PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19966058-0	2010	Morphine prevents the mitochondrial permeability transition pore opening through NO/cGMP/PKG/Zn2+/GSK-3beta signal pathway in cardiomyocytes.	Morphine	0-8	protein kinase cGMP-dependent 1	Homo sapiens	89-92	
22363980-1	2011	Protein kinase C (PKC) belongs to the AGC (cAMP-dependent protein kinase/PKG/PKC) protein kinase family which plays an important role in the morphine-induced desensitization of R-opioid receptors.	Morphine	141-149	protein kinase cGMP-dependent 1	Homo sapiens	73-76	
19966058-7	2010	The effect of morphine on Zn(2+) release was also abolished by KT5823, a specific inhibitor of protein kinase G (PKG).	Morphine	14-22	protein kinase cGMP-dependent 1	Homo sapiens	95-111	
19966058-7	2010	The effect of morphine on Zn(2+) release was also abolished by KT5823, a specific inhibitor of protein kinase G (PKG).	Morphine	14-22	protein kinase cGMP-dependent 1	Homo sapiens	113-116	
19966058-13	2010	In conclusion, morphine mobilizes intracellular Zn(2+) through the NO/cGMP/PKG signaling pathway and prevents the mPTP opening by inactivating GSK-3beta through Zn(2+).	Morphine	15-23	protein kinase cGMP-dependent 1	Homo sapiens	75-78	
26596557-5	2016	Specifically, the nNOS, sGC and PKG protein levels in the CA1 were increased after the expression of morphine conditioned place preference (CPP).	Morphine	101-109	protein kinase cGMP-dependent 1	Homo sapiens	32-35	
26596557-6	2016	Intra-CA1 injection of an NOS, sGC or PKG inhibitor prevented morphine CPP expression.	Morphine	62-70	protein kinase cGMP-dependent 1	Homo sapiens	38-41	
26596557-13	2016	The membrane level of GluR1 in the CA1 was increased after morphine CPP expression, and this effect was prevented by pre-injection of a PKG inhibitor into the CA1.	Morphine	59-67	protein kinase cGMP-dependent 1	Homo sapiens	136-139	
26596557-15	2016	Collectively, the results of our study demonstrated that the activation of the NR2B-NMDAR/NO/sGC/PKG signaling pathway is necessary for the retrieval of morphine-associated reward memory.	Morphine	153-161	protein kinase cGMP-dependent 1	Homo sapiens	97-100	
25046820-0	2014	The NO/sGC/PKG signaling pathway in the NAc shell is necessary for the acquisition of morphine-induced place preference.	Morphine	86-94	protein kinase cGMP-dependent 1	Homo sapiens	11-14	
25046820-2	2014	We therefore investigated the effect of the NO/sGC/PKG signaling pathway in the nucleus accumbens (NAc) on morphine-induced conditioned place preference (CPP).	Morphine	107-115	protein kinase cGMP-dependent 1	Homo sapiens	51-54	
25046820-7	2014	These findings indicate that the NO/sGC/PKG signaling pathway in the NAc shell is critical for the acquisition of morphine-induced place preference, whereas the same signaling pathway in the NAc shell or core is not involved in the retrieval of morphine-induced place preference.	Morphine	114-122	protein kinase cGMP-dependent 1	Homo sapiens	40-43	
14990791-3	2004	In the present study, it was shown that the blockade was caused by a specific PKG inhibitor (KT5823) of the antinociceptive effect of morphine and dipyrone on acute hypernociception and of dipyrone on persistent hypernociception.	Morphine	134-142	protein kinase cGMP-dependent 1	Homo sapiens	78-81