PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23690397-6 2013 Dietary supplementation of malarial-parasite-infected mice with L-arginine or L-citrulline reduced levels of ileal transcripts encoding interleukin-4 (IL-4), a key mediator of intestinal mastocytosis and macromolecular permeability. Arginine 64-74 interleukin 4 Mus musculus 136-149 23690397-6 2013 Dietary supplementation of malarial-parasite-infected mice with L-arginine or L-citrulline reduced levels of ileal transcripts encoding interleukin-4 (IL-4), a key mediator of intestinal mastocytosis and macromolecular permeability. Arginine 64-74 interleukin 4 Mus musculus 151-155 16525354-16 2006 In addition, Arg supplementation reduced intracellular interferon-gamma and enhanced IL-4 expression. Arginine 13-16 interleukin 4 Mus musculus 85-89 20463604-4 2010 The experimental data show that activation of alternatively activated macrophages (aaMacs) within type-2 infiltrates by IL-4 or IL-13 can inhibit B16-F1 melanoma cell proliferation through a mechanism that is dependent on arginase-1 depletion of L-arginine within the tumor cell microenvironment. Arginine 246-256 interleukin 4 Mus musculus 120-124 20133688-2 2010 The NFAT-interacting protein, (NIP45), augments NFAT-driven IL-4 expression by a mechanism that relies on arginine methylation. Arginine 106-114 interleukin 4 Mus musculus 60-64 16703566-1 2006 In murine macrophages, as a result of arginine catabolism during activation, citruline is produced under the effect of IFN-gamma and LPS, and ornithine and polyamines by IL-4 and IL-10. Arginine 38-46 interleukin 4 Mus musculus 170-174 22865229-2 2012 IL-4-induced activation of macrophages produced arginase-1, which converts arginine into ornithine, a precursor of polyamines and proline. Arginine 75-83 interleukin 4 Mus musculus 0-4 19783080-10 2010 Levels of gut tissue cytokines were significantly altered with enteral Arg supplementation: levels of IL-4 and IL-10 were increased, and levels of IFN-gamma and IL-2 declined, when compared with the EN-fed mice (p<0.05). Arginine 71-74 interleukin 4 Mus musculus 102-106 15922518-2 2005 Changes in levels of Th2 cytokines such as interleukin-4 (IL-4) can play important roles in these conditions via effects on arginine metabolism. Arginine 124-132 interleukin 4 Mus musculus 43-56 15922518-2 2005 Changes in levels of Th2 cytokines such as interleukin-4 (IL-4) can play important roles in these conditions via effects on arginine metabolism. Arginine 124-132 interleukin 4 Mus musculus 58-62 15922518-3 2005 IL-4 alters macrophage arginine metabolism by inducing arginase I expression and inhibiting nitric oxide production. Arginine 23-31 interleukin 4 Mus musculus 0-4 11160269-2 2001 We show here that IL-4 and IL-13 regulate NO production through depletion of arginine, the substrate of inducible NO synthase (iNOS). Arginine 77-85 interleukin 4 Mus musculus 18-22 15327772-3 2004 Inhibition of arginine methylation impaired the expression of several cytokine genes, including the signature type 1 and type 2 helper cytokines, interferon gamma, and interleukin-4. Arginine 14-22 interleukin 4 Mus musculus 168-181 15638127-11 2004 Higher arginine consumption was observed in BMMphi from both strains upon activation with IL-4 or IFNgamma which further increased, in this case, when the cells were infected with MHV3. Arginine 7-15 interleukin 4 Mus musculus 90-94 11160269-4 2001 Addition of exogenous arginine completely restored NO production in IL-4-treated macrophages. Arginine 22-30 interleukin 4 Mus musculus 68-72 26577684-5 2015 In an in vivo model of stimulated peritoneal macrophages, IP administration of HA-PEI/pDNA-IL4 and HA-PEI/pDNA-IL10 to C57BL/6 mice significantly increased the Arg/iNOS ratio and CD163 expression in the cells. Arginine 160-163 interleukin 4 Mus musculus 91-94 11160269-5 2001 Furthermore, impaired killing of the intracellular pathogen Toxoplasma gondii in IL-4-treated macrophages was overcome by supplementing L-arginine. Arginine 136-146 interleukin 4 Mus musculus 81-85 30151521-9 2018 In the in vitro experiment, 6-G reset the IL-4-induced arginase+ M2 cells toward iNOS+ M1 cells and exhibited reduced levels of arginase 1 and ROS and elevated levels of L-arginine and NO. Arginine 170-180 interleukin 4 Mus musculus 42-46 29115630-7 2018 TIPE2 overexpression accelerated IL-4 induced M2 polarization by dampening mTORC1 activation via the accelerated process of arginine to urea. Arginine 124-132 interleukin 4 Mus musculus 33-37 9887201-6 1999 Together with the enhanced expression of AI, IL-4 induced the expression of the cationic amino acid transporter MCAT-2 and increased L-arginine transport into the cells. Arginine 133-143 interleukin 4 Mus musculus 45-49 1900240-8 1991 Evidence is presented that the synergistic action of IL 4 and IFN-gamma occurs via an L-arginine-dependent killing pathway. Arginine 86-96 interleukin 4 Mus musculus 53-57 32337959-9 2020 RESULTS: LPS induced M1 polarization in BV-2 cells with increasing of CD86, iNOS and miR-155, while IL-4 induced M2 polarization in BV-2 cells with increasing of CD206, Arg and decreasing of miR-155. Arginine 169-172 interleukin 4 Mus musculus 100-104 30206632-2 2018 Arginase (Arg)-1 expressed in interleukin-4 (IL-4)-induced M2 microglia reduces nitric oxide (NO) production by competing with inducible NO synthase for l-arginine, which contributes to the attenuation of brain inflammation. Arginine 153-163 interleukin 4 Mus musculus 30-43 30206632-2 2018 Arginase (Arg)-1 expressed in interleukin-4 (IL-4)-induced M2 microglia reduces nitric oxide (NO) production by competing with inducible NO synthase for l-arginine, which contributes to the attenuation of brain inflammation. Arginine 153-163 interleukin 4 Mus musculus 45-49