PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33341652-7 2021 Morphine is known to have analgesic effects via mu-opioid receptor activation and neuroinflammatory effects through Toll-like receptor 4 activation. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 116-136 34142718-0 2021 Acute morphine blocks spinal respiratory motor plasticity via long- latency mechanisms that require toll-like receptor 4 signaling. Morphine 6-14 toll-like receptor 4 Rattus norvegicus 100-120 34142718-2 2021 In adult rats, pre-treatment with a single dose of morphine blocked long-term facilitation (LTF) of phrenic motor output via a long-latency TLR4-dependent mechanism. Morphine 51-59 toll-like receptor 4 Rattus norvegicus 140-144 34142718-3 2021 In the phrenic motor nucleus, morphine triggered TLR4-dependent activation of microglial p38 MAPK - a key enzyme that orchestrates inflammatory signaling and is known to undermine phrenic LTF. Morphine 30-38 toll-like receptor 4 Rattus norvegicus 49-53 34142718-13 2021 Morphine blocked phrenic LTF via TLR4-dependent mechanisms because pre-treatment with (+)-naloxone-the opioid inactive stereoisomer and novel small molecule TLR4 inhibitor-prevented impairment of phrenic LTF in morphine-treated rats. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 33-37 34142718-13 2021 Morphine blocked phrenic LTF via TLR4-dependent mechanisms because pre-treatment with (+)-naloxone-the opioid inactive stereoisomer and novel small molecule TLR4 inhibitor-prevented impairment of phrenic LTF in morphine-treated rats. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 157-161 34142718-14 2021 Morphine triggered TLR4-dependent activation of microglial p38 MAPK within the phrenic motor system - a key enzyme that orchestrates inflammatory signaling and undermines phrenic LTF. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 19-23 33341652-9 2021 In support of this, aged, laparotomized, and morphine-treated rats exhibited increased gene expression of various proinflammatory markers (IL-1beta, IL-6, TNFalpha, NLRP3, HMGB1, TLR2, and TLR4) in the hippocampus at the 2-week time point. Morphine 45-53 toll-like receptor 4 Rattus norvegicus 189-193 32926257-0 2022 Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-Dependent Pyroptosis in the Dorsal Raphe Nucleus of Male Rats via Cell-Specific Activation of TLR4 and Opioid Receptors. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 174-178 32926257-13 2022 In conclusion, morphine and fentanyl differentially induce cell-specific activation of NLRP3 inflammasome and pyroptosis in the DRN through TLR4 receptors in astrocytes and through opioid receptors in neurons, indicating that neuroinflammation is involved in opioid-induced analgesia and fentanyl-induced hyperalgesia after repeated administrations. Morphine 15-23 toll-like receptor 4 Rattus norvegicus 140-144 32533604-4 2022 For CCI rats, systemic co-administration of morphine with antagonists of either P2X7 (A438079) or TLR4 ((+)-naloxone) (receptors critical to the activation of NLRP3 inflammasomes and consequent inflammatory cascades) returned running behavior of CCI rats to that of shams through 5+ weeks after dosing ceased. Morphine 44-52 toll-like receptor 4 Rattus norvegicus 98-102 32533604-7 2022 Given that our data to date point to morphine amplifying neuroinflammatory processes put into motion by nerve injury, it is intriguing to speculate that co-administration of TLR4 and/or P2X7 antagonists can intervene in these inflammatory processes in a beneficial way. Morphine 37-45 toll-like receptor 4 Rattus norvegicus 174-178 30487293-10 2019 Our findings indicate that the inhibition of morphine tolerance by MrgC receptor was associated with the modulation of astrocytes and microglia in the spinal dorsal horn and fractalkine and TLR4 expressions in DRG. Morphine 45-53 toll-like receptor 4 Rattus norvegicus 190-194 32131713-6 2020 The inhibition of miR-146a remarkably decreased paw withdrawal latency as well as increased the expression levels of TLR4 signaling pathway-related molecules, IRAK1 and TRAF6.Conclusion: This study suggests that miR-146a attenuates morphine tolerance by inhibiting the expression of IRAK1/TRAF6 in TLR4 pathway, which could provide an essential experimental basis for the settlement of morphine resistance-associated matters. Morphine 232-240 toll-like receptor 4 Rattus norvegicus 117-121 32131713-6 2020 The inhibition of miR-146a remarkably decreased paw withdrawal latency as well as increased the expression levels of TLR4 signaling pathway-related molecules, IRAK1 and TRAF6.Conclusion: This study suggests that miR-146a attenuates morphine tolerance by inhibiting the expression of IRAK1/TRAF6 in TLR4 pathway, which could provide an essential experimental basis for the settlement of morphine resistance-associated matters. Morphine 386-394 toll-like receptor 4 Rattus norvegicus 117-121 31879851-17 2020 Together, these results suggest that morphine-mediated upregulation of spinal HMGB1 contributes to analgesic tolerance and hyperalgesia via activation of TLR4/NF-kappaB signaling, and the HMGB1 inhibitor might be a promising adjuvant to morphine in the treatment of intractable pain in the clinic. Morphine 37-45 toll-like receptor 4 Rattus norvegicus 154-158 31209174-3 2019 In male rats, we first evaluated the role of nociceptor Toll-like receptor 4 (TLR4) in OIH and priming induced by systemic low-dose morphine (LDM, 0.03 mg/kg). Morphine 132-140 toll-like receptor 4 Rattus norvegicus 78-82 31209174-5 2019 In contrast, high-dose morphine (HDM, 3 mg/kg) increased nociceptive threshold (analgesia) and induced priming, neither of which was attenuated by TLR4 AS-ODN. Morphine 23-31 toll-like receptor 4 Rattus norvegicus 147-151 31209174-13 2019 We demonstrate that OIH and priming induced by systemic low-dose morphine (LDM) share action at Toll-like receptor 4 (TLR4) and signaling via protein kinase C epsilon (PKCepsilon) in common, whereas systemic high-dose morphine (HDM)-induced analgesia and priming are neither TLR4 nor PKCepsilon dependent. Morphine 65-73 toll-like receptor 4 Rattus norvegicus 96-116 31209174-13 2019 We demonstrate that OIH and priming induced by systemic low-dose morphine (LDM) share action at Toll-like receptor 4 (TLR4) and signaling via protein kinase C epsilon (PKCepsilon) in common, whereas systemic high-dose morphine (HDM)-induced analgesia and priming are neither TLR4 nor PKCepsilon dependent. Morphine 65-73 toll-like receptor 4 Rattus norvegicus 118-122 31209174-13 2019 We demonstrate that OIH and priming induced by systemic low-dose morphine (LDM) share action at Toll-like receptor 4 (TLR4) and signaling via protein kinase C epsilon (PKCepsilon) in common, whereas systemic high-dose morphine (HDM)-induced analgesia and priming are neither TLR4 nor PKCepsilon dependent. Morphine 65-73 toll-like receptor 4 Rattus norvegicus 275-279 32131713-4 2020 Paw withdrawal latency test was performed every day, and spinal cord samples were dissected on the seventh day for Q-PCR and Western blotting to detect the expression level of miR-146a, and IRAK1/TRAF6 participated in TLR4 signaling pathway.Results: The expression of miR-146 was significantly decreased in morphine-tolerant model. Morphine 307-315 toll-like receptor 4 Rattus norvegicus 218-222 31879851-5 2020 morphine exposure led to increased expression of HMGB1, Toll-like receptor 4 (TLR4), and receptor for advanced glycation end products (RAGE) and their mRNAs in the dorsal horn. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 56-76 31879851-5 2020 morphine exposure led to increased expression of HMGB1, Toll-like receptor 4 (TLR4), and receptor for advanced glycation end products (RAGE) and their mRNAs in the dorsal horn. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 78-82 31879851-6 2020 Morphine challenge also promoted HMGB1 expression and release in cultured spinal neurons, but these effects were inhibited by TAK-242, naloxone (antagonists of TLR4), and TLR4 siRNA. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 160-164 31879851-6 2020 Morphine challenge also promoted HMGB1 expression and release in cultured spinal neurons, but these effects were inhibited by TAK-242, naloxone (antagonists of TLR4), and TLR4 siRNA. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 171-175 31646595-0 2019 Morphine alleviates myocardial ischemia/reperfusion injury in rats by inhibiting TLR4/NF-kappaB signaling pathway. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 81-85 31646595-10 2019 Finally, the influence of morphine on TLR4/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling pathway was detected using Western blotting. Morphine 26-34 toll-like receptor 4 Rattus norvegicus 38-42 31646595-15 2019 Immuno-histochemical staining results revealed that morphine overtly reversed decreased expressions of TLR4 and p65 induced by I/R in rats (p<0.05). Morphine 52-60 toll-like receptor 4 Rattus norvegicus 103-107 31646595-16 2019 Furthermore, Western blotting found that morphine significantly inhibited the protein expressions of TLR4 and phosphorylated p65. Morphine 41-49 toll-like receptor 4 Rattus norvegicus 101-105 30660614-6 2019 Chronic morphine exposure also increased TLR4 and PKA expression in the PAG. Morphine 8-16 toll-like receptor 4 Rattus norvegicus 41-45 29199028-4 2018 In contrast, M3G binds to toll-like receptor 4 (TLR4), initiating a neuroinflammatory response that directly opposes the analgesic effects of morphine and M6G. Morphine 142-150 toll-like receptor 4 Rattus norvegicus 26-46 28860068-7 2018 We conclude that after peripheral nerve injury, morphine treatment results in persistent DAMP release via TLR4, P2X7R and caspase-1, which are involved in formation/activation of NLRP3 inflammasomes. Morphine 48-56 toll-like receptor 4 Rattus norvegicus 106-110 29723521-2 2018 Maintenance of this morphine-induced persistent sensitization was dependent on microglial reactivity and Toll-like receptor 4 signaling. Morphine 20-28 toll-like receptor 4 Rattus norvegicus 105-125 29199028-6 2018 The present studies test the hypothesis that increased M3G, and subsequent TLR4-mediated activation of glia, is a primary mechanism driving the attenuated response to morphine in females. Morphine 167-175 toll-like receptor 4 Rattus norvegicus 75-79 29199028-4 2018 In contrast, M3G binds to toll-like receptor 4 (TLR4), initiating a neuroinflammatory response that directly opposes the analgesic effects of morphine and M6G. Morphine 142-150 toll-like receptor 4 Rattus norvegicus 48-52 28219988-2 2017 In addition to binding to the neuronal mu-opioid receptor, morphine binds to the innate immune receptor toll-like receptor 4 (TLR4) localized primarily on microglia. Morphine 59-67 toll-like receptor 4 Rattus norvegicus 104-124 28219988-7 2017 Blockade of morphine binding to PAG TLR4 with (+)-naloxone potentiated morphine antinociception significantly in females such that no sex differences in ED50 were observed. Morphine 71-79 toll-like receptor 4 Rattus norvegicus 36-40 28219988-10 2017 Our data further implicate the innate immune receptor toll-like receptor 4 (TLR4) as an underlying mechanism mediating these effects and establish that TLR4 inhibition in the PAG of females reverses the sex differences in morphine responsiveness. Morphine 222-230 toll-like receptor 4 Rattus norvegicus 54-74 28219988-10 2017 Our data further implicate the innate immune receptor toll-like receptor 4 (TLR4) as an underlying mechanism mediating these effects and establish that TLR4 inhibition in the PAG of females reverses the sex differences in morphine responsiveness. Morphine 222-230 toll-like receptor 4 Rattus norvegicus 76-80 28219988-10 2017 Our data further implicate the innate immune receptor toll-like receptor 4 (TLR4) as an underlying mechanism mediating these effects and establish that TLR4 inhibition in the PAG of females reverses the sex differences in morphine responsiveness. Morphine 222-230 toll-like receptor 4 Rattus norvegicus 152-156 29310498-2 2018 Toll-like receptor 4 (TLR4), a pattern-recognition molecule, has a critical role in both neuropathic pain and morphine tolerance. Morphine 110-118 toll-like receptor 4 Rattus norvegicus 0-20 29310498-2 2018 Toll-like receptor 4 (TLR4), a pattern-recognition molecule, has a critical role in both neuropathic pain and morphine tolerance. Morphine 110-118 toll-like receptor 4 Rattus norvegicus 22-26 28827130-0 2017 Activation of TLR4/STAT3 signaling in VTA contributes to the acquisition and maintenance of morphine-induced conditioned place preference. Morphine 92-100 toll-like receptor 4 Rattus norvegicus 14-18 28827130-3 2017 The present study showed that intra-VTA microinjection of TLR4 antagonist LPS-RS prevented the acquisition and maintenance, but not the expression, of morphine-induced CPP in rats. Morphine 151-159 toll-like receptor 4 Rattus norvegicus 58-62 28827130-6 2017 Importantly, the TLR4 expression is colocalized with p-STAT3-positive cell in VTA, and repeated injection of LPS-RS significantly attenuated the STAT3 activation in VTA induced by chronic morphine treatment. Morphine 188-196 toll-like receptor 4 Rattus norvegicus 17-21 28827130-7 2017 Collectively, these data suggest that TLR4/STAT3 signaling pathway in VTA might play a critical role in the acquisition and maintenance of morphine CPP, and provides new evidence that TLR4/STAT3 signaling pathway might be a potential target for treatment of morphine addiction. Morphine 139-147 toll-like receptor 4 Rattus norvegicus 38-42 28827130-7 2017 Collectively, these data suggest that TLR4/STAT3 signaling pathway in VTA might play a critical role in the acquisition and maintenance of morphine CPP, and provides new evidence that TLR4/STAT3 signaling pathway might be a potential target for treatment of morphine addiction. Morphine 139-147 toll-like receptor 4 Rattus norvegicus 184-188 28827130-7 2017 Collectively, these data suggest that TLR4/STAT3 signaling pathway in VTA might play a critical role in the acquisition and maintenance of morphine CPP, and provides new evidence that TLR4/STAT3 signaling pathway might be a potential target for treatment of morphine addiction. Morphine 258-266 toll-like receptor 4 Rattus norvegicus 38-42 28827130-7 2017 Collectively, these data suggest that TLR4/STAT3 signaling pathway in VTA might play a critical role in the acquisition and maintenance of morphine CPP, and provides new evidence that TLR4/STAT3 signaling pathway might be a potential target for treatment of morphine addiction. Morphine 258-266 toll-like receptor 4 Rattus norvegicus 184-188 28219988-2 2017 In addition to binding to the neuronal mu-opioid receptor, morphine binds to the innate immune receptor toll-like receptor 4 (TLR4) localized primarily on microglia. Morphine 59-67 toll-like receptor 4 Rattus norvegicus 126-130 28219988-3 2017 Morphine action at TLR4 initiates a neuroinflammatory response that directly opposes the analgesic effects of morphine. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 19-23 28219988-3 2017 Morphine action at TLR4 initiates a neuroinflammatory response that directly opposes the analgesic effects of morphine. Morphine 110-118 toll-like receptor 4 Rattus norvegicus 19-23 28219988-7 2017 Blockade of morphine binding to PAG TLR4 with (+)-naloxone potentiated morphine antinociception significantly in females such that no sex differences in ED50 were observed. Morphine 12-20 toll-like receptor 4 Rattus norvegicus 36-40 26962463-8 2016 Blockade of TLR2 and TLR4 produced analgesia and enhanced buprenorphine"s effectiveness, which suggests that they may be a putative target for future pharmacological pain relief tools, especially for opioid rotation, when the effect of morphine is tolerated. Morphine 236-244 toll-like receptor 4 Rattus norvegicus 21-25 27519154-0 2016 Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 44-48 27519154-6 2016 Co-administering the non-opioid toll-like receptor 4 (TLR4) antagonist (+)-naltrexone throughout the morphine regimen prevented morphine-induced amplification of SNAP. Morphine 101-109 toll-like receptor 4 Rattus norvegicus 32-52 27519154-6 2016 Co-administering the non-opioid toll-like receptor 4 (TLR4) antagonist (+)-naltrexone throughout the morphine regimen prevented morphine-induced amplification of SNAP. Morphine 101-109 toll-like receptor 4 Rattus norvegicus 54-58 27519154-6 2016 Co-administering the non-opioid toll-like receptor 4 (TLR4) antagonist (+)-naltrexone throughout the morphine regimen prevented morphine-induced amplification of SNAP. Morphine 128-136 toll-like receptor 4 Rattus norvegicus 32-52 27519154-6 2016 Co-administering the non-opioid toll-like receptor 4 (TLR4) antagonist (+)-naltrexone throughout the morphine regimen prevented morphine-induced amplification of SNAP. Morphine 128-136 toll-like receptor 4 Rattus norvegicus 54-58 27519154-7 2016 Exploration of changes induced by early post-trauma morphine revealed that this elevated gene expression of TLR4, TNF, IL-1beta, and NLRP3, as well as IL-1beta protein at the site of spinal cord injury. Morphine 52-60 toll-like receptor 4 Rattus norvegicus 108-112 27461080-0 2017 Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling. Morphine 30-38 toll-like receptor 4 Rattus norvegicus 0-20 27461080-5 2017 By expression of a dominant-negative TNF peptide via lentiviral vector injection in rat PAG to sequester soluble TNF (solTNF), we demonstrate that solTNF mediates morphine tolerance induced by TLR4 signaling, stimulates neuroinflammation (increased IL-1beta and TLR4 mRNA), and disrupts glutamate reuptake (decreased GLT-1 and GLAST mRNA). Morphine 163-171 toll-like receptor 4 Rattus norvegicus 193-197 28306133-0 2016 Injection of Toll-like receptor 4 siRNA into the ventrolateral periaqueductal gray attenuates withdrawal syndrome in morphine-dependent rats. Morphine 117-125 toll-like receptor 4 Rattus norvegicus 13-33 28306133-1 2016 We assessed the role of the Toll-like receptor 4 (TLR4) gene in the ventrolateral periaqueductal gray (vlPAG) region of morphine-dependent rats on attenuating withdrawal syndrome, and regulating glutamic acid decarboxylase (GAD67), glutamic acid (Glu), and gamma-aminobutyric acid (GABA). Morphine 120-128 toll-like receptor 4 Rattus norvegicus 28-48 28306133-1 2016 We assessed the role of the Toll-like receptor 4 (TLR4) gene in the ventrolateral periaqueductal gray (vlPAG) region of morphine-dependent rats on attenuating withdrawal syndrome, and regulating glutamic acid decarboxylase (GAD67), glutamic acid (Glu), and gamma-aminobutyric acid (GABA). Morphine 120-128 toll-like receptor 4 Rattus norvegicus 50-54 25182346-3 2014 Toll-like receptors (TLRs), especially TLR-4, have also been reported to contribute to the development of morphine analgesic tolerance. Morphine 106-114 toll-like receptor 4 Rattus norvegicus 39-44 25446875-0 2014 Toll-like receptor 4-mediated nuclear factor-kappaB activation in spinal cord contributes to chronic morphine-induced analgesic tolerance and hyperalgesia in rats. Morphine 101-109 toll-like receptor 4 Rattus norvegicus 0-20 25446875-8 2014 Meanwhile, intrathecal pretreatment with lipopolysaccharide from Rhodobacter sphaeroides, an antagonist of toll-like receptor 4 (TLR4), blocked the activation of NF-kappaB, and prevented the development of morphine tolerance and withdrawal-induced abnormal pain. Morphine 206-214 toll-like receptor 4 Rattus norvegicus 107-127 25446875-8 2014 Meanwhile, intrathecal pretreatment with lipopolysaccharide from Rhodobacter sphaeroides, an antagonist of toll-like receptor 4 (TLR4), blocked the activation of NF-kappaB, and prevented the development of morphine tolerance and withdrawal-induced abnormal pain. Morphine 206-214 toll-like receptor 4 Rattus norvegicus 129-133 25446875-9 2014 These data indicated that TLR4-mediated NF-kappaB activation in the spinal cord is involved in the development and maintenance of morphine analgesic tolerance and withdrawal-induced pain hypersensitivity. Morphine 130-138 toll-like receptor 4 Rattus norvegicus 26-30 25241065-8 2014 (-)-Morphine-induced upregulation of TNFalpha mRNA and PGE2 release were unmasked by pre-treatment with nalmefene, a MOR antagonist without TLR4 activity (unlike CTAP, shown to have both MOR- and TLR4-activity), suggestive of an interplay between MOR and TLR4 co-activation by (-)-morphine. Morphine 4-12 toll-like receptor 4 Rattus norvegicus 196-200 25241065-8 2014 (-)-Morphine-induced upregulation of TNFalpha mRNA and PGE2 release were unmasked by pre-treatment with nalmefene, a MOR antagonist without TLR4 activity (unlike CTAP, shown to have both MOR- and TLR4-activity), suggestive of an interplay between MOR and TLR4 co-activation by (-)-morphine. Morphine 4-12 toll-like receptor 4 Rattus norvegicus 196-200 25241065-9 2014 In support, MOR-dependent Protein Kinase A (PKA) opposed TLR4 signaling, as PKA inhibition (H-89) also unmasked (-)-morphine-induced TNFalpha and COX2 mRNA upregulation. Morphine 116-124 toll-like receptor 4 Rattus norvegicus 57-61 25241065-13 2014 These data indicate that (-)-morphine and M3G can activate CNS endothelial cells via TLR4, inducing proinflammatory, biochemical, morphological, and behavioral sequelae. Morphine 25-37 toll-like receptor 4 Rattus norvegicus 85-89 23325235-7 2013 Thus, we examined the role of microglia within the nucleus accumbens of these rats and determined that rats exposed to morphine during adolescence had a significant increase in Toll-like receptor 4 (TLR4) mRNA and protein expression specifically on microglia. Morphine 119-127 toll-like receptor 4 Rattus norvegicus 177-197 23325235-7 2013 Thus, we examined the role of microglia within the nucleus accumbens of these rats and determined that rats exposed to morphine during adolescence had a significant increase in Toll-like receptor 4 (TLR4) mRNA and protein expression specifically on microglia. Morphine 119-127 toll-like receptor 4 Rattus norvegicus 199-203 23325235-8 2013 Morphine binds to TLR4 directly, and this increase in TLR4 was associated with exaggerated morphine-induced TLR4 signaling and microglial activation in rats previously exposed to morphine during adolescence. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 18-22 23325235-8 2013 Morphine binds to TLR4 directly, and this increase in TLR4 was associated with exaggerated morphine-induced TLR4 signaling and microglial activation in rats previously exposed to morphine during adolescence. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 54-58 23325235-8 2013 Morphine binds to TLR4 directly, and this increase in TLR4 was associated with exaggerated morphine-induced TLR4 signaling and microglial activation in rats previously exposed to morphine during adolescence. Morphine 0-8 toll-like receptor 4 Rattus norvegicus 54-58 23325235-8 2013 Morphine binds to TLR4 directly, and this increase in TLR4 was associated with exaggerated morphine-induced TLR4 signaling and microglial activation in rats previously exposed to morphine during adolescence. Morphine 91-99 toll-like receptor 4 Rattus norvegicus 18-22 23325235-8 2013 Morphine binds to TLR4 directly, and this increase in TLR4 was associated with exaggerated morphine-induced TLR4 signaling and microglial activation in rats previously exposed to morphine during adolescence. Morphine 91-99 toll-like receptor 4 Rattus norvegicus 54-58 23325235-8 2013 Morphine binds to TLR4 directly, and this increase in TLR4 was associated with exaggerated morphine-induced TLR4 signaling and microglial activation in rats previously exposed to morphine during adolescence. Morphine 91-99 toll-like receptor 4 Rattus norvegicus 54-58 23325235-8 2013 Morphine binds to TLR4 directly, and this increase in TLR4 was associated with exaggerated morphine-induced TLR4 signaling and microglial activation in rats previously exposed to morphine during adolescence. Morphine 179-187 toll-like receptor 4 Rattus norvegicus 18-22 23325235-8 2013 Morphine binds to TLR4 directly, and this increase in TLR4 was associated with exaggerated morphine-induced TLR4 signaling and microglial activation in rats previously exposed to morphine during adolescence. Morphine 179-187 toll-like receptor 4 Rattus norvegicus 54-58 23325235-8 2013 Morphine binds to TLR4 directly, and this increase in TLR4 was associated with exaggerated morphine-induced TLR4 signaling and microglial activation in rats previously exposed to morphine during adolescence. Morphine 179-187 toll-like receptor 4 Rattus norvegicus 54-58 22895704-7 2012 Similar to our recent reports of morphine-TLR4/MD2 binding, here we provide a combination of in silico and biophysical data to support (+)-naloxone and remifentanil binding to TLR4/MD2. Morphine 33-41 toll-like receptor 4 Rattus norvegicus 42-46 22895704-7 2012 Similar to our recent reports of morphine-TLR4/MD2 binding, here we provide a combination of in silico and biophysical data to support (+)-naloxone and remifentanil binding to TLR4/MD2. Morphine 33-41 toll-like receptor 4 Rattus norvegicus 176-180 24121451-4 2014 In this study we investigated the neurodegenerative effects of morphine through its effects on Toll-Like Receptor 4 (TLR4) in the male rat hippocampus and evaluated the level of Interleukin-1 beta (IL-1beta). Morphine 63-71 toll-like receptor 4 Rattus norvegicus 95-115 24121451-4 2014 In this study we investigated the neurodegenerative effects of morphine through its effects on Toll-Like Receptor 4 (TLR4) in the male rat hippocampus and evaluated the level of Interleukin-1 beta (IL-1beta). Morphine 63-71 toll-like receptor 4 Rattus norvegicus 117-121 24089500-0 2013 Blockade of Toll-like receptor 4 attenuates morphine tolerance and facilitates the pain relieving properties of morphine. Morphine 44-52 toll-like receptor 4 Rattus norvegicus 12-32 24089500-0 2013 Blockade of Toll-like receptor 4 attenuates morphine tolerance and facilitates the pain relieving properties of morphine. Morphine 112-120 toll-like receptor 4 Rattus norvegicus 12-32 24089500-5 2013 To date, the brain loci through which TLR4 modulates morphine tolerance have not been identified. Morphine 53-61 toll-like receptor 4 Rattus norvegicus 38-42 24089500-9 2013 Further, antagonizing vlPAG TLR4 dose dependently prevented the development of morphine tolerance, and vlPAG microinjections of TLR4 agonists dose dependently produced a "naive" tolerance to subsequent challenge doses of morphine. Morphine 79-87 toll-like receptor 4 Rattus norvegicus 28-32 24089500-9 2013 Further, antagonizing vlPAG TLR4 dose dependently prevented the development of morphine tolerance, and vlPAG microinjections of TLR4 agonists dose dependently produced a "naive" tolerance to subsequent challenge doses of morphine. Morphine 221-229 toll-like receptor 4 Rattus norvegicus 128-132 24089500-10 2013 Finally, using a model of persistent inflammatory pain and pharmacological manipulation of TLR4 we demonstrate that systemic antagonism of TLR4 potentiated acute morphine antihyperalgesia. Morphine 162-170 toll-like receptor 4 Rattus norvegicus 91-95 24089500-10 2013 Finally, using a model of persistent inflammatory pain and pharmacological manipulation of TLR4 we demonstrate that systemic antagonism of TLR4 potentiated acute morphine antihyperalgesia. Morphine 162-170 toll-like receptor 4 Rattus norvegicus 139-143 22895704-5 2012 Moreover, pharmacological blockade of morphine-TLR4/MD2 activity potently reduced morphine-induced elevations of extracellular dopamine in rat nucleus accumbens, a region critical for opioid reinforcement. Morphine 38-46 toll-like receptor 4 Rattus norvegicus 47-51 22895704-5 2012 Moreover, pharmacological blockade of morphine-TLR4/MD2 activity potently reduced morphine-induced elevations of extracellular dopamine in rat nucleus accumbens, a region critical for opioid reinforcement. Morphine 82-90 toll-like receptor 4 Rattus norvegicus 47-51 19788917-1 2009 Spinal cord microglial toll-like receptor 4 (TLR4) has been implicated in enhancing neuropathic pain and opposing morphine analgesia. Morphine 114-122 toll-like receptor 4 Rattus norvegicus 45-49