PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15680959-0 2005 Alterations in morphine-induced reward, locomotor activity, and thermoregulation in CREB-deficient mice. Morphine 15-23 cAMP responsive element binding protein 1 Mus musculus 84-88 15680959-5 2005 Morphine-induced thermoregulation is attenuated in CREB(alphaDelta) mutant mice at high doses of morphine compared to wild type animals. Morphine 97-105 cAMP responsive element binding protein 1 Mus musculus 51-55 15680959-6 2005 The behavioral differences in response to morphine seen in CREB(alphaDelta) mutant mice are not due to changes in mu opioid receptor (MOR) mRNA expression, as the CREB deletion has no effect on baseline MOR mRNA in three of the brain regions involved in mediating these behaviors: the ventral tegmental area (VTA), nucleus accumbens (NAc), and hypothalamus. Morphine 42-50 cAMP responsive element binding protein 1 Mus musculus 59-63 15680959-7 2005 These data demonstrate that at low doses, deficits in morphine-induced changes in CREB deficient mice are limited to reward and thermoregulation. Morphine 54-62 cAMP responsive element binding protein 1 Mus musculus 82-86 15680959-8 2005 However, at higher doses, CREB mutant mice actually find morphine more rewarding and exhibit increased locomotor activity compared to their wild type littermates. Morphine 57-65 cAMP responsive element binding protein 1 Mus musculus 26-30 15680959-9 2005 Together, these results indicate that the role of CREB in dose-dependent changes in behaviors induced by morphine is different depending on the brain regions involved in mediating the behavior. Morphine 105-113 cAMP responsive element binding protein 1 Mus musculus 50-54 15680959-1 2005 Previous studies in our lab have shown a robust decrease in the rewarding properties of morphine in CREB(alphaDelta) mutant mice. Morphine 88-96 cAMP responsive element binding protein 1 Mus musculus 100-104 15680959-3 2005 At low doses of morphine (5 and 10 mg/kg), CREB(alphaDelta) mutant mice show a reduction in reward yet similar locomotor activity in response to morphine compared to wild type littermates. Morphine 16-24 cAMP responsive element binding protein 1 Mus musculus 43-47 15680959-3 2005 At low doses of morphine (5 and 10 mg/kg), CREB(alphaDelta) mutant mice show a reduction in reward yet similar locomotor activity in response to morphine compared to wild type littermates. Morphine 145-153 cAMP responsive element binding protein 1 Mus musculus 43-47 15680959-5 2005 Morphine-induced thermoregulation is attenuated in CREB(alphaDelta) mutant mice at high doses of morphine compared to wild type animals. Morphine 0-8 cAMP responsive element binding protein 1 Mus musculus 51-55 15029152-0 2004 Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. Morphine 40-48 cAMP responsive element binding protein 1 Mus musculus 63-67 15451364-4 2004 The results showed that F9202, F9204 or morphine, which could induce CPP, enhanced CREB phosphorylation and the expression of CaMKIV in hippocampus from CPP mice without affecting total CREB protein level. Morphine 40-48 cAMP responsive element binding protein 1 Mus musculus 83-87 15451364-4 2004 The results showed that F9202, F9204 or morphine, which could induce CPP, enhanced CREB phosphorylation and the expression of CaMKIV in hippocampus from CPP mice without affecting total CREB protein level. Morphine 40-48 cAMP responsive element binding protein 1 Mus musculus 186-190 15451364-5 2004 The CREB phosphorylation of cultured hippocampal neurons was also enhanced and reached its peak level at 30 min upon exposure to F9202 (100 nM), F9204 (100 nM) or morphine (1 microM), while the total CREB protein level was not altered. Morphine 163-171 cAMP responsive element binding protein 1 Mus musculus 4-8 15451364-5 2004 The CREB phosphorylation of cultured hippocampal neurons was also enhanced and reached its peak level at 30 min upon exposure to F9202 (100 nM), F9204 (100 nM) or morphine (1 microM), while the total CREB protein level was not altered. Morphine 163-171 cAMP responsive element binding protein 1 Mus musculus 200-204 15451364-6 2004 KN-62 (10 microM), an inhibitor of CaM kinases, prevented CREB phosphorylation induced by morphine, F9202, and F9204 without change of total CREB level. Morphine 90-98 cAMP responsive element binding protein 1 Mus musculus 58-62 14975676-10 2004 In contrast, chronic morphine treatment in mu-KO mice, but not in delta- or kappa-KO, resulted in a paradoxical upregulation of Galphai1/2 (12-19%), PKA (19-21%,) and phosphorylated CREB (21-73%), but not total CREB, in cortex and/or striatum. Morphine 21-29 cAMP responsive element binding protein 1 Mus musculus 182-186 14975676-10 2004 In contrast, chronic morphine treatment in mu-KO mice, but not in delta- or kappa-KO, resulted in a paradoxical upregulation of Galphai1/2 (12-19%), PKA (19-21%,) and phosphorylated CREB (21-73%), but not total CREB, in cortex and/or striatum. Morphine 21-29 cAMP responsive element binding protein 1 Mus musculus 211-215 14622103-7 2003 However, morphine-induced increases of phospho-CREB levels are seen in the VTA of wild-type mice but not CREBalphaDelta mutant mice. Morphine 9-17 cAMP responsive element binding protein 1 Mus musculus 47-51 12643347-6 2003 Ketamine could suppress not only the place preference but also the phosphorylation of CREB produced by morphine, F9202 and F9204. Morphine 103-111 cAMP responsive element binding protein 1 Mus musculus 86-90 11717377-9 2001 We demonstrate that the aversive properties of morphine are still present in CREB mutant mice despite a reduction of physical withdrawal. Morphine 47-55 cAMP responsive element binding protein 1 Mus musculus 77-81 12165570-4 2002 Using viral-mediated gene transfer to locally alter the activity of CREB, we show that this manipulation affects morphine reward, as well as the preference for sucrose, a more natural reward. Morphine 113-121 cAMP responsive element binding protein 1 Mus musculus 68-72 11979726-5 2002 In conclusion, the results of mutant mice suggest that the alternation of catecholamine biosynthesis and cAMP signal pathways may play a key role in development of latent learning and morphine dependence, and they furthermore show that the expression of genes mediated by phosphorylated CREB may be involved in the development of latent learning and morphine dependence. Morphine 184-192 cAMP responsive element binding protein 1 Mus musculus 287-291 11979726-5 2002 In conclusion, the results of mutant mice suggest that the alternation of catecholamine biosynthesis and cAMP signal pathways may play a key role in development of latent learning and morphine dependence, and they furthermore show that the expression of genes mediated by phosphorylated CREB may be involved in the development of latent learning and morphine dependence. Morphine 350-358 cAMP responsive element binding protein 1 Mus musculus 287-291 8662559-0 1996 Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB. Morphine 13-21 cAMP responsive element binding protein 1 Mus musculus 78-82 10708700-3 2000 The effect of morphine on the level of the transcription factor CREB, as well as CREB phosphorylation, was investigated in NG108-15 cells. Morphine 14-22 cAMP responsive element binding protein 1 Mus musculus 64-68 10708700-4 2000 Morphine and the delta-opioid receptor agonist [D-Pen(2,5)]enkephalin (DPDPE) produced a dose-dependent increase in CREB phosphorylation. Morphine 0-8 cAMP responsive element binding protein 1 Mus musculus 116-120 10507546-3 1999 Western blots demonstrate a 1.9-fold increase in cyclic AMP response element binding protein (CREB) and a 2.4-fold increase phospho-CREB immunoreactivities in spinal cord homogenates from morphine tolerant animals. Morphine 188-196 cAMP responsive element binding protein 1 Mus musculus 132-136 34512242-0 2021 Effect of Electro-Acupuncture at ST36 and SP6 on the cAMP -CREB Pathway and mRNA Expression Profile in the Brainstem of Morphine Tolerant Mice. Morphine 120-128 cAMP responsive element binding protein 1 Mus musculus 59-63 34647651-8 2022 Local infusion of D1R antagonist SCH-23390 reverses the morphine-induced synaptic abnormalities and activation of the D1R-ERK-CREB pathway in medial prefrontal cortex (mPFC). Morphine 56-64 cAMP responsive element binding protein 1 Mus musculus 126-130 34512242-12 2021 Similarly, western blot revealed the phosphorylation levels of PKA, ERK, and CREB were up-regulated in morphine tolerant mice, whereas the EA group showed a significantly reduced expression level instead. Morphine 103-111 cAMP responsive element binding protein 1 Mus musculus 77-81 32252200-12 2020 The DNA-binding activity of CREB in the saline group was (0.23+-0.07) Pu, significantly lower than (0.89+-0.23) Pu of morphine combined with naloxone group and (0.80+-0.23) Pu of morphine group (P<0.05). Morphine 118-126 cAMP responsive element binding protein 1 Mus musculus 28-32 33609567-10 2021 Suvorexant decreased morphine-enhanced levels of CREB and p-ERK proteins but did not affect the expression of NMDA and AMPA proteins compared to the morphine group. Morphine 21-29 cAMP responsive element binding protein 1 Mus musculus 49-53 32304763-11 2020 In C57BL/6 mice, 17-AAG decreased morphine-induced acute anti-nociception in the hot plate test, with an increase in phosphorylated PKA and phosphorylated JNK and a decrease in phosphorylated CREB and phosphorylated ERK in murine brains. Morphine 34-42 cAMP responsive element binding protein 1 Mus musculus 192-196 32113678-7 2020 Significantly reduced phosphorylation of cAMP-response element binding protein (CREB) in the mPFC was observed in the mice exposed to morphine after the extinction training. Morphine 134-142 cAMP responsive element binding protein 1 Mus musculus 41-78 32113678-7 2020 Significantly reduced phosphorylation of cAMP-response element binding protein (CREB) in the mPFC was observed in the mice exposed to morphine after the extinction training. Morphine 134-142 cAMP responsive element binding protein 1 Mus musculus 80-84 32252200-12 2020 The DNA-binding activity of CREB in the saline group was (0.23+-0.07) Pu, significantly lower than (0.89+-0.23) Pu of morphine combined with naloxone group and (0.80+-0.23) Pu of morphine group (P<0.05). Morphine 179-187 cAMP responsive element binding protein 1 Mus musculus 28-32 32252200-13 2020 While the CREB DNA binding activity of morphine combined with compound matrine injection (300 mg/kg) group was (0.79+-0.21) Pu, implicated that compound matrine had marginal effect on the DNA-binding activity of CREB (P>0.05). Morphine 39-47 cAMP responsive element binding protein 1 Mus musculus 10-14 32252200-13 2020 While the CREB DNA binding activity of morphine combined with compound matrine injection (300 mg/kg) group was (0.79+-0.21) Pu, implicated that compound matrine had marginal effect on the DNA-binding activity of CREB (P>0.05). Morphine 39-47 cAMP responsive element binding protein 1 Mus musculus 212-216 30227624-6 2018 Moreover, sinomenine inhibited the expressions of p-NMDAR1/NMDAR1, p-CAMKII/CAMKII, and p-CREB/CREB in the hippocampusof morphine-dependent mice and SH-SY5Y cells. Morphine 121-129 cAMP responsive element binding protein 1 Mus musculus 90-94 31081159-11 2019 In addition, repeated morphine administration decreased the expression of postsynaptic density protein 95 (PSD95) and cAMP response element binding protein (CREB) phosphorylation in the prefrontal cortex (PFC) and hippocampus (HIP), and these effects were significantly reversed by naloxone in PFC. Morphine 22-30 cAMP responsive element binding protein 1 Mus musculus 118-155 31081159-11 2019 In addition, repeated morphine administration decreased the expression of postsynaptic density protein 95 (PSD95) and cAMP response element binding protein (CREB) phosphorylation in the prefrontal cortex (PFC) and hippocampus (HIP), and these effects were significantly reversed by naloxone in PFC. Morphine 22-30 cAMP responsive element binding protein 1 Mus musculus 157-161 30227624-6 2018 Moreover, sinomenine inhibited the expressions of p-NMDAR1/NMDAR1, p-CAMKII/CAMKII, and p-CREB/CREB in the hippocampusof morphine-dependent mice and SH-SY5Y cells. Morphine 121-129 cAMP responsive element binding protein 1 Mus musculus 95-99 23745716-5 2013 Morphine exposure induced an increase in CREB phosphorylated at Ser133 in the PVN and central amygdale (CeA), whereas mice exhibiting morphine CPP had higher levels of pCREB in the PVN, CeA and bed nucleus of the stria terminalis (BNST). Morphine 0-8 cAMP responsive element binding protein 1 Mus musculus 41-45 28611691-0 2017 Morphine Reward Promotes Cue-Sensitive Learning: Implication of Dorsal Striatal CREB Activity. Morphine 0-8 cAMP responsive element binding protein 1 Mus musculus 80-84 26313266-0 2015 CP-154,526 Modifies CREB Phosphorylation and Thioredoxin-1 Expression in the Dentate Gyrus following Morphine-Induced Conditioned Place Preference. Morphine 101-109 cAMP responsive element binding protein 1 Mus musculus 20-24 23682813-5 2014 Furthermore, NaHS also attenuated morphine/naloxone-elevated mRNA levels of AC isoform 1 and 8, production of cAMP, and phosphorylation of cAMP response element-binding protein (CREB) in mice striatum. Morphine 34-42 cAMP responsive element binding protein 1 Mus musculus 139-176 23682813-5 2014 Furthermore, NaHS also attenuated morphine/naloxone-elevated mRNA levels of AC isoform 1 and 8, production of cAMP, and phosphorylation of cAMP response element-binding protein (CREB) in mice striatum. Morphine 34-42 cAMP responsive element binding protein 1 Mus musculus 178-182 27461790-0 2016 Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus. Morphine 67-75 cAMP responsive element binding protein 1 Mus musculus 149-153 27461790-8 2016 Both morphine CPP and NO-CPP induced an upregulation of ERK, CREB phosphorylation and BDNF expression. Morphine 5-13 cAMP responsive element binding protein 1 Mus musculus 61-65 27461790-11 2016 (2) CB1R antagonist mediated blockade of ERK-CREB-BDNF signaling activation in the NAc and hippocampus may be an important mechanism underlying the attenuation of morphine CPP. Morphine 163-171 cAMP responsive element binding protein 1 Mus musculus 45-49 22454534-6 2012 In contrast to the CREB stimulation found in NG108-15 cells, we observed an inhibitory effect of morphine in F11 cells, indicating cell type-specific regulation of CREB by morphine. Morphine 172-180 cAMP responsive element binding protein 1 Mus musculus 164-168 24073333-0 2013 Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake. Morphine 104-112 cAMP responsive element binding protein 1 Mus musculus 30-34 24073333-4 2013 Chronic morphine pellet implantation for 7 days raised P-CREB levels in the LH, VTA, and dorsomedial nucleus of the hypothalamus (DM) but not in the nucleus accumbens and amygdala. Morphine 8-16 cAMP responsive element binding protein 1 Mus musculus 57-61 24073333-5 2013 Increased P-CREB levels in LH, VTA, and DM following 7-day treatment with morphine pellets and increased P-CREB levels in the VTA following escalating doses of morphine were associated with decreased food intake and body weight. Morphine 74-82 cAMP responsive element binding protein 1 Mus musculus 12-16 24073333-5 2013 Increased P-CREB levels in LH, VTA, and DM following 7-day treatment with morphine pellets and increased P-CREB levels in the VTA following escalating doses of morphine were associated with decreased food intake and body weight. Morphine 160-168 cAMP responsive element binding protein 1 Mus musculus 107-111 24073333-6 2013 CONCLUSION: The morphine regulation of P-CREB may explain some of the physiological sequelae of opioid exposure including altered food intake and body weight. Morphine 16-24 cAMP responsive element binding protein 1 Mus musculus 41-45 22454534-4 2012 Previous studies with glioma cell lines such as NG108-15 cells attributed morphine-induced gene expression to the activation of the cAMP-responsive element binding protein (CREB). Morphine 74-82 cAMP responsive element binding protein 1 Mus musculus 132-171 22454534-4 2012 Previous studies with glioma cell lines such as NG108-15 cells attributed morphine-induced gene expression to the activation of the cAMP-responsive element binding protein (CREB). Morphine 74-82 cAMP responsive element binding protein 1 Mus musculus 173-177 22454534-5 2012 Thus, we also analyzed morphine-dependent activation of CREB in F11 and NG108-15 cells. Morphine 23-31 cAMP responsive element binding protein 1 Mus musculus 56-60 23292329-8 2013 For the protein expression, there was a significant increment of cAMP and CREB levels (p < 0.05) in group treated with 5 mg/kg morphine but there was no significant change of these protein expressions when MG was combined with morphine. Morphine 131-139 cAMP responsive element binding protein 1 Mus musculus 74-78 20367754-3 2010 Here, we test whether the cAMP-dependent transcription factors cAMP responsive element binding protein (CREB) and cAMP-responsive element modulator (CREM) in noradrenergic neurons control the cellular markers and the physical signs of morphine withdrawal in mice. Morphine 235-243 cAMP responsive element binding protein 1 Mus musculus 63-102 20367754-3 2010 Here, we test whether the cAMP-dependent transcription factors cAMP responsive element binding protein (CREB) and cAMP-responsive element modulator (CREM) in noradrenergic neurons control the cellular markers and the physical signs of morphine withdrawal in mice. Morphine 235-243 cAMP responsive element binding protein 1 Mus musculus 104-108 19289113-0 2009 Chronic morphine administration induces over-expression of aldolase C with reduction of CREB phosphorylation in the mouse hippocampus. Morphine 8-16 cAMP responsive element binding protein 1 Mus musculus 88-92 20837544-6 2010 Overexpression of a dominant negative CREB mutant blocked the increase in LC excitability induced by morphine- or cAMP-pathway activation. Morphine 101-109 cAMP responsive element binding protein 1 Mus musculus 38-42 20837544-8 2010 Furthermore, the ability of morphine or CREB overexpression to up-regulate LC firing was blocked by knockout of the CREB target adenylyl cyclase 8. Morphine 28-36 cAMP responsive element binding protein 1 Mus musculus 116-120 20837544-9 2010 Together, these findings provide direct evidence that prolonged exposure to morphine induces homeostatic plasticity intrinsic to LC neurons, involving up-regulation of the cAMP-CREB signaling pathway, which then enhances LC neuronal excitability. Morphine 76-84 cAMP responsive element binding protein 1 Mus musculus 177-181 19826619-0 2009 Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine--and morphine withdrawal-related cues. Morphine 123-131 cAMP responsive element binding protein 1 Mus musculus 14-53 19826619-0 2009 Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine--and morphine withdrawal-related cues. Morphine 137-145 cAMP responsive element binding protein 1 Mus musculus 14-53 19826619-1 2009 To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. Morphine 103-111 cAMP responsive element binding protein 1 Mus musculus 68-72 19826619-2 2009 The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance. Morphine 55-63 cAMP responsive element binding protein 1 Mus musculus 20-24 19826619-2 2009 The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance. Morphine 105-113 cAMP responsive element binding protein 1 Mus musculus 20-24 19212318-3 2009 Previous studies have implicated nucleus accumbens (NAc) CREB activity in the modulation of cocaine and morphine reward, and have shown that nicotine conditioned place preference (CPP) is associated with NAc CREB activation. Morphine 104-112 cAMP responsive element binding protein 1 Mus musculus 57-61 19289113-8 2009 The results suggest potential links between the morphine-induced alteration of aldolase C and the regulation of CREB phosphorylation, a possible mechanism of morphine dependence. Morphine 48-56 cAMP responsive element binding protein 1 Mus musculus 112-116 19289113-8 2009 The results suggest potential links between the morphine-induced alteration of aldolase C and the regulation of CREB phosphorylation, a possible mechanism of morphine dependence. Morphine 158-166 cAMP responsive element binding protein 1 Mus musculus 112-116 19826621-4 2009 Here we show, in startling contrast, that inhibition of striatal CREB facilitates cocaine- and morphine-place conditioning and enhances locomotor sensitization to cocaine. Morphine 95-103 cAMP responsive element binding protein 1 Mus musculus 65-69 19341783-7 2009 Chronic administration of morphine made the expression of RACK1 and CREB mRNA increase in hippocampus and prefrontal cortex. Morphine 26-34 cAMP responsive element binding protein 1 Mus musculus 68-72 19341783-8 2009 The expression of RACK1 and CREB protein was strongly positive in CA1, CA3 and dentate gyrus (DG) of the hippocampus of morphine-treated mice brain, especially the pyramidal neurons in the DG of the hippocampus. Morphine 120-128 cAMP responsive element binding protein 1 Mus musculus 28-32 19341783-9 2009 Using the small interfering RNA technology, we determined that the expression of CREB mRNA was decreased in hippocampus and prefrontal cortex of morphine-treated mice. Morphine 145-153 cAMP responsive element binding protein 1 Mus musculus 81-85 19341783-11 2009 These findings suggest that morphine reward can influence the expression of RACK1 in mouse hippocampus and prefrontal cortex through regulating CREB transcription. Morphine 28-36 cAMP responsive element binding protein 1 Mus musculus 144-148 19289113-5 2009 Naloxone pretreatment before morphine administration suppressed withdrawal jumping, weight loss, and overexpression of aldolase C. CREB is a transcription factor regulated through phosphorylation on Ser133, which is known to play a key role in the mechanism of morphine dependence. Morphine 29-37 cAMP responsive element binding protein 1 Mus musculus 131-135 19289113-5 2009 Naloxone pretreatment before morphine administration suppressed withdrawal jumping, weight loss, and overexpression of aldolase C. CREB is a transcription factor regulated through phosphorylation on Ser133, which is known to play a key role in the mechanism of morphine dependence. Morphine 261-269 cAMP responsive element binding protein 1 Mus musculus 131-135 19289113-6 2009 When detecting the expression of phosphorylated CREB (p-CREB) in the mouse hippocampus using Western blot and immunohistochemistry, we found CREB phosphorylation was clearly decreased following chronic morphine treatment. Morphine 202-210 cAMP responsive element binding protein 1 Mus musculus 48-52 19289113-6 2009 When detecting the expression of phosphorylated CREB (p-CREB) in the mouse hippocampus using Western blot and immunohistochemistry, we found CREB phosphorylation was clearly decreased following chronic morphine treatment. Morphine 202-210 cAMP responsive element binding protein 1 Mus musculus 56-60 19289113-6 2009 When detecting the expression of phosphorylated CREB (p-CREB) in the mouse hippocampus using Western blot and immunohistochemistry, we found CREB phosphorylation was clearly decreased following chronic morphine treatment. Morphine 202-210 cAMP responsive element binding protein 1 Mus musculus 56-60 16914643-7 2006 Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8. Morphine 240-248 cAMP responsive element binding protein 1 Mus musculus 221-225 17957220-8 2008 In addition, morphine-induced ERK1/2 phosphorylation was increased in the VTA of both wild-type and GKO mice, but only the GKO mice showed increases in ERK1/2 and CREB phosphorylation in the amygdala or nucleus accumbens. Morphine 13-21 cAMP responsive element binding protein 1 Mus musculus 163-167 18850497-0 2008 Inhibition of Period1 gene attenuates the morphine-induced ERK-CREB activation in frontal cortex, hippocampus, and striatum in mice. Morphine 42-50 cAMP responsive element binding protein 1 Mus musculus 63-67 18850497-2 2008 We explored the effects of inhibiting expression in brain of Per1 on morphine conditioned place preference (CPP) and morphine-induced phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element binding protein (CREB) in mice. Morphine 117-125 cAMP responsive element binding protein 1 Mus musculus 201-238 18850497-2 2008 We explored the effects of inhibiting expression in brain of Per1 on morphine conditioned place preference (CPP) and morphine-induced phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element binding protein (CREB) in mice. Morphine 117-125 cAMP responsive element binding protein 1 Mus musculus 240-244 18850497-9 2008 Pretreatment with DRz164 significant attenuated the morphine-induced activation of ERK and CREB in the frontal cortex, hippocampus, and striatum. Morphine 52-60 cAMP responsive element binding protein 1 Mus musculus 91-95 16914643-7 2006 Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8. Morphine 157-165 cAMP responsive element binding protein 1 Mus musculus 56-93 16914643-7 2006 Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8. Morphine 157-165 cAMP responsive element binding protein 1 Mus musculus 95-99 16914643-7 2006 Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8. Morphine 157-165 cAMP responsive element binding protein 1 Mus musculus 221-225 16914643-7 2006 Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8. Morphine 240-248 cAMP responsive element binding protein 1 Mus musculus 56-93 16914643-7 2006 Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8. Morphine 240-248 cAMP responsive element binding protein 1 Mus musculus 95-99 16417577-0 2006 Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures. Morphine 107-115 cAMP responsive element binding protein 1 Mus musculus 66-70 16630062-3 2006 The increase in phosphorylated CREB expression observed in wild-type mice after chronic morphine was absent in CaMKIV-KO mice, while there was no difference in the expression or phosphorylation of the micro-opioid receptor between groups. Morphine 88-96 cAMP responsive element binding protein 1 Mus musculus 31-35