PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15743275-0 2005 Interaction of the endothelial nitric oxide synthase with the CAT-1 arginine transporter enhances NO release by a mechanism not involving arginine transport. Arginine 68-76 nitric oxide synthase 3 Bos taurus 19-52 22696221-1 2012 Endothelial nitric-oxide synthase (eNOS) utilizes l-arginine as its principal substrate, converting it to l-citrulline and nitric oxide (NO). Arginine 50-60 nitric oxide synthase 3 Bos taurus 0-33 21914450-8 2011 Simvastatin induced an increase in eNOS mRNA expression and protein levels in the presence of arginine or citrulline. Arginine 94-102 nitric oxide synthase 3 Bos taurus 35-39 21914450-10 2011 Combining statin with arginine or citrulline increased NO production in endothelial cells by increasing eNOS protein levels. Arginine 22-30 nitric oxide synthase 3 Bos taurus 104-108 17822962-1 2007 Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO), an important modulator of vascular function. Arginine 69-79 nitric oxide synthase 3 Bos taurus 0-33 17822962-1 2007 Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO), an important modulator of vascular function. Arginine 69-79 nitric oxide synthase 3 Bos taurus 35-39 15743275-1 2005 eNOS (endothelial nitric oxide synthase) catalyses the conversion of L-arginine into L-citrulline and NO. Arginine 69-79 nitric oxide synthase 3 Bos taurus 0-4 15743275-1 2005 eNOS (endothelial nitric oxide synthase) catalyses the conversion of L-arginine into L-citrulline and NO. Arginine 69-79 nitric oxide synthase 3 Bos taurus 6-39 15743275-2 2005 Evidence has been presented previously that eNOS is associated with the CAT (cationic amino acid transporter)-1 arginine transporter in endothelial caveolae, and it has been proposed that eNOS-CAT-1 association facilitates the delivery of extracellular L-arginine to eNOS. Arginine 253-263 nitric oxide synthase 3 Bos taurus 44-48 15743275-2 2005 Evidence has been presented previously that eNOS is associated with the CAT (cationic amino acid transporter)-1 arginine transporter in endothelial caveolae, and it has been proposed that eNOS-CAT-1 association facilitates the delivery of extracellular L-arginine to eNOS. Arginine 253-263 nitric oxide synthase 3 Bos taurus 188-192 15743275-2 2005 Evidence has been presented previously that eNOS is associated with the CAT (cationic amino acid transporter)-1 arginine transporter in endothelial caveolae, and it has been proposed that eNOS-CAT-1 association facilitates the delivery of extracellular L-arginine to eNOS. Arginine 253-263 nitric oxide synthase 3 Bos taurus 188-192 15743275-9 2005 Taken together, these data suggest that direct interaction of eNOS with CAT-1 enhances NO release by a mechanism not involving arginine transport. Arginine 127-135 nitric oxide synthase 3 Bos taurus 62-66 7680289-1 1993 Endothelial cell nitric oxide synthase (ECNOS) is a membrane-associated enzyme that generates endothelium-derived relaxing factor/nitric oxide (EDRF/NO) from L-arginine. Arginine 158-168 nitric oxide synthase 3 Bos taurus 0-38 11433181-2 2001 L-arginine is the substrate required for NO production by endothelial NOS (eNOS). Arginine 0-10 nitric oxide synthase 3 Bos taurus 58-73 11433181-2 2001 L-arginine is the substrate required for NO production by endothelial NOS (eNOS). Arginine 0-10 nitric oxide synthase 3 Bos taurus 75-79 11433181-8 2001 eNOS activity in forming NO was determined by assay for 3H-L-arginine to 3H-citrulline conversion. Arginine 56-69 nitric oxide synthase 3 Bos taurus 0-4 8646406-16 1996 In contrast to their potent effects on iNOS, some AATUs and MAGs were 20-100 times weaker than NG-methyl-L-arginine and NG-nitro-L-arginine as inhibitors of ecNOS as assessed by their effects on the conversion of L-arginine to L-citrulline in homogenates of bovine endothelial cells and by their pressor effects in anaesthetized rats. Arginine 105-115 nitric oxide synthase 3 Bos taurus 157-162 11796200-3 2002 Whereas the Km of eNOS for L-arginine was 2 microM in cell extracts, the L-arginine concentration of half-maximal eNOS stimulation was increased to 29 microM in intact cells. Arginine 27-37 nitric oxide synthase 3 Bos taurus 18-22 11796200-3 2002 Whereas the Km of eNOS for L-arginine was 2 microM in cell extracts, the L-arginine concentration of half-maximal eNOS stimulation was increased to 29 microM in intact cells. Arginine 73-83 nitric oxide synthase 3 Bos taurus 114-118 11796200-5 2002 The effects of inhibitors of endothelial nitric oxide synthesis also suggested that extracellular L-arginine availability limits intracellular eNOS activity. Arginine 98-108 nitric oxide synthase 3 Bos taurus 143-147 11796200-6 2002 Treatment of intact cells with the calcium ionophore A23187 reduced the L-arginine concentration of half-maximal eNOS activity, which is consistent with a measured increase in L-arginine uptake. Arginine 72-82 nitric oxide synthase 3 Bos taurus 113-117 11796200-6 2002 Treatment of intact cells with the calcium ionophore A23187 reduced the L-arginine concentration of half-maximal eNOS activity, which is consistent with a measured increase in L-arginine uptake. Arginine 176-186 nitric oxide synthase 3 Bos taurus 113-117 11796200-7 2002 Increases in eNOS activity induced by several agents were closely correlated with enhanced L-arginine uptake into cells (r = 0.89). Arginine 91-101 nitric oxide synthase 3 Bos taurus 13-17 11796200-8 2002 The "arginine paradox" may be explained in part by regulated L-arginine uptake into a compartment, probably represented by caveolae, that contains eNOS and that is distinct from the bulk cytosolic L-arginine. Arginine 5-13 nitric oxide synthase 3 Bos taurus 147-151 11796200-8 2002 The "arginine paradox" may be explained in part by regulated L-arginine uptake into a compartment, probably represented by caveolae, that contains eNOS and that is distinct from the bulk cytosolic L-arginine. Arginine 61-71 nitric oxide synthase 3 Bos taurus 147-151 7689333-1 1993 L-NG-Nitroarginine (NA) inhibited both the L-arginine oxidation and the L-arginine-independent NADPH oxidation reactions catalyzed by the calcium/calmodulin-dependent constitutive nitric oxide synthase (cNOS) from bovine brain. Arginine 72-82 nitric oxide synthase 3 Bos taurus 203-207 7689333-7 1993 The Km for L-arginine in the cNOS reaction was 1.2 microM. Arginine 11-21 nitric oxide synthase 3 Bos taurus 29-33 7689333-8 1993 The NA binding sites of cNOS were titrated with NA, which enabled a kcat of 0.7 s-1, for the oxidation of L-arginine, to be calculated. Arginine 106-116 nitric oxide synthase 3 Bos taurus 24-28 7680289-1 1993 Endothelial cell nitric oxide synthase (ECNOS) is a membrane-associated enzyme that generates endothelium-derived relaxing factor/nitric oxide (EDRF/NO) from L-arginine. Arginine 158-168 nitric oxide synthase 3 Bos taurus 40-45 28654706-8 2017 ENOS-cofactors dynamic assay showed that Hsp90 enhanced WT eNOS affinity to NADPH, L-arginine, and CaM but not to Ca2+ and BH4. Arginine 83-93 nitric oxide synthase 3 Bos taurus 0-4 28654706-8 2017 ENOS-cofactors dynamic assay showed that Hsp90 enhanced WT eNOS affinity to NADPH, L-arginine, and CaM but not to Ca2+ and BH4. Arginine 83-93 nitric oxide synthase 3 Bos taurus 59-63 28654706-13 2017 In conclusion, by changing eNOS structure, Hsp90 profoundly affected eNOS functions, including change of affinity of eNOS to cofactors like Ca2+, L-arginine, BH4 and further affecting NO generation capability. Arginine 146-156 nitric oxide synthase 3 Bos taurus 27-31 28654706-13 2017 In conclusion, by changing eNOS structure, Hsp90 profoundly affected eNOS functions, including change of affinity of eNOS to cofactors like Ca2+, L-arginine, BH4 and further affecting NO generation capability. Arginine 146-156 nitric oxide synthase 3 Bos taurus 69-73 28654706-13 2017 In conclusion, by changing eNOS structure, Hsp90 profoundly affected eNOS functions, including change of affinity of eNOS to cofactors like Ca2+, L-arginine, BH4 and further affecting NO generation capability. Arginine 146-156 nitric oxide synthase 3 Bos taurus 69-73