PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19494510-0	2009	15-Deoxy-Delta(12,14)-prostaglandin J2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H292).	15-deoxy-delta(12,14)-prostaglandin J2	0-38	C-X-C motif chemokine ligand 8	Homo sapiens	47-51	
19494510-4	2009	Although our studies have shown that PGD2 (metabolic precursor of 15d-PGJ2) induces IL-8 and GM-CSF production, the role of 15d-PGJ2 (metabolite of PGD2) is unknown in human bronchial epithelial cells.	15-deoxy-delta(12,14)-prostaglandin J2	66-74	C-X-C motif chemokine ligand 8	Homo sapiens	84-88	
19494510-8	2009	RESULTS: We demonstrated that 15d-PGJ2 induced production of IL-8 and GM-CSF from NCI-H292.	15-deoxy-delta(12,14)-prostaglandin J2	30-38	C-X-C motif chemokine ligand 8	Homo sapiens	61-65	
11801678-0	2002	15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway.	15-deoxy-delta(12,14)-prostaglandin J2	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	34-38	
14518569-8	2003	15d-PGJ2 induced, by itself, the expression of interleukin-8, a potent proinflammatory chemokine, in HUVEC.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	47-60	
19494510-12	2009	CONCLUSION: These data showed that 15d-PGJ2 is a potent inducer of IL-8 and GM-CSF production through ERK1/2 kinase activation, but this is independent of CRTH2 or PPARgamma activation.	15-deoxy-delta(12,14)-prostaglandin J2	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	67-71	
33033709-8	2020	15d-PGJ2-induced up-regulation of IL-8/CXCL8 expression was abrogated by silencing of Snail short interfering RNA.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	34-38	
11755918-3	2002	We report for the first time that the expression of human IL-8 gene in THP-1 macrophages is upregulated in a time- and concentration-dependent manner by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2), which is a natural ligand for activation of peroxisome proliferator-activated receptor-gamma transcription factor.	15-deoxy-delta(12,14)-prostaglandin J2	220-228	C-X-C motif chemokine ligand 8	Homo sapiens	58-62	
11755918-4	2002	Studies to identify the signal transduction pathways involved showed that IL-8 upregulation-mediated by 15d-PGJ2 was markedly inhibited when the THP-1 macrophages were incubated with a highly selective and cell-permeable inhibitor of the mitogen-activated protein kinase (MAPK) signaling pathway, 2"-amino-3"-methoxyflavone (PD98059).	15-deoxy-delta(12,14)-prostaglandin J2	104-112	C-X-C motif chemokine ligand 8	Homo sapiens	74-78	
11755918-5	2002	This inhibition was concentration-dependent, suggesting that 15d-PGJ2 regulates the expression of IL-8 gene in THP-1 macrophages through a MAPK signaling pathway.	15-deoxy-delta(12,14)-prostaglandin J2	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	98-102	
11577781-2	2001	We investigated the influence of PPARgamma-ligands, 15-deoxy-delta12,14 prostaglandin-J2 (15d-PGJ2), and ciglitazone, on the generation of interleukin-8 (IL-8) by the human microvascular endothelial cell line (HMEC- 1).	15-deoxy-delta(12,14)-prostaglandin J2	90-98	C-X-C motif chemokine ligand 8	Homo sapiens	139-152	
11577781-7	2001	15d-PGJ2 potently and dose-dependently increased both the steady-state and LPS-induced generation of IL-8 mRNA and IL-8 protein.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	101-105	
11577781-7	2001	15d-PGJ2 potently and dose-dependently increased both the steady-state and LPS-induced generation of IL-8 mRNA and IL-8 protein.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	115-119	
11577781-9	2001	We conclude, that 15d-PGJ2 is a potent inducer of IL-8 production and can be a mediator of inflammatory response, but this effect is independent of PPARgamma activation.	15-deoxy-delta(12,14)-prostaglandin J2	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	50-54	
11390455-3	2001	Here we demonstrate that the 15d-PGJ2 can induce IL-8 gene expression.	15-deoxy-delta(12,14)-prostaglandin J2	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	49-53	
11390455-5	2001	Furthermore, concomitant treatment of monocytes/macrophages with 15d-PGJ2 (2.5 x 10(-6) M) potentiated LPS-induced gene expression of IL-8 mRNA, but suppressed PMA-induction of IL-8 mRNA.	15-deoxy-delta(12,14)-prostaglandin J2	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	134-138	
11390455-5	2001	Furthermore, concomitant treatment of monocytes/macrophages with 15d-PGJ2 (2.5 x 10(-6) M) potentiated LPS-induced gene expression of IL-8 mRNA, but suppressed PMA-induction of IL-8 mRNA.	15-deoxy-delta(12,14)-prostaglandin J2	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	177-181	
11390455-6	2001	In addition, treatment of U937 and THP-1 cells with 15d-PGJ2 also resulted in induction of IL-8 gene expression.	15-deoxy-delta(12,14)-prostaglandin J2	52-60	C-X-C motif chemokine ligand 8	Homo sapiens	91-95	
11390455-7	2001	Further studies demonstrated that 15d-PGJ2 regulated IL-8 gene expression via a ligand-specific and PPARgamma-dependent pathway.	15-deoxy-delta(12,14)-prostaglandin J2	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	53-57	
33033709-8	2020	15d-PGJ2-induced up-regulation of IL-8/CXCL8 expression was abrogated by silencing of Snail short interfering RNA.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	39-44	
26535717-7	2015	The expression of NF-kappaBp65 and IL-8 in CSE-stimulated normal HBE cells was inhibited by 15d-PGJ2 at both the mRNA level and the protein level.	15-deoxy-delta(12,14)-prostaglandin J2	92-100	C-X-C motif chemokine ligand 8	Homo sapiens	35-39	
24204381-8	2013	These results suggest that 15d-PGJ2 suppresses activin-induced ActR and Smad expression, down-regulates IL-6 production, and up-regulates IL-8 production via suppression of NF- kappa B and MAPK signaling pathway in HepG2 cells.	15-deoxy-delta(12,14)-prostaglandin J2	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	138-142	
20174873-0	2011	Effects of 15-deoxy- 12,14-prostaglandin J2 on the production of IL-8 and the expression of Toll-like receptor 2 in human primary keratinocytes stimulated with lipopolysaccharide.	15-deoxy-delta(12,14)-prostaglandin J2	11-43	C-X-C motif chemokine ligand 8	Homo sapiens	65-69