PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11061552-8 2000 Furthermore, 15deltaPGJ2, but not troglitazone, up-regulates p53 expression and promotes trophoblast apoptosis. 15-deoxy-delta(12,14)-prostaglandin J2 13-24 tumor protein p53 Homo sapiens 61-64 26801686-3 2016 Therefore, the present study aimed to elucidate the impact of 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2, a stable PGD2 degradation product) on cell death/cell survival pathways in p53-deficient MG-63 OS cells. 15-deoxy-delta(12,14)-prostaglandin J2 62-88 tumor protein p53 Homo sapiens 175-178 16006125-1 2005 15-Deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2), a dehydration product of prostaglandin D2, is an important pharmacological molecule, which with the virtue of its electrophilicity, has been reported to covalently modify some cellular proteins (such as nuclear factor-kappa B (NF-kappaB), AP-1, p53, and thioredoxin) and elicit its physiological effects. 15-deoxy-delta(12,14)-prostaglandin J2 0-38 tumor protein p53 Homo sapiens 296-299 16006125-1 2005 15-Deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2), a dehydration product of prostaglandin D2, is an important pharmacological molecule, which with the virtue of its electrophilicity, has been reported to covalently modify some cellular proteins (such as nuclear factor-kappa B (NF-kappaB), AP-1, p53, and thioredoxin) and elicit its physiological effects. 15-deoxy-delta(12,14)-prostaglandin J2 40-48 tumor protein p53 Homo sapiens 296-299 16006125-3 2005 Another aim is to characterize whether p53 is a direct target for covalent modification by 15d-PGJ2. 15-deoxy-delta(12,14)-prostaglandin J2 91-99 tumor protein p53 Homo sapiens 39-42 16006125-7 2005 Further, comparative results indicate that p53 protein may also be a target for direct modification by 15d-PGJ2. 15-deoxy-delta(12,14)-prostaglandin J2 103-111 tumor protein p53 Homo sapiens 43-46 24568186-4 2014 Treatment of MCF-7 cells with 15d-PGJ2 led to time-dependent increases in the expression of p53 as well as HO-1. 15-deoxy-delta(12,14)-prostaglandin J2 30-38 tumor protein p53 Homo sapiens 92-95 24568186-5 2014 Upregulation of p53 expression by 15d-PGJ2 was abrogated by si-RNA knock-down of HO-1. 15-deoxy-delta(12,14)-prostaglandin J2 34-42 tumor protein p53 Homo sapiens 16-19 24568186-8 2014 We speculated that iron, a by-product of HO-1-catalyzed reactions, could mediate 15d-PGJ2-induced p53 expression. 15-deoxy-delta(12,14)-prostaglandin J2 81-89 tumor protein p53 Homo sapiens 98-101 24568186-9 2014 Upregulation of p53 expression by 15d-PGJ2 was abrogated by the iron chelator desferrioxamine in MCF-7 cells. 15-deoxy-delta(12,14)-prostaglandin J2 34-42 tumor protein p53 Homo sapiens 16-19 24568186-11 2014 When MCF-7 cells were treated with the Fe(2+)-specific chelator phenanthroline, 15d-PGJ2-induced p53 expression was attenuated. 15-deoxy-delta(12,14)-prostaglandin J2 80-88 tumor protein p53 Homo sapiens 97-100 18718914-0 2008 15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53. 15-deoxy-delta(12,14)-prostaglandin J2 0-38 tumor protein p53 Homo sapiens 130-133