PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17477906-3 2007 A mutant p21(Cip1) in which all six lysines were changed to arginines was protected against H(2)O(2) treatment. Arginine 60-69 H3 histone pseudogene 16 Homo sapiens 9-12 16697770-9 2006 Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033]. Arginine 88-91 H3 histone pseudogene 16 Homo sapiens 150-153 16697770-9 2006 Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033]. Arginine 88-91 H3 histone pseudogene 16 Homo sapiens 150-153 16697770-9 2006 Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033]. Arginine 88-91 H3 histone pseudogene 16 Homo sapiens 150-153 16697770-9 2006 Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033]. Arginine 88-91 H3 histone pseudogene 16 Homo sapiens 150-153 16697770-9 2006 Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033]. Arginine 88-91 H3 histone pseudogene 16 Homo sapiens 150-153 15530866-0 2004 MIBG, an inhibitor of arginine-dependent mono(ADP-ribosyl)ation, prevents differentiation of L6 skeletal myoblasts by inhibiting expression of myogenin and p21(cip1). Arginine 22-30 H3 histone pseudogene 16 Homo sapiens 156-159 16054204-6 2005 Significant independent association was evident between the p21 arginine allele (rare allele with frequency of 0.1) at codon 31 and CaCx, compared to HPV-negative cytologically normal controls (OR(age-adjusted) = 2.01; 95% CI = 1.00-4.06; P = 0.05). Arginine 64-72 H3 histone pseudogene 16 Homo sapiens 60-63 16054204-8 2005 The p21 arginine allele was significantly associated with CaCx in the p53 proline non-homozygous group of subjects (OR(age-adjusted) = 2.68; 95% CI: 1.21-5.91; P = 0.01), and specifically in the p53 heterozygous group (OR(age-adjusted) = 2.91; 95% CI = 1.12-7.56; P = 0.03). Arginine 8-16 H3 histone pseudogene 16 Homo sapiens 4-7 16054204-10 2005 However, the two risk factors, p53 proline homozygosity and p21 arginine allele, although part of a common causal pathway, appear to act in a mutually exclusive manner. Arginine 64-72 H3 histone pseudogene 16 Homo sapiens 60-63 15807891-9 2005 Patients and controls were genotyped for a single nucleotide polymorphism (C/A transversion) in the third base of codon 31 of p21, which leads to a serine (Ser)/arginine (Arg) substitution. Arginine 161-169 H3 histone pseudogene 16 Homo sapiens 126-129 15807891-9 2005 Patients and controls were genotyped for a single nucleotide polymorphism (C/A transversion) in the third base of codon 31 of p21, which leads to a serine (Ser)/arginine (Arg) substitution. Arginine 171-174 H3 histone pseudogene 16 Homo sapiens 126-129 15598783-6 2004 However, for p21 polymorphism, the frequencies of p21 Ser/Ser, Ser/Arg and Arg/Arg were 52 (26.0%), 85 (42.5%), 63 (31.5%) in case patients, 48 (26.5%), 82 (45.3%), 51 (28.2%) in BPH patients, and 76 (30.8%), 119 (48.2%), 52 (21.1%) in controls, respectively. Arginine 75-78 H3 histone pseudogene 16 Homo sapiens 13-16 15598783-6 2004 However, for p21 polymorphism, the frequencies of p21 Ser/Ser, Ser/Arg and Arg/Arg were 52 (26.0%), 85 (42.5%), 63 (31.5%) in case patients, 48 (26.5%), 82 (45.3%), 51 (28.2%) in BPH patients, and 76 (30.8%), 119 (48.2%), 52 (21.1%) in controls, respectively. Arginine 75-78 H3 histone pseudogene 16 Homo sapiens 13-16 15099969-3 2004 An association between endometrial cancer and the polymorphism at codon 31 (AGC/serine to AGA/arginine [Ser(31)Arg]) of the p21 gene, which is known to be a downstream mediator of p53, has also been reported. Arginine 94-102 H3 histone pseudogene 16 Homo sapiens 124-127 15099969-8 2004 Also, homozygous carriers of the p21 Ser allele showed a substantially increased risk of developing endometrial cancer (OR 2.68, 95% CI 1.59-4.51) as compared to homozygous and heterozygous carriers of the Arg allele. Arginine 206-209 H3 histone pseudogene 16 Homo sapiens 33-36 12474524-11 2002 An individual possessing one allele of arginine form in p21 codon 31 has a higher risk of developing bladder cancer than the serine form. Arginine 39-47 H3 histone pseudogene 16 Homo sapiens 56-59 14607331-2 2003 One polymorphism in the p21 codon 31 produces variant proteins with an amino acid change (serine (ser) or arginine (arg)). Arginine 106-114 H3 histone pseudogene 16 Homo sapiens 24-27 14607331-2 2003 One polymorphism in the p21 codon 31 produces variant proteins with an amino acid change (serine (ser) or arginine (arg)). Arginine 106-109 H3 histone pseudogene 16 Homo sapiens 24-27 10735543-1 2000 BACKGROUND: Previous in vitro experiments have indicated that if the ninth codon of the hepatitis C virus (HCV) core gene is mutated from arginine to lysine, a short 16-kDa (P16) instead of a 21-kDa (P21) core protein will be produced. Arginine 138-146 H3 histone pseudogene 16 Homo sapiens 200-203 11436200-0 2001 p21 gene codon 31 arginine/serine polymorphism: non-association with endometriosis. Arginine 18-26 H3 histone pseudogene 16 Homo sapiens 0-3 11436200-4 2001 The gene polymorphism for p21 codon 31 involved a base change from AGC to AGA and amino acid changes from serine (Ser) to arginine (Arg). Arginine 122-130 H3 histone pseudogene 16 Homo sapiens 26-29 10866325-8 2000 N-Hydroxy-L-arginine (NOHA), a stable intermediate product formed during conversion of L-arginine to NO, inhibited proliferation of the high arginase-expressing MDA-MB-468 cells and induced apoptosis after 48 h. NOHA arrested these cells in the S phase, increased the expression of p21, and reduced spermine content. Arginine 10-20 H3 histone pseudogene 16 Homo sapiens 282-285 11436200-4 2001 The gene polymorphism for p21 codon 31 involved a base change from AGC to AGA and amino acid changes from serine (Ser) to arginine (Arg). Arginine 132-135 H3 histone pseudogene 16 Homo sapiens 26-29 11188692-3 2000 Mutagenesis studies, however, have shown that the arginine can only partially account for the 10(5)-fold increase in the GAP-accelerated GTPase rate of p21. Arginine 50-58 H3 histone pseudogene 16 Homo sapiens 152-155 10837517-7 2000 The most abundant variants in coding sequence of p21 gene were a C to A transversion at codon 31 which resulted in Ser to Arg and had been identified being polymorphism. Arginine 122-125 H3 histone pseudogene 16 Homo sapiens 49-52 1639630-8 1992 TCC B and I were restricted by HLA-DR molecules, and recognized the mutated p21 ras-derived peptide carrying Arg and Lys at residue 12, respectively. Arginine 109-112 H3 histone pseudogene 16 Homo sapiens 76-79 8246952-7 1993 In contrast to the results obtained with p120GAP, the Pro-34-->Arg p21 species is effectively coupled to the raf-1 product, as judged from electrophoretic mobility shifts of the Raf-1 phosphoprotein. Arginine 66-69 H3 histone pseudogene 16 Homo sapiens 70-73 7691613-0 1993 Overlapping epitopes encompassing a point mutation (12 Gly-->Arg) in p21 ras can be recognized by HLA-DR, -DP and -DQ restricted T cells. Arginine 64-67 H3 histone pseudogene 16 Homo sapiens 72-75 7691613-5 1993 By repeated in vitro stimulation of peripheral blood mononuclear cells, several T cells clones could be generated which recognized a p21 ras derived peptide carrying a position 12 Gly-->Arg substitution. Arginine 189-192 H3 histone pseudogene 16 Homo sapiens 133-136 7971997-7 1994 Deletion analysis of p21 indicated that the sequences essential for inhibition of RSV LTR function include the previously identified ARg/Ser-rich region and zinc finger-like motif. Arginine 133-136 H3 histone pseudogene 16 Homo sapiens 21-24 3035212-7 1987 At position 12 in the p21 coding region, arginine is substituted for the naturally occurring glycine present in c-ras. Arginine 41-49 H3 histone pseudogene 16 Homo sapiens 22-25 2164357-2 1990 EPR signals of Mn(II) in the GDP complex with viral-Harvey p21pRAS1 (Arg 12, Thr 59), p21EC (Gly 12, Thr 59), and p21EJ (Val 12, Thr 59) have narrow line-widths that permit ready observation of inhomogeneous broadening from unresolved superhyperfine coupling with the nuclear spin of 17O of directly coordinated oxygen ligands. Arginine 69-72 H3 histone pseudogene 16 Homo sapiens 59-67 2471068-1 1989 We have generated deletion mutants of the H-ras p21 protein which lack residues 58 to 63 or 64 to 68 and contain either the normal glycine or an activating mutation, arginine, at position 12. Arginine 166-174 H3 histone pseudogene 16 Homo sapiens 48-51 2669815-2 1989 For example, the P21 proteins with Arg 12 or Val 13 are both known to be actively transforming. Arginine 35-38 H3 histone pseudogene 16 Homo sapiens 17-20 2052624-7 1991 (iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini. Arginine 245-248 H3 histone pseudogene 16 Homo sapiens 270-273 2052624-7 1991 (iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini. Arginine 245-248 H3 histone pseudogene 16 Homo sapiens 307-310 2052624-7 1991 (iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini. Arginine 311-314 H3 histone pseudogene 16 Homo sapiens 270-273 2052624-7 1991 (iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini. Arginine 311-314 H3 histone pseudogene 16 Homo sapiens 307-310 35500745-5 2022 PRMT5 and symmetric dimethylation at histone H4 arginine 3 (H4R3me2s) directly associate with chromatin of P21 to suppress its transcription. Arginine 48-56 H3 histone pseudogene 16 Homo sapiens 107-110 33682127-6 2021 The gels containing 15/20 mM Lys/Arg exhibited a significant increase in the proportion of immobilized water (P21 ). Arginine 33-36 H3 histone pseudogene 16 Homo sapiens 110-113 6311615-2 1983 A tridecapeptide: Arg-Arg-Leu56-Asp-Thr-Thr59-Gly-Gln-Glu-Tyr-Ser-Ala66 containing residues 56-66 of p21 is phosphorylated solely on tyrosine by the epidermal growth factor (EGF)-stimulated tyrosine kinase of A431 cell membranes. Arginine 18-21 H3 histone pseudogene 16 Homo sapiens 101-104 6311615-2 1983 A tridecapeptide: Arg-Arg-Leu56-Asp-Thr-Thr59-Gly-Gln-Glu-Tyr-Ser-Ala66 containing residues 56-66 of p21 is phosphorylated solely on tyrosine by the epidermal growth factor (EGF)-stimulated tyrosine kinase of A431 cell membranes. Arginine 22-25 H3 histone pseudogene 16 Homo sapiens 101-104 33682127-7 2021 CONCLUSION: The enhancement of WHC, gel strength, and P21 was closely associated with the increased solubility and the dense microstructure induced by Lys and Arg with high concentrations of 15 mM and 20 mM. Arginine 159-162 H3 histone pseudogene 16 Homo sapiens 54-57 26405550-6 2015 Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P<0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC. Arginine 247-255 H3 histone pseudogene 16 Homo sapiens 48-51 32821748-7 2020 Results: In the control group and ALL patients, p21 Ser/Arg, and MDM2 TG and GG genotypes were associated with significant 1.81-fold (95% confidence interval CI= 1.008-3.267; P < 0.05), 11.07-fold (95% CI= 5.10-24.05; P < 0.0001), and 19.41-fold (95% CI= 8.56-43.99; P < 0.0001) increased risks for ALL, respectively. Arginine 56-59 H3 histone pseudogene 16 Homo sapiens 48-51 29568320-3 2018 The enzymes responsible for arginine methylation, protein arginine methyltransferases (PRMTs), have been shown to methylate or associate with important regulatory proteins of the cell cycle and DNA damage repair pathways, such as cyclin D1, p53, p21 and the retinoblastoma protein. Arginine 28-36 H3 histone pseudogene 16 Homo sapiens 246-249 26405550-6 2015 Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P<0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC. Arginine 368-371 H3 histone pseudogene 16 Homo sapiens 48-51 26405550-6 2015 Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P<0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC. Arginine 368-371 H3 histone pseudogene 16 Homo sapiens 48-51 28367100-6 2017 The recruitment of PADI4 and histone H3 arginine modifications to p21 promoter was measured by chromatin immunoprecipitation. Arginine 40-48 H3 histone pseudogene 16 Homo sapiens 66-69 28367100-12 2017 PADI4 suppresses p21 transcription through altering histone H3 arginine modifications on p21 promoter region. Arginine 63-71 H3 histone pseudogene 16 Homo sapiens 17-20 28367100-12 2017 PADI4 suppresses p21 transcription through altering histone H3 arginine modifications on p21 promoter region. Arginine 63-71 H3 histone pseudogene 16 Homo sapiens 89-92 26420673-3 2015 Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces KLF4 turnover, resulting in the elevation of KLF4 protein levels concomitant with increased transcription of KLF4-dependent p21 and reduced expression of KLF4-repressed Bax. Arginine 18-26 H3 histone pseudogene 16 Homo sapiens 236-239 26405550-6 2015 Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P<0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC. Arginine 257-260 H3 histone pseudogene 16 Homo sapiens 48-51 24384472-8 2014 Through this study, we have provided the first evidence on the pivotal role of arginine 213 that determines the p53 mediated functions of p21 in human cancer cells. Arginine 79-87 H3 histone pseudogene 16 Homo sapiens 138-141 25232917-9 2015 P53/p21 combination had a better median OS and disease-free survival (DFS) of 12.1 and 13.7 months for wild type cases (GG + Ser/ser) and 20.3 and 20.7 months for patients with either variant genes (GC + Ser/arg) compared with 1.1 and 1.9 months for patients with both variant genes (CC + arg/arg), (P = 0.037 and 0.004). Arginine 208-211 H3 histone pseudogene 16 Homo sapiens 4-7 25232917-9 2015 P53/p21 combination had a better median OS and disease-free survival (DFS) of 12.1 and 13.7 months for wild type cases (GG + Ser/ser) and 20.3 and 20.7 months for patients with either variant genes (GC + Ser/arg) compared with 1.1 and 1.9 months for patients with both variant genes (CC + arg/arg), (P = 0.037 and 0.004). Arginine 289-292 H3 histone pseudogene 16 Homo sapiens 4-7 25232917-9 2015 P53/p21 combination had a better median OS and disease-free survival (DFS) of 12.1 and 13.7 months for wild type cases (GG + Ser/ser) and 20.3 and 20.7 months for patients with either variant genes (GC + Ser/arg) compared with 1.1 and 1.9 months for patients with both variant genes (CC + arg/arg), (P = 0.037 and 0.004). Arginine 289-292 H3 histone pseudogene 16 Homo sapiens 4-7 23167335-10 2012 Although the MDM2 309G allele was itself without affect, it showed a synergistic effect with P21 ser/arg polymorphism (P value=0.003, OR= 6.807, 95% CI= 1.909-24.629). Arginine 101-104 H3 histone pseudogene 16 Homo sapiens 93-96 23071787-7 2012 The median mRNA levels of p21 and BAX in the tumors of Pro-allele carriers were significantly reduced to 55.7% and 76.9% compared to Arg/Arg patients, whereas p53, MDM2 and PERP expression were hardly altered. Arginine 133-136 H3 histone pseudogene 16 Homo sapiens 26-29 20022955-4 2010 In a promoter-specific context, inhibition of H3R17 methylation represses expression of p21, a p53-responsive gene, thus implicating a possible role for H3 Arg-17 methylation in tumor suppressor function. Arginine 156-159 H3 histone pseudogene 16 Homo sapiens 88-91 21790217-4 2011 p21 expression was significantly higher in HHUA cells transfected with the proline variant gene than in those transfected with the arginine variant gene. Arginine 131-139 H3 histone pseudogene 16 Homo sapiens 0-3 23071787-7 2012 The median mRNA levels of p21 and BAX in the tumors of Pro-allele carriers were significantly reduced to 55.7% and 76.9% compared to Arg/Arg patients, whereas p53, MDM2 and PERP expression were hardly altered. Arginine 137-140 H3 histone pseudogene 16 Homo sapiens 26-29 21454715-7 2011 A citrulline-mimicking Arg-NLS-Gln ING4 mutant, which has all Arg residues in the NLS mutated to Gln, loses its affinity for p53, can no longer promote p53 acetylation, and results in repression of downstream p21 expression. Arginine 23-26 H3 histone pseudogene 16 Homo sapiens 209-212 20732856-5 2010 In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes. Arginine 208-211 H3 histone pseudogene 16 Homo sapiens 49-52 20732856-5 2010 In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes. Arginine 208-211 H3 histone pseudogene 16 Homo sapiens 220-223 20732856-5 2010 In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes. Arginine 212-215 H3 histone pseudogene 16 Homo sapiens 49-52 20732856-5 2010 In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes. Arginine 212-215 H3 histone pseudogene 16 Homo sapiens 220-223 20524403-6 2010 Also, homozygous carriers of the p21 Ser allele showed a substantially increased risk of developing cervical adenocarcinoma (OR 2.07; 95% CI 1.13-3.79) compared to genotypes containing the Arg allele. Arginine 189-192 H3 histone pseudogene 16 Homo sapiens 33-36 18640142-7 2008 RESULTS: Subjects carrying the p21 Arg/Arg genotype had an increased UC risk (age and gender adjusted OR=1.53; 95% CI, 1.02-2.29). Arginine 35-38 H3 histone pseudogene 16 Homo sapiens 31-34 18640142-7 2008 RESULTS: Subjects carrying the p21 Arg/Arg genotype had an increased UC risk (age and gender adjusted OR=1.53; 95% CI, 1.02-2.29). Arginine 39-42 H3 histone pseudogene 16 Homo sapiens 31-34