PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12524231-7 2003 In contrast to apoE/iNOS dko mice without arginine supplementation, lesion areas were increased in apoE/iNOS double-ko mice with arginine supplementation at 24 weeks. Arginine 129-137 apolipoprotein E Mus musculus 99-103 16291938-5 2005 In the CSF, Arg-61 apoE level was 40% lower than the wild-type level. Arginine 12-15 apolipoprotein E Mus musculus 19-23 16291938-6 2005 Arg-61 apoE mRNA levels were similar to or slightly higher than wild-type apoE mRNA levels. Arginine 0-3 apolipoprotein E Mus musculus 7-11 16291938-7 2005 Thus, the lower Arg-61 apoE levels were not attributable to decreased mRNA levels. Arginine 16-19 apolipoprotein E Mus musculus 23-27 16291938-8 2005 In culture medium from heterozygous Arg-61/wild-type and apoE4/apoE3 primary astrocytes, Arg-61 apoE and apoE4 levels were lower than wild-type apoE and apoE3, respectively, suggesting that primary astrocytes secrete lower amounts of Arg-61 apoE and apoE4. Arginine 89-92 apolipoprotein E Mus musculus 57-61 16291938-8 2005 In culture medium from heterozygous Arg-61/wild-type and apoE4/apoE3 primary astrocytes, Arg-61 apoE and apoE4 levels were lower than wild-type apoE and apoE3, respectively, suggesting that primary astrocytes secrete lower amounts of Arg-61 apoE and apoE4. Arginine 89-92 apolipoprotein E Mus musculus 57-61 16291938-9 2005 These results demonstrate that domain interaction is responsible for the lower levels of both human apoE4 and mouse Arg-61 apoE in mouse brain. Arginine 116-119 apolipoprotein E Mus musculus 100-104 15704254-0 2004 L-arginine increases plasma homocysteine in apoE-/-/iNOS-/- double knockout mice. Arginine 0-10 apolipoprotein E Mus musculus 44-48 15704254-1 2004 Previous studies have shown that L-arginine (L-Arg) administration to apoE-/-/iNOS-/- double knockout mice (dKO) on a Western diet paradoxically results in an increase in atherosclerotic lesion size. Arginine 33-43 apolipoprotein E Mus musculus 70-74 15704254-1 2004 Previous studies have shown that L-arginine (L-Arg) administration to apoE-/-/iNOS-/- double knockout mice (dKO) on a Western diet paradoxically results in an increase in atherosclerotic lesion size. Arginine 45-50 apolipoprotein E Mus musculus 70-74 15569838-8 2004 Interestingly, l-arginine (1 mmol/L), despite a significantly higher eNOS expression in aortas of apoE-/- mice, evoked a more pronounced contraction, which was reverted to a greater vasodilation by the arginase inhibitor l-norvaline (20 mmol/L) compared with the wild-type animals (n=5, P<0.001). Arginine 15-25 apolipoprotein E Mus musculus 98-102 11553788-4 2001 Mouse apoE, like apoE4, contains the equivalent of Arg-112 and Glu-255, but lacks the critical Arg-61 equivalent (it contains Thr-61). Arginine 51-54 apolipoprotein E Mus musculus 6-10 12392781-10 2002 Increased transport is consistent with an increased production of NO and may reflect a direct or indirect effect of the APOE genotype on microglial arginine uptake and microglial activation in general. Arginine 148-156 apolipoprotein E Mus musculus 120-124 11792702-2 2002 Insertion of a neo cassette flanked by loxP sites in the third intron of Apoe reduced expression of the Arg-61 allelic variant in hypoE mice and resulted in plasma apoE levels that were approximately 2-5% of normal. Arginine 104-107 apolipoprotein E Mus musculus 73-77 11792702-4 2002 Further reduction of apoE expression in hypoE/Apoe(-/-) heterozygous mice led to an increase in remnant lipoprotein-associated cholesterol levels, demonstrating that hypoE mice express close to the threshold level of Arg-61 apoE required for a normal lipoprotein profile. Arginine 217-220 apolipoprotein E Mus musculus 21-25 12089072-8 2002 These differences were eliminated after either neutralization of arginine residues on apo E or digestion of matrix with chondroitin ABC lyase, suggesting that chondroitin and/or dermatan sulfate proteoglycans were responsible for apo E-mediated increased binding. Arginine 65-73 apolipoprotein E Mus musculus 86-91 11553788-4 2001 Mouse apoE, like apoE4, contains the equivalent of Arg-112 and Glu-255, but lacks the critical Arg-61 equivalent (it contains Thr-61). Arginine 95-98 apolipoprotein E Mus musculus 6-10 11553788-7 2001 Replacing Thr-61 in mouse apoE with arginine converted the binding preference from HDL to very low density lipoproteins in vitro, suggesting that apoE4 domain interaction could be introduced into mouse apoE in vivo. Arginine 36-44 apolipoprotein E Mus musculus 146-150 11553788-8 2001 Using gene targeting in embryonic stem cells, we created mice expressing Arg-61 apoE. Arginine 73-76 apolipoprotein E Mus musculus 80-84 11553788-9 2001 Heterozygous Arg-61/wild-type apoE mice displayed two phenotypes found in human apoE4/E3 heterozygotes: preferential binding to lower density lipoproteins and reduced abundance of Arg-61 apoE in the plasma, reflecting its more rapid catabolism. Arginine 13-16 apolipoprotein E Mus musculus 30-34 11553788-9 2001 Heterozygous Arg-61/wild-type apoE mice displayed two phenotypes found in human apoE4/E3 heterozygotes: preferential binding to lower density lipoproteins and reduced abundance of Arg-61 apoE in the plasma, reflecting its more rapid catabolism. Arginine 180-183 apolipoprotein E Mus musculus 30-34 11553788-11 2001 The Arg-61 apoE mouse model will allow the effects of apoE4 domain interaction in lipoprotein metabolism, atherosclerosis, and neurodegeneration to be determined. Arginine 4-7 apolipoprotein E Mus musculus 11-15 11342002-0 2001 Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport. Arginine 88-96 apolipoprotein E Mus musculus 0-16 11342002-6 2001 Furthermore, this increase was observed at submaximal extracellular arginine concentrations, suggesting that apoE altered arginine (substrate) availability. Arginine 68-76 apolipoprotein E Mus musculus 109-113 11342002-7 2001 Examination of [(3)H]arginine uptake across the cell membrane demonstrated that arginine uptake was increased by PIC but further increased by PIC plus apoE. Arginine 80-88 apolipoprotein E Mus musculus 151-155 11342002-8 2001 Treatment of RAW cells with apoE was associated with an increased apparent V(max) and decreased affinity for arginine as well as a switch in the induction of mRNA for subtypes of cationic amino acid transporters (CAT). Arginine 109-117 apolipoprotein E Mus musculus 28-32 11342002-10 2001 Regulation of arginine availability is a novel action of apoE on the regulation of macrophage function and the immune response. Arginine 14-22 apolipoprotein E Mus musculus 57-61 8376602-2 1993 Among eight founder mice, plasma apo E (Arg-112, Cys-142) levels varied 100-fold and directly correlated with plasma cholesterol and triglyceride levels. Arginine 40-43 apolipoprotein E Mus musculus 33-38 8376602-8 1993 Thus, transgenic mice expressing high levels of the dysfunctional apo E (Arg-112, Cys-142) variant have many characteristics of the human type III HLP phenotype and appear to be a suitable animal model for this disorder. Arginine 73-76 apolipoprotein E Mus musculus 66-71 32884268-9 2020 The phosphor imaging autoradiography (PI-ARG) results corroborated the PET and gamma counter measurements, showing higher accumulation of 89Zr-Mal-HSA in the aortas of Apoe-/- mice than in WT mice (9.4+-1.4 vs 0.8+-0.3%; P<0.001). Arginine 41-44 apolipoprotein E Mus musculus 168-172 31155612-8 2019 In mAoSMCs from ApoE-null mice fed a high-cholesterol diet (ApoE-/- +HCD), Arg activity was increased, and spermine concentration was higher than that of wild-type mice. Arginine 75-78 apolipoprotein E Mus musculus 16-20 31155612-8 2019 In mAoSMCs from ApoE-null mice fed a high-cholesterol diet (ApoE-/- +HCD), Arg activity was increased, and spermine concentration was higher than that of wild-type mice. Arginine 75-78 apolipoprotein E Mus musculus 60-64 30954674-1 2019 We have previously reported cognitive impairments in both young and old mice, particularly in female mice expressing mouse Arg-61 apoE, with a point mutation to mimic the domain interaction feature of human apoE4, as compared to the wildtype mouse (C57BL/6J) apoE. Arginine 123-126 apolipoprotein E Mus musculus 130-134 30954674-3 2019 The results of behavioral performance consistently support our previous report that the young female Arg-61 apoE showed cognitive impairment versus C57BL/6J at the same age. Arginine 101-104 apolipoprotein E Mus musculus 108-112 30954674-4 2019 The cyto-architectural results showed that volume of the granular cell layer (GCL) was significantly larger in both 5- and 10-month old Arg-61 apoE mice versus C57BL/6J mice. Arginine 136-139 apolipoprotein E Mus musculus 143-147 30954674-7 2019 In conclusion, impaired cognitive functions in female Arg-61 apoE mice appear correlated with larger GCL volume and higher calretinin-positive cell number and suggest a compensatory cellular response that may be related to amyloid beta perturbations early in life. Arginine 54-57 apolipoprotein E Mus musculus 61-65 19666463-2 2009 Arg-61 apoE mice, a gene-targeted mouse model specific for domain interaction, have lower brain apoE levels and synaptic, functional, and cognitive deficits. Arginine 0-3 apolipoprotein E Mus musculus 96-100 19666463-3 2009 We hypothesized that domain interaction elicits an endoplasmic reticulum (ER) stress in astrocytes and an unfolded protein response that targets Arg-61 apoE for degradation. Arginine 145-148 apolipoprotein E Mus musculus 152-156 19666463-4 2009 Primary Arg-61 apoE astrocytes had less intracellular apoE than wild-type astrocytes, and unfolded protein response markers OASIS (old astrocyte specifically induced substance), ATF4, and XBP-1 and downstream effectors were up-regulated. Arginine 8-11 apolipoprotein E Mus musculus 15-19 19666463-4 2009 Primary Arg-61 apoE astrocytes had less intracellular apoE than wild-type astrocytes, and unfolded protein response markers OASIS (old astrocyte specifically induced substance), ATF4, and XBP-1 and downstream effectors were up-regulated. Arginine 8-11 apolipoprotein E Mus musculus 54-58 19666463-5 2009 ER stress appears to cause global astrocyte dysfunction as glucose uptake was decreased in Arg-61 apoE astrocytes, and astrocyte-conditioned medium promoted neurite outgrowth less efficiently than wild-type medium in Neuro-2a cell cultures. Arginine 91-94 apolipoprotein E Mus musculus 98-102 19666463-6 2009 We showed age-dependent up-regulation of brain OASIS levels and processing in Arg-61 apoE mice. Arginine 78-81 apolipoprotein E Mus musculus 85-89 11342002-6 2001 Furthermore, this increase was observed at submaximal extracellular arginine concentrations, suggesting that apoE altered arginine (substrate) availability. Arginine 122-130 apolipoprotein E Mus musculus 109-113 8940032-0 1996 In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice. Arginine 72-75 apolipoprotein E Mus musculus 53-69 8940032-0 1996 In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice. Arginine 72-75 apolipoprotein E Mus musculus 53-69 8940032-5 1996 5 mmol/liter), whereas the expression of the APOE*2(Arg-158 --> Cys) gene in Apoe-/- mice minimally reduced serum cholesterol levels (APOE*2.Apoe-/-; 16.6 +/- 2.9 mmol/liter). Arginine 52-55 apolipoprotein E Mus musculus 45-49 8940032-5 1996 5 mmol/liter), whereas the expression of the APOE*2(Arg-158 --> Cys) gene in Apoe-/- mice minimally reduced serum cholesterol levels (APOE*2.Apoe-/-; 16.6 +/- 2.9 mmol/liter). Arginine 52-55 apolipoprotein E Mus musculus 80-84 23130157-10 2012 Furthermore, apolipoprotein E (ApoE)-deficient mice with Arg-II deficiency (ApoE(-/-)Arg-II(-/-)) display reduced lesion size with characteristics of stable plaques, such as decreased macrophage inflammation and necrotic core. Arginine 57-60 apolipoprotein E Mus musculus 13-29 23130157-10 2012 Furthermore, apolipoprotein E (ApoE)-deficient mice with Arg-II deficiency (ApoE(-/-)Arg-II(-/-)) display reduced lesion size with characteristics of stable plaques, such as decreased macrophage inflammation and necrotic core. Arginine 57-60 apolipoprotein E Mus musculus 31-35 23130157-10 2012 Furthermore, apolipoprotein E (ApoE)-deficient mice with Arg-II deficiency (ApoE(-/-)Arg-II(-/-)) display reduced lesion size with characteristics of stable plaques, such as decreased macrophage inflammation and necrotic core. Arginine 57-60 apolipoprotein E Mus musculus 76-80 19666463-2 2009 Arg-61 apoE mice, a gene-targeted mouse model specific for domain interaction, have lower brain apoE levels and synaptic, functional, and cognitive deficits. Arginine 0-3 apolipoprotein E Mus musculus 7-11 18631967-3 2008 METHODS: We analyzed Arg-61 apoE mice, a gene-targeted model that selectively displays domain interaction. Arginine 21-24 apolipoprotein E Mus musculus 28-32 18631967-9 2008 Consistent with the reduced secretion of Arg-61 apoE by astrocytes in this model, cholesterol secretion was also reduced 34%. Arginine 41-44 apolipoprotein E Mus musculus 48-52