PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30026883-12	2018	Conclusion: Ozone may augment the production of interleukin-8 in response to ambient particulate matter by a mechanism unrelated to reactive oxygen species.	Ozone	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	48-61	
32139669-4	2020	In vitro, both knockdown of TRPC6 expression with shRNA and TRPC6 blockage markedly attenuated the release of cytokines IL-6 and IL-8 induced by O3 or H2O2 in 16HBE cells (human bronchial epithelial cell line).	Ozone	145-147	C-X-C motif chemokine ligand 8	Homo sapiens	129-133	
31476115-7	2019	Our results show that APZ and the known DHCR7 inhibitor, AY9944, increase 7-DHC levels in airway epithelial cells and potentiate O3-induced IL-6 and IL-8 expression and cytokine release.	Ozone	129-131	C-X-C motif chemokine ligand 8	Homo sapiens	149-153	
31476115-9	2019	Additionally, we find that APZ increases O3-induced IL-6 and IL-8 expression in human nasal epithelial cells from male but not female donors.	Ozone	41-43	C-X-C motif chemokine ligand 8	Homo sapiens	61-65	
7988196-16	1994	CONCLUSIONS: We conclude that asthmatics exposed to ozone develop a significant BALF neutrophilia and increased levels of the cytokines, IL-8 and IL-6.	Ozone	52-57	C-X-C motif chemokine ligand 8	Homo sapiens	137-141	
29925859-8	2018	We observed a significant correlation between ERK1/2 phosphorylation and IL-8 expression, suggesting that ERK1/2 modulates the ozone-mediated IL-8 response; however, we found that simultaneous inhibition of both kinases was required to achieve the greatest IL-8 inhibition.	Ozone	127-132	C-X-C motif chemokine ligand 8	Homo sapiens	73-77	
29925859-8	2018	We observed a significant correlation between ERK1/2 phosphorylation and IL-8 expression, suggesting that ERK1/2 modulates the ozone-mediated IL-8 response; however, we found that simultaneous inhibition of both kinases was required to achieve the greatest IL-8 inhibition.	Ozone	127-132	C-X-C motif chemokine ligand 8	Homo sapiens	142-146	
29925859-8	2018	We observed a significant correlation between ERK1/2 phosphorylation and IL-8 expression, suggesting that ERK1/2 modulates the ozone-mediated IL-8 response; however, we found that simultaneous inhibition of both kinases was required to achieve the greatest IL-8 inhibition.	Ozone	127-132	C-X-C motif chemokine ligand 8	Homo sapiens	142-146	
29721026-8	2017	Preincubation of ozone at 50 mug/ml decreases IL-8, IL-6, and IL-1beta production by 50, 56, and 70%, respectively, compared to untreated cells.	Ozone	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	46-50	
20816188-8	2010	Atopic and atopic asthmatic subjects had increased sputum neutrophil numbers and IL-8 levels after ozone exposure; values did not significantly change in healthy volunteers.	Ozone	99-104	C-X-C motif chemokine ligand 8	Homo sapiens	81-85	
10226072-8	1999	Furthermore, we found significant increases in the release of IL-4, IL-6, IL-8, and TNF-alpha of ozone-exposed (0.1 ppm) samples of atopic versus nonatopic patients and to a lesser extent for histamine following exposure to 0.15 ppm ozone.	Ozone	97-102	C-X-C motif chemokine ligand 8	Homo sapiens	74-78	
8947075-4	1996	At concentrations of 10-100 ppb, O3 induced maximal release of interleukin-8 (IL-8), granulocyte/macrophage colony-stimulating factor (GM-CSF), tumour necrosis factor-alpha (TNF-alpha) and sICAM-1.	Ozone	33-35	C-X-C motif chemokine ligand 8	Homo sapiens	63-76	
8947075-4	1996	At concentrations of 10-100 ppb, O3 induced maximal release of interleukin-8 (IL-8), granulocyte/macrophage colony-stimulating factor (GM-CSF), tumour necrosis factor-alpha (TNF-alpha) and sICAM-1.	Ozone	33-35	C-X-C motif chemokine ligand 8	Homo sapiens	78-82	
8947075-6	1996	10(-5) M nedocromil sodium significantly attenuated the O3-induced release of both IL-8 and GM-CSF (p<0.01).	Ozone	56-58	C-X-C motif chemokine ligand 8	Homo sapiens	83-87	
8947075-8	1996	Similarly, the antioxidant, glutathione, at concentrations of 400-600 microM, significantly reduced the O3-induced release of IL-8 (p<0.05).	Ozone	104-106	C-X-C motif chemokine ligand 8	Homo sapiens	126-130	
29925859-7	2018	Recent evidence suggests that the MAP kinases ERK1/2 and p38 mediate ozone-induced IL-8 transcription, thus we hypothesized that differences in their activation may control IL-8 inter-individual variability.	Ozone	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	83-87	
29925859-7	2018	Recent evidence suggests that the MAP kinases ERK1/2 and p38 mediate ozone-induced IL-8 transcription, thus we hypothesized that differences in their activation may control IL-8 inter-individual variability.	Ozone	69-74	C-X-C motif chemokine ligand 8	Homo sapiens	173-177	
19059883-5	2009	In primary human airway epithelial cells, inhibition of NQO1 by dicumarol blocks ozone-induced F(2)-isoprostane production and IL-8 gene expression.	Ozone	81-86	C-X-C motif chemokine ligand 8	Homo sapiens	127-131	
16860297-7	2007	Exposure to the photochemically generated products of BD (primarily acrolein, acetaldehyde, formaldehyde, furan and ozone) induced significant increases in cytotoxicity, IL-8, and IL-6 gene expression compared to a synthetic mixture of primary products that was created by injecting the correct concentrations of the detected products from the irradiation experiments.	Ozone	116-121	C-X-C motif chemokine ligand 8	Homo sapiens	170-174	
16819095-7	2005	In the present study we determined whether ozone exposure enhances DEP effect on interleukin-8 (IL-8) gene expression in human airway epithelial cells.	Ozone	43-48	C-X-C motif chemokine ligand 8	Homo sapiens	81-94	
16819095-7	2005	In the present study we determined whether ozone exposure enhances DEP effect on interleukin-8 (IL-8) gene expression in human airway epithelial cells.	Ozone	43-48	C-X-C motif chemokine ligand 8	Homo sapiens	96-100	
16819095-9	2005	The increased DEP-induced IL-8 gene expression following ozone exposure was attributed to ozone-induced increase in the activity of the transcription factors NF-kappaB and NF-IL6.	Ozone	57-62	C-X-C motif chemokine ligand 8	Homo sapiens	26-30	
15379216-5	2004	Ozone exposure (3.0 ppm, 3 min) time-dependently changed the redox state, while increasing production of interleukin(IL)-8 and IL-6, mRNA and protein.	Ozone	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	105-122	
11174195-2	2001	OBJECTIVE: We aimed to investigate the effects of O3 and NO2 on the release of IL-8, GM-CSF, RANTES, and soluble intercellular adhesion molecule 1 (sICAM-1) from human bronchial epithelial cells (HBECs) of nonatopic nonasthmatic subjects (nonasthmatic subjects) and atopic subjects with mild asthma (asthmatic subjects) in vitro.	Ozone	50-52	C-X-C motif chemokine ligand 8	Homo sapiens	79-83	
35546010-0	2022	Ozone improved the wound healing in type 2 diabetics via down-regulation of IL- 8, 10 and induction of FGFR expression.	Ozone	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	76-81	
34126877-8	2021	O3-induced pro-inflammatory gene expression for CXCL2 and CXCL8/IL8 was further enhanced in NLRP2 knockout cells, suggesting a negative regulatory role.	Ozone	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	58-63	
34126877-8	2021	O3-induced pro-inflammatory gene expression for CXCL2 and CXCL8/IL8 was further enhanced in NLRP2 knockout cells, suggesting a negative regulatory role.	Ozone	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	64-67	
34126877-9	2021	Reconstitution of NLRP2 KO cells with K1019R mutant NLRP2 partially blocked SecoA adduction and enhanced O3-induced IL-8 release as compared to wild type NLRP2.	Ozone	105-107	C-X-C motif chemokine ligand 8	Homo sapiens	116-120