PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34677149-9	2022	The rectal ozone protocol is rectal ozone insufflation, resulting in clinical improvement in oxygen saturation and biochemical improvement (fibrinogen, D-dimer, urea, ferritin, LDH, interleukin-6, and C-reactive protein).	Ozone	11-16	interleukin 6	Homo sapiens	182-195	
34760922-0	2021	STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.	Ozone	69-74	interleukin 6	Homo sapiens	10-14	
34760922-14	2021	A positive correlation between IL-6 or IL-17A and STAT3 and negative correlation between SOCS3 and STAT3 were shown, suggesting that the IL-6/STAT3 pathway may be involved in OVA + ozone-induced corticosteroid-resistant airway inflammation.	Ozone	181-186	interleukin 6	Homo sapiens	31-35	
34760922-14	2021	A positive correlation between IL-6 or IL-17A and STAT3 and negative correlation between SOCS3 and STAT3 were shown, suggesting that the IL-6/STAT3 pathway may be involved in OVA + ozone-induced corticosteroid-resistant airway inflammation.	Ozone	181-186	interleukin 6	Homo sapiens	137-141	
34760922-16	2021	The IL-6/STAT3 pathway may contribute to corticosteroid insensitivity in OVA + ozone-induced neutrophilic airway inflammation through regulation of Th17 cells and could provide new targets for individual treatment of corticosteroid resistance in asthma.	Ozone	79-84	interleukin 6	Homo sapiens	4-8	
34677149-9	2022	The rectal ozone protocol is rectal ozone insufflation, resulting in clinical improvement in oxygen saturation and biochemical improvement (fibrinogen, D-dimer, urea, ferritin, LDH, interleukin-6, and C-reactive protein).	Ozone	36-41	interleukin 6	Homo sapiens	182-195	
32139669-4	2020	In vitro, both knockdown of TRPC6 expression with shRNA and TRPC6 blockage markedly attenuated the release of cytokines IL-6 and IL-8 induced by O3 or H2O2 in 16HBE cells (human bronchial epithelial cell line).	Ozone	145-147	interleukin 6	Homo sapiens	120-124	
31553636-11	2019	Gonadectomy also reduced ozone-induced expression of lung IL-6 and macrophage inflammatory protein-3 in females, which was restored by treatment with 17beta-estradiol.	Ozone	25-30	interleukin 6	Homo sapiens	58-62	
31476115-7	2019	Our results show that APZ and the known DHCR7 inhibitor, AY9944, increase 7-DHC levels in airway epithelial cells and potentiate O3-induced IL-6 and IL-8 expression and cytokine release.	Ozone	129-131	interleukin 6	Homo sapiens	140-144	
31476115-9	2019	Additionally, we find that APZ increases O3-induced IL-6 and IL-8 expression in human nasal epithelial cells from male but not female donors.	Ozone	41-43	interleukin 6	Homo sapiens	52-56	
19201813-8	2009	Collectively, our data for the first time suggest a dual role of ozone in modulating IL-6 secretion and TEER outcomes in a PGE(2)-dependent (in presence of TNF stimulus) and -independent manner (in absence of cytokine stimulus).	Ozone	65-70	interleukin 6	Homo sapiens	85-89	
20816188-9	2010	After ozone exposure, atopic asthmatic subjects had significantly increased sputum IL-6 and IL-1beta levels and airway macrophage Toll-like receptor 4, Fc(epsilon)RI, and CD23 expression; values in healthy volunteers and atopic nonasthmatic subjects showed no significant change.	Ozone	6-11	interleukin 6	Homo sapiens	83-87	
31572383-10	2019	O3 stimulated release of pro-neutrophilic mediators including CCL20 and IL-6 into the airways and impaired the inhibitory effects of budesonide on CCL11, IL-13 and IL-23.	Ozone	0-2	interleukin 6	Homo sapiens	72-76	
29721026-8	2017	Preincubation of ozone at 50 mug/ml decreases IL-8, IL-6, and IL-1beta production by 50, 56, and 70%, respectively, compared to untreated cells.	Ozone	17-22	interleukin 6	Homo sapiens	52-56	
19201813-0	2009	Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells.	Ozone	0-5	interleukin 6	Homo sapiens	16-20	
16860297-7	2007	Exposure to the photochemically generated products of BD (primarily acrolein, acetaldehyde, formaldehyde, furan and ozone) induced significant increases in cytotoxicity, IL-8, and IL-6 gene expression compared to a synthetic mixture of primary products that was created by injecting the correct concentrations of the detected products from the irradiation experiments.	Ozone	116-121	interleukin 6	Homo sapiens	180-184	
15379216-5	2004	Ozone exposure (3.0 ppm, 3 min) time-dependently changed the redox state, while increasing production of interleukin(IL)-8 and IL-6, mRNA and protein.	Ozone	0-5	interleukin 6	Homo sapiens	127-131	
10226072-8	1999	Furthermore, we found significant increases in the release of IL-4, IL-6, IL-8, and TNF-alpha of ozone-exposed (0.1 ppm) samples of atopic versus nonatopic patients and to a lesser extent for histamine following exposure to 0.15 ppm ozone.	Ozone	97-102	interleukin 6	Homo sapiens	68-72	
7988196-16	1994	CONCLUSIONS: We conclude that asthmatics exposed to ozone develop a significant BALF neutrophilia and increased levels of the cytokines, IL-8 and IL-6.	Ozone	52-57	interleukin 6	Homo sapiens	146-150