PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16407834-3	2006	Here we show that the SH3 domain of betaPix specifically interacts with a proline-arginine motif (PxxxPR) present within the ubiquitin ligase Cbl and Pak1 kinase.	Arginine	82-90	Cbl proto-oncogene	Homo sapiens	142-145	
21163258-0	2011	An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding.	Arginine	12-20	Cbl proto-oncogene	Homo sapiens	121-126	
21163258-4	2011	Collated data indicates that both binding and orientation is dictated by the phosphorylated tyrosine and an adjacent arginine forming intra-peptide hydrogen bonds and aligning unidirectionally with complementary charges in the phosphotyrosine binding pocket of c-Cbl.	Arginine	117-125	Cbl proto-oncogene	Homo sapiens	261-266	
18273061-3	2008	An obligatory, intrapeptidyl H-bond between the phosphotyrosine and the conserved asparagine or adjacent arginine is essential for binding and orients the peptide into a positively charged pocket on c-Cbl.	Arginine	105-113	Cbl proto-oncogene	Homo sapiens	199-204	
28676638-8	2017	Using lysine-to-arginine site-directed mutagenesis, K970 in the kinase domain of JAK2 was identified as the ubiquitination site important for promoting full JAK2 activation by Cbl via K63-conjugated poly-ubiquitination.	Arginine	16-24	Cbl proto-oncogene	Homo sapiens	176-179	
21830225-2	2011	The proline-arginine motif PXXXPR in c-Cbl and SH3 domains of CIN85 are essential to this interaction.	Arginine	12-20	Cbl proto-oncogene	Homo sapiens	37-42	
16228008-2	2005	Their function is modulated through interactions with regulatory proteins including CIN85 and PIX, which recognize a proline-arginine motif in Cbl and thus promote or inhibit receptor endocytosis.	Arginine	125-133	Cbl proto-oncogene	Homo sapiens	143-146	
15123609-6	2004	The substitution of Tyr(1003) with phenylalanine or substitution of either aspartate or arginine residues with alanine impairs c-Cbl-recruitment and ubiquitination of Met and results in the oncogenic activation of the Met receptor.	Arginine	88-96	Cbl proto-oncogene	Homo sapiens	127-132	
15123609-8	2004	Modeling studies suggest the presence of a salt bridge between the aspartate and arginine residues that would position pTyr(1003) for binding to the c-Cbl TKB domain.	Arginine	81-89	Cbl proto-oncogene	Homo sapiens	149-154	
12874286-0	2003	Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.	Arginine	34-42	Cbl proto-oncogene	Homo sapiens	91-94