PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9579536-5 1998 In contrast, the construct containing the VDRE of the human 24-hydroxylase gene was induced several fold by 1,25(OH)2D3 in normal human keratinocytes and by both 1,25(OH)2D3 and all-trans retinoic acid in SCC4 and SCC12B2 cells. Calcitriol 108-119 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 60-74 10340962-1 1999 OBJECTIVE: This study was designed to investigate whether 1, 25-dihydroxyvitamin D3 (1,25-(OH)2D3), produced by activated synovial fluid macrophages, promotes its own catabolism by upregulating vitamin D-24-hydroxylase (24-OHase) in synovial fibroblasts through a vitamin D receptor (VDR) mediated mechanism. Calcitriol 58-83 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 194-218 10340962-1 1999 OBJECTIVE: This study was designed to investigate whether 1, 25-dihydroxyvitamin D3 (1,25-(OH)2D3), produced by activated synovial fluid macrophages, promotes its own catabolism by upregulating vitamin D-24-hydroxylase (24-OHase) in synovial fibroblasts through a vitamin D receptor (VDR) mediated mechanism. Calcitriol 58-83 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 220-228 10340962-1 1999 OBJECTIVE: This study was designed to investigate whether 1, 25-dihydroxyvitamin D3 (1,25-(OH)2D3), produced by activated synovial fluid macrophages, promotes its own catabolism by upregulating vitamin D-24-hydroxylase (24-OHase) in synovial fibroblasts through a vitamin D receptor (VDR) mediated mechanism. Calcitriol 85-97 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 194-218 10340962-1 1999 OBJECTIVE: This study was designed to investigate whether 1, 25-dihydroxyvitamin D3 (1,25-(OH)2D3), produced by activated synovial fluid macrophages, promotes its own catabolism by upregulating vitamin D-24-hydroxylase (24-OHase) in synovial fibroblasts through a vitamin D receptor (VDR) mediated mechanism. Calcitriol 85-97 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 220-228 10340962-6 1999 1,25-(OH)2D3 increased fibroblast 24-OHase activity, yielding 24-hydroxylated, and more polar, metabolites. Calcitriol 0-12 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 34-42 10340962-8 1999 CONCLUSIONS: 1, 25-(OH)2D3 is produced by macrophages in vitro at biologically relevant concentrations and can increase its own catabolism by synovial fibroblasts; this effect is probably mediated via upregulation of both synovial fibroblast VDR and 24-OHase. Calcitriol 13-26 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 250-258 9687155-1 1998 Repression of basal transcription of a 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) responsive 25-hydroxyvitamin D3-24-hydroxylase (CYP24) promoter construct as observed in kidney cells in the absence of ligand and this repression was dependent on a functional vitamin D response element (VDRE). Calcitriol 39-63 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 127-132 9687155-1 1998 Repression of basal transcription of a 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) responsive 25-hydroxyvitamin D3-24-hydroxylase (CYP24) promoter construct as observed in kidney cells in the absence of ligand and this repression was dependent on a functional vitamin D response element (VDRE). Calcitriol 65-77 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 127-132 9579536-5 1998 In contrast, the construct containing the VDRE of the human 24-hydroxylase gene was induced several fold by 1,25(OH)2D3 in normal human keratinocytes and by both 1,25(OH)2D3 and all-trans retinoic acid in SCC4 and SCC12B2 cells. Calcitriol 162-173 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 60-74 9077483-7 1997 1,25(OH)2D3 caused a concentration-dependent increase in 24-OHase mRNA expression as determined by northern blot analysis. Calcitriol 0-11 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 57-65 9077483-8 1997 The activity of epidermal 24-OHase was also induced by 1,25(OH)2D3. Calcitriol 55-66 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 26-34 9077483-11 1997 Similarly, 1,25(OH)2D3 plus ketoconazole increased 24-OHase mRNA synergistically. Calcitriol 11-22 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 51-59 9077483-12 1997 Ketoconazole inhibited ex vivo 1,25(OH)2D3-induced epidermal 24-OHase activity. Calcitriol 31-42 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 61-69 34662328-1 2021 BACKGROUND Loss-of-function mutations of the CYP24A1 gene cause a deficiency of the CYP24A1 enzyme, which is involved in the catabolism of 1,25-dihydroxyvitamin D3. Calcitriol 139-163 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 45-52 34662328-1 2021 BACKGROUND Loss-of-function mutations of the CYP24A1 gene cause a deficiency of the CYP24A1 enzyme, which is involved in the catabolism of 1,25-dihydroxyvitamin D3. Calcitriol 139-163 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 84-91 34337279-1 2021 Context: CYP24A1 encodes 24-hydroxylase, which converts 25(OH)D3 and 1,25(OH)2D3 to inactive metabolites. Calcitriol 69-80 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 9-16 34593422-6 2021 The inhibitory effect of 25(OH)D3 on cell proliferation was potentiated after inhibition of CYP17B1 and CYP24 by genistein, preventing further metabolism of 25(OH)D3 to 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3). Calcitriol 169-193 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-109 34593422-6 2021 The inhibitory effect of 25(OH)D3 on cell proliferation was potentiated after inhibition of CYP17B1 and CYP24 by genistein, preventing further metabolism of 25(OH)D3 to 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3). Calcitriol 195-206 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-109 34389675-5 2021 There were two unexpected findings: 1) a strong induction of CYPs involved in activation of fatty acids (CYP4), and in inactivation of calcitriol (CYP24A1) and retinoic acid (CYP26A1); and 2) a marked down-regulation of FOS, FRA1, and JUN, known tethering partners of ERbeta. Calcitriol 135-145 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 147-154 34337279-1 2021 Context: CYP24A1 encodes 24-hydroxylase, which converts 25(OH)D3 and 1,25(OH)2D3 to inactive metabolites. Calcitriol 69-80 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 25-39 34093587-7 2021 Furthermore, we demonstrate that vitamin A inhibits 1,25(OH)2D3-induced translocation of the VDR to the nucleus and 1,25(OH)2D3-induced up-regulation of CYP24A1. Calcitriol 116-127 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 153-160 34307984-1 2021 Introduction: Loss-of-function variants in the CYP24A1 gene cause a rare hereditary disease characterized by reduced 24-hydroxylase enzyme activity, increased serum 1,25-dihydroxycholecalciferol levels, hypercalcemia, hypercalciuria, and nephrocalcinosis and/or nephrolithiasis. Calcitriol 165-194 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 47-54 34980721-4 2021 In this cell line, significant induction of CYP24A1 gene expression by 1alpha,25(OH)2D3 was seen within 4 h by qRT-PCR, and this was mediated by the VD receptor, as shown in a mutant cell line genetically deficient in this receptor. Calcitriol 71-87 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 44-51 35482362-9 2022 At the same site, the 25-hydroxyvitamin D 24-hydroxlase enzyme encoded by CYP24A1 can hydroxylate 25-hydroxyvitamin D or calcitriol to deactivate the hormone. Calcitriol 121-131 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 74-81 35482362-10 2022 Plasma calcitriol levels are primarily determined by the regulated expression of CYP27B1 and CYP24A1. Calcitriol 7-17 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 93-100 35482362-11 2022 This occurs in response to parathyroid hormone (increases CYP27B1), calcitriol itself (decreases CYP27B1 and increases CYP24A1), calcitonin (increases or decreases CYP24A1 and increases CYP27B1), FGF23 (decreases CYP27B1 and increases CYP24A1) and potentially plasma calcium and phosphate levels themselves (mixed effects). Calcitriol 68-78 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 119-126 35482362-11 2022 This occurs in response to parathyroid hormone (increases CYP27B1), calcitriol itself (decreases CYP27B1 and increases CYP24A1), calcitonin (increases or decreases CYP24A1 and increases CYP27B1), FGF23 (decreases CYP27B1 and increases CYP24A1) and potentially plasma calcium and phosphate levels themselves (mixed effects). Calcitriol 68-78 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 235-242 3166448-6 1988 Our study has allowed us to dissociate the effects of 1,25(OH)2D3 on 24-OHase enhancement from those on Ca2+ transport. Calcitriol 54-65 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 69-77 35179903-2 2022 Herein, we report a nanofiber dressing for topical codelivery of immunomodulating compounds including 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and VID400, a CYP24A1 inhibitor in a sustained manner, for inducing the expression of the endogenous cathelicidin antimicrobial peptide (CAMP) gene encoding the hCAP18 protein, which is processed into the LL-37 peptide. Calcitriol 102-131 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 160-167 3872316-2 1985 UNLABELLED: 1,25(OH)2D3 induces 25(OH)D3-24-hydroxylase (24-OHase) in cultured skin fibroblasts from normal subjects. Calcitriol 12-23 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 57-65 3872316-3 1985 We evaluated 24-OHase induction by 1,25(OH)2D3 in skin fibroblasts from 10 normal subjects and from four unrelated patients with hereditary resistance to 1,25(OH)2D or vitamin D-dependent rickets type II (DD II). Calcitriol 35-46 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 13-21 3872316-11 1985 The two patients whose cells had a detectable 24-OHase induction by 1,25(OH)2D3 showed a calcemic response to high doses of calciferols in vivo. Calcitriol 68-79 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 46-54 34003583-4 2022 As such, ERRalpha deregulated the calcitriol-VDR transcription by enhancing the expression of CYP24A1 as well as of both ERalpha and aromatase (CYP19A1) in calcitriol-treated cells. Calcitriol 34-44 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 94-101 33895119-0 2021 Inhibition of calcitriol inactivating enzyme CYP24A1 gene expression by flavonoids in hepatocellular carcinonoma cells under normoxia and hypoxia. Calcitriol 14-24 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 45-52 33895119-2 2021 However, for the implementation of a vitamin D based cancer therapy the increased deactivation of calcitriol in cancer cells by overexpressed CYP24A1 hydroxylase should be suppressed. Calcitriol 98-108 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 142-149 33895119-4 2021 Herein, we investigated the impact of genistein, biochanin A, formonentin and kaempferol on the expression of the CYP24A1 gene induced by calcitriol in hepatocellular cancer cells Huh7 under normoxia (21%O2) or hypoxia (1%O2). Calcitriol 138-148 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 114-121 33895119-5 2021 We demonstrate that calcitriol induces CYP24A1 under normoxia and hypoxia, but this induction is significantly more potent under hypoxia, the typical microenvironment of solid tumors. Calcitriol 20-30 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 39-46 33791222-9 2021 Additionally, we also found that the expression of CYP24A1, the main enzyme determining the biological half-life of calcitriol, was significantly inhibited by miR-1278, according to data from clinical, RNA-seq and functional assays, which allowed miR-1278 to sensitize CRC cells to vitamin D. Calcitriol 116-126 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 51-58 33329593-5 2020 Addition of 1,25(OH)2D3 led to a differential expression of adhesion molecules on CD28- and CD46-costimulated T cells isolated from both healthy donors or from patients with MS. 1,25(OH)2D3 favored Tr1 motility though a Vitamin D-CD46 crosstalk highlighted by increased VDR expression as well as increased CYP24A1 and miR-9 in CD46-costimulated T cells. Calcitriol 12-23 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 306-313 31471674-6 2019 However, caffeine significantly decreased calcitriol-inducible CYP24A1, TNSF11, and SPP1 transcripts in osteoblasts. Calcitriol 42-52 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 63-70 32259445-1 2020 Metabolic inactivation of 1,25(OH)2D3 requires molecular recognition between the mitochondrial enzyme cytochrome P450 24A1 (CYP24A1) and its cognate redox partner adrenodoxin (Adx). Calcitriol 26-37 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 102-122 32259445-1 2020 Metabolic inactivation of 1,25(OH)2D3 requires molecular recognition between the mitochondrial enzyme cytochrome P450 24A1 (CYP24A1) and its cognate redox partner adrenodoxin (Adx). Calcitriol 26-37 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 124-131 31789978-5 2020 In hypercalcuria, for example, the commonly used definition of idiopathic hypercalciuria was adopted to the genetic background, here three autosomal recessive hereditary forms of CYP24A1, SLC34A1 and SLC34A3 associated nephrocalcinosis/urolithiasis with elevated 1.25-dihydroxy-vitamin D3 (1.25-dihydroxy-vitamin D3) (calcitriol) levels. Calcitriol 318-328 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 179-186 31704333-6 2020 In cells, calcioic acid reduced the transcription of VDR target gene CYP24A1 in the presence 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) but did not induce the transcription of CYP24A1. Calcitriol 93-136 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 69-76 31638226-2 2019 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] has been shown to possess significant antitumor potential and is degraded by 25-hydroxyvitamin D-24-hydroxylase (CYP24A1). Calcitriol 0-24 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 152-159 31638226-2 2019 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] has been shown to possess significant antitumor potential and is degraded by 25-hydroxyvitamin D-24-hydroxylase (CYP24A1). Calcitriol 26-37 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 152-159 31638226-9 2019 Furthermore, RAPA blocked the increase of CYP24A1 and vitamin D receptor (VDR) expression induced by 1,25(OH)2D3. Calcitriol 101-112 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 42-49 31638226-16 2019 RAPA increased the cell cycle arrest induced by 1,25(OH)2D3 by blocking the upregulated expression of CYP24A1 and VDR. Calcitriol 48-59 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 102-109 30729229-2 2019 Loss-of-function mutations in CYP24A1 result in impaired dehydroxylation of active vitamin D (calcitriol). Calcitriol 94-104 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-37 30326825-12 2018 In addition, calcitriol induced VDR-associated signaling, resulting in upregulation of CYP24A1, TNFalpha and CAMP expression level in HepG2 cells but not in the HepG2.2.15 cells. Calcitriol 13-23 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 87-94 27769055-0 2016 Progesterone potentiates the growth inhibitory effects of calcitriol in endometrial cancer via suppression of CYP24A1. Calcitriol 58-68 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 110-117 29489902-5 2018 Consistently, calcitriol-induced expression of CYP24A1 mRNA was also significantly decreased by IL-4 and IL-13. Calcitriol 14-24 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 47-54 28578001-6 2017 Knockdown experiments showed that p38alpha is involved in 1,25(OH)2D3-induced expression of TRPV6 but not CYP24A1. Calcitriol 58-69 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 106-113 28242615-1 2017 CYP24A1, the primary inactivating enzyme for vitamin D, is often overexpressed in human cancers, potentially neutralizing the antitumor effects of calcitriol, the active form of vitamin D. Calcitriol 147-157 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 30052060-0 2018 CYP24A1 Inhibition Facilitates the Antiproliferative Effect of 1,25(OH)2D3 Through Downregulation of the WNT/beta-Catenin Pathway and Methylation-Mediated Regulation of CYP24A1 in Colorectal Cancer Cells. Calcitriol 63-74 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 30052060-0 2018 CYP24A1 Inhibition Facilitates the Antiproliferative Effect of 1,25(OH)2D3 Through Downregulation of the WNT/beta-Catenin Pathway and Methylation-Mediated Regulation of CYP24A1 in Colorectal Cancer Cells. Calcitriol 63-74 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 169-176 30052060-2 2018 In the present study, experiments were designed to test whether CYP24A1 inhibition facilitated the antiproliferative effect of 1,25(OH)2D3. Calcitriol 127-138 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 64-71 30052060-7 2018 We also found that CYP24A1 inhibition induced beta-catenin to translocate from the nucleus to the plasma membrane in SW480 cells and enhanced the inhibitory effect of 1,25(OH)2D3 on C-myc. Calcitriol 167-178 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 19-26 30052060-8 2018 Furthermore, CYP24A1 mRNA expression in Caco2 cells was increased after demethylation treatment, and the expression of CYP24A1 induced by 1,25(OH)2D3 was significantly higher in cells treated with 5-aza-2"-deoxycytidine (DAC) than in an untreated group. Calcitriol 138-149 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 13-20 30052060-8 2018 Furthermore, CYP24A1 mRNA expression in Caco2 cells was increased after demethylation treatment, and the expression of CYP24A1 induced by 1,25(OH)2D3 was significantly higher in cells treated with 5-aza-2"-deoxycytidine (DAC) than in an untreated group. Calcitriol 138-149 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 119-126 29080636-2 2017 Mutations of the activating enzymes CYP2R1 and CYP27B1 cause lack of normal 1,25-(OH)2D3 synthesis and result in rickets whereas mutations of the inactivating enzyme CYP24A1 cause build-up of excess 1,25-(OH)2D3 and result in hypercalcemia, nephrolithiasis, and nephrocalcinosis. Calcitriol 199-211 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 166-173 29127362-7 2017 This mutant had no effect on the nuclear localization of VDR, VDR-RXR heterodimerization, but it impaired CYP24A1 promoter activity in the presence of 1,25 (OH)2 vitamin D3, at least in part, mediated through specific nuclear receptor coactivator. Calcitriol 151-172 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 106-113 28601511-1 2017 CYP24A1 (25-hydroxyvitamin D-24-hydroxylase) is a useful enzyme target for a range of medical conditions including cancer, cardiovascular and autoimmune disease, which show elevated CYP24A1 levels and corresponding reduction of calcitriol (the biologically active form of vitamin D). Calcitriol 228-238 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 28218743-8 2017 Paradoxically, this correlation was reversed for CYP24A1 (inactivating 24-hydroxylase), indicating that this enzyme, while inactivating 1,25(OH)2D3, can activate other forms of D3 that are products of the non-canonical pathway initiated by CYP11A1. Calcitriol 136-147 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 49-56 28324001-2 2017 Biallelic loss-of-function mutations in CYP24A1 are associated with elevated serum levels of 1,25-dihydroxyvitamin D3 with consequent hypercalcemia and hypercalciuria and represent the most common form of idiopathic infantile hypercalcemia (IIH). Calcitriol 93-117 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 40-47 26729468-1 2016 AIM: Abnormal upregulation of CYP24 contributes to vitamin D insufficiency and resistance to vitamin D therapy in chronic kidney disease (CKD), because human CYP24 is a key enzyme involved in the inactivation of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3; calcitriol) and 1,25(OH)2D3. Calcitriol 253-263 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-35 26729468-1 2016 AIM: Abnormal upregulation of CYP24 contributes to vitamin D insufficiency and resistance to vitamin D therapy in chronic kidney disease (CKD), because human CYP24 is a key enzyme involved in the inactivation of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3; calcitriol) and 1,25(OH)2D3. Calcitriol 253-263 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 158-163 27769055-4 2016 RT-PCR and Western blotting were used to examine CYP24A1 mRNA and protein levels in endometrial cancer cells after 8, 24, 72, and 120 h of exposure to progesterone, progestin derivatives and calcitriol, either alone or in combination. Calcitriol 191-201 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 49-56 27769055-5 2016 Progestins inhibited calcitriol-induced expression of CYP24A1 and splice variant CYP24SV mRNA and protein in cancer cells. Calcitriol 21-31 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 54-61 27769055-5 2016 Progestins inhibited calcitriol-induced expression of CYP24A1 and splice variant CYP24SV mRNA and protein in cancer cells. Calcitriol 21-31 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 54-59 27769055-6 2016 Furthermore, actinomycin D, but not cycloheximide, blocked calcitriol-induced CYP24A1 splicing. Calcitriol 59-69 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 78-85 27769055-7 2016 siRNA-induced knockdown of CYP24A1 expression sensitized endometrial cancer cells to calcitriol-induced growth inhibition. Calcitriol 85-95 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 27-34 27769055-8 2016 These data suggest that CYP24A1 overexpression reduces the antitumor effects of calcitriol in cancer cells and that progestins may be beneficial for maintaining calcitriol"s anti-endometrial cancer activity. Calcitriol 80-90 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 24-31 27195054-7 2016 The functional significance of the modulation of VDR and RXRalpha levels by TNF is manifested by increased induction of VDR target gene CYP24A1 by calcitriol. Calcitriol 147-157 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 136-143 27889974-9 2016 CONCLUSIONS: The presence of CYP24A1 mRNA and the reduced expression of VDR and CYP27B1 mRNA in human hepatocellular carcinoma samples indicate decreased bioavailability of 1,25-Dihydroxy vitamin D3, providing an escape mechanism from the anti-tumor effect. Calcitriol 173-198 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 29-36 26047794-2 2016 Recently, mutations in the vitamin D catabolizing enzyme 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) were described that lead to increased sensitivity to vitamin D due to accumulation of the active metabolite 1,25-(OH)2D3. Calcitriol 211-223 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 94-101 27889974-2 2016 AIM: We examined mRNA and protein expression differences in 1,25-Dihydroxy vitamin D3-inactivating CYP24A1, mRNA of activating CYP27B1 enzymes, and that of VDR between human hepatocellular carcinoma and surrounding non-tumorous liver. Calcitriol 60-85 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 99-106 27210415-3 2016 Calcitriol availability depends on CYP27B1 and CYP24A1 expression, the cytochromes involved in its synthesis and degradation, respectively. Calcitriol 0-10 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 47-54 27530414-9 2016 A significant increase (p <0.01) in the mRNA expression of CYP24A1, CYP27B1, and VDR was observed after stimulation of ADMSCs with calcitriol (10 nM). Calcitriol 134-144 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 62-69 26794222-7 2016 RESULTS: Human corneal epithelial cells (HCEC) expressed the vitamin D receptor (VDR) and retinoid x receptor (RXR) and were responsive to 1,25- dihydroxyvitamin D3, as shown by induction of the 1,25- dihydroxyvitamin D3 responsive gene cyp-24A1 and slightly reduced abundance of IL-6 mRNA. Calcitriol 139-164 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 237-245 26827951-1 2016 One of the most pronounced effects of the hormonally active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is increased synthesis of 25-hydroxyvitamin D3 24-hydroxylase (CYP24A1), the enzyme responsible for the catabolism of 1,25(OH)2D3. Calcitriol 79-103 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 182-189 26827958-7 2016 Androgen inhibits vitamin D-mediated induction of CYP24A1, the calcitriol-degrading enzyme, while vitamin D promotes androgen inactivation by inducing phase I monooxygenases (e.g., CYP3A4) and phase II transferases (e.g., SULT2B1b, a DHEA-sulfotransferase). Calcitriol 63-73 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 50-57 26097993-0 2015 Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. Calcitriol 41-65 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 95-102 25727742-9 2015 CYP24A1 was able to further oxidize these metabolites in a series of reactions which included the cleavage of C23-C24 bond, as indicated by high resolution mass spectrometry of the products, analogous to the catabolism of 1,25(OH)2D3 via the C24-oxidation pathway. Calcitriol 222-233 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 25639477-5 2015 Exposure to 1,25(OH)2D3 had no effect on the basal expression levels of VDR; however, CYP27A1 transcript was suppressed and CYP24A1 transcript was substantively elevated. Calcitriol 12-23 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 124-131 24120915-5 2014 As expected, treatment with 1,25-D3 resulted in an upregulation of CYP24A1, whereas expression of CYP27B1 was not affected. Calcitriol 28-35 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 67-74 25866638-8 2015 The biological activity of calci(po)triol in human skin samples was demonstrated by the increased expression of the VD3-responsive Cyp24a1 gene. Calcitriol 36-41 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 131-138 25584965-6 2015 Calcitriol synthesis and degradation depend on the expression and activity of CYP27B1 and CYP24A1 cytochromes, respectively, for which regulation is tissue specific. Calcitriol 0-10 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 90-97 24361583-2 2014 During pregnancy, calcitriol, the active metabolite of vitamin D, is also metabolized by decidua and placental tissue by means of CYP27B1 and CYP24A1 for synthesis and inactivation of calcitriol respectively. Calcitriol 18-28 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 142-149 24361583-2 2014 During pregnancy, calcitriol, the active metabolite of vitamin D, is also metabolized by decidua and placental tissue by means of CYP27B1 and CYP24A1 for synthesis and inactivation of calcitriol respectively. Calcitriol 184-194 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 142-149 25716812-2 2015 To express its biological action, active vitamin D3 (1alpha,25-dihydroxyvitamin D3) interacts with three proteins : vitamin D binding protein (DBP), vitamin D receptor (VDR), and CYP24A1. Calcitriol 53-82 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 179-186 25324546-0 2014 Novel mechanism of negative regulation of 1,25-dihydroxyvitamin D3-induced 25-hydroxyvitamin D3 24-hydroxylase (Cyp24a1) Transcription: epigenetic modification involving cross-talk between protein-arginine methyltransferase 5 and the SWI/SNF complex. Calcitriol 42-66 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 112-119 24572979-8 2014 Patients suffering from transient infantile hypercalcaemia were recently described to have mutations in CYP24A1, the key enzyme in 1,25-dihydroxyvitamin D3 degradation. Calcitriol 131-155 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-111 24926821-3 2014 The level of the active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), is controlled in part by VDR-dependent induction of cytochrome P450, family 24, subfamily 1, polypeptide1 (CYP24A1), which metabolizes 1,25D to an inactive form. Calcitriol 49-78 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 195-202 25568836-3 2014 We hypothesized that genotypes of this locus could increase the risk of MS by regulating expression of neighboring gene, CYP24A1 which encodes the enzyme responsible for initiating degradation of 1,25-dihydroxyvitamin D3. Calcitriol 196-220 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 121-128 24736069-1 2014 INTRODUCTION: 1alpha,25-Dihydroxyvitamin D3 (1,25-D3) is antiproliferative in preclinical models of lung cancer, but in tumor tissues, its efficacy may be limited by CYP24A1 expression. Calcitriol 14-43 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 166-173 24736069-1 2014 INTRODUCTION: 1alpha,25-Dihydroxyvitamin D3 (1,25-D3) is antiproliferative in preclinical models of lung cancer, but in tumor tissues, its efficacy may be limited by CYP24A1 expression. Calcitriol 45-52 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 166-173 24235083-9 2014 CONCLUSIONS: This natural model indicates that vitamin D-24 hydroxylase is a key physiologic regulator of calcitriol and plasma calcium levels, and that balanced reduction of 1,25(OH)(2)D and GFR is instrumental for the maintenance of physiologic calcium levels and balance in chronic kidney diseases. Calcitriol 106-116 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 47-71 23485543-1 2013 Idiopathic infantile hypercalcemia (IIH) is a rare disorder caused by CYP24A1 loss-of-function mutation, resulting in impaired degradation of 1,25-dihydroxyvitamin D3. Calcitriol 142-166 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 70-77 23463632-1 2013 In colorectal cancer (CRC) the vitamin D catabolizing enzyme 1,25-dihydroxyvitamin D 24-hydroxylase (CYP24A1) is overexpressed with a potentially significant, positive impact on the catabolism of 1,25-dihydroxyvitamin D3 (1,25-D3 ). Calcitriol 196-220 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 101-108 23463632-1 2013 In colorectal cancer (CRC) the vitamin D catabolizing enzyme 1,25-dihydroxyvitamin D 24-hydroxylase (CYP24A1) is overexpressed with a potentially significant, positive impact on the catabolism of 1,25-dihydroxyvitamin D3 (1,25-D3 ). Calcitriol 222-229 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 101-108 23770368-7 2013 Moreover, real-time RT-PCR demonstrated that IGFBP-3 can inhibit the osteocalcin and CYP24a1 mRNA transcription induced by 1,25-(OH)2D3 in osteoblastic cells. Calcitriol 123-135 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 85-92 23026510-1 2013 We previously demonstrated that non-small cell lung cancer (NSCLC) cells and primary human lung tumors aberrantly express the vitamin D3-catabolizing enzyme, CYP24, and that CYP24 restricts transcriptional regulation and growth control by 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) in NSCLC cells. Calcitriol 239-268 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 174-179 23026510-6 2013 Because of their differential basal expression of VDR and CYP24, we hypothesized that NSCLC cells with an EGFR mutation would be more responsive to 1,25(OH)2D3 treatment than those with a K-ras mutation. Calcitriol 148-159 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 58-63 23059474-3 2013 24-Hydroxylase, encoded by the CYP24A1 gene, is the key enzyme which converts 1,25(OH)2D3 to less active calcitroic acid. Calcitriol 78-89 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 31-38 22940288-2 2013 Calcitriol and its precursor calcidiol (25(OH)D3) are degraded by the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1). Calcitriol 0-10 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 70-109 22940288-2 2013 Calcitriol and its precursor calcidiol (25(OH)D3) are degraded by the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1). Calcitriol 0-10 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 111-118 22940288-8 2013 In addition, calcitriol and DAC had synergistic effects on CYP24A1 gene transcription. Calcitriol 13-23 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 59-66 23805323-12 2013 FokI genotype, however, did not influence VDR expression or VDR level, but influenced overall transactivation of CAMP and 1,25(OH)2D3-elicited CYP24A1 induction; the latter, interacting with ethnicity. Calcitriol 122-133 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 143-150 23805323-14 2013 Instead, VDR transactivation of CAMP is influenced by FokI genotype and, together with ethnicity, influence 1,25(OH)2D3-elicited CYP24A1 expression. Calcitriol 108-119 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 129-136 23674869-2 2013 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological half-life of 1,25-D3. Calcitriol 108-132 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 37-44 23674869-2 2013 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological half-life of 1,25-D3. Calcitriol 134-141 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 37-44 23674869-2 2013 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological half-life of 1,25-D3. Calcitriol 220-227 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 37-44 23674869-3 2013 During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. Calcitriol 185-192 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 70-77 23059474-7 2013 The combination of 1,25(OH)2D3 with CYP24A1 inhibitors enhances 1,25(OH)2D3 mediated signaling and anti-proliferative effects and may be useful in overcoming effects of aberrant CYP24A1 expression. Calcitriol 19-30 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 178-185 23059474-7 2013 The combination of 1,25(OH)2D3 with CYP24A1 inhibitors enhances 1,25(OH)2D3 mediated signaling and anti-proliferative effects and may be useful in overcoming effects of aberrant CYP24A1 expression. Calcitriol 64-75 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 36-43 23298900-6 2013 The mRNA expression levels of VDR, CYP24A1, and p21 were increased significantly following 1,25-dihydroxyvitamin D3 treatment. Calcitriol 91-115 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 35-42 22337913-0 2012 Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: effects of ketoconazole therapy. Calcitriol 44-54 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 114-121 23001465-6 2013 Molecular genetic testing revealed a homozygous mutation (R396W) in the CYP24A1 gene (MIM 126065) encoding 25-hydroxyvitamin D3 24-hydroxylase, which is the key enzyme responsible for 1,25-dihydroxyvitamin D3 degradation. Calcitriol 184-208 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 72-79 22652890-6 2012 1alpha,25-Dihydroxyvitamin D3 has an inhibitory effect on the proliferation of cancer tissues, and is converted to its inactive 24-hydroxylated derivatives by CYP24, which is frequently expressed in lung cancer tissues. Calcitriol 0-29 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 159-164 22285938-0 2012 A local effect of CYP24 inhibition on lung tumor xenograft exposure to 1,25-dihydroxyvitamin D(3) is revealed using a novel LC-MS/MS assay. Calcitriol 71-97 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 18-23 21664249-6 2011 Metabolism of vitamin D in target tissues is mediated by two key enzymes: 1alpha-hydroxylase (CYP27B1), which catalyzes the synthesis of calcitriol from 25(OH)D and 24-hydroxylase (CYP24), which catalyzes the initial step in the conversion of calcitriol to less active metabolites. Calcitriol 137-147 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 181-186 22984610-10 2012 Astemizole inhibited basal and calcitriol-induced CYP24A1 and CYP3A4 mRNA expression (cytochromes involved in calcitriol and astemizole degradation) in breast and hepatoma cancer cells, respectively, while upregulated vitamin D receptor (VDR) expression. Calcitriol 31-41 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 50-57 22068926-0 2012 Regulation of CYP24 splicing by 1,25-dihydroxyvitamin D3 in human colon cancer cells. Calcitriol 32-56 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 14-19 22068926-5 2012 In this study, we investigated the functional significance of 1,25(OH)2D3 in CYP24 RNA splicing in colon cancer cells. Calcitriol 62-73 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 77-82 22068926-6 2012 Using RT-PCR, we found that 1,25(OH)2D3 actively induces CYP24 splicing in a time-dependent manner and CYP24 splicing pattern could be cell type or tissue specific. Calcitriol 28-39 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 57-62 22068926-7 2012 The induction of RNA splicing by 1,25(OH)2D3 was mainly CYP24 selective. Calcitriol 33-44 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 56-61 21664249-6 2011 Metabolism of vitamin D in target tissues is mediated by two key enzymes: 1alpha-hydroxylase (CYP27B1), which catalyzes the synthesis of calcitriol from 25(OH)D and 24-hydroxylase (CYP24), which catalyzes the initial step in the conversion of calcitriol to less active metabolites. Calcitriol 243-253 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 181-186 21529994-3 2011 We show for the first time that the 24-hydroxylase enzyme is activated in bone marrow-derived dendritic cell (BMDC), due to 1,25(OH)2D3 stimulation which resulted in the induction of its gene, CYP24A1. Calcitriol 124-135 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 193-200 21793032-5 2011 Treatment with vitamin D(3) resulted in calcitriol production and induction of calcitriol target gene CYP24A1, indicating that these cells contain the full machinery for vitamin D metabolism and activity. Calcitriol 79-89 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 102-109 21793032-9 2011 Intriguingly, HCV infection increased calcitriol production by inhibiting CYP24A1 induction, the enzyme responsible for the first step in calcitriol catabolism. Calcitriol 38-48 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 74-81 21793032-9 2011 Intriguingly, HCV infection increased calcitriol production by inhibiting CYP24A1 induction, the enzyme responsible for the first step in calcitriol catabolism. Calcitriol 138-148 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 74-81 20587525-1 2010 Calcitriol, a regulator of calcium homeostasis with antitumor properties, is degraded by the product of the CYP24A1 gene, which is downregulated in human prostate cancer by unknown mechanisms. Calcitriol 0-10 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 108-115 21592821-6 2011 The positive control CYP24A1, a highly VDR-responsive gene, was stimulated by calcitriol, effect that was stronger in resting than in activated-PBMNC (P<0.05), and without effect in Jurkat cells. Calcitriol 78-88 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 21-28 21592821-7 2011 Calcitriol upregulation of PRL and CYP24A1 was significantly inhibited by the VDR antagonist TEI-9647. Calcitriol 0-10 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 35-42 21592821-10 2011 In summary, calcitriol stimulated PRL and CYP24A1 gene expression in quiescent lymphocytes through a VDR-mediated mechanism. Calcitriol 12-22 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 42-49 21610497-4 2011 RECENT FINDINGS: CYP24A1 is the cytochrome P450 enzyme that catalyzes the conversion of 25-hydroxyvitamin D3 (25-OHD3) and its hormonal form, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], into 24-hydroxylated products targeted for excretion. Calcitriol 168-180 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 17-24 21420936-4 2011 Naive B cells were predominantly targeted by calcitriol in comparison with memory B cells as shown by pronounced induction of the VDR target gene cyp24a1. Calcitriol 45-55 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 146-153 20304059-8 2010 Lastly, treatment of TDEC with a DNA methyltransferase inhibitor restores calcitriol-mediated induction of CYP24 and resistance to calcitriol. Calcitriol 74-84 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 107-112 20398751-0 2010 CYP24A1 splice variants--implications for the antitumorigenic actions of 1,25-(OH)2D3 in colorectal cancer. Calcitriol 73-85 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 20304059-9 2010 These data suggest that epigenetic silencing of CYP24 modulates cellular responses to calcitriol. Calcitriol 86-96 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 48-53 19922790-1 2010 The molecular mechanisms that underlie non-genomic induction of the 25-hydroxyvitamin D3 24-hydroxylase (CYP24) gene promoter by the steroid hormone, 1,25-Dihydroxyvitamin D3 (1,25D), are poorly understood. Calcitriol 150-174 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 105-110 20236932-0 2010 A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3. Calcitriol 110-139 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 88-95 19244278-4 2009 BaP effectively enhanced the 1,25(OH)2D3-dependent induction of cytochrome P450 24A1 (CYP24A1) in human monocyte/macrophage-derived THP-1 cells and breast cancer MCF-7 cells. Calcitriol 29-40 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 64-84 19819974-10 2009 When transfected into HaCaT cells, the full-length HR inhibited endogenous CYP24A1 basal gene expression as well as 1,25-dihydroxyvitamin D3-stimulated CYP24A1 expression. Calcitriol 116-140 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 152-159 19667159-3 2009 The goal of this study was to detect possible differences in the expression of the calcitriol-degrading enzyme 24-hydroxylase (24-OHase) between malignant and benign ovarian cell lines and tissue. Calcitriol 83-93 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 127-135 19667159-7 2009 An increased 24-OHase expression could indicate a decrease in available calcitriol. Calcitriol 72-82 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 13-21 19570947-0 2009 Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b. Calcitriol 43-53 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 6-11 19570947-1 2009 Human vitamin D3 hydroxylase (CYP24) catalyzes the inactivation of 1alpha,25-dihydroxyvitamin D3 (calcitriol), which exerts antiproliferative effects. Calcitriol 67-96 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-35 19570947-1 2009 Human vitamin D3 hydroxylase (CYP24) catalyzes the inactivation of 1alpha,25-dihydroxyvitamin D3 (calcitriol), which exerts antiproliferative effects. Calcitriol 98-108 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-35 19667161-15 2009 Simultaneous treatment with the PPAR ligands bezafibrate or ALA resulted in an up to 6-fold reduction of the 1,25(OH)2D3-induced elevation of the 1alpha,25-dihydroxyvitamin D3-24-hydroxylase (CYP24A1) expression. Calcitriol 109-120 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 192-199 19244278-10 2009 Analysis of 1,25(OH)2D3 metabolism showed that BaP enhanced the hydroxylation of 1,25(OH)2D3 by CYP24A1 in THP-1 cells. Calcitriol 81-92 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 96-103 19244278-4 2009 BaP effectively enhanced the 1,25(OH)2D3-dependent induction of cytochrome P450 24A1 (CYP24A1) in human monocyte/macrophage-derived THP-1 cells and breast cancer MCF-7 cells. Calcitriol 29-40 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 86-93 18651709-4 2008 In activated B cells calcitriol induces expression of the genes Cyp24, encoding a vitamin D hydroxylase, and Trpv6, encoding a calcium selective channel protein. Calcitriol 21-31 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 64-69 19429444-9 2009 A proteasome inhibitor also enhanced 1,25(OH)(2)D(3)-induced CYP24A1 expression and nuclear VDR expression. Calcitriol 37-52 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 61-68 17368180-0 2007 CYP24 splicing variants are associated with different patterns of constitutive and calcitriol-inducible CYP24 activity in human prostate cancer cell lines. Calcitriol 83-93 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-5 19787078-5 2008 TO-901317 increases both basal and calcitriol induced 25-hydroxyvitamin D(3)-24-hydroxylase (CYP24) mRNA expression and it slightly but significantly inhibits VDR mRNA expression. Calcitriol 35-45 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 93-98 17693608-6 2007 As HKC-8 cells also express the enzyme 1alpha-hydroxylase, both 25-OHD3 (200 nM) and 1,25(OH)2D3 (5 nM) were able to induce CYP24 promoter activity. Calcitriol 85-96 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 124-129 17214957-4 2007 ADMI3 (1 microM) suppressed the endogenous CYP24A1 gene expression induced by 1,25(OH)2D3 (10 nM) in HEK293 cells to nearly control level. Calcitriol 78-89 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 43-50 17224124-1 2007 A systematic analysis of conserved H-bonding patterns and tertiary structural motifs from 13 crystal structures was used to create a homology model for the human multicatalytic cytochrome P450, CYP24A1, involved in catabolism of 1alpha,25-dihydroxyvitamin D3. Calcitriol 229-258 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 194-201 17368191-7 2007 Calcitriol significantly induced CYP24 expression in MDEC but not in TDEC and inhibition of CYP24 activity in MDEC restores their sensitivity to calcitriol. Calcitriol 0-10 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 33-38 17368191-7 2007 Calcitriol significantly induced CYP24 expression in MDEC but not in TDEC and inhibition of CYP24 activity in MDEC restores their sensitivity to calcitriol. Calcitriol 145-155 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 92-97 17368191-8 2007 These findings indicate that the induction of CYP24 expression differs in endothelial cells isolated from different microenvironments (TDEC versus MDEC) and that this distinction contributes to selective calcitriol-mediated growth inhibition in these cell types. Calcitriol 204-214 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 46-51 17368180-0 2007 CYP24 splicing variants are associated with different patterns of constitutive and calcitriol-inducible CYP24 activity in human prostate cancer cell lines. Calcitriol 83-93 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-109 17368180-1 2007 24-Hydroxylase (CYP24) activity modulates in vitro and in vivo calcitriol metabolism and biologic effects. Calcitriol 63-73 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 16-21 17368180-3 2007 DU145 cells exhibit baseline CYP24 activity that is further induced by calcitriol. Calcitriol 71-81 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 29-34 17368180-5 2007 In PC3, baseline CYP24 activity was undetectable but induced by calcitriol. Calcitriol 64-74 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 17-22 17368180-9 2007 These results demonstrate that calcitriol treatment modulates CYP24 splicing, and suggests that differences in CYP24 splicing are associated with different patterns of CYP24 activity. Calcitriol 31-41 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 62-67 17368180-9 2007 These results demonstrate that calcitriol treatment modulates CYP24 splicing, and suggests that differences in CYP24 splicing are associated with different patterns of CYP24 activity. Calcitriol 31-41 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 111-116 17368180-9 2007 These results demonstrate that calcitriol treatment modulates CYP24 splicing, and suggests that differences in CYP24 splicing are associated with different patterns of CYP24 activity. Calcitriol 31-41 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 111-116 16902422-0 2007 Wavelength-dependent induction of CYP24A1-mRNA after UVB-triggered calcitriol synthesis in cultured human keratinocytes. Calcitriol 67-77 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 34-41 17029768-0 2007 1alpha,25-dihydroxyvitamin D3 downregulates CYP27B1 and induces CYP24A1 in colon cells. Calcitriol 0-29 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 64-71 16902422-7 2007 We conclude from these experiments a constitutive gene expression of the vitamin D3 hydroxylases, whereas the catabolic enzyme CYP24A1 is markedly regulated by UVB, calcitriol, and perhaps cell proliferation. Calcitriol 165-175 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 127-134 16680461-3 2007 Baseline and calcitriol-induced changes in FBPase, CDDase and CYP24 activities were measured in PBM collected before, 6, 24, and 48 h after administration of calcitriol, prior to carboplatin, in doses ranging from 4 to 11 mug daily for 3 consecutive days (QDx3). Calcitriol 13-23 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 62-67 16680461-6 2007 All calcitriol doses achieved peak serum calcitriol levels > x3 the physiological levels, increased cancer patient PBM FBPase activity to normal levels and decreased CDDase activity to undetectable levels within 48 h, with no significant change in CYP24 activity. Calcitriol 4-14 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 251-256 16902422-2 2007 In the research presented here, we have investigated the influence of UVB-triggered calcitriol production on gene expression of the vitamin D3 hydroxylating enzymes catabolic 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), active vitamin-D3-25-hydroxylase (CYP27A1), and 25-hydroxyvitamin-D3-1alpha-hydroxylase (CYP27B1) using real-time PCR. Calcitriol 84-94 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 212-219 16902422-3 2007 Our results demonstrate a marked and wavelength-dependent induction of CYP24A1-mRNA in cultured human keratinocytes supplemented with 7-DHC, which parallels the spectral optimum at about 300 nm of calcitriol production as detected by HPLC and radioimmunoassay. Calcitriol 197-207 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 71-78 16457885-0 2006 HIV-1 protease inhibitor ritonavir potentiates the effect of 1,25-dihydroxyvitamin D3 to induce growth arrest and differentiation of human myeloid leukemia cells via down-regulation of CYP24. Calcitriol 61-85 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 185-190 17182827-5 2007 Genistein, a major component of soy, is a potent inhibitor of the activity of CYP24, the enzyme that initiates the degradation of calcitriol. Calcitriol 130-140 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 78-83 17121927-1 2006 The enzyme 24-hydroxylase, also known as CYP24, metabolizes 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] and is an established marker of vitamin D activity. Calcitriol 60-86 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 41-46 16824767-2 2006 Dermal fibroblasts contain the vitamin D receptor and induce 1alpha,25-dihydroxyvitamin D3-24-hydroxylase [CYP24] mRNA upon stimulation with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Calcitriol 141-165 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 107-112 16457885-2 2006 This study explored the effects of RTV on CYP24 which converts 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] to its inactive form 1,24,25,(OH)(3). Calcitriol 63-88 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 42-47 16691293-2 2006 Cytochrome P450, family 24-mediated (CYP24-mediated) 24-hydroxylation of 1,25(OH)2D3 is an important step in the catabolism of 1,25(OH)2D3. Calcitriol 73-84 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 37-42 16886663-12 2006 The data clearly indicate that agents which inhibit the major vitamin D catabolizing enzyme, CYP24 (24 hydroxylase), potentiate calcitriol killing of prostate tumor cells in vitro and in vivo. Calcitriol 128-138 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 93-98 16691293-2 2006 Cytochrome P450, family 24-mediated (CYP24-mediated) 24-hydroxylation of 1,25(OH)2D3 is an important step in the catabolism of 1,25(OH)2D3. Calcitriol 127-138 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 37-42 16180015-2 2006 The over-expression of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1), an enzyme involved in the metabolism of 1,25(OH)2D3 and its analogues, is associated with poor prognosis of some human cancers. Calcitriol 109-120 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 59-66 16483768-3 2006 This appears to be due to increased 1,25-(OH)(2)D(3)-metabolism, as a result of CYP24 enzyme-induction, which in turn leads to decreased anti-proliferative efficacy. Calcitriol 36-52 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 80-85 16600026-5 2006 At least one positive SNP with a TDT of p < 0.05 for asthma or total IgE and calcidiol or calcitriol was seen in IL10, GC, IL12B, CYP2R1, IL4R, and CYP24A1. Calcitriol 93-103 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 151-158 16600026-7 2006 Haplotype association were found only for CYP24A1, the main calcidiol degrading enzyme, where a frequent 5-point-haplotype was associated with asthma (p = 0.00063), total IgE (p = 0.0014), calcidiol (p = 0.0043) and calcitriol (p = 0.0046). Calcitriol 216-226 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 42-49 16524720-1 2006 25-Hydroxyvitamin D3-24-hydroxylase (24-hydroxylase, CYP24) is an important inactivating enzyme controlling the concentrations of both active metabolites 25-hydroxyvitamin D3 and 1alpha,25-dihydroxyvitamin D3. Calcitriol 179-208 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 53-58 15919092-0 2005 Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3. Calcitriol 92-121 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 53-58 15955619-4 2005 1,25(OH)2D3 induces the expression of the CYP24 gene, which codes for the enzyme that initiates the catabolism of 1,25(OH)2D3. Calcitriol 0-11 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 42-47 15955619-4 2005 1,25(OH)2D3 induces the expression of the CYP24 gene, which codes for the enzyme that initiates the catabolism of 1,25(OH)2D3. Calcitriol 114-125 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 42-47 16061850-4 2005 A cell line was treated with calcitriol to determine the effect on the expression of CYP27B1, 1alpha,25-dihydroxyvitamin D(3)-24-hydroxylase (CYP24), and vitamin D(3) receptor (VDR). Calcitriol 29-39 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 85-140 16061850-11 2005 The administration of calcitriol led to an elevated expression of CYP27B1 and CYP24 but left the expression of the VDR unaltered. Calcitriol 22-32 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 78-83 15489002-7 2004 24(R),25-dihydroxyvitamin D3 (24,25(OH)2D3), a compound metabolically related to 1,25(OH)2D3, also stimulated the CYP24 gene transcription, though at much higher concentrations. Calcitriol 81-92 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 114-119 15538745-0 2005 5alpha-dihydrotestosterone inhibits 1alpha,25-dihydroxyvitamin D3-induced expression of CYP24 in human prostate cancer cells. Calcitriol 36-65 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 88-93 15225804-6 2004 In contrast to SkMel5 cells, treatment of MeWo cells with calcitriol resulted in a dose-dependent increase in mRNA for VDR and 24-OHase as well as in a suppression of cell proliferation (up to approximately 50%). Calcitriol 58-68 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 127-135 15358094-0 2004 Metabolism of A-ring diastereomers of 1alpha,25-dihydroxyvitamin D3 by CYP24A1. Calcitriol 38-67 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 71-78 15225785-0 2004 Using chromatin immunoprecipitation to monitor 1alpha,25-dihydroxyvitamin D3-dependent chromatin activity on the human CYP24 promoter. Calcitriol 47-76 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 119-124 15078099-0 2004 Novel metabolism of 1 alpha,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1. Calcitriol 20-50 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 97-104 14765994-1 2004 Regulation of the gene for renal 25-hydroxyvitamin D-24-hydroxylase (CYP24) is important for controlling the level of circulating 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Calcitriol 130-154 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 69-74 12899539-5 2003 In prostate tumor cells, the 1,25-dihydroxyvitamin D3 catabolizing enzyme CYP24 is frequently highly expressed. Calcitriol 29-53 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 74-79 12528474-4 2002 Although C-24 position hydroxylation catalyzed by Cyp24 inactivates calcitriol, falecarcitriol is metabolized to C-23S hydroxylated metabolite by the same enzyme Cyp24 and this metabolite still has strong activity. Calcitriol 68-78 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 50-55 12027461-2 2002 Expression of VDR, CYP27B1, and CYP24 determines the efficacy of the antimitotic action of 1,25-D3 and is distinctly related to the degree of differentiation of cancerous lesions. Calcitriol 91-98 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 32-37 12899522-5 2003 Our group followed a different strategy, namely, blocking 1,25(OH)2D3 metabolism with inhibitors of CYP24. Calcitriol 58-69 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 100-105 12270218-4 2002 CYP24 is also responsible for degradation of the active vitamin D metabolite 1,25-dihydroxyvitamin D3 which is known to be antimitotic and prodifferentiating in prostate cancer cells. Calcitriol 77-101 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-5 12016462-9 2002 This suggested that F6-D3 as well as 1,25(OH)2D3 is metabolized by CYP24. Calcitriol 37-48 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 67-72 11686044-6 2001 Furthermore, in vivo and in vitro metabolic studies on 1 alpha,25-dihydroxyvitamin D3 clearly indicated that CYP24 catalyzed six-step monooxygenation to convert 1 alpha,25-dihydroxyvitamin D3 into calcitroic acid which is known as a final metabolite of 1 alpha,25-dihydroxyvitamin D3 for excretion in bile. Calcitriol 55-85 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 109-114 11686044-6 2001 Furthermore, in vivo and in vitro metabolic studies on 1 alpha,25-dihydroxyvitamin D3 clearly indicated that CYP24 catalyzed six-step monooxygenation to convert 1 alpha,25-dihydroxyvitamin D3 into calcitroic acid which is known as a final metabolite of 1 alpha,25-dihydroxyvitamin D3 for excretion in bile. Calcitriol 161-191 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 109-114 11686044-6 2001 Furthermore, in vivo and in vitro metabolic studies on 1 alpha,25-dihydroxyvitamin D3 clearly indicated that CYP24 catalyzed six-step monooxygenation to convert 1 alpha,25-dihydroxyvitamin D3 into calcitroic acid which is known as a final metabolite of 1 alpha,25-dihydroxyvitamin D3 for excretion in bile. Calcitriol 161-191 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 109-114 11686044-7 2001 These results strongly suggest that CYP24 is highly responsible for the metabolism of both 25-hydroxyvitamin D3 and 1 alpha,25-dihydroxyvitamin D3. Calcitriol 116-146 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 36-41