PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32108526-8 2020 SFN prevented SuHx-induced RV dysfunction and remodeling, reduced RV inflammation and fibrosis, upregulated Nrf2 expression and its downstream gene NQO1, and reduced the inflammatory mediator leucine-rich repeat and pyrin domain-containing 3 (NLRP3). suhx 14-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 108-112 32108526-11 2020 Thus, SuHx-induced RV and pulmonary dysfunction, inflammation, and fibrosis can be attenuated or prevented by SFN, supporting the rationale for further studies to investigate SFN and the role of Nrf2 and NLRP3 pathways in preclinical and clinical PAH studies.NEW & NOTEWORTHY Pulmonary arterial hypertension (PAH) in this murine model (SU5416 + hypoxia) is associated with early changes in right ventricular (RV) diastolic and systolic function. suhx 6-10 nuclear factor, erythroid derived 2, like 2 Mus musculus 195-199