PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8036014-2 1994 It contains a functional gly-arg-gly-asp-ser (GRGDS) integrin binding domain (Oldberg et al., 1986), promotes the adhesion of a variety of cell types (Somerman et al., 1989; Brown et al., 1992) and is a ligand for the vitronectin binding integrin alpha v beta 3 (Miyauchi et al., 1991). Arginine 29-32 integrin subunit alpha V Homo sapiens 238-261 8636223-1 1996 Integrin alpha v beta 3 is distinct in its capacity to recognize the sequence Arg-Gly-Asp (RGD) in many extra-cellular matrix (ECM) components. Arginine 78-81 integrin subunit alpha V Homo sapiens 0-23 31306580-3 2019 Herein, we have identified a linear peptide RWrNK, containing an unnatural d-arginine (r), as the integrin alphavbeta3-specific ligand. Arginine 2-3 integrin subunit alpha V Homo sapiens 98-118 32688289-1 2020 PURPOSE: Integrin alphavbeta3, a member of the arginine-glycine-aspartate (RGD)-binding subfamily, is associated with tumor angiogenesis and metastasis. Arginine 47-55 integrin subunit alpha V Homo sapiens 9-29 1717468-0 1991 Arginine-glycine-aspartic acid binding leading to molecular stabilization between integrin alpha v beta 3 and its ligand. Arginine 0-8 integrin subunit alpha V Homo sapiens 82-105 29558951-5 2018 HM-3, an antitumor peptide including an Arg-Gly-Asp sequence, can specifically target integrin alphavbeta3 that is presented on some tumor cells. Arginine 40-43 integrin subunit alpha V Homo sapiens 86-106 29497956-1 2018 PURPOSE: This study aimed to investigate the value of 99mtechnetium-three polyethylene glycol spacers-arginine-glycine-aspartic acid ([99mTc]3PRGD2) imaging in diagnosis and staging of breast cancer compared with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) imaging, and to explore the expression of integrin alphavbeta3 in tumor vascular endothelial cells. Arginine 102-110 integrin subunit alpha V Homo sapiens 298-318 29053416-1 2017 Integrin alphavbeta3 is a molecular marker for the estimation of tumor angiogenesis and is an imaging target for radiolabeled Arg-Gly-Asp (RGD) peptides. Arginine 126-129 integrin subunit alpha V Homo sapiens 0-20 24206140-2 2013 In the last decades, a series of radiolabeled Arg-Gly-Asp (RGD) peptides targeting integrin alphavbeta3 has been prepared and optimized for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) imaging of integrin alphavbeta3 expression. Arginine 46-49 integrin subunit alpha V Homo sapiens 83-103 26905697-1 2016 PURPOSE: Multimeric arginine-glycine-aspartic acid (RGD) peptides have advantages for imaging integrin alphavbeta3 expression. Arginine 20-28 integrin subunit alpha V Homo sapiens 94-114 26491644-1 2015 A dual-action ligand targeting both integrin alphaVbeta3 and vascular endothelial growth factor receptors (VEGFRs), was synthesized via conjugation of a cyclic peptidomimetic alphaVbeta3 Arg-Gly-Asp (RGD) ligand with a decapentapeptide. Arginine 187-190 integrin subunit alpha V Homo sapiens 36-56 23796630-2 2014 Carboxymethyl dextran-coated ultrasmall superparamagnetic iron oxide nanoparticles with carboxyl groups were coupled to cyclic arginine-glycine-aspartic peptides for integrin alpha(v)beta3 targeting. Arginine 127-135 integrin subunit alpha V Homo sapiens 166-188 28004516-1 2017 Peptides with an exposed arginine-glycine-aspartate (Arg-Gly-Asp, RGD) sequence targeting the integrin alphaV beta3 play an important role in targeted anticancer drug delivery. Arginine 25-33 integrin subunit alpha V Homo sapiens 94-115 28004516-1 2017 Peptides with an exposed arginine-glycine-aspartate (Arg-Gly-Asp, RGD) sequence targeting the integrin alphaV beta3 play an important role in targeted anticancer drug delivery. Arginine 53-56 integrin subunit alpha V Homo sapiens 94-115 26722375-3 2016 Of the imaging techniques that target angiogenesis, radiolabeled Arg-Gly-Asp (RGD) peptides have been a major focus because of their high affinity and selectivity for integrin alphavbeta3--one of the most extensively examined target of angiogenesis. Arginine 65-68 integrin subunit alpha V Homo sapiens 167-187 25207865-2 2014 Herein, we report the construction of arginine-glycine-aspartic acid-cysteine (RGDC) tetrapeptide functionalized and 10-hydroxycamptothecin (HCPT)-encapsulated magnetic nanohybrids (RFHEMNs) for integrin alphaVbeta3-targeted drug delivery. Arginine 38-46 integrin subunit alpha V Homo sapiens 195-215 24206140-2 2013 In the last decades, a series of radiolabeled Arg-Gly-Asp (RGD) peptides targeting integrin alphavbeta3 has been prepared and optimized for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) imaging of integrin alphavbeta3 expression. Arginine 46-49 integrin subunit alpha V Homo sapiens 241-261 22457888-4 2004 Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4). Arginine 127-130 integrin subunit alpha V Homo sapiens 12-32 22457887-4 2004 Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4). Arginine 127-130 integrin subunit alpha V Homo sapiens 12-32 23651498-2 2013 Integrin alphavbeta3 can be imaged with arginine-glycine-aspartic acid (RGD) peptide agents. Arginine 40-48 integrin subunit alpha V Homo sapiens 0-20 22455451-3 2012 It is well-documented that the RGD (Arg-Gly-Asp) motif exhibits high binding affinity to integrin alpha(v)beta(3), which is abundantly expressed in cancer cells and specifically associated with angiogenesis on tumors. Arginine 36-39 integrin subunit alpha V Homo sapiens 89-113 22457890-4 2004 Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4). Arginine 127-130 integrin subunit alpha V Homo sapiens 12-32 22272823-3 2012 Peptide RGD sequence Arg-Gly-Asp targeted and combined to integrin alphavbeta3 which has been overexpressed on tumor endothelial cells and many different tumor cellsis a robust site for tumor angiogenesis molecular imaging and targeted therapy. Arginine 21-24 integrin subunit alpha V Homo sapiens 58-78 22664242-2 2012 Of these, the radiolabeled Arg-Gly- Asp (RGD) peptide has been focused because it has high affinity and selectivity for integrin alpha(v)beta3. Arginine 27-30 integrin subunit alpha V Homo sapiens 120-142 21447361-3 2011 The cyclic RGD (Arg-Gly-Asp) peptide, a specific ligand with affinity for Integrin alpha(v)beta(3) was coupled to the distal end of the PEG on the PEG-LP (RGD-PEG-LP). Arginine 16-19 integrin subunit alpha V Homo sapiens 74-98 22655084-3 2012 The Arg-Gly-Asp (RGD) motif-containing peptides are specifically bound to integrin-alphavbeta3, and to inhibit neovasculature underlying competition to normal extracellular matrix proteins. Arginine 4-7 integrin subunit alpha V Homo sapiens 74-94 19225614-1 2009 A one-step S(N)Ar(H) reaction has been used for the synthesis of photostable probe , which has good water solubility and low cytotoxicity; this probe can be used for targeted imaging of tumour cells by virtue of specific binding between integrin alpha(v)beta(3) and an arginine-glycine-aspartic acid tripeptide sequence. Arginine 269-277 integrin subunit alpha V Homo sapiens 237-261 20184307-2 2010 Radiolabeled RGD (Arg-Gly-Asp) peptides that specifically target integrin alphavbeta3 have great potential for tumor early detection and noninvasively monitoring the status of tumor angiogenesis. Arginine 18-21 integrin subunit alpha V Homo sapiens 65-85 19882657-0 2010 Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Arginine 113-116 integrin subunit alpha V Homo sapiens 28-51 19719118-1 2009 Integrin alpha(v)beta(3) plays a significant role in tumor angiogenesis and is a receptor for the extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide sequence. Arginine 145-153 integrin subunit alpha V Homo sapiens 0-24 19360404-1 2009 PURPOSE: Radiolabeled Arg-Gly-Asp (RGD) and bombesin (BBN) peptide analogs have been extensively investigated for the imaging of tumor integrin alpha(v)beta(3) and gastrin-releasing peptide receptor (GRPR) expression, respectively. Arginine 22-25 integrin subunit alpha V Homo sapiens 135-159 19259068-2 2009 We have developed a peptide-like scaffold (regioselectively addressable functionalized template, RAFT), which holds four cyclo(-RGDfK-) (cRGD) motifs and proved that this molecule (called regioselectively addressable functionalized template-arginine-glycine-aspartic acid, RAFT-RGD) targets integrin alpha(v)beta(3) in vitro and in vivo. Arginine 241-249 integrin subunit alpha V Homo sapiens 291-314 21780371-3 2011 The covalent bond between cyclic RGD (cRGD) containing an Arg-Gly-Asp sequence targeting integrin-alphavbeta3, and USPIO was conducted by chemical crosslinking. Arginine 58-61 integrin subunit alpha V Homo sapiens 89-109 20540537-1 2009 Radiolabeled RGD (Arg-Gly-Asp) and bombesin (BBN) radiotracers that specifically target integrin alpha(v)beta(3) and gastrin releasing peptide receptor (GRPR) are both promising radiopharmaceuticals for tumor imaging. Arginine 18-21 integrin subunit alpha V Homo sapiens 88-112 17983645-2 2008 The plasma membrane receptor is located on integrin alphaVbeta3 at the Arg-Gly-Asp recognition site important to the binding by the integrin of extracellular matrix proteins. Arginine 71-74 integrin subunit alpha V Homo sapiens 43-63 18580570-3 2008 The technetium-99m-labeled Arg-Gly-Asp peptide, with high affinity to integrin alphavbeta3, was prepared for biodistribution and gamma-imaging. Arginine 27-30 integrin subunit alpha V Homo sapiens 70-90 17166537-7 2007 Crystal structure of the extracellular segment of integrin alphavbeta3 in complexing with an Arg-Gly-Asp ligand. Arginine 93-96 integrin subunit alpha V Homo sapiens 50-70 17009846-1 2006 Integrin alphavbeta3 plays a significant role in tumor angiogenesis and is a receptor for the extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide sequence. Arginine 141-149 integrin subunit alpha V Homo sapiens 0-20 16418218-8 2006 Immunoprecipitation analysis showed that JAM-A interacts with integrin alpha(v)beta(3), and this association was increased by engagement of the ligand-binding site of the integrin by Arg-Gly-Asp-Ser (RGDS) peptide. Arginine 183-186 integrin subunit alpha V Homo sapiens 62-85 14499613-6 2003 A docking model using the crystal structure of integrin alphaVbeta3 suggests that the Arg binds to the propeller domain, and Asp to the betaA domain. Arginine 86-89 integrin subunit alpha V Homo sapiens 47-67 15898744-6 2005 The FP assay was successfully applied to measure the binding affinity to integrin alpha(v)beta(3) of several cyclic peptides containing the Arg-Gly-Asp (RGD) motif. Arginine 140-143 integrin subunit alpha V Homo sapiens 73-97 11779085-2 2001 Integrin alpha(v)beta3 interacts with RGD (Arg-Gly-Asp) sequence-containing proteins in the extracellular matrix. Arginine 43-46 integrin subunit alpha V Homo sapiens 0-22 11884718-3 2002 Here we report the crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence. Arginine 138-141 integrin subunit alpha V Homo sapiens 69-89 11676501-1 2001 Arg-Gly-Asp (RGD)-containing peptide is a ligand for integrin alpha(V)beta3 and acts as an angiogenic inhibitor. Arginine 0-3 integrin subunit alpha V Homo sapiens 53-75 12702756-2 2003 As a prototype, we developed a targeting device that is based on the formation of a covalent bond of defined stoichiometry between a 1,3-diketone derivative of an integrin alpha(v)beta(3) and alpha(v)beta(5) targeting Arg-Gly-Asp peptidomimetic and the reactive lysine of aldolase antibody 38C2. Arginine 218-221 integrin subunit alpha V Homo sapiens 163-187 10773347-3 2000 The Arg-Gly-Asp sequence (RGD), is recognized by many integrins, including integrin alphavbeta3 (CD51/61). Arginine 4-7 integrin subunit alpha V Homo sapiens 75-95 10773347-4 2000 Coxsackievirus A9 (CAV-9), a human pathogen that has an Arg-Gly-Asp sequence in the VP1 capsid protein, has been known to be one of the many viruses that utilise integrin alphavbeta3 as a receptor. Arginine 56-59 integrin subunit alpha V Homo sapiens 162-182 10998238-1 2000 Integrin alpha(V)beta(3) plays a crucial role in angiogenesis, apoptosis, and bone remodeling, mainly by interacting with matrix proteins through recognition of an Arg-Gly-Asp (RGD) motif. Arginine 164-167 integrin subunit alpha V Homo sapiens 0-24