PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27089209-4	2016	This research not only confirmed the analgesic effect of the DAAO inhibitors but provided a new class of chemical entities with oral application potential for the treatment of chronic pain and morphine analgesic tolerance.	Morphine	193-201	D-amino acid oxidase	Homo sapiens	61-65	
22587944-0	2012	Interactions of the potent D-amino acid oxidase inhibitor CBIO with morphine in pain and tolerance to analgesia.	Morphine	68-76	D-amino acid oxidase	Homo sapiens	27-47	
22587944-7	2012	These results, for the first time, identified DAAO as an efficacious molecule mediating morphine tolerance, in addition to clarifying the complex interactions between morphine and DAAO inhibitors probed by CBIO, and provided a pharmacological basis for DAAO inhibitors in combination with morphine to clinically manage pain.	Morphine	88-96	D-amino acid oxidase	Homo sapiens	46-50	
22587944-7	2012	These results, for the first time, identified DAAO as an efficacious molecule mediating morphine tolerance, in addition to clarifying the complex interactions between morphine and DAAO inhibitors probed by CBIO, and provided a pharmacological basis for DAAO inhibitors in combination with morphine to clinically manage pain.	Morphine	167-175	D-amino acid oxidase	Homo sapiens	46-50	
22587944-7	2012	These results, for the first time, identified DAAO as an efficacious molecule mediating morphine tolerance, in addition to clarifying the complex interactions between morphine and DAAO inhibitors probed by CBIO, and provided a pharmacological basis for DAAO inhibitors in combination with morphine to clinically manage pain.	Morphine	167-175	D-amino acid oxidase	Homo sapiens	46-50	
31059710-3	2019	Furthermore, the upregulation of DAAO also results in the development of morphine tolerance as well as morphine-induced hyperalgesia.	Morphine	73-81	D-amino acid oxidase	Homo sapiens	33-37	
31059710-3	2019	Furthermore, the upregulation of DAAO also results in the development of morphine tolerance as well as morphine-induced hyperalgesia.	Morphine	103-111	D-amino acid oxidase	Homo sapiens	33-37	
31059710-4	2019	Accordingly, the knockdown of DAAO gene or pharmacological inhibition of DAAO reduces pain, reverses tolerance to morphine and hyperalgesia.	Morphine	114-122	D-amino acid oxidase	Homo sapiens	30-34	
31059710-4	2019	Accordingly, the knockdown of DAAO gene or pharmacological inhibition of DAAO reduces pain, reverses tolerance to morphine and hyperalgesia.	Morphine	114-122	D-amino acid oxidase	Homo sapiens	73-77