 85-114 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-22 31034649-1 2019 The vitamin D receptor (VDR) is a nuclear receptor for the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 , and regulates various physiologic processes, such as bone and calcium metabolism, cellular proliferation and differentiation, and immunity. Calcitriol 85-114 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 24-27 31002352-0 2019 1alpha,25-Dihydroxyvitamin D3 restrains stem cell-like properties of ovarian cancer cells by enhancing vitamin D receptor and suppressing CD44. Calcitriol 0-29 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 103-121 30508318-7 2019 Cyp27b1 null fetuses differ from Vdr null fetuses, possibly through high levels of calcitriol acting on Pdia3 in Vdr nulls to upregulate placental calcium transport and expression of Trpv6 and Pthrp. Calcitriol 83-93 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 33-36 30508318-7 2019 Cyp27b1 null fetuses differ from Vdr null fetuses, possibly through high levels of calcitriol acting on Pdia3 in Vdr nulls to upregulate placental calcium transport and expression of Trpv6 and Pthrp. Calcitriol 83-93 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 113-116 30508318-1 2019 Vitamin D receptor (VDR) null fetuses have normal serum minerals, parathyroid hormone (PTH), skeletal morphology, and mineralization but increased serum calcitriol, placental calcium transport, and placental expression of Pthrp, Trpv6, and (as reported in this study) Pdia3. Calcitriol 153-163 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 20-23 30210711-6 2018 The JAK/STAT pathway was activated by 1,25(OH)2D3 addition in both VDR-/- and wild type T cells. Calcitriol 38-49 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 67-70 30540970-8 2019 As expected, 1,25(OH)2D3 transformed lipopolysaccharide-induced M1 macrophages to the M2 subset, downregulated tumor necrosis factor-alpha and interleukin (IL)-6 expression and interferon regulatory factor 5 (IRF5) phosphorylation, and upregulated IL-10, arginase-1, VDR, and IRF4 expression. Calcitriol 13-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 267-270 30197603-1 2018 Calcitriol, the bioactive metabolite of vitamin D, interacts with the ubiquitously expressed nuclear vitamin D receptor (VDR) to induce genomic effects, but it can also elicit rapid responses via membrane-associated VDR through mechanisms that are poorly understood. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 101-119 30197603-1 2018 Calcitriol, the bioactive metabolite of vitamin D, interacts with the ubiquitously expressed nuclear vitamin D receptor (VDR) to induce genomic effects, but it can also elicit rapid responses via membrane-associated VDR through mechanisms that are poorly understood. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 121-124 30197603-1 2018 Calcitriol, the bioactive metabolite of vitamin D, interacts with the ubiquitously expressed nuclear vitamin D receptor (VDR) to induce genomic effects, but it can also elicit rapid responses via membrane-associated VDR through mechanisms that are poorly understood. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 216-219 30197603-7 2018 Calcitriol treatment of cardiomyocytes induced an increase in the density of Itof and Ikur, which was lost in myocytes isolated from VDR-knockout mice. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 133-136 30197603-9 2018 In conclusion, we demonstrate that calcitriol via VDR and Akt increases both Itof and Ikur densities in mouse ventricular cardiomyocytes. Calcitriol 35-45 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 50-53 29535889-6 2018 RT-PCR showed that the gene expression levels of ALP, Col-I, OCN, and vitamin D receptor (VDR) were higher at a low concentration of 1,25-dihydroxyvitamin D3 (10-12 M). Calcitriol 133-157 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 70-88 29986424-1 2018 The vitamin D receptor (VDR) is a nuclear receptor that mediates the biological action of the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], and regulates calcium and bone metabolism. Calcitriol 120-149 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-22 29986424-1 2018 The vitamin D receptor (VDR) is a nuclear receptor that mediates the biological action of the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], and regulates calcium and bone metabolism. Calcitriol 120-149 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 24-27 29986424-4 2018 In this study, in order to elucidate the differences in VDR action induced by 1,25(OH)2D3 and LCA, we compared their effect on the VDR target gene induction in the intestine of mice. Calcitriol 78-89 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 56-59 29986424-4 2018 In this study, in order to elucidate the differences in VDR action induced by 1,25(OH)2D3 and LCA, we compared their effect on the VDR target gene induction in the intestine of mice. Calcitriol 78-89 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 131-134 28887147-0 2018 Both ligand and VDR expression levels critically determine the effect of 1alpha,25-dihydroxyvitamin-D3 on osteoblast differentiation. Calcitriol 73-102 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 16-19 28887147-1 2018 Previous studies have shown that 1alpha,25-dihydroxyvitamin D3 (1,25D) through vitamin D receptor (VDR) signalling has both catabolic and anabolic effects on osteoblast differentiation. Calcitriol 33-62 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 79-97 28887147-1 2018 Previous studies have shown that 1alpha,25-dihydroxyvitamin D3 (1,25D) through vitamin D receptor (VDR) signalling has both catabolic and anabolic effects on osteoblast differentiation. Calcitriol 33-62 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 99-102 29854030-10 2018 VDR expression in the combined treatment group was significantly higher than that of the calcitriol treatment group. Calcitriol 89-99 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 28602960-1 2018 The vitamin D receptor (VDR) mediates the pleiotropic biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Calcitriol 76-100 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-22 28602960-1 2018 The vitamin D receptor (VDR) mediates the pleiotropic biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Calcitriol 76-100 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 24-27 29107178-9 2018 These effects of pre-incubation with calcitriol were abolished in fibers from VDR-knockout mice. Calcitriol 37-47 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 78-81 29107736-1 2018 Mature osteoclasts express the vitamin D receptor (VDR) and are able to synthesise and respond to 1,25(OH)2D3 via CYP27B1 enzyme activity. Calcitriol 98-109 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 51-54 29535889-6 2018 RT-PCR showed that the gene expression levels of ALP, Col-I, OCN, and vitamin D receptor (VDR) were higher at a low concentration of 1,25-dihydroxyvitamin D3 (10-12 M). Calcitriol 133-157 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 90-93 29084783-1 2018 We expanded our published physiologically based pharmacokinetic model (PBPK) on 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], ligand of the vitamin D receptor (VDR), to appraise VDR-mediated pharmacodynamics in mice. Calcitriol 80-109 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 139-157 29084783-1 2018 We expanded our published physiologically based pharmacokinetic model (PBPK) on 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], ligand of the vitamin D receptor (VDR), to appraise VDR-mediated pharmacodynamics in mice. Calcitriol 80-109 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 159-162 29109124-2 2017 The physiologic vitamin D receptor agonist, 1,25(OH)2D3 (calcitriol), is synthesized by the essential enzyme 25-hydroxyvitamin D3-1alpha-hydroxylase (CYP27B1), which can be expressed by activated immune cells. Calcitriol 44-55 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 16-34 29272316-0 2017 Vitamin D receptor expression is essential during retinal vascular development and attenuation of neovascularization by 1, 25(OH)2D3. Calcitriol 120-132 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-18 29272316-5 2017 However, the role VDR expression plays in vascular development and inhibition of neovascularization by 1, 25(OH)2D3 remains unknown. Calcitriol 103-115 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 18-21 29272316-10 2017 In addition, the adverse impact of 1, 25(OH)2D3 treatment on the mouse bodyweight was also dependent on VDR expression. Calcitriol 35-47 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 104-107 29208972-5 2017 1,25(OH)2D3 did not affect WT cell proliferation, but did stimulate VDR KO cell proliferation. Calcitriol 0-11 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 68-71 29109124-2 2017 The physiologic vitamin D receptor agonist, 1,25(OH)2D3 (calcitriol), is synthesized by the essential enzyme 25-hydroxyvitamin D3-1alpha-hydroxylase (CYP27B1), which can be expressed by activated immune cells. Calcitriol 57-67 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 16-34 28765896-14 2017 However, 1,25(OH)2D3 treatment attenuated HG-induced EMT and apoptosis, and decreased peritoneal thickness, which may partially occur through inhibition of transforming growth factor TGF-beta/Smad pathways via 1,25(OH)2D3 binding to VDR. Calcitriol 210-221 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 233-236 28765896-14 2017 However, 1,25(OH)2D3 treatment attenuated HG-induced EMT and apoptosis, and decreased peritoneal thickness, which may partially occur through inhibition of transforming growth factor TGF-beta/Smad pathways via 1,25(OH)2D3 binding to VDR. Calcitriol 9-20 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 233-236 28370465-4 2017 Although calcitriol modestly promoted osteoclast maturation, it strongly inhibited osteoclast lineage commitment from its progenitor monocyte by increasing Smad1 transcription via the vitamin D receptor and enhancing BMP-Smad1 activation, which in turn led to increased IkappaBalpha expression and decreased NF-kappaB activation and NFATc1 expression, with IkappaBalpha being a Smad1 target gene. Calcitriol 9-19 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 184-202 27998003-7 2017 Exposure to calcitriol in the culture increased the expression of VitD receptor (VDR) in mast cells. Calcitriol 12-22 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 66-79 27998003-7 2017 Exposure to calcitriol in the culture increased the expression of VitD receptor (VDR) in mast cells. Calcitriol 12-22 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 81-84 28414049-3 2017 It is now time to focus on the metabolic results of vitamin D receptor (VDR) action in mitochondria, which can explain the pleiotropic effects of 1,25(OH)2D3 and may elucidate few contrasting aspects of its activity. Calcitriol 146-157 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 52-70 28414049-3 2017 It is now time to focus on the metabolic results of vitamin D receptor (VDR) action in mitochondria, which can explain the pleiotropic effects of 1,25(OH)2D3 and may elucidate few contrasting aspects of its activity. Calcitriol 146-157 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 72-75 28414049-4 2017 The perturbation of lipid metabolism described in VDR knockout mice and vitamin D deficient animals can be revisited based on the newly identified mechanism of action of 1,25(OH)2D3 in mitochondria. Calcitriol 170-181 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 50-53 28177161-2 2017 Derivatives of 1alpha,25(OH)2 D3 , including eldecalcitol (ELD), exert their actions through the vitamin D receptor (VDR). Calcitriol 15-32 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 97-115 28177161-2 2017 Derivatives of 1alpha,25(OH)2 D3 , including eldecalcitol (ELD), exert their actions through the vitamin D receptor (VDR). Calcitriol 15-32 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 117-120 28025137-1 2017 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1alpha,25D3), plays an important role in the maintenance of calcium (Ca) homeostasis, bone formation, and cell proliferation and differentiation via nuclear vitamin D receptor (VDR). Calcitriol 30-59 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 238-241 28025137-1 2017 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1alpha,25D3), plays an important role in the maintenance of calcium (Ca) homeostasis, bone formation, and cell proliferation and differentiation via nuclear vitamin D receptor (VDR). Calcitriol 30-59 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 218-236 27989685-1 2017 BACKGROUND: Calcitriol, the bioactive metabolite of vitamin D, exerts its effects through interaction with the nuclear vitamin D receptor (VDR) to induce genomic responses. Calcitriol 12-22 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 119-137 27989685-1 2017 BACKGROUND: Calcitriol, the bioactive metabolite of vitamin D, exerts its effects through interaction with the nuclear vitamin D receptor (VDR) to induce genomic responses. Calcitriol 12-22 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 139-142 27989685-2 2017 Calcitriol may also induce rapid responses via plasma membrane-associated VDR, involving the activation of second messengers and modulation of voltage-dependent channels. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 74-77 27989685-3 2017 VDR is expressed in cardiomyocytes, but the molecular and cellular mechanisms involved in the rapid responses of calcitriol in the heart are poorly understood. Calcitriol 113-123 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 27989685-9 2017 The effect of calcitriol on ICaL was absent in myocytes isolated from VDR knockout mice. Calcitriol 14-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 70-73 27989685-10 2017 CONCLUSION: Calcitriol induces a rapid response in mouse ventricular myocytes that involves a VDR-PKA-dependent increase in ICaL density, enhancing [Ca2+]i transients and contraction. Calcitriol 12-22 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 94-97 27106018-1 2016 OBJECTIVES: Previously we have shown in endometrial cells that progesterone (P4) and calcitriol (CAL, 1,25(OH)2D3) synergistically promote apoptosis and that progestins induce expression of the vitamin D receptor. Calcitriol 85-95 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 194-212 26323657-0 2016 The vitamin D receptor functions as a transcription regulator in the absence of 1,25-dihydroxyvitamin D3. Calcitriol 80-104 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-22 26323657-1 2016 The vitamin D receptor (VDR) is a critical mediator of the biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Calcitriol 81-105 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-22 26323657-1 2016 The vitamin D receptor (VDR) is a critical mediator of the biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Calcitriol 81-105 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 24-27 26323657-5 2016 Recently, we generated a mouse model of HVDRR without alopecia wherein a mutant human VDR lacking 1,25(OH)2D3-binding activity was expressed in the absence of endogenous mouse VDR. Calcitriol 98-109 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 86-89 26323657-14 2016 We suggest that the VDR may function as a selective suppressor/de-repressor of gene expression in the absence of 1,25(OH)2D3. Calcitriol 113-124 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 20-23 27283745-3 2016 This study evaluates the effect of oral treatment with the vitamin D3 receptor (VDR) ligand, calcitriol, on dissecting AAA induced by angiotensin-II (Ang-II) infusion in apoE(-/-) mice. Calcitriol 93-103 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 59-78 27428295-7 2016 In the in vitro study, naturally occurring VDR ligand 1alpha,25-dihydroxyvitamin D3 (1,25[OH]2D3) and RXR ligand 9-cis retinoic acid (9-cis-RA), both significantly inhibited high-glucose-induced endothelial cell apoptosis. Calcitriol 54-83 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 43-46 27428295-7 2016 In the in vitro study, naturally occurring VDR ligand 1alpha,25-dihydroxyvitamin D3 (1,25[OH]2D3) and RXR ligand 9-cis retinoic acid (9-cis-RA), both significantly inhibited high-glucose-induced endothelial cell apoptosis. Calcitriol 85-96 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 43-46 27283745-3 2016 This study evaluates the effect of oral treatment with the vitamin D3 receptor (VDR) ligand, calcitriol, on dissecting AAA induced by angiotensin-II (Ang-II) infusion in apoE(-/-) mice. Calcitriol 93-103 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 80-83 27283745-7 2016 These effects were accompanied by a marked increase in VDR-retinoid X receptor (RXR) interaction in the aortas of calcitriol-treated mice. Calcitriol 114-124 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 55-58 27032903-6 2016 Administration of 1alpha,25(OH)2D3 at physiological and supraphysiological doses enhanced VDR expression in regenerative muscle. Calcitriol 18-34 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 90-93 27473111-10 2016 Luciferase activity was dose-dependently associated with calcitriol/VDR levels. Calcitriol 57-67 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 68-71 26041780-0 2015 1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium-regulating Components. Calcitriol 0-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 46-64 26820600-7 2016 Additionally, we explored the correlation between the corresponding effects of 1,25(OH)2D3 and its nuclear hormone receptor vitamin D receptor (VDR) level. Calcitriol 79-90 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 124-142 26820600-7 2016 Additionally, we explored the correlation between the corresponding effects of 1,25(OH)2D3 and its nuclear hormone receptor vitamin D receptor (VDR) level. Calcitriol 79-90 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 144-147 26820600-8 2016 We found that VDR expression was upregulated after 1,25(OH)2D3 treatment both in vivo and in vitro. Calcitriol 51-62 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 14-17 26820600-10 2016 And the action of 1,25(OH)2D3 might be associated with the VDR pathway. Calcitriol 18-29 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 59-62 26211511-1 2016 1,25 Dihydroxyvitamin D3 (1,25(OH)2 D) increases intestinal Ca absorption when dietary Ca intake is low by inducing gene expression through the vitamin D receptor (VDR). Calcitriol 0-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 144-162 26211511-1 2016 1,25 Dihydroxyvitamin D3 (1,25(OH)2 D) increases intestinal Ca absorption when dietary Ca intake is low by inducing gene expression through the vitamin D receptor (VDR). Calcitriol 0-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 164-167 26504088-1 2015 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the vitamin D receptor (VDR), whose expression in bone cells is regulated positively by 1,25(OH)2D3, retinoic acid, and parathyroid hormone through both intergenic and intronic enhancers. Calcitriol 26-50 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 85-103 26504088-1 2015 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the vitamin D receptor (VDR), whose expression in bone cells is regulated positively by 1,25(OH)2D3, retinoic acid, and parathyroid hormone through both intergenic and intronic enhancers. Calcitriol 26-50 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 105-108 26504088-1 2015 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the vitamin D receptor (VDR), whose expression in bone cells is regulated positively by 1,25(OH)2D3, retinoic acid, and parathyroid hormone through both intergenic and intronic enhancers. Calcitriol 52-63 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 85-103 26504088-1 2015 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the vitamin D receptor (VDR), whose expression in bone cells is regulated positively by 1,25(OH)2D3, retinoic acid, and parathyroid hormone through both intergenic and intronic enhancers. Calcitriol 52-63 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 105-108 26504088-1 2015 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the vitamin D receptor (VDR), whose expression in bone cells is regulated positively by 1,25(OH)2D3, retinoic acid, and parathyroid hormone through both intergenic and intronic enhancers. Calcitriol 169-180 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 85-103 26504088-1 2015 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the vitamin D receptor (VDR), whose expression in bone cells is regulated positively by 1,25(OH)2D3, retinoic acid, and parathyroid hormone through both intergenic and intronic enhancers. Calcitriol 169-180 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 105-108 25296887-0 2015 1,25-Dihydroxyvitamin D3/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration. Calcitriol 0-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 25-43 26071405-2 2015 Both VDREs bound the vitamin D receptor (VDR)-retinoid X receptor (RXR) complex and drove reporter gene transcription in response to 1,25-dihydroxyvitamin D3 (1,25D). Calcitriol 133-157 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 5-8 25829051-1 2015 BACKGROUND AND PURPOSE: Concentrations of 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ], the active ligand of the vitamin D receptor, are tightly regulated by CYP27B1 for synthesis and CYP24A1 for degradation. Calcitriol 42-71 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 114-132 25829051-1 2015 BACKGROUND AND PURPOSE: Concentrations of 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ], the active ligand of the vitamin D receptor, are tightly regulated by CYP27B1 for synthesis and CYP24A1 for degradation. Calcitriol 73-85 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 114-132 26041780-8 2015 We then conducted a ChIP sequence analysis of binding sites for the vitamin D receptor (VDR) across the proximal intestine in vitamin D-sufficient normal mice treated with vehicle or 1,25(OH)2D3. Calcitriol 183-194 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 68-86 26041780-10 2015 Interestingly, the majority of the genes regulated by 1,25(OH)2D3 in each diet group as well as those found in common in both groups contained frequent VDR sites that likely regulated their expression. Calcitriol 54-65 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 152-155 25961000-0 2015 1,25-Dihydroxyvitamin D3 Promotes High Glucose-Induced M1 Macrophage Switching to M2 via the VDR-PPARgamma Signaling Pathway. Calcitriol 0-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 93-96 25326845-11 2015 Knocking down VDR expression in SEMF abolished the effect of 1,25(OH)2D3. Calcitriol 61-72 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 14-17 25620699-1 2015 The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). Calcitriol 33-44 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 177-195 25620699-1 2015 The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). Calcitriol 33-44 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 197-200 25620699-3 2015 On the basis of structure-function correlations, we generated a point-mutated VDR (VDR(gem)) that is unresponsive to 1,25(OH)2D3, but the activity of which is efficiently induced by the gemini ligands. Calcitriol 117-128 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 78-81 25620699-3 2015 On the basis of structure-function correlations, we generated a point-mutated VDR (VDR(gem)) that is unresponsive to 1,25(OH)2D3, but the activity of which is efficiently induced by the gemini ligands. Calcitriol 117-128 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 83-91 26030589-4 2015 In response to 1, 25-(OH)2D3 (1, 10, and 100 nM), lipid accumulation and the expression of PPARgamma, C/EBPalpha, FABP4 and SCD-1 were inhibited through day 10, and vitamin D receptor expression was inhibited in the early time points. Calcitriol 15-28 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 165-183 25961000-7 2015 However, the above effects of 1,25-dihydroxyvitamin D3 were abolished when the expression of VDR and PPARgamma was inhibited by VDR siRNA and a PPARgamma antagonist. Calcitriol 30-54 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 93-96 25961000-7 2015 However, the above effects of 1,25-dihydroxyvitamin D3 were abolished when the expression of VDR and PPARgamma was inhibited by VDR siRNA and a PPARgamma antagonist. Calcitriol 30-54 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 128-131 24924628-5 2014 1alpha,25-dihydroxyvitamin D3 (1,25D) and eldecalcitol, an active vitamin D analog, induced the expression of MyoD, myogenin and OGN, and these effects were abolished by vitamin D receptor (VDR) suppression by siRNA in C2C12 cells. Calcitriol 0-29 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 170-188 25316911-0 2014 Actions of 1,25(OH)2-vitamin D3 on the cellular cycle depend on VDR and p38 MAPK in skeletal muscle cells. Calcitriol 11-31 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 64-67 25316911-1 2014 Previously, we have reported that 1,25(OH)2-vitamin D3 (1,25D) activates p38 MAPK (p38) in a vitamin D receptor (VDR)-dependent manner in proliferative C2C12 myoblast cells. Calcitriol 34-54 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 93-111 25316911-1 2014 Previously, we have reported that 1,25(OH)2-vitamin D3 (1,25D) activates p38 MAPK (p38) in a vitamin D receptor (VDR)-dependent manner in proliferative C2C12 myoblast cells. Calcitriol 34-54 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 113-116 24756753-2 2014 A signaling partner of RUNX2 is the nuclear vitamin D receptor (VDR) that becomes active when bound by its ligand 1,25-dihydroxyvitamin D3 (VD3). Calcitriol 114-138 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 44-62 24756753-2 2014 A signaling partner of RUNX2 is the nuclear vitamin D receptor (VDR) that becomes active when bound by its ligand 1,25-dihydroxyvitamin D3 (VD3). Calcitriol 114-138 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 64-67 24777663-6 2014 Treatment with 1,25(OH)2D3 decreased PTHrP protein production, an effect which was prevented by silencing of the VDR. Calcitriol 15-26 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 113-116 24777663-10 2014 1,25(OH)2D3 decreases PTHrP production, while PTHrP increases chondrocyte sensitivity to 1,25(OH)2D3 by increasing VDR production. Calcitriol 89-100 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 115-118 24821711-9 2014 Finally, administration of calcitriol [1,25-(OH)2D3], an active vitamin D metabolite, exerted similar antimetastatic effects in breast cancer cells in vitro and a mouse model of breast cancer in vivo with preservation of VDR and suppression of beta-catenin. Calcitriol 27-37 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 221-224 24821711-9 2014 Finally, administration of calcitriol [1,25-(OH)2D3], an active vitamin D metabolite, exerted similar antimetastatic effects in breast cancer cells in vitro and a mouse model of breast cancer in vivo with preservation of VDR and suppression of beta-catenin. Calcitriol 39-51 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 221-224 24891508-3 2014 We observed that the 1,25(OH)2D3-induced transcriptomes of POBs and OBs were quantitatively and qualitatively different, supporting not only the altered biology observed but the potential for a change in VDR interaction at the genome as well. Calcitriol 21-32 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 204-207 24924628-5 2014 1alpha,25-dihydroxyvitamin D3 (1,25D) and eldecalcitol, an active vitamin D analog, induced the expression of MyoD, myogenin and OGN, and these effects were abolished by vitamin D receptor (VDR) suppression by siRNA in C2C12 cells. Calcitriol 0-29 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 190-193 25009502-5 2014 However, the molecular basis of the interactions of 1,25(OH)2D3, vitamin D binding proteins (VDBPs) and nuclear vitamin D receptor (VDR) after sequestration in adipose tissue and their regulations are still unclear. Calcitriol 52-63 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 112-130 24849345-2 2014 Short-term treatment of two human amyloid precursor protein-expressing models, Tg2576 and TgCRND8 mice, with 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], the endogenous active ligand of VDR, resulted in higher brain P-glycoprotein (P-gp) and lower soluble Abeta levels, effects negated with coadministration of elacridar, a P-gp inhibitor. Calcitriol 109-138 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 186-189 24693968-1 2014 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the vitamin D receptor (VDR), which is expressed in numerous target tissues in a cell type-selective manner. Calcitriol 26-50 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 85-103 24693968-1 2014 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the vitamin D receptor (VDR), which is expressed in numerous target tissues in a cell type-selective manner. Calcitriol 26-50 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 105-108 24693968-1 2014 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the vitamin D receptor (VDR), which is expressed in numerous target tissues in a cell type-selective manner. Calcitriol 52-63 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 85-103 24693968-1 2014 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the vitamin D receptor (VDR), which is expressed in numerous target tissues in a cell type-selective manner. Calcitriol 52-63 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 105-108 24693968-5 2014 The mouse VDR transgene was also regulated by 1,25(OH)2D3 and dibutyryl-cAMP. Calcitriol 46-57 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 10-13 24849345-3 2014 Long-term treatment of TgCRND8 mice with 1,25(OH)2D3 during the period of plaque formation reduced soluble and insoluble plaque-associated Abeta, particularly in the hippocampus in which the VDR is abundant and P-gp induction is greatest after 1,25(OH)2D3 treatment, and this led to improved conditioned fear memory. Calcitriol 41-52 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 191-194 24184698-0 2013 WITHDRAWN: VDR involvement in 1a,25-dihydroxyvitamin D3-action on cellular cycle in C2C12 skeletal muscle cells. Calcitriol 30-55 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 11-14 24365583-12 2014 In addition, chromatin immunoprecipitation analysis of livers from mice showed that injection of 1,25(OH)2D3 increased recruitment of Vdr and rodent retinoid X receptor to the Shp promoter. Calcitriol 97-108 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 134-137 25207374-6 2014 Furthermore, as evident from studies in Vdr deficient mice, calcitriol may also repress the activity of Hh signaling in a Vdr-dependent fashion thereby establishing an additional inhibitory feedback on Hh signaling activity. Calcitriol 60-70 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 40-43 25207374-6 2014 Furthermore, as evident from studies in Vdr deficient mice, calcitriol may also repress the activity of Hh signaling in a Vdr-dependent fashion thereby establishing an additional inhibitory feedback on Hh signaling activity. Calcitriol 60-70 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 122-125 24135137-3 2013 Here, we found that 1,25-dihydroxyvitamin D3-bound [1,25(OH)2D3-bound] vitamin D receptor (VDR) specifically inhibits TGF-beta-SMAD signal transduction through direct interaction with SMAD3. Calcitriol 20-44 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 71-89 24135137-3 2013 Here, we found that 1,25-dihydroxyvitamin D3-bound [1,25(OH)2D3-bound] vitamin D receptor (VDR) specifically inhibits TGF-beta-SMAD signal transduction through direct interaction with SMAD3. Calcitriol 20-44 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 91-94 24135137-3 2013 Here, we found that 1,25-dihydroxyvitamin D3-bound [1,25(OH)2D3-bound] vitamin D receptor (VDR) specifically inhibits TGF-beta-SMAD signal transduction through direct interaction with SMAD3. Calcitriol 52-63 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 71-89 24135137-3 2013 Here, we found that 1,25-dihydroxyvitamin D3-bound [1,25(OH)2D3-bound] vitamin D receptor (VDR) specifically inhibits TGF-beta-SMAD signal transduction through direct interaction with SMAD3. Calcitriol 52-63 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 91-94 24783016-9 2012 CONCLUSIONS: In mice, the VDR is redundant for normal thyrocyte function, but not for C cell function, where it mediates the negative control of calcitonin by 1,25-dihydroxyvitamin D3. Calcitriol 159-183 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 26-29 23579488-9 2013 A vitamin D receptor/retinoid X receptor-alpha-bound DNA element (with a DR7 motif) mediated induction of the transfected SULT2B1 promoter in calcitriol-treated cells. Calcitriol 142-152 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 2-20 23482451-2 2013 Studies that examined the intricate relationships between plasma and tissue 1,25(OH)2D3 levels and changes in VDR target genes and plasma calcium and PTH are virtually nonexistent. Calcitriol 76-87 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 110-113 23992309-6 2013 Secondly, 1,25(OH)2D3 can inhibit vitamin D receptor (VDR) shRNA interfered tumor cell growth through decreasing inflammatory cytokine secretion in vitro and in vivo. Calcitriol 10-21 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 34-52 23992309-6 2013 Secondly, 1,25(OH)2D3 can inhibit vitamin D receptor (VDR) shRNA interfered tumor cell growth through decreasing inflammatory cytokine secretion in vitro and in vivo. Calcitriol 10-21 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 54-57 23652552-15 2013 By contrast, the induction of 25-hydroxyvitamin D 24-hydroxylase and the reduction in serum 1,25(OH)2D3 levels induced by FGF23 were dependent on the VDR. Calcitriol 92-103 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 150-153 22791341-10 2012 The VDR ligand calcitriol reversed the VDR loss and inhibited EMT in the mouse UUO model, and late administration of active vitamin D was effective in restoring VDR expression as well, and reduced collagen accumulation and deposition compared with the vehicle control. Calcitriol 15-25 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-7 22791341-10 2012 The VDR ligand calcitriol reversed the VDR loss and inhibited EMT in the mouse UUO model, and late administration of active vitamin D was effective in restoring VDR expression as well, and reduced collagen accumulation and deposition compared with the vehicle control. Calcitriol 15-25 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 39-42 22791341-10 2012 The VDR ligand calcitriol reversed the VDR loss and inhibited EMT in the mouse UUO model, and late administration of active vitamin D was effective in restoring VDR expression as well, and reduced collagen accumulation and deposition compared with the vehicle control. Calcitriol 15-25 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 39-42 22537547-2 2012 Calcitriol exerts its action through Vitamin D receptor (VDR), which is a high affinity nuclear receptor. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 37-55 22537547-2 2012 Calcitriol exerts its action through Vitamin D receptor (VDR), which is a high affinity nuclear receptor. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 57-60 22537547-11 2012 Calcitriol significantly increased and TNF-alpha decreased the protein and mRNA expression of prohibitin and VDR in HBSMCs. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 109-112 21740543-8 2011 injection of 1,25(OH)2D3, while no significant effect was observed at 48 or 72 h. Vitamin D receptor (VDR) mRNA was detected in mouse brain capillaries, suggesting that 1,25(OH)2D3 has a VDR-mediated genomic action. Calcitriol 169-180 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 82-100 22550417-0 2012 Calcitriol inhibits hedgehog signaling and induces vitamin d receptor signaling and differentiation in the patched mouse model of embryonal rhabdomyosarcoma. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 51-69 22550417-6 2012 Concomitantly, calcitriol activates vitamin D receptor (Vdr) signaling and induces tumor differentiation. Calcitriol 15-25 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 36-54 22550417-6 2012 Concomitantly, calcitriol activates vitamin D receptor (Vdr) signaling and induces tumor differentiation. Calcitriol 15-25 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 56-59 22525840-0 2012 The vitamin D receptor: new paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D3. Calcitriol 79-103 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-22 22093484-0 2012 VDR dependent and independent effects of 1,25-dihydroxyvitamin D3 on nitric oxide production by osteoblasts. Calcitriol 41-65 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 21740543-8 2011 injection of 1,25(OH)2D3, while no significant effect was observed at 48 or 72 h. Vitamin D receptor (VDR) mRNA was detected in mouse brain capillaries, suggesting that 1,25(OH)2D3 has a VDR-mediated genomic action. Calcitriol 13-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 82-100 21740543-8 2011 injection of 1,25(OH)2D3, while no significant effect was observed at 48 or 72 h. Vitamin D receptor (VDR) mRNA was detected in mouse brain capillaries, suggesting that 1,25(OH)2D3 has a VDR-mediated genomic action. Calcitriol 13-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 102-105 21740543-8 2011 injection of 1,25(OH)2D3, while no significant effect was observed at 48 or 72 h. Vitamin D receptor (VDR) mRNA was detected in mouse brain capillaries, suggesting that 1,25(OH)2D3 has a VDR-mediated genomic action. Calcitriol 13-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 187-190 21740543-8 2011 injection of 1,25(OH)2D3, while no significant effect was observed at 48 or 72 h. Vitamin D receptor (VDR) mRNA was detected in mouse brain capillaries, suggesting that 1,25(OH)2D3 has a VDR-mediated genomic action. Calcitriol 169-180 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 102-105 21740543-8 2011 injection of 1,25(OH)2D3, while no significant effect was observed at 48 or 72 h. Vitamin D receptor (VDR) mRNA was detected in mouse brain capillaries, suggesting that 1,25(OH)2D3 has a VDR-mediated genomic action. Calcitriol 169-180 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 187-190 21159735-9 2011 Treatment with both paricalcitol and calcitriol caused significant elevation of VDR expression in the aorta. Calcitriol 37-47 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 80-83 21421739-0 2011 1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo. Calcitriol 0-29 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 66-84 21287548-0 2011 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Calcitriol 0-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 59-77 17212358-10 2007 This difference is, at least in part, due to ligand-dependent actions of the VDR, since 1,25-dihydroxyvitamin D3 suppressed DKK1 and SFRP2 expression in wild-type cultures. Calcitriol 88-112 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 77-80 20566739-12 2010 VDR expression, distribution, transcriptional activity, and target genes were regulated by Salmonella stimulation, independent of 1,25-dihydroxyvitamin D3. Calcitriol 130-154 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 20362670-0 2010 The 1,25-dihydroxyvitamin D3-independent actions of the vitamin D receptor in skin. Calcitriol 4-28 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 56-74 19951695-2 2010 Biological effects of 1,25(OH)2D3 are mediated through a nuclear steroid hormone receptor, known as the vitamin D receptor (VDR). Calcitriol 22-33 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 104-122 19951695-2 2010 Biological effects of 1,25(OH)2D3 are mediated through a nuclear steroid hormone receptor, known as the vitamin D receptor (VDR). Calcitriol 22-33 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 124-127 19631778-0 2009 Improvement of impaired calcium and skeletal homeostasis in vitamin D receptor knockout mice by a high dose of calcitriol and maxacalcitol. Calcitriol 111-121 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 60-78 19705334-2 2009 Calcitriol binds to the vitamin D receptor (VDR), a nuclear receptor. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 24-42 19705334-2 2009 Calcitriol binds to the vitamin D receptor (VDR), a nuclear receptor. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 44-47 19705334-3 2009 The binding of calcitriol to the VDR activates the recruitment of cofactors that form a transcriptional complex that binds vitamin D response elements in the promoter region of target genes. Calcitriol 15-25 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 33-36 19141646-0 2009 Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo. Calcitriol 63-73 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 8-26 19141646-2 2009 These actions of calcitriol are mediated at least in part by vitamin D receptor (VDR), which is expressed in many tissues including endothelial cells. Calcitriol 17-27 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 61-79 19141646-2 2009 These actions of calcitriol are mediated at least in part by vitamin D receptor (VDR), which is expressed in many tissues including endothelial cells. Calcitriol 17-27 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 81-84 19141646-6 2009 Treatment with calcitriol resulted in growth inhibition in TDEC expressing VDR. Calcitriol 15-25 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 75-78 19141646-7 2009 However, TDEC from KO mice were relatively resistant, suggesting that calcitriol-mediated growth inhibition on TDEC is VDR-dependent. Calcitriol 70-80 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 119-122 19141646-11 2009 These results indicate that calcitriol-mediated antiproliferative effects on TDEC are VDR-dependent and loss of VDR can lead to abnormal tumor angiogenesis. Calcitriol 28-38 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 86-89 19141646-11 2009 These results indicate that calcitriol-mediated antiproliferative effects on TDEC are VDR-dependent and loss of VDR can lead to abnormal tumor angiogenesis. Calcitriol 28-38 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 112-115 17513186-3 2007 Calcitriol (1,25D(3)), which is the active hormonal ligand for the vitamin D receptor (VDR), a member of the NR superfamily, induces osteoblastic cell cycle arrest and expression of genes involved in matrix mineralization in vitro, with over-expression of VDR in mature osteoblasts increasing bone mass in mice. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 67-85 17513186-3 2007 Calcitriol (1,25D(3)), which is the active hormonal ligand for the vitamin D receptor (VDR), a member of the NR superfamily, induces osteoblastic cell cycle arrest and expression of genes involved in matrix mineralization in vitro, with over-expression of VDR in mature osteoblasts increasing bone mass in mice. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 87-90 17513186-3 2007 Calcitriol (1,25D(3)), which is the active hormonal ligand for the vitamin D receptor (VDR), a member of the NR superfamily, induces osteoblastic cell cycle arrest and expression of genes involved in matrix mineralization in vitro, with over-expression of VDR in mature osteoblasts increasing bone mass in mice. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 256-259 17310066-0 2007 Evidence for 1,25-dihydroxyvitamin D3-independent transactivation by the vitamin D receptor: uncoupling the receptor and ligand in keratinocytes. Calcitriol 13-37 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 73-91 17310066-8 2007 The 1,25(OH)2D3-independent activation of VDR was also observed in keratinocytes from 1alpha-hydroxylase knock-out mice, indicating that it is not due to endogenous 1,25(OH)2D3 production. Calcitriol 4-15 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 42-45 20302580-7 2010 RESULTS: Epidermis co-treated with topical calcitriol showed an improvement of stratum corneum integrity and barrier recovery, more intense fluorescence staining with Nile red, and an increase in lamellar body (LB) maturation and density, as well as upregulation of major epidermal lipid synthesis-related enzymes (3-hydroxy-3-methylglutaryl-CoA, serine-palmitoyl transferase and fatty acid synthase), mouse beta-defensin 3, cathelin-related antimicrobial peptide and vitamin D receptor. Calcitriol 43-53 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 468-486 17556365-8 2007 These studies provide the first evidence for 1,25(OH)(2)D(3)-induced VDR interaction at key target genes in vivo, revealing the consequences of that interaction on the Cyp24a1 and Trpv6 genes. Calcitriol 45-60 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 69-72 17244627-2 2007 Although both cell types have an intact vitamin D receptor-signaling axis, this study demonstrates that upon treatment with calcitriol, 24-hydroxylase (CYP24) mRNA, protein and enzymatic activity were markedly induced in MDEC in a time-dependent manner but not in TDEC. Calcitriol 124-134 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 40-58 17035339-0 2007 VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3. Calcitriol 61-85 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 17280828-7 2007 Vitamin D receptor (VDR) expression was up-regulated by calcitriol in both naive and VDI cells. Calcitriol 56-66 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-18 17280828-7 2007 Vitamin D receptor (VDR) expression was up-regulated by calcitriol in both naive and VDI cells. Calcitriol 56-66 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 20-23 17237620-5 2006 The vitamin D receptor (VDR) is present in TDEC and MYSEC, and was upregulated in calcitriol-treated TDEC and MYSEC; dexamethasone further increased VDR expression following 48 h of treatment. Calcitriol 82-92 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-22 16984385-4 2006 In vitro and vitamin D receptor (VDR) knockout mouse studies predict that nanomolar concentrations of calcitriol may act as an antithrombotic agent. Calcitriol 102-112 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 13-31 16984385-4 2006 In vitro and vitamin D receptor (VDR) knockout mouse studies predict that nanomolar concentrations of calcitriol may act as an antithrombotic agent. Calcitriol 102-112 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 33-36 16507601-9 2006 This is supported by the observation that IkappaBalpha degradation induced by TNF-alpha was inhibited by 1,25(OH)2D3 in VDR+/- cells, but not in VDR-/- cells. Calcitriol 105-116 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 120-123 16880407-2 2006 We show here that topical application of the physiologically active ligand [1alpha,25-(OH)(2)D(3); calcitriol] of the vitamin D receptor, or of its low-calcemic analog MC903 (calcipotriol; Dovonex), induces TSLP expression in epidermal keratinocytes, which results in an atopic dermatitis-like syndrome mimicking that seen in RXRalphabeta(ep-/-) mutants and transgenic mice overexpressing TSLP in keratinocytes. Calcitriol 99-109 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 118-136 16497728-0 2006 Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3. Calcitriol 110-134 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 44-62 16497728-1 2006 The biological actions of 1,25-(OH)2D3 are mediated by the vitamin D receptor (VDR), a protein that binds to target genes and alters their expression. Calcitriol 26-38 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 59-77 16497728-1 2006 The biological actions of 1,25-(OH)2D3 are mediated by the vitamin D receptor (VDR), a protein that binds to target genes and alters their expression. Calcitriol 26-38 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 79-82 16497728-3 2006 In the present study, we explored both the capacity of 1,25-(OH)2D3 to induce VDR gene expression in bone cells and the mechanism instrumental to this up-regulation. Calcitriol 55-67 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 78-81 16497728-6 2006 VDR binding to these sites in response to 1,25-(OH)2D3 was confirmed by ChIP analysis and was accompanied by differential localization of retinoid X receptor, histone acetylation, and RNA polymerase II recruitment. Calcitriol 42-54 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 16497728-9 2006 Our results demonstrate that 1,25-(OH)2D3 and its receptor autoregulate the expression of the VDR gene. Calcitriol 29-41 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 94-97 16467308-1 2006 The vitamin D receptor (VDR) and its ligand 1,25-OH2-VD3 (calcitriol) play an essential role in mineral homeostasis in mammals. Calcitriol 58-68 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-22 16467308-1 2006 The vitamin D receptor (VDR) and its ligand 1,25-OH2-VD3 (calcitriol) play an essential role in mineral homeostasis in mammals. Calcitriol 58-68 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 24-27 16467308-4 2006 In this study, we have further defined the molecular mechanism by which the unliganded VDR and calcitriol-liganded VDR regulate adipogenesis. Calcitriol 95-105 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 115-118 16467308-5 2006 In the presence of calcitriol, the VDR blocks adipogenesis by down-regulating both C/EBPbeta mRNA expression and C/EBPbeta nuclear protein levels at a critical stage of differentiation. Calcitriol 19-29 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 35-38 16467308-8 2006 Taken together, these data support the notion that the intracellular concentrations of calcitriol can play an important role in either promoting or inhibiting adipogenesis via the VDR and the transcriptional pathways that it targets. Calcitriol 87-97 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 180-183 17237620-5 2006 The vitamin D receptor (VDR) is present in TDEC and MYSEC, and was upregulated in calcitriol-treated TDEC and MYSEC; dexamethasone further increased VDR expression following 48 h of treatment. Calcitriol 82-92 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 24-27 17237620-5 2006 The vitamin D receptor (VDR) is present in TDEC and MYSEC, and was upregulated in calcitriol-treated TDEC and MYSEC; dexamethasone further increased VDR expression following 48 h of treatment. Calcitriol 82-92 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 149-152 15727633-1 2005 BACKGROUND: 1alpha,25-dihydroxyvitamin D(3)[1,25(OH)(2)D(3)], the active metabolite of vitamin D, exerts its activities by binding to the vitamin D receptor (VDR) with subsequent function as a transcription factor. Calcitriol 12-43 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 138-156 15885032-6 2005 The degree of 24-hydroxylase induction by FGF23M was dependent on the VDR, since FGF23M significantly reduced the levels of serum 1,25(OH)2D3 [1,25-hydroxyvitamin D3] in VDR(+/+) mice, but not in VDR(-/-) mice. Calcitriol 130-141 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 70-73 15885032-6 2005 The degree of 24-hydroxylase induction by FGF23M was dependent on the VDR, since FGF23M significantly reduced the levels of serum 1,25(OH)2D3 [1,25-hydroxyvitamin D3] in VDR(+/+) mice, but not in VDR(-/-) mice. Calcitriol 130-141 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 170-173 15885032-6 2005 The degree of 24-hydroxylase induction by FGF23M was dependent on the VDR, since FGF23M significantly reduced the levels of serum 1,25(OH)2D3 [1,25-hydroxyvitamin D3] in VDR(+/+) mice, but not in VDR(-/-) mice. Calcitriol 130-141 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 170-173 15885032-8 2005 In contrast, the induction of 25-hydroxyvitamin D 24-hydroxylase and the reduction of serum 1,25(OH)2D3 levels induced by FGF23 are dependent on the VDR. Calcitriol 92-103 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 149-152 15639181-1 2005 Vitamin D (calcitriol) is a nuclear transcription regulator acting via a nuclear hormone receptor (VDR). Calcitriol 11-21 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 99-102 15647825-0 2005 1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts. Calcitriol 0-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 43-61 15647825-3 2005 Our studies show that 1,25(OH)2D3-induced transactivation is a dynamic process that involves promoter-specific localization of VDR and RXR, recruitment of histone acetyltransferase complexes, and in the case of the Cyp24 gene, modification of histone 4. Calcitriol 22-33 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 127-130 15647825-10 2005 RESULTS: 1,25(OH)2D3 induces rapid association of the VDR and RXR with both the Cyp24 and the Opn gene promoters in both MC3T3-E1 osteoblasts and MOBs, interactions that are both rapid and cyclic in nature. Calcitriol 9-20 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 54-57 15647825-14 2005 Our studies indicate that 1,25(OH)2D3-induced transactivation in intact osteoblasts is a dynamic process that involves promoter-specific localization of VDR and RXR as well as the recruitment of a number of co-regulators essential to 1,25(OH)2D3-induced transcription. Calcitriol 26-37 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 153-156 15528275-3 2005 Herein, we identified a novel 1alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] response element in the promoter region of Insig-2 gene, which specifically binds to the heterodimer of retinoid X receptor and vitamin D receptor (VDR) and directs VDR-mediated transcriptional activation in a 1,25-(OH)2D3-dependent manner. Calcitriol 30-59 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 203-221 15528275-3 2005 Herein, we identified a novel 1alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] response element in the promoter region of Insig-2 gene, which specifically binds to the heterodimer of retinoid X receptor and vitamin D receptor (VDR) and directs VDR-mediated transcriptional activation in a 1,25-(OH)2D3-dependent manner. Calcitriol 30-59 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 223-226 15528275-3 2005 Herein, we identified a novel 1alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] response element in the promoter region of Insig-2 gene, which specifically binds to the heterodimer of retinoid X receptor and vitamin D receptor (VDR) and directs VDR-mediated transcriptional activation in a 1,25-(OH)2D3-dependent manner. Calcitriol 30-59 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 240-243 15581603-0 2005 1,25-Dihydroxyvitamin D3 up-regulates the renal vitamin D receptor through indirect gene activation and receptor stabilization. Calcitriol 0-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 48-66 15727633-1 2005 BACKGROUND: 1alpha,25-dihydroxyvitamin D(3)[1,25(OH)(2)D(3)], the active metabolite of vitamin D, exerts its activities by binding to the vitamin D receptor (VDR) with subsequent function as a transcription factor. Calcitriol 12-43 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 158-161 15503649-5 2004 Studies performed in mice rendered deficient for VDR suggest that calcitriol and VDR may inhibit the renin-angiotensin system and reduce blood pressure in the long-term. Calcitriol 66-76 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 49-52 11796525-6 2002 Furthermore, the normal genetic responses to administered 1,25-(OH)2D3, such as down-regulation of the 25-hydroxyvitamin D 1alpha-hydroxylase gene and up-regulation of 24-hydroxylase and VDR genes, were apparently impaired in kl-/- mice. Calcitriol 58-70 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 187-190 12900504-0 2003 Regulation of the murine renal vitamin D receptor by 1,25-dihydroxyvitamin D3 and calcium. Calcitriol 53-77 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 31-49 12900504-6 2003 When dietary calcium was present, 50 ng of 1,25(OH)2D3 elevated the VDR levels 2- to 10-fold, depending on vitamin D status and the level of calcium. Calcitriol 43-54 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 68-71 12900504-10 2003 This in vivo study demonstrates that 1,25(OH)2D3 and calcium are both required for renal VDR mRNA expression above a basal level, furthering our understanding of the complex regulation of renal VDR by 1,25(OH)2D3 and calcium. Calcitriol 37-48 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 89-92 12900504-10 2003 This in vivo study demonstrates that 1,25(OH)2D3 and calcium are both required for renal VDR mRNA expression above a basal level, furthering our understanding of the complex regulation of renal VDR by 1,25(OH)2D3 and calcium. Calcitriol 37-48 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 194-197 12900504-10 2003 This in vivo study demonstrates that 1,25(OH)2D3 and calcium are both required for renal VDR mRNA expression above a basal level, furthering our understanding of the complex regulation of renal VDR by 1,25(OH)2D3 and calcium. Calcitriol 201-212 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 89-92 12900504-10 2003 This in vivo study demonstrates that 1,25(OH)2D3 and calcium are both required for renal VDR mRNA expression above a basal level, furthering our understanding of the complex regulation of renal VDR by 1,25(OH)2D3 and calcium. Calcitriol 201-212 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 194-197 11371626-0 2001 Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Calcitriol 29-58 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 78-96 11721090-7 2001 Recently discovered 64.5 kDa protein from chick epithelium, which specifically binds 1,25-dihydroxyvitamin D(3) and is responsible for some rapid cellular actions of 1,25-dihydroxyvitamin D(3) is a candidate for mVDR. Calcitriol 85-111 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 212-216 11697802-1 2001 Immune cells carry receptors for 1,25-dihydroxyvitamin D3 [1,25(OH)2D3; vitamin D receptor (VDR)] and individuals with severe vitamin D deficiency have immune abnormalities. Calcitriol 33-57 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 72-90 11697802-1 2001 Immune cells carry receptors for 1,25-dihydroxyvitamin D3 [1,25(OH)2D3; vitamin D receptor (VDR)] and individuals with severe vitamin D deficiency have immune abnormalities. Calcitriol 33-57 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 92-95 11532865-1 2001 The vitamin D receptor knockout (VDR-KO) mouse presents with a skeletal phenotype typical for complete lack of genomic 1,25-dihydroxycholecalciferol effects. Calcitriol 119-148 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-22 11532865-1 2001 The vitamin D receptor knockout (VDR-KO) mouse presents with a skeletal phenotype typical for complete lack of genomic 1,25-dihydroxycholecalciferol effects. Calcitriol 119-148 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 33-36 10830288-1 2000 The biological effects of 1,25-dihydroxyvitamin D3 are mediated by a nuclear receptor, the vitamin D receptor (VDR). Calcitriol 26-50 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 91-109 11730564-4 2001 Calcitriol and its analogues with the same affinity to vitamin D receptor up-regulated the gene expression of both MCP-1 and its receptors, enhanced MCP-1 protein production and promoted the migratory ability of MoDC to MCP-1. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 55-73 10830288-1 2000 The biological effects of 1,25-dihydroxyvitamin D3 are mediated by a nuclear receptor, the vitamin D receptor (VDR). Calcitriol 26-50 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 111-114 10322128-8 1999 CONCLUSIONS: These novel VDR modulators may have potential as therapeutics for cancer, leukemia and psoriasis with less calcium mobilization side effects than are associated with secosteroidal 1,25(OH)2D3 analogs. Calcitriol 193-204 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 25-28 10366427-4 1999 No VDR was detected in untreated WEHI-3B D- cells; however, RA and 1,25-(OH)2D3 when used as single agents caused a slight induction of the VDR and in combination produced a marked increase in the VDR. Calcitriol 67-79 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 140-143 10366427-4 1999 No VDR was detected in untreated WEHI-3B D- cells; however, RA and 1,25-(OH)2D3 when used as single agents caused a slight induction of the VDR and in combination produced a marked increase in the VDR. Calcitriol 67-79 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 140-143 10366427-8 1999 Expression of the VDR conferred differentiation responsiveness to 1,25-(OH)2D3 in WEHI-3B D+ cells. Calcitriol 66-78 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 18-21 10366427-9 1999 These findings suggest that (a) induction of VDR expression is a key component in the synergistic differentiation induced by 1,25-(OH)2D3 and RA and (b) RAR and not RXR must be activated for enhanced induction of the VDR and for the synergistic differentiation produced by RA and 1, 25-(OH)2D3. Calcitriol 125-137 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 45-48 10366427-9 1999 These findings suggest that (a) induction of VDR expression is a key component in the synergistic differentiation induced by 1,25-(OH)2D3 and RA and (b) RAR and not RXR must be activated for enhanced induction of the VDR and for the synergistic differentiation produced by RA and 1, 25-(OH)2D3. Calcitriol 280-293 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 45-48 10418998-2 1999 The transactivation function of VDR is activated by binding 1alpha,25-dihydroxyvitamin D3[1alpha,25(OH)2D3], an active form of vitamin D. Calcitriol 60-89 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 32-35 9614072-7 1998 In addition, in a Northern blot assay, we observed 1alpha-25-(OH)2D3 synergism of TGF-beta1-induced expression of the c-jun gene in the cells transfected with the VDR expression vector and also found that the synergistic action was clearly blocked by VDR antisense oligonucleotide pretreatment. Calcitriol 51-68 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 163-166 9344042-9 1997 These studies suggest that a VDR-independent pathway, perhaps stimulation of calcium influx, and a VDR-dependent mechanism, which directly affects transcription, are involved in calcitriol"s enhancement of TPA-induced tumorigenic transformation in JB6 Cl41.5a cells. Calcitriol 178-188 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 29-32 9564171-1 1998 The vitamin D hormone, 1,25-dihydroxyvitamin D3, functions by way of a nuclear receptor (vitamin D receptor [VDR]) in a manner analogous to the other members of the steroid-thyroid hormone superfamily. Calcitriol 23-47 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 89-107 9564171-1 1998 The vitamin D hormone, 1,25-dihydroxyvitamin D3, functions by way of a nuclear receptor (vitamin D receptor [VDR]) in a manner analogous to the other members of the steroid-thyroid hormone superfamily. Calcitriol 23-47 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 109-112 9344042-0 1997 Calcitriol enhancement of TPA-induced tumorigenic transformation is mediated through vitamin D receptor-dependent and -independent pathways. Calcitriol 0-10 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 85-103 9344042-3 1997 In JB6 Cl41.5a cells, 1alpha,24-dihydroxy-22-ene-24-cyclopropyl-vitamin D3 (BT), which like calcitriol binds to VDR and regulates transcription, inhibited cell growth, stimulated expression of nonphosphorylated osteopontin (OPN), and enhanced TPA-induced anchorage-independent growth (AIG, an in vitro assay which highly correlates with tumorigenicity of these cells). Calcitriol 92-102 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 112-115 9525962-2 1998 Gel mobility shift analysis was utilized to investigate the molecular function of 1alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and 9-cis-retinoic acid (9-cis-RA) ligands in the binding of the vitamin D receptor (VDR) and retinoid X receptor (RXR) to mouse osteopontin and rat osteocalcin vitamin D-response elements (VDREs). Calcitriol 82-111 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 192-210 9525962-2 1998 Gel mobility shift analysis was utilized to investigate the molecular function of 1alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and 9-cis-retinoic acid (9-cis-RA) ligands in the binding of the vitamin D receptor (VDR) and retinoid X receptor (RXR) to mouse osteopontin and rat osteocalcin vitamin D-response elements (VDREs). Calcitriol 82-111 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 212-215 9525962-2 1998 Gel mobility shift analysis was utilized to investigate the molecular function of 1alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and 9-cis-retinoic acid (9-cis-RA) ligands in the binding of the vitamin D receptor (VDR) and retinoid X receptor (RXR) to mouse osteopontin and rat osteocalcin vitamin D-response elements (VDREs). Calcitriol 113-125 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 192-210 9525962-2 1998 Gel mobility shift analysis was utilized to investigate the molecular function of 1alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and 9-cis-retinoic acid (9-cis-RA) ligands in the binding of the vitamin D receptor (VDR) and retinoid X receptor (RXR) to mouse osteopontin and rat osteocalcin vitamin D-response elements (VDREs). Calcitriol 113-125 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 212-215 9389537-3 1997 In contrast, the specific binding of 1,25-(OH)2D3 to spleen cytosol and the number of monocyte/macrophages expressing 1,25-(OH)2D3 receptors (VDR) were markedly increased. Calcitriol 37-49 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 142-145 9344042-9 1997 These studies suggest that a VDR-independent pathway, perhaps stimulation of calcium influx, and a VDR-dependent mechanism, which directly affects transcription, are involved in calcitriol"s enhancement of TPA-induced tumorigenic transformation in JB6 Cl41.5a cells. Calcitriol 178-188 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 99-102