PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18718914-0	2008	15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53.	15-deoxy-delta(12,14)-prostaglandin J2	0-38	tumor protein p53	Homo sapiens	130-133	
16006125-1	2005	15-Deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2), a dehydration product of prostaglandin D2, is an important pharmacological molecule, which with the virtue of its electrophilicity, has been reported to covalently modify some cellular proteins (such as nuclear factor-kappa B (NF-kappaB), AP-1, p53, and thioredoxin) and elicit its physiological effects.	15-deoxy-delta(12,14)-prostaglandin J2	0-38	tumor protein p53	Homo sapiens	296-299	
16006125-1	2005	15-Deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2), a dehydration product of prostaglandin D2, is an important pharmacological molecule, which with the virtue of its electrophilicity, has been reported to covalently modify some cellular proteins (such as nuclear factor-kappa B (NF-kappaB), AP-1, p53, and thioredoxin) and elicit its physiological effects.	15-deoxy-delta(12,14)-prostaglandin J2	40-48	tumor protein p53	Homo sapiens	296-299	
16006125-3	2005	Another aim is to characterize whether p53 is a direct target for covalent modification by 15d-PGJ2.	15-deoxy-delta(12,14)-prostaglandin J2	91-99	tumor protein p53	Homo sapiens	39-42	
16006125-7	2005	Further, comparative results indicate that p53 protein may also be a target for direct modification by 15d-PGJ2.	15-deoxy-delta(12,14)-prostaglandin J2	103-111	tumor protein p53	Homo sapiens	43-46	
24568186-4	2014	Treatment of MCF-7 cells with 15d-PGJ2 led to time-dependent increases in the expression of p53 as well as HO-1.	15-deoxy-delta(12,14)-prostaglandin J2	30-38	tumor protein p53	Homo sapiens	92-95	
24568186-5	2014	Upregulation of p53 expression by 15d-PGJ2 was abrogated by si-RNA knock-down of HO-1.	15-deoxy-delta(12,14)-prostaglandin J2	34-42	tumor protein p53	Homo sapiens	16-19	
24568186-8	2014	We speculated that iron, a by-product of HO-1-catalyzed reactions, could mediate 15d-PGJ2-induced p53 expression.	15-deoxy-delta(12,14)-prostaglandin J2	81-89	tumor protein p53	Homo sapiens	98-101	
24568186-9	2014	Upregulation of p53 expression by 15d-PGJ2 was abrogated by the iron chelator desferrioxamine in MCF-7 cells.	15-deoxy-delta(12,14)-prostaglandin J2	34-42	tumor protein p53	Homo sapiens	16-19	
24568186-11	2014	When MCF-7 cells were treated with the Fe(2+)-specific chelator phenanthroline, 15d-PGJ2-induced p53 expression was attenuated.	15-deoxy-delta(12,14)-prostaglandin J2	80-88	tumor protein p53	Homo sapiens	97-100	
11061552-8	2000	Furthermore, 15deltaPGJ2, but not troglitazone, up-regulates p53 expression and promotes trophoblast apoptosis.	15-deoxy-delta(12,14)-prostaglandin J2	13-24	tumor protein p53	Homo sapiens	61-64	
26801686-3	2016	Therefore, the present study aimed to elucidate the impact of 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2, a stable PGD2 degradation product) on cell death/cell survival pathways in p53-deficient MG-63 OS cells.	15-deoxy-delta(12,14)-prostaglandin J2	62-88	tumor protein p53	Homo sapiens	175-178