PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35549865-9	2022	Of interest, restoration of NO by L-arginine may attenuate SARS-CoV-2 infection through different mechanisms, including reduction binding of SARS-CoV-2 to ACE2, inhibition of transmembrane protease serine type 2 (TMPRSS2) a critical for activation of SARS-CoV-2 spike protein and cellular entry, inhibition proliferation and replication of SARS-CoV-2, and prevention of SARS-CoV-2-induced coagulopathy.	Arginine	34-44	angiotensin converting enzyme 2	Homo sapiens	155-159	
35458513-3	2022	Accordingly, point mutations that result in an increase in electropositively charged residues, e.g., arginine and lysine, especially in the RBD of spike proteins in the SARS-CoV-2 variants, could contribute to their spreading capacity by favoring their recognition by the electronegatively charged ACE2 receptors.	Arginine	101-109	angiotensin converting enzyme 2	Homo sapiens	298-302	
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	Arginine	11-19	angiotensin converting enzyme 2	Homo sapiens	66-70	
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	Arginine	11-19	angiotensin converting enzyme 2	Homo sapiens	194-198	
35458513-6	2022	However, the effects of lysine- and arginine-generating point mutations on infectivity is more contrasted, since the overall binding affinity of omicron RBD for ACE2 apparently results from some epistasis among the whole set of point mutations.	Arginine	36-44	angiotensin converting enzyme 2	Homo sapiens	161-165	
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	150-158	angiotensin converting enzyme 2	Homo sapiens	0-31	
35251533-6	2022	We identified residue 493 in delta (glutamine) and omicron (arginine) with altered binding properties towards ACE2.	Arginine	60-68	angiotensin converting enzyme 2	Homo sapiens	110-114	
33657325-7	2021	This weakening of binding strength was observed to be due to the destabilization of the interactions between ACE2 residues Glu-35, Glu-37, Tyr-83, Lys-353, and Arg-393 and the SARS-CoV-2 s-protein receptor binding domain (RBD).	Arginine	160-163	angiotensin converting enzyme 2	Homo sapiens	109-113	
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	150-158	angiotensin converting enzyme 2	Homo sapiens	33-38	
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	159-167	angiotensin converting enzyme 2	Homo sapiens	0-31	
21563828-3	2011	In this study, we demonstrate that purified recombinant human ADAM17 is able to cleave a 20-amino acid peptide mimetic corresponding to the extracellular juxtamembrane region of human ACE2 between Arg(708) and Ser(709).	Arginine	197-200	angiotensin converting enzyme 2	Homo sapiens	184-188	
24227843-4	2014	Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases.	Arginine	19-27	angiotensin converting enzyme 2	Homo sapiens	55-59	
21563828-7	2011	In summary, we have demonstrated that ADAM17 is able to cleave ACE2 peptide sequence analogues between Arg(708) and Ser(709).	Arginine	103-106	angiotensin converting enzyme 2	Homo sapiens	63-67	
21563828-8	2011	These findings also indicate that Arg(708) and Arg(710) play a role in site recognition in the regulation of ACE2 ectodomain shedding mediated by ADAM17.	Arginine	34-37	angiotensin converting enzyme 2	Homo sapiens	109-113	
21563828-8	2011	These findings also indicate that Arg(708) and Arg(710) play a role in site recognition in the regulation of ACE2 ectodomain shedding mediated by ADAM17.	Arginine	47-50	angiotensin converting enzyme 2	Homo sapiens	109-113