PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18940611-0	2008	Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism.	Arginine	94-102	programmed cell death 6 interacting protein	Homo sapiens	56-60	
19143629-4	2009	Binding of Ca(2+) to EF3 (third EF-hand) enables the side chain of Arg(125), present in the loop connecting EF3 and EF4 (fourth EF-hand), to move sufficiently to make a primary hydrophobic pocket accessible to the critical PPYP (Pro-Pro-Tyr-Pro) motif in Alix, which partially overlaps with the GPP (Gly-Pro-Pro) motif for binding to Cep55 (centrosome protein of 55 kDa).	Arginine	67-70	programmed cell death 6 interacting protein	Homo sapiens	255-259	
34730397-3	2022	In this study, we identified a cluster of six arginine residues in the disordered domain of UL34 as a minimal region required for the interaction with ALIX as well as the recruitment of ALIX and an ESCRT-III protein CHMP4B to the INM in HSV-1-infected cells.	Arginine	46-54	programmed cell death 6 interacting protein	Homo sapiens	151-155	
34730397-3	2022	In this study, we identified a cluster of six arginine residues in the disordered domain of UL34 as a minimal region required for the interaction with ALIX as well as the recruitment of ALIX and an ESCRT-III protein CHMP4B to the INM in HSV-1-infected cells.	Arginine	46-54	programmed cell death 6 interacting protein	Homo sapiens	186-190	
34730397-5	2022	We also showed that the effect of the arginine cluster in UL34 on HSV-1 replication was dependent primarily on ALIX.	Arginine	38-46	programmed cell death 6 interacting protein	Homo sapiens	111-115	
34730397-6	2022	These results indicated that the arginine cluster in the disordered domain of UL34 was required for the interaction with ALIX and the recruitment of ESCRT-III machinery to the INM to promote primary envelopment.	Arginine	33-41	programmed cell death 6 interacting protein	Homo sapiens	121-125	
34730397-10	2022	In this study, we present data suggesting that the arginine cluster in the disordered domain of HSV-1 UL34 mediates the interaction with ALIX, thereby leading to the recruitment of ESCRT-III machinery to the INM for efficient primary envelopment.	Arginine	51-59	programmed cell death 6 interacting protein	Homo sapiens	137-141	
18940611-4	2008	Based on these results, together with the results of in vitro binding assay with mutant ALG-2 and Alix proteins, we propose a Ca(2+)/EF3-driven arginine switch mechanism for ALG-2 binding to Alix.	Arginine	144-152	programmed cell death 6 interacting protein	Homo sapiens	191-195	
18940611-4	2008	Based on these results, together with the results of in vitro binding assay with mutant ALG-2 and Alix proteins, we propose a Ca(2+)/EF3-driven arginine switch mechanism for ALG-2 binding to Alix.	Arginine	144-152	programmed cell death 6 interacting protein	Homo sapiens	98-102