PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19249120-1 2010 High Mphi:T cell ratios suppress the immune response to the retroviral superantigen Mls by IFNgamma-triggered production of the arg- and trp-consuming enzymes iNOS and IDO. Arginine 128-131 interferon gamma Homo sapiens 91-99 16254053-10 2005 Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II. Arginine 67-75 interferon gamma Homo sapiens 149-158 19597544-3 2009 The high arginase activity causes local depletion of L-arginine, which impairs the capacity of T cells in the lesion to proliferate and to produce interferon-gamma, while T cells in the local draining lymph nodes respond normally. Arginine 53-63 interferon gamma Homo sapiens 147-163 17666360-5 2007 TPN supplemented with arginine resulted in significant increase in CD4+ T cells, NK cells and CD4+/CD8+ T cell ratio in the peripheral blood, as well as in IL-2 and IFN-gamma levels. Arginine 22-30 interferon gamma Homo sapiens 165-174 17666360-7 2007 CONCLUSION: TPN with arginine supplementation can augment the percentages of CD4+ T lymphocytes and NK cells, and increase IL-2 and IFN-gamma levels, suggesting that arginine can enhance cell-mediated immunity in postoperative patients with HCC. Arginine 21-29 interferon gamma Homo sapiens 132-141 17666360-7 2007 CONCLUSION: TPN with arginine supplementation can augment the percentages of CD4+ T lymphocytes and NK cells, and increase IL-2 and IFN-gamma levels, suggesting that arginine can enhance cell-mediated immunity in postoperative patients with HCC. Arginine 166-174 interferon gamma Homo sapiens 132-141 16254053-10 2005 Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II. Arginine 105-113 interferon gamma Homo sapiens 149-158 14572312-1 2003 BACKGROUND: Arginine metabolism in tumor cell lines can be influenced by various cytokines, including recombinant human interferon-gamma (rIFN-gamma), a cytokine that shows promising clinical activity in epithelial ovarian cancer (EOC). Arginine 12-20 interferon gamma Homo sapiens 120-136 12351936-11 2002 Induction of nitrite production by a cytomix [IFNgamma (100 ng/ml) + TNFalpha (30 ng/ml) + IL-1beta (5 ng/ml)] was differentially enhanced by exposure to supplemental factors including LPS, L-arginine, and BH4. Arginine 190-200 interferon gamma Homo sapiens 46-54 11994457-4 2002 While 2DL4 can activate IFN-gamma production, dependent upon the transmembrane arginine, the function of the single ITIM of 2DL4 remains unknown. Arginine 79-87 interferon gamma Homo sapiens 24-33 9568729-3 1998 Similarly, arginine uptake and expression of the inducible nitric oxide synthase (iNOS) gene in response to bacterial DNA in BMM occurred only after IFN-gamma priming. Arginine 11-19 interferon gamma Homo sapiens 149-158 12112002-5 2002 L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production. Arginine 0-10 interferon gamma Homo sapiens 137-146 11306718-7 2001 In cells stimulated with IFN-gamma and LPS in Arg-free medium, CPD activity increased 2- to 3-fold between 8 and 16 h after treatment, but did not change in cells stimulated in medium containing 0.4 mM Arg. Arginine 46-49 interferon gamma Homo sapiens 25-34 11306718-7 2001 In cells stimulated with IFN-gamma and LPS in Arg-free medium, CPD activity increased 2- to 3-fold between 8 and 16 h after treatment, but did not change in cells stimulated in medium containing 0.4 mM Arg. Arginine 202-205 interferon gamma Homo sapiens 25-34 9202399-10 1997 Thus, in culture medium with lower amounts of L-arginine, L-NMMA blocked the IFN-gamma-induced inhibition of GHRH-stimulated GH release at a lower dose. Arginine 46-56 interferon gamma Homo sapiens 77-86 9182722-0 1997 Interaction of truncated human interferon gamma variants with the interferon gamma receptor: crucial importance of Arg-129. Arginine 115-118 interferon gamma Homo sapiens 31-47 9182722-0 1997 Interaction of truncated human interferon gamma variants with the interferon gamma receptor: crucial importance of Arg-129. Arginine 115-118 interferon gamma Homo sapiens 66-82 9202399-11 1997 The inhibition of PRL and GH release by IFN-gamma was markedly reduced in L-arginine-depleted medium. Arginine 74-84 interferon gamma Homo sapiens 40-49 7544575-3 1995 The addition of NG-monomethyl-L-arginine, a selective inhibitor of NO synthesis, reduced the effect of interferon-gamma and lipopolysaccharide, while the effect of NG-monomethyl-L-arginine was suppressed by the addition of L-arginine, a substrate of NO synthase. Arginine 30-40 interferon gamma Homo sapiens 103-119 8894440-2 1996 Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma). Arginine 27-35 interferon gamma Homo sapiens 248-275 7543491-8 1995 NG-Monomethyl-L-arginine (MM-Arg), an NOS inhibitor, partially reversed the effects of TNF-alpha and, to a lesser extent, IFN-gamma in methylcellulose culture of total BM and CD34+ cells, and inhibited apoptosis of BM cells induced by these cytokines. Arginine 28-32 interferon gamma Homo sapiens 122-131 7628352-4 1995 It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations. Arginine 210-218 interferon gamma Homo sapiens 43-59 7628352-4 1995 It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations. Arginine 210-218 interferon gamma Homo sapiens 61-70 7628352-4 1995 It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations. Arginine 285-293 interferon gamma Homo sapiens 43-59 7628352-4 1995 It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations. Arginine 285-293 interferon gamma Homo sapiens 61-70 7628352-9 1995 Both adult rat islets exposed to IL-1 beta and human pancreatic islets cultured in the presence of IL-1 beta, tumor necrosis factor-alpha, and IFN gamma were able to use citrulline to regenerate arginine and produce NO. Arginine 195-203 interferon gamma Homo sapiens 143-152 7514193-3 1994 24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline. Arginine 155-165 interferon gamma Homo sapiens 20-29 7534807-5 1995 Incubation of washed platelets in Ca(++)-free buffer with cytokines (tumor necrosis factor-alpha and interferon-gamma) or cytokines plus lipopolysaccharide caused a marked increase in the conversion of [3H]L-arginine to [3H]L-citrulline, suggesting the presence of inducible form of NO synthase. Arginine 206-216 interferon gamma Homo sapiens 101-117 7514170-11 1994 Together, these results demonstrate that both exogenous and endogenous NO inhibit IDO activity and that oxidative arginine and tryptophan metabolism in IFN gamma-primed mononuclear phagocytes are functionally related. Arginine 114-122 interferon gamma Homo sapiens 152-161 7664177-1 1995 In a number of mammalian cell types, pteridine biosynthesis from guanosine 5"-triphosphate and formation of nitric oxide from L-arginine are induced by gamma interferon (IFN-gamma) and bacterial lipopolysaccharide (LPS). Arginine 126-136 interferon gamma Homo sapiens 152-179 7538426-3 1995 Although ineffective by itself, LPL in combination with IFN-gamma increased L-arginine-dependent NO production in a dose-dependent manner. Arginine 76-86 interferon gamma Homo sapiens 56-65 7511593-10 1994 Taken together, these results suggest that the sequential exposure of monocytes to IFN-gamma and IL-4 elicits the release of NO from L-arginine, which in turn is capable to stimulate soluble guanylyl cyclase. Arginine 133-143 interferon gamma Homo sapiens 83-92 1310709-3 1992 Macrophages exposed to A23187 or IFN-gamma in the presence of LPS and FCS secreted significant amounts of PGE2 independently of the presence of L-arginine in the incubation medium. Arginine 144-154 interferon gamma Homo sapiens 33-42 1541678-1 1992 An interferon-gamma, tumor necrosis factor, and interleukin-1-inducible, high-output pathway synthesizing nitric oxide (NO) from L-arginine was recently identified in rodents. Arginine 129-139 interferon gamma Homo sapiens 3-19 34893694-6 2021 CECs differentiated from peripheral blood mononuclear cells potently suppress T-cell activation, proliferation, and IFN-gamma production in an ARG- and ROS-dependent manner. Arginine 143-146 interferon gamma Homo sapiens 116-125 1560730-1 1992 Macrophages and other host cells activated by interferon-gamma (IFN-gamma) can be induced to form a flavoprotein that converts L-arginine to nitric oxide+L-citrulline. Arginine 127-137 interferon gamma Homo sapiens 46-62 1560730-1 1992 Macrophages and other host cells activated by interferon-gamma (IFN-gamma) can be induced to form a flavoprotein that converts L-arginine to nitric oxide+L-citrulline. Arginine 127-137 interferon gamma Homo sapiens 64-73 1839957-8 1991 Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser. Arginine 130-133 interferon gamma Homo sapiens 28-37 2005387-3 1991 Cytotoxicity of M phi activated by IFN-gamma plus LPS was detected in the presence of about 0.1 mM or more of L-arginine. Arginine 110-120 interferon gamma Homo sapiens 35-44 35619558-5 2022 Although perioperative arginine did not prevent immediate NK cell immunoparalysis after surgery, it did accelerate their return to preoperative cytotoxicity, IFN-gamma secretion, and activating receptor expression. Arginine 23-31 interferon gamma Homo sapiens 158-167 6180381-4 1982 Nucleotide sequence analysis of several IFN-gamma cDNA clones showed the presence of a CGA (Arg) codon at position 140 of mature IFN-gamma in contrast with the CAA (Gln) codon, which is found in p69 (1). Arginine 92-95 interferon gamma Homo sapiens 40-49 3116090-11 1987 A similar synergism with C5a/C5a des Arg was seen with interferon-gamma. Arginine 37-40 interferon gamma Homo sapiens 55-71 6180381-4 1982 Nucleotide sequence analysis of several IFN-gamma cDNA clones showed the presence of a CGA (Arg) codon at position 140 of mature IFN-gamma in contrast with the CAA (Gln) codon, which is found in p69 (1). Arginine 92-95 interferon gamma Homo sapiens 129-138 33644712-3 2021 c-Abl/Arg could mediate STAT1 phosphorylation independent of Janus kinases in the absence of IFNgamma and potentiate IFNgamma-mediated STAT1 phosphorylation. Arginine 6-9 interferon gamma Homo sapiens 117-125 30348823-3 2018 When human islets were exposed to inflammatory stress induced by interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma, arginine residue R510 within GRP78 was converted into citrulline, as evidenced by liquid chromatography-tandem mass spectrometry. Arginine 135-143 interferon gamma Homo sapiens 117-133 30829471-6 2019 More importantly, the probe revealed that NO induced by interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), and l-arginine (l-Arg) could also elicit the augmentation of intracellular GSH. Arginine 116-126 interferon gamma Homo sapiens 56-72 33160404-6 2020 We carried out a multivariate Cox regression analysis and developed six ARG-related prognostic signature for the survival prediction of patients with squamous cell cervical cancer (Risk score = - 0.63*ATG3-0.42*BCL2 + 0.85*CD46-0.38*IFNG+ 0.23*NAMPT+ 0.82*TM9SF1). Arginine 72-75 interferon gamma Homo sapiens 233-237 30829471-6 2019 More importantly, the probe revealed that NO induced by interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), and l-arginine (l-Arg) could also elicit the augmentation of intracellular GSH. Arginine 128-133 interferon gamma Homo sapiens 56-72 30829471-6 2019 More importantly, the probe revealed that NO induced by interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), and l-arginine (l-Arg) could also elicit the augmentation of intracellular GSH. Arginine 128-133 interferon gamma Homo sapiens 74-83 29746817-0 2018 Arginine inhibits the malignant transformation induced by interferon-gamma through the NF-kappaB-GCN2/eIF2alpha signaling pathway in mammary epithelial cells in vitro and in vivo. Arginine 0-8 interferon gamma Homo sapiens 58-74 30081186-5 2018 The levels of fractalkine on day 0 and 7th day, IP-10 on 4th and 7th day, and IFN-gamma on 7th day in ARG was significantly higher than that in NRG. Arginine 102-105 interferon gamma Homo sapiens 78-87 30142362-6 2018 Higher release of IL-1alpha, IL-1beta, IFN-gamma, IL-12p70 and TNF-alpha and a reduced IL-10 secretion after lipopolysaccharide (LPS) stimulation were observed in PBMCs from Arg/Arg T2DM carriers as compared to subjects with the Trp variant. Arginine 174-177 interferon gamma Homo sapiens 39-48 29746817-5 2018 The results indicate that arginine addition could alleviate the malignant transformation of mammary epithelial cells induced by IFN-gamma, including reducing cell proliferation, cell migration and colony formation, through the NF-kappaB-GCN2/eIF2alpha pathway. Arginine 26-34 interferon gamma Homo sapiens 128-137 29746817-7 2018 Furthermore, the investigation of the clinical data also revealed that the plasma or tissue from human breast cancer patients owned lower arginine level and higher IFN-gamma level than that from patients with benign breast disease, showing IFN-gamma may be a potential control target. Arginine 138-146 interferon gamma Homo sapiens 240-249 29746817-8 2018 Our findings demonstrate that arginine supplement could antagonize the malignant transformation of mammary epithelial cells induced by IFN-gamma (nutritionally induced) both in vitro and in vivo, and IFN-gamma was higher in breast cancer women. Arginine 30-38 interferon gamma Homo sapiens 135-144 29746817-8 2018 Our findings demonstrate that arginine supplement could antagonize the malignant transformation of mammary epithelial cells induced by IFN-gamma (nutritionally induced) both in vitro and in vivo, and IFN-gamma was higher in breast cancer women. Arginine 30-38 interferon gamma Homo sapiens 200-209 23399839-6 2012 L-Arg depletion reduced the expression of NK-92 activating receptors, NKp46 and NKp30, the expression of NK zeta chain and the NK-92 intracellular production of IFN-gamma. Arginine 0-5 interferon gamma Homo sapiens 161-170 26826241-11 2016 Suppression of IFN-gamma production was reversed by l-arginine supplementation, consistent with increased MDSC arginase-1 activity. Arginine 52-62 interferon gamma Homo sapiens 15-24 25925198-6 2015 L-Arg treatment increased the population of CD4(+)T-bet(+)IFN-gamma(+) Th1 cells and the activated macrophages (F4/80(+)CD36(+)) in the spleen. Arginine 0-5 interferon gamma Homo sapiens 58-67 25925198-7 2015 The levels of pro-inflammatory cytokines, IFN-gamma and TNF-alpha, in splenocyte cultures were also increased by L-Arg treatment. Arginine 113-118 interferon gamma Homo sapiens 42-51 27025389-0 2016 Arginine Supplementation Recovered the IFN-gamma-Mediated Decrease in Milk Protein and Fat Synthesis by Inhibiting the GCN2/eIF2alpha Pathway, Which Induces Autophagy in Primary Bovine Mammary Epithelial Cells. Arginine 0-8 interferon gamma Homo sapiens 39-48 23726607-6 2013 The intensity of TNF-alpha and IFN-gamma in ARG (144.47 +- 81.21 and 116.61 +- 53.89, respectively) was significant higher than STA (P < .001). Arginine 44-47 interferon gamma Homo sapiens 31-40 23726607-8 2013 The intensity in noncultured plasma from ARG or STA was significant lower than that in culture supernates from ARG and STA with sensitivity and specificity to predict acute rejection episodes of 63.6% and 73.3%, respectively, when combining TNF-alpha and IFN-gamma. Arginine 41-44 interferon gamma Homo sapiens 255-264 23255592-3 2013 In inflamed HLMVEC (pretreated with interleukin-1beta and interferon-gamma), we found enhanced binding of eNOS to calcium-calmodulin at basal Ca(2+) levels, thereby increasing its basal activity that was dependent on extracellular l-Arg. Arginine 231-236 interferon gamma Homo sapiens 58-74 21549779-8 2011 Taken together, these results suggest a novel way for local kinin and des-Arg-kinin generation in the nervous tissue during pathological states accompanied by interferon-gamma release. Arginine 74-77 interferon gamma Homo sapiens 159-175 20811799-2 2011 IFNG-inducible KYN/pteridines inflammation cascade is characterized by up-regulation of nitric oxide synthase (NOS) activity (induced by KYN) and decreased formation of NOS cofactor, BH4, that results in uncoupling of NOS that shifting arginine from NO to superoxide anion production. Arginine 236-244 interferon gamma Homo sapiens 0-4 21986138-4 2011 IFN-gamma production was also measured after addition of L-arginine and/or antitransforming growth factor-beta (TGF-beta) neutralizing monoclonal antibody, and in PBMCs depleted of CD14(+)HLA-DR(-/low) cells. Arginine 57-67 interferon gamma Homo sapiens 0-9 21040785-5 2011 In GVHD patients, increasing arginine concentration resulted in down-regulation of IFNgamma and TNFalpha mRNA expression, whereas IL10 was up-regulated especially at physiological plasma levels (between 0 and 100 muM). Arginine 29-37 interferon gamma Homo sapiens 83-91