PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20187783-1 2010 BACKGROUND: Tetraiodothyroacetic acid (tetrac) is a deaminated analogue of L-thyroxine that blocks the actions of L-thyroxine and 3,5,3"-triiodo-L-thyronine at the cell surface receptor for thyroid hormone on integrin alpha v beta 3. Thyroxine 75-86 integrin subunit alpha V Homo sapiens 209-232 19903697-1 2010 The endogenous thyroid hormones L-thyroxine (T(4)) and 3,5,3"-triiodo-L-thyronine (T(3)) induce angiogenesis via an endothelial cell iodothyronine receptor on integrin alphaVbeta3. Thyroxine 32-43 integrin subunit alpha V Homo sapiens 159-179 20187783-1 2010 BACKGROUND: Tetraiodothyroacetic acid (tetrac) is a deaminated analogue of L-thyroxine that blocks the actions of L-thyroxine and 3,5,3"-triiodo-L-thyronine at the cell surface receptor for thyroid hormone on integrin alpha v beta 3. Thyroxine 114-125 integrin subunit alpha V Homo sapiens 209-232 18310446-1 2008 The aim of the present study was to examine whether triiodo-l-thyronine (T(3)) or l-thyroxine (T(4)) rapidly activated the mitogen-activated protein kinase (MAPK) intracellular signalling cascade in osteoblast-like cells and investigate whether this activation was initiated at the integrin alpha(V)beta(3) cell surface receptor. Thyroxine 82-93 integrin subunit alpha V Homo sapiens 282-305 31600974-4 2019 Additionally, L-thyroxine (T4) binding to integrin alphavbeta3 is reported to induce gene expression through initiating non-genomic actions, further influencing angiogenesis and cell proliferation. Thyroxine 14-25 integrin subunit alpha V Homo sapiens 42-62 34775877-1 2022 BACKGROUND: Integrin alphavbeta3 is a cell membrane structural protein whose extracellular domain contains a receptor for L-thyroxine (T4). Thyroxine 122-133 integrin subunit alpha V Homo sapiens 12-32 35237605-5 2022 In our previous study, thyroxine hormones can interact with integrin alphavbeta3 to activate the extracellular signal-regulated kinase 1/2 (ERK1/2), and upregulate programmed death-ligand 1 (PD-L1) expression. Thyroxine 23-32 integrin subunit alpha V Homo sapiens 60-80 35237605-11 2022 Our findings show that modulation on integrin alphavbeta3 binding activities changed both thyroxine- and doxycycline-induced signal transductions by an integrin alphavbeta3 inhibitor (HSDVHK-NH2). Thyroxine 90-99 integrin subunit alpha V Homo sapiens 37-57 35237605-11 2022 Our findings show that modulation on integrin alphavbeta3 binding activities changed both thyroxine- and doxycycline-induced signal transductions by an integrin alphavbeta3 inhibitor (HSDVHK-NH2). Thyroxine 90-99 integrin subunit alpha V Homo sapiens 152-172 33827580-7 2021 In this review, we evaluate the contribution of thyroxine interacting with integrin alphavbeta3 and crosstalking with EGFR/Ras signaling pathway non-genomically in CRC proliferation. Thyroxine 48-57 integrin subunit alpha V Homo sapiens 75-95 32584192-3 2021 The principal ligand for this receptor is L-thyroxine (T4), usually regarded only as a prohormone for 3,5,3"-triiodo-L-thyronine (T3), the hormone analogue that expresses thyroid hormone in the cell nucleus via nuclear receptors that are unrelated structurally to integrin alphavbeta3. Thyroxine 42-53 integrin subunit alpha V Homo sapiens 264-284 16849576-1 2006 Recent evidence suggests that the thyroid hormone L-thyroxine (T4) stimulates growth of cancer cells via a plasma membrane receptor on integrin alphaVbeta3. Thyroxine 50-61 integrin subunit alpha V Homo sapiens 135-155 34234745-1 2021 L-Thyroxine (T4) is the principal ligand of the thyroid hormone analogue receptor on the extracellular domain of integrin alphavbeta3. Thyroxine 0-11 integrin subunit alpha V Homo sapiens 113-133 35448512-1 2022 Chemically modified forms of tetraiodothyroacetic acid (tetrac), an L-thyroxine derivative, have been shown to exert their anticancer activity at plasma membrane integrin alphavbeta3 of tumor cells. Thyroxine 68-79 integrin subunit alpha V Homo sapiens 162-182 31838715-3 2020 Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin alphavbeta3 on tumor cells and platelets. Thyroxine 19-30 integrin subunit alpha V Homo sapiens 86-106 31714064-3 2019 Tetraiodothyroacetic acid (tetrac), a deaminated derivative of l-thyroxine (T4), is a "thyrointegrin" antagonist that blocks the actions of l-triiodothyronine (T3) and T4 with an interaction site that is located at or near the RGD recognition site identified on integrin alphavbeta3"s binding pocket (thyrointegrin alphavbeta3 receptors). Thyroxine 63-74 integrin subunit alpha V Homo sapiens 262-282 31528253-3 2019 Acting at a cell surface receptor on plasma membrane integrin alphavbeta3, thyroxine stimulates intracellular accumulation of PD-L1 in cancer cells. Thyroxine 75-84 integrin subunit alpha V Homo sapiens 53-73 31507530-1 2019 Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin alphavbeta3. Thyroxine 151-160 integrin subunit alpha V Homo sapiens 186-206 29742907-3 2018 Genomic actions of thyroid hormone as 3,5,3"-triiodo-L-thyronine (T3) via a nuclear thyroid hormone receptor have been implicated, but recent evidence shows that nongenomic mechanisms initiated at the receptor for L-thyroxine (T4) on platelet integrin alphavbeta3 are prothrombotic. Thyroxine 214-225 integrin subunit alpha V Homo sapiens 243-263 29125479-2 2018 On the other hand, L-thyroxine (T4), via a thyroid hormone receptor on plasma membrane integrin alphavbeta3, promotes solid tumor growth and neoangiogenesis, therefore lowering endogenous T4 reduces tumor growth rate. Thyroxine 19-30 integrin subunit alpha V Homo sapiens 87-107 29555649-1 2018 Thyroid hormone, l-thyroxine (T4), has been shown to promote ovarian cancer cell proliferation via a receptor on plasma membrane integrin alphavbeta3 and to induce the activation of ERK1/2 and expression of programmed death-ligand 1 (PD-L1) in cancer cells. Thyroxine 17-28 integrin subunit alpha V Homo sapiens 129-149 24532656-5 2014 Therefore, we examined the hypothesis that a novel signaling pathway through integrin alphavbeta3/PKD/HDAC5 might contribute to thyroxine (T4)-induced angiogenesis. Thyroxine 128-137 integrin subunit alpha V Homo sapiens 77-97 25866761-3 2015 A cell surface receptor for thyroid hormone on integrin alphavbeta3 also binds tetraiodothyroacetic acid (tetrac), a derivative of L-thyroxine (T4) that blocks nongenomic actions of T4 and of 3,5,3"-triiodo-L-thyronine (T3) at alphavbeta3. Thyroxine 131-142 integrin subunit alpha V Homo sapiens 47-67 29407448-4 2018 Reviewed here are nongenomic effects of the hormone-T3 or, in some cases, l-thyroxine (T4)-that are initiated at (a) truncated TRalpha isoforms, e.g., p30 TRalpha1, (b) cytoplasmic proteins, or (c) plasma membrane integrin alphavbeta3. Thyroxine 74-85 integrin subunit alpha V Homo sapiens 214-234