PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31838715-3	2020	Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin alphavbeta3 on tumor cells and platelets.	Thyroxine	19-30	integrin subunit alpha V	Homo sapiens	86-106	
34775877-1	2022	BACKGROUND: Integrin alphavbeta3 is a cell membrane structural protein whose extracellular domain contains a receptor for L-thyroxine (T4).	Thyroxine	122-133	integrin subunit alpha V	Homo sapiens	12-32	
34234745-1	2021	L-Thyroxine (T4) is the principal ligand of the thyroid hormone analogue receptor on the extracellular domain of integrin alphavbeta3.	Thyroxine	0-11	integrin subunit alpha V	Homo sapiens	113-133	
35448512-1	2022	Chemically modified forms of tetraiodothyroacetic acid (tetrac), an L-thyroxine derivative, have been shown to exert their anticancer activity at plasma membrane integrin alphavbeta3 of tumor cells.	Thyroxine	68-79	integrin subunit alpha V	Homo sapiens	162-182	
35237605-5	2022	In our previous study, thyroxine hormones can interact with integrin alphavbeta3 to activate the extracellular signal-regulated kinase 1/2 (ERK1/2), and upregulate programmed death-ligand 1 (PD-L1) expression.	Thyroxine	23-32	integrin subunit alpha V	Homo sapiens	60-80	
35237605-11	2022	Our findings show that modulation on integrin alphavbeta3 binding activities changed both thyroxine- and doxycycline-induced signal transductions by an integrin alphavbeta3 inhibitor (HSDVHK-NH2).	Thyroxine	90-99	integrin subunit alpha V	Homo sapiens	37-57	
35237605-11	2022	Our findings show that modulation on integrin alphavbeta3 binding activities changed both thyroxine- and doxycycline-induced signal transductions by an integrin alphavbeta3 inhibitor (HSDVHK-NH2).	Thyroxine	90-99	integrin subunit alpha V	Homo sapiens	152-172	
33827580-7	2021	In this review, we evaluate the contribution of thyroxine interacting with integrin alphavbeta3 and crosstalking with EGFR/Ras signaling pathway non-genomically in CRC proliferation.	Thyroxine	48-57	integrin subunit alpha V	Homo sapiens	75-95	
32584192-3	2021	The principal ligand for this receptor is L-thyroxine (T4), usually regarded only as a prohormone for 3,5,3"-triiodo-L-thyronine (T3), the hormone analogue that expresses thyroid hormone in the cell nucleus via nuclear receptors that are unrelated structurally to integrin alphavbeta3.	Thyroxine	42-53	integrin subunit alpha V	Homo sapiens	264-284	
31714064-3	2019	Tetraiodothyroacetic acid (tetrac), a deaminated derivative of l-thyroxine (T4), is a "thyrointegrin" antagonist that blocks the actions of l-triiodothyronine (T3) and T4 with an interaction site that is located at or near the RGD recognition site identified on integrin alphavbeta3"s binding pocket (thyrointegrin alphavbeta3 receptors).	Thyroxine	63-74	integrin subunit alpha V	Homo sapiens	262-282	
31507530-1	2019	Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin alphavbeta3.	Thyroxine	151-160	integrin subunit alpha V	Homo sapiens	186-206	
31600974-4	2019	Additionally, L-thyroxine (T4) binding to integrin alphavbeta3 is reported to induce gene expression through initiating non-genomic actions, further influencing angiogenesis and cell proliferation.	Thyroxine	14-25	integrin subunit alpha V	Homo sapiens	42-62	
31528253-3	2019	Acting at a cell surface receptor on plasma membrane integrin alphavbeta3, thyroxine stimulates intracellular accumulation of PD-L1 in cancer cells.	Thyroxine	75-84	integrin subunit alpha V	Homo sapiens	53-73	
29742907-3	2018	Genomic actions of thyroid hormone as 3,5,3"-triiodo-L-thyronine (T3) via a nuclear thyroid hormone receptor have been implicated, but recent evidence shows that nongenomic mechanisms initiated at the receptor for L-thyroxine (T4) on platelet integrin alphavbeta3 are prothrombotic.	Thyroxine	214-225	integrin subunit alpha V	Homo sapiens	243-263	
29407448-4	2018	Reviewed here are nongenomic effects of the hormone-T3 or, in some cases, l-thyroxine (T4)-that are initiated at (a) truncated TRalpha isoforms, e.g., p30 TRalpha1, (b) cytoplasmic proteins, or (c) plasma membrane integrin alphavbeta3.	Thyroxine	74-85	integrin subunit alpha V	Homo sapiens	214-234	
29125479-2	2018	On the other hand, L-thyroxine (T4), via a thyroid hormone receptor on plasma membrane integrin alphavbeta3, promotes solid tumor growth and neoangiogenesis, therefore lowering endogenous T4 reduces tumor growth rate.	Thyroxine	19-30	integrin subunit alpha V	Homo sapiens	87-107	
29555649-1	2018	Thyroid hormone, l-thyroxine (T4), has been shown to promote ovarian cancer cell proliferation via a receptor on plasma membrane integrin alphavbeta3 and to induce the activation of ERK1/2 and expression of programmed death-ligand 1 (PD-L1) in cancer cells.	Thyroxine	17-28	integrin subunit alpha V	Homo sapiens	129-149	
25866761-3	2015	A cell surface receptor for thyroid hormone on integrin alphavbeta3 also binds tetraiodothyroacetic acid (tetrac), a derivative of L-thyroxine (T4) that blocks nongenomic actions of T4 and of 3,5,3"-triiodo-L-thyronine (T3) at alphavbeta3.	Thyroxine	131-142	integrin subunit alpha V	Homo sapiens	47-67	
19903697-1	2010	The endogenous thyroid hormones L-thyroxine (T(4)) and 3,5,3"-triiodo-L-thyronine (T(3)) induce angiogenesis via an endothelial cell iodothyronine receptor on integrin alphaVbeta3.	Thyroxine	32-43	integrin subunit alpha V	Homo sapiens	159-179	
24532656-5	2014	Therefore, we examined the hypothesis that a novel signaling pathway through integrin alphavbeta3/PKD/HDAC5 might contribute to thyroxine (T4)-induced angiogenesis.	Thyroxine	128-137	integrin subunit alpha V	Homo sapiens	77-97	
16849576-1	2006	Recent evidence suggests that the thyroid hormone L-thyroxine (T4) stimulates growth of cancer cells via a plasma membrane receptor on integrin alphaVbeta3.	Thyroxine	50-61	integrin subunit alpha V	Homo sapiens	135-155	
20187783-1	2010	BACKGROUND: Tetraiodothyroacetic acid (tetrac) is a deaminated analogue of L-thyroxine that blocks the actions of L-thyroxine and 3,5,3"-triiodo-L-thyronine at the cell surface receptor for thyroid hormone on integrin alpha v beta 3.	Thyroxine	75-86	integrin subunit alpha V	Homo sapiens	209-232	
20187783-1	2010	BACKGROUND: Tetraiodothyroacetic acid (tetrac) is a deaminated analogue of L-thyroxine that blocks the actions of L-thyroxine and 3,5,3"-triiodo-L-thyronine at the cell surface receptor for thyroid hormone on integrin alpha v beta 3.	Thyroxine	114-125	integrin subunit alpha V	Homo sapiens	209-232	
18310446-1	2008	The aim of the present study was to examine whether triiodo-l-thyronine (T(3)) or l-thyroxine (T(4)) rapidly activated the mitogen-activated protein kinase (MAPK) intracellular signalling cascade in osteoblast-like cells and investigate whether this activation was initiated at the integrin alpha(V)beta(3) cell surface receptor.	Thyroxine	82-93	integrin subunit alpha V	Homo sapiens	282-305