PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32090339-5	2020	Among OCT1 wild-type patients, pediatric morphine clearance showed a significant decreasing trend by MRP3 genotypes in the order of CC > CT > TT (P = .014), whereas for neonates, an identical but nonsignificant trend was observed.	Morphine	41-49	ATP binding cassette subfamily C member 3	Homo sapiens	101-105	
31630405-4	2020	Physiologically-based pharmacokinetic models verified with PK data from healthy subjects well recovered the PK in NASH subjects for morphine (involving OCT1) and its glucuronide metabolites (MRP2/MRP3/OATP1B), 99m TC-mebrofenen (OATP1B/MRP2/MRP3), and rosuvastatin (OATP1B/breast cancer resistance protein).	Morphine	132-140	ATP binding cassette subfamily C member 3	Homo sapiens	196-200	
31630405-4	2020	Physiologically-based pharmacokinetic models verified with PK data from healthy subjects well recovered the PK in NASH subjects for morphine (involving OCT1) and its glucuronide metabolites (MRP2/MRP3/OATP1B), 99m TC-mebrofenen (OATP1B/MRP2/MRP3), and rosuvastatin (OATP1B/breast cancer resistance protein).	Morphine	132-140	ATP binding cassette subfamily C member 3	Homo sapiens	241-245	
29994939-3	2018	The recent pharmacogenetics studies revealed an association of the organic cation transporter 1 (OCT1) and ATP-binding cassette C3 (ABCC3) polymorphisms with morphine-related adverse effects, an effect of polymorphisms in cytochrome P450 gene CYP2D6 on the analgesic efficacy of tramadol and no effect of CYP2C8 and CYP2C9 variants on efficacy of piroxicam.	Morphine	158-166	ATP binding cassette subfamily C member 3	Homo sapiens	107-130	
29994939-3	2018	The recent pharmacogenetics studies revealed an association of the organic cation transporter 1 (OCT1) and ATP-binding cassette C3 (ABCC3) polymorphisms with morphine-related adverse effects, an effect of polymorphisms in cytochrome P450 gene CYP2D6 on the analgesic efficacy of tramadol and no effect of CYP2C8 and CYP2C9 variants on efficacy of piroxicam.	Morphine	158-166	ATP binding cassette subfamily C member 3	Homo sapiens	132-137	
26810133-0	2017	ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children.	Morphine	57-65	ATP binding cassette subfamily C member 3	Homo sapiens	0-5	
26810133-0	2017	ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children.	Morphine	101-109	ATP binding cassette subfamily C member 3	Homo sapiens	0-5	
26810133-2	2017	We reported that variants of the ATP binding cassette gene ABCC3 (facilitates hepatic morphine metabolite efflux) affect morphine metabolite clearance.	Morphine	86-94	ATP binding cassette subfamily C member 3	Homo sapiens	59-64	
26810133-2	2017	We reported that variants of the ATP binding cassette gene ABCC3 (facilitates hepatic morphine metabolite efflux) affect morphine metabolite clearance.	Morphine	121-129	ATP binding cassette subfamily C member 3	Homo sapiens	59-64	
32090339-2	2020	In the latter study, plasma morphine-glucuronide levels correlated with patient genotype for the rs4793665 single-nucleotide polymorphism (SNP) at the locus of MRP3, an efflux transporter of morphine glucuronides between hepatocytes and circulating blood.	Morphine	28-36	ATP binding cassette subfamily C member 3	Homo sapiens	160-164	
32090339-2	2020	In the latter study, plasma morphine-glucuronide levels correlated with patient genotype for the rs4793665 single-nucleotide polymorphism (SNP) at the locus of MRP3, an efflux transporter of morphine glucuronides between hepatocytes and circulating blood.	Morphine	191-199	ATP binding cassette subfamily C member 3	Homo sapiens	160-164	
25155932-0	2014	ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children.	Morphine	55-63	ATP binding cassette subfamily C member 3	Homo sapiens	0-5	
25155932-7	2014	CONCLUSION: Our data suggest that besides bodyweight, OCT1 and ABCC3 genotypes play a significant role in the pharmacokinetics of intravenous morphine and its metabolites in children.	Morphine	142-150	ATP binding cassette subfamily C member 3	Homo sapiens	63-68