PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12844133-8 2003 The area under the concentration-time curve ratio of S-nirvanol/S-mephenytoin, an index of CYP2B6 activity, increased 1.9-fold (P <.05) in CYP2C19 poor metabolizers during artemisinin multiple-dose administration, whereas the urinary excretion ratio of hydroxytolbutamide plus carboxytolbutamide/tolbutamide remained constant during the study period. Mephenytoin 64-77 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 91-97 26126958-8 2015 Using microsomal preparations from nine different human liver samples, (-)-9-hydroxy-cis- and (-)-9-hydroxy-trans-rose oxide formations correlated with (S)-mephenytoin N-demethylase activity (CYP2B6 marker activity). Mephenytoin 152-167 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 192-198 25500267-9 2015 S-Mephenytoin, a substrate of CYP2B6, mildly prevented the enzyme from the inactivation induced by IIMP. Mephenytoin 0-13 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 30-36 18071681-0 2008 Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity. Mephenytoin 22-33 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 71-77 18350255-1 2008 The study aim was to assess the inductive properties of artemisinin antimalarials using mephenytoin as a probe for CYP2B6 and CYP2C19 enzymatic activity. Mephenytoin 88-99 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 115-121 23648676-4 2013 In the present study, P450 metabolic activity was investigated in the small intestine of MacfaCAM and MacfaCHN, and cynomolgus macaques bred in Indonesia (MacfaIDN) using P450 substrates, including 7-ethoxyresorufin, coumarin, bupropion, paclitaxel, diclofenac, S-mephenytoin, bufuralol, chlorzoxazone, and testosterone. Mephenytoin 262-275 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 22-26 12844133-9 2003 CONCLUSIONS: These results indicate that artemisinin induces the N-demethylation of S-mephenytoin probably by an increased capacity of CYP2B6. Mephenytoin 84-97 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 135-141 9241656-8 1997 Methoxychlor and S-mephenytoin inhibited expressed CYP2B6 but not CYP1A2 mediated 7-EFC O-deethylation. Mephenytoin 17-30 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 51-57 11950782-7 2002 Enzyme activity was reduced 78.1 +/- 0.2% by 50 microM thioTEPA when CYP2B6 activity was measured by following the metabolism of 200 microM S-mephenytoin to nirvanol. Mephenytoin 140-153 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 69-75 10997936-6 2000 Bupropion hydroxylation activity at 250 microM was highly correlated with S-mephenytoin N-demethylation activity (yielding nirvanol), another CYP2B6-mediated reaction, in a panel of 32 human livers (r = 0.94). Mephenytoin 74-87 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 142-148 10101147-10 1999 The antibody also was found to immunoinhibit CYP2B6-catalyzed N-demethylation of (S)-mephenytoin in human liver microsomes by 68 to 79%. Mephenytoin 81-96 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 45-51 9732386-5 1998 CYP2B6 levels were found to significantly (P < .0001) correlate with S-mephenytoin N-demethylation to nirvanol (r2 = 0.89), 7-hydroxy-4-trifluoromethylcoumarin formation (r2 = 0.81) and several markers of CYP3A levels and activity. Mephenytoin 72-85 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-6 9732386-10 1998 In conclusion, the highly specific MAb 49-10-20 was used to provide further confirmation that S-mephenytoin N-demethylation to nirvanol is a CYP2B6 selective probe. Mephenytoin 94-107 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 141-147 15618670-7 2002 Selegiline inhibited CYP2B6-mediated (S)-mephenytoin N-demethylation activity and CYP2C19-mediated (S)-mephenytoin 4"-hydroxylation activity. Mephenytoin 37-52 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 21-27 1997003-1 1991 Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation. Mephenytoin 71-82 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 26-30 8886603-12 1996 Taken together, these studies indicate that the N-demethylation of S-mephenytoin by human liver microsomes is catalyzed primarily by CYP2B6. Mephenytoin 67-80 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 133-139 8647857-1 1996 Human P450 2C19 is selective for 4"-hydroxylation of S-mephenytoin and 5-hydroxylation of omeprazole, while the structurally homologous P450 2C9 has low activity toward these substrates. Mephenytoin 53-66 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 6-10 8647857-1 1996 Human P450 2C19 is selective for 4"-hydroxylation of S-mephenytoin and 5-hydroxylation of omeprazole, while the structurally homologous P450 2C9 has low activity toward these substrates. Mephenytoin 53-66 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 136-140 1997003-7 1991 However cross inhibition experiments indicate that tienilic acid hydroxylation and mephenytoin hydroxylation, a typical reaction of some human liver P450 IIC isoenzymes, are not catalysed by the same member of the P450 IIC subfamily. Mephenytoin 83-94 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 149-153 1997003-7 1991 However cross inhibition experiments indicate that tienilic acid hydroxylation and mephenytoin hydroxylation, a typical reaction of some human liver P450 IIC isoenzymes, are not catalysed by the same member of the P450 IIC subfamily. Mephenytoin 83-94 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 214-218 2134689-2 1990 Microsomal 4"-hydroxylation of S-mephenytoin, but not of R-mephenytoin, was correlated to the content of cytochrome P-450 human-2. Mephenytoin 31-44 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 116-121 2134689-4 1990 The expressed P-450 showed stereoselectivities similar to those in human livers for hydroxylations of mephenytoin and hexobarbital enantiomers. Mephenytoin 102-113 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 14-19 35194103-4 2022 Strong association was observed between hepatic S-mephenytoin N-demethylase activity and CYP2B6 mRNA expression (P < 0.0001). Mephenytoin 48-61 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 89-95 31610395-8 2020 The abundance of CYP2B6 was 7.4 +- 7.8 pmol mg-1 microsomal protein and showed good correlation with activity against mephenytoin (Rs = 0.91, p < 0.0001; R2 = 0.93). Mephenytoin 118-129 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 17-23