PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30267995-6 2018 We hypothesize that calcitriol drives a transition from encephalitogenic CD4+ T cell to Treg cell dominance by upregulating Ikzf2 and Bhmt1, recycling homocysteine to methionine, reducing homocysteine toxicity, maintaining DNA methylation, and stabilizing CD4+Helios+FoxP3+Tregulatory cells. Calcitriol 20-30 betaine--homocysteine S-methyltransferase Homo sapiens 134-139