PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25466545-6	2014	Klotho may influence cellular transport processes across the cell membrane by inhibiting calcitriol (1,25(OH) (2)D(3)), formation or by directly affecting transporter proteins, including ion channels, carriers and pumps.	Calcitriol	89-99	klotho	Homo sapiens	0-6	
25453654-1	2014	The Klotho protein, whose gene has predominant renal expression, acts in the control of serum phosphorus and 1,25-dihydroxyvitamin D3 and regulates the function of ion channels.	Calcitriol	109-133	klotho	Homo sapiens	4-10	
24553631-3	2014	RECENT FINDINGS: The pathogenesis of renal osteodystrophy is under strong influence of the fibroblast growth factor 23/Klotho system, which is able to enhance phosphate excretion and reduce calcitriol synthesis in the kidney.	Calcitriol	190-200	klotho	Homo sapiens	119-125	
25531216-1	2014	BACKGROUND/AIMS: The transmembrane Klotho protein contributes to inhibition of 1,25(OH)2D3 formation.	Calcitriol	79-90	klotho	Homo sapiens	35-41	
25571875-1	2014	BACKGROUND/AIMS: Klotho, a protein mainly produced in the kidney and released into circulating blood, contributes to the negative regulation of 1,25(OH)2D3 formation and is thus a powerful regulator of mineral metabolism.	Calcitriol	144-155	klotho	Homo sapiens	17-23	
24247665-15	2013	CONCLUSION: Besides blocking the effects of aldosterone, spironolactone upregulates KLOTHO gene expression by upregulation of 25-hydroxyvitamin D3 1-alpha-hydroxylase with subsequent activation of the vitamin D3 receptor by 1,25(OH)2D3, an effect possibly independent from the mineralocorticoid receptor.	Calcitriol	224-235	klotho	Homo sapiens	84-90	
23923038-3	2013	Klotho may modify transport by inhibiting 1,25(OH)2D3 formation or by directly affecting channel and carrier proteins.	Calcitriol	42-53	klotho	Homo sapiens	0-6	
23129826-8	2013	After adjustment for age, gender, serum 25-hydroxyvitamin D levels and concomitant medications (calcium, supplemental vitamin D and calcitriol), we estimated that the mean Klotho change was 3.2 pg/mL (95% CI 1.2-5.2 pg/mL, P = 0.0019) for each 1 mL/min/1.73 m(2) GFR change.	Calcitriol	132-142	klotho	Homo sapiens	172-178	
24247665-1	2013	BACKGROUND: Klotho, a transmembrane protein, protease and hormone mainly expressed in kidney, is required for the suppression of 1,25(OH)2D3-generating 25-hydroxyvitamin D3 1-alpha-hydroxylase (Cyp27b1) by FGF23.	Calcitriol	129-140	klotho	Homo sapiens	12-18	
24247665-2	2013	Conversely, 1,25(OH)2D3 stimulates, by activating the vitamin D3 receptor (Vdr), the expression of klotho, thus establishing a negative feedback loop.	Calcitriol	12-23	klotho	Homo sapiens	99-105	
24247665-4	2013	Klotho deficiency accelerates aging and early death, effects at least partially due to excessive formation of 1,25(OH)2D3 and subsequent hyperphosphatemia.	Calcitriol	110-121	klotho	Homo sapiens	0-6	
17332731-1	2007	Klotho gene mutation leads to a syndrome strangely resembling chronic kidney disease patients undergoing dialysis with multiple accelerated age-related disorders, including hypoactivity, sterility, skin thinning, muscle atrophy, osteoporosis, vascular calcifications, soft-tissue calcifications, defective hearing, thymus atrophy, pulmonary emphysema, ataxia, and abnormalities of the pituitary gland, as well as hypoglycemia, hyperphosphatemia, and paradoxically high-plasma calcitriol levels.	Calcitriol	476-486	klotho	Homo sapiens	0-6	
20798257-9	2010	In turn, calcitriol stimulates FGF23 and Klotho expression.	Calcitriol	9-19	klotho	Homo sapiens	41-47	
23214203-4	2012	FGF-23 with a coreceptor (Klotho protein) inhibits renal phosphate reabsorption and synthesis of calcitriol by reducing 1alpha-hydroxylase (CYP27B1) activity, reducing vitamin D-dependent phosphate intestinal absorption.	Calcitriol	97-107	klotho	Homo sapiens	26-32	
19121771-7	2009	By modulating FGF23 action, klotho regulates urinary phosphate excretion and calcitriol synthesis.	Calcitriol	77-87	klotho	Homo sapiens	28-34	
19121771-10	2009	Finally, klotho extends life span via several mechanisms, including the reduction of calcitriol synthesis, serum calcium, and phosphorus levels; the induction of insulin resistance; and by increasing the resistance to oxidative stress.	Calcitriol	85-95	klotho	Homo sapiens	9-15	
33694274-6	2021	FGF-23 and Klotho were recently described in mineral and bone disorders in CKD, resulting in reductions in calcitriol levels.	Calcitriol	107-117	klotho	Homo sapiens	11-17	
33382545-9	2020	Phosphate excess stimulates the release of fibroblast growth factor FGF23, which suppresses 1,25(OH)2D3 formation, an effect requiring Klotho.	Calcitriol	92-103	klotho	Homo sapiens	135-141	
33393746-9	2020	Phosphate excess stimulates the release of fibroblast growth factor FGF23, which suppresses 1,25(OH)2D3 formation, an effect requiring Klotho.	Calcitriol	92-103	klotho	Homo sapiens	135-141	
30504710-2	2018	In cooperation with the transmembrane protein Klotho, FGF23 is a powerful inhibitor of 1alpha 25OH Vitamin D Hydroxylase (Cyp27b1) and thus of the formation of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).	Calcitriol	160-184	klotho	Homo sapiens	46-52	
26287968-10	2016	Moreover, PTH-induced increase of cyclic AMP secretion and 1alpha,25-dihydroxyvitamin D3 (1,25VD) was attenuated by recombinant human klotho in vivo.	Calcitriol	59-88	klotho	Homo sapiens	134-140	
27125738-7	2016	Klotho, an enzyme and hormone, has been reported to participate in the regulation of cellular transport processes across the plasma membrane either indirectly through inhibiting calcitriol (1,25(OH)2D3) formation or other mechanism, or by directly affecting transporter proteins, including ion channels, cellular carriers, and Na(+)/K(+)-ATPase.	Calcitriol	178-188	klotho	Homo sapiens	0-6	
27125738-7	2016	Klotho, an enzyme and hormone, has been reported to participate in the regulation of cellular transport processes across the plasma membrane either indirectly through inhibiting calcitriol (1,25(OH)2D3) formation or other mechanism, or by directly affecting transporter proteins, including ion channels, cellular carriers, and Na(+)/K(+)-ATPase.	Calcitriol	190-201	klotho	Homo sapiens	0-6	
29179169-4	2017	FGF23 inhibits Cyp27b1, an enzyme to produce an active vitamin D3, 1,25(OH)2D3, through FGF receptor/Klotho complex.	Calcitriol	67-78	klotho	Homo sapiens	101-107