PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1531356-0 1992 Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus. Morphine 102-110 cAMP responsive element binding protein 1 Rattus norvegicus 14-57 7971989-2 1994 In the course of investigating effects of chronic morphine on the cAMP pathway in the locus coeruleus, a brain region important for opiate addiction, we found that levels of CREB immunoreactivity and CRE binding were increased by chronic morphine administration. Morphine 50-58 cAMP responsive element binding protein 1 Rattus norvegicus 174-178 7971989-2 1994 In the course of investigating effects of chronic morphine on the cAMP pathway in the locus coeruleus, a brain region important for opiate addiction, we found that levels of CREB immunoreactivity and CRE binding were increased by chronic morphine administration. Morphine 238-246 cAMP responsive element binding protein 1 Rattus norvegicus 174-178 1531356-0 1992 Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus. Morphine 102-110 cAMP responsive element binding protein 1 Rattus norvegicus 59-63 1531356-3 1992 To understand better the mechanism by which opiates produce these intracellular adaptations, we studied morphine regulation of the state of phosphorylation of cyclic AMP response element-binding protein (CREB), a transcription factor that mediates some of the effects of the cyclic AMP system on gene expression. Morphine 104-112 cAMP responsive element binding protein 1 Rattus norvegicus 159-202 1531356-3 1992 To understand better the mechanism by which opiates produce these intracellular adaptations, we studied morphine regulation of the state of phosphorylation of cyclic AMP response element-binding protein (CREB), a transcription factor that mediates some of the effects of the cyclic AMP system on gene expression. Morphine 104-112 cAMP responsive element binding protein 1 Rattus norvegicus 204-208 1531356-4 1992 We show here, by use of a back phosphorylation and immunoprecipitation procedure, that acute morphine decreases the state of phosphorylation of CREB, an effect that becomes completely attenuated after chronic morphine administration. Morphine 93-101 cAMP responsive element binding protein 1 Rattus norvegicus 144-148 1531356-4 1992 We show here, by use of a back phosphorylation and immunoprecipitation procedure, that acute morphine decreases the state of phosphorylation of CREB, an effect that becomes completely attenuated after chronic morphine administration. Morphine 209-217 cAMP responsive element binding protein 1 Rattus norvegicus 144-148 32404265-0 2020 Inhibition of orexin receptor 1 contributes to the development of morphine dependence via attenuation of cAMP response element-binding protein and phospholipase Cbeta3. Morphine 66-74 cAMP responsive element binding protein 1 Rattus norvegicus 105-142 34720901-5 2021 We also investigated the effect of melatonin and morphine on the expression of GLT-1, BDNF, NF-kappaB, and CREB within the nucleus accumbens. Morphine 49-57 cAMP responsive element binding protein 1 Rattus norvegicus 107-111 34720901-10 2021 Morphine treatment reduced the mRNA expression of GLT-1, BDNF, and CREB and increased that of NF-kappaB. Morphine 0-8 cAMP responsive element binding protein 1 Rattus norvegicus 67-71 34951394-0 2021 Effect of Methadone Maintenance on Expression of BDNF and CREB Genes in Brain VTA of Male Morphine Treated Rats. Morphine 90-98 cAMP responsive element binding protein 1 Rattus norvegicus 58-62 34951394-1 2021 BACKGROUND: Morphine independent reduces the expression level of Brain-derived Neurotrophic Factor (BDNF) and Cyclic-AMP Response Element Binding protein (CREB). Morphine 12-20 cAMP responsive element binding protein 1 Rattus norvegicus 110-153 34951394-1 2021 BACKGROUND: Morphine independent reduces the expression level of Brain-derived Neurotrophic Factor (BDNF) and Cyclic-AMP Response Element Binding protein (CREB). Morphine 12-20 cAMP responsive element binding protein 1 Rattus norvegicus 155-159 34951394-4 2021 Therefore, this study was conducted to examine the effect of methadone maintenance on the expression of BDNF and CREB genes in brain VTA of male morphine treated rats. Morphine 145-153 cAMP responsive element binding protein 1 Rattus norvegicus 113-117 34951394-5 2021 METHODS: I Morphine independent reduces the expression level of Brain-derived Neurotrophic Factor (BDNF) and Cyclic-AMP Response Element Binding protein (CREB). Morphine 11-19 cAMP responsive element binding protein 1 Rattus norvegicus 109-152 34951394-5 2021 METHODS: I Morphine independent reduces the expression level of Brain-derived Neurotrophic Factor (BDNF) and Cyclic-AMP Response Element Binding protein (CREB). Morphine 11-19 cAMP responsive element binding protein 1 Rattus norvegicus 154-158 34951394-8 2021 Therefore, this study was conducted to examine the effect of methadone maintenance on the expression of BDNF and CREB genes in brain VTA of male morphine treated rats Results: According to the findings of this study, similar to morphine treated group, methadone maintenance in morphine treated animals led to significant reduction in the expression of BDNF and CREB genes at VTA as well as BDNF serum level compared with control group. Morphine 145-153 cAMP responsive element binding protein 1 Rattus norvegicus 113-117 34720901-11 2021 However, melatonin treatment administered 30 min before morphine treatment attenuated morphine place preference and reversed GLT-1, BDNF, NF-kappaB, and CREB expression levels. Morphine 56-64 cAMP responsive element binding protein 1 Rattus norvegicus 153-157 34951394-8 2021 Therefore, this study was conducted to examine the effect of methadone maintenance on the expression of BDNF and CREB genes in brain VTA of male morphine treated rats Results: According to the findings of this study, similar to morphine treated group, methadone maintenance in morphine treated animals led to significant reduction in the expression of BDNF and CREB genes at VTA as well as BDNF serum level compared with control group. Morphine 277-285 cAMP responsive element binding protein 1 Rattus norvegicus 113-117 34951394-8 2021 Therefore, this study was conducted to examine the effect of methadone maintenance on the expression of BDNF and CREB genes in brain VTA of male morphine treated rats Results: According to the findings of this study, similar to morphine treated group, methadone maintenance in morphine treated animals led to significant reduction in the expression of BDNF and CREB genes at VTA as well as BDNF serum level compared with control group. Morphine 277-285 cAMP responsive element binding protein 1 Rattus norvegicus 361-365 34951394-9 2021 CONCLUSION: It was concluded that methadone, like morphine, causes significant reduction in the expression of BDNF and CREB genes in brain VTA area of rat as well as BDNF serum level compared with control group. Morphine 50-58 cAMP responsive element binding protein 1 Rattus norvegicus 119-123 32574519-0 2020 Changes in c-fos and p-CREB signaling following exposure to forced swim stress or exogenous corticosterone during morphine-induced place preference are dependent on glucocorticoid receptor in the basolateral amygdala. Morphine 114-122 cAMP responsive element binding protein 1 Rattus norvegicus 23-27 32574519-4 2020 Our results showed that morphine-induced CPP could increase c-fos level and p-CREB/CREB ratio in all regions (except in the HIP). Morphine 24-32 cAMP responsive element binding protein 1 Rattus norvegicus 78-82 32574519-4 2020 Our results showed that morphine-induced CPP could increase c-fos level and p-CREB/CREB ratio in all regions (except in the HIP). Morphine 24-32 cAMP responsive element binding protein 1 Rattus norvegicus 83-87 32574519-7 2020 In conclusion, it seems that the intra-BLA administration of RU38486 differently modulates the effect of morphine-induced CPP on the expression of c-fos and p-CREB/CREB ratio in animals that underwent FSS or corticosterone administration. Morphine 105-113 cAMP responsive element binding protein 1 Rattus norvegicus 159-163 32574519-7 2020 In conclusion, it seems that the intra-BLA administration of RU38486 differently modulates the effect of morphine-induced CPP on the expression of c-fos and p-CREB/CREB ratio in animals that underwent FSS or corticosterone administration. Morphine 105-113 cAMP responsive element binding protein 1 Rattus norvegicus 164-168 32404265-5 2020 Results showed that cAMP, CREB and PLCbeta3 levels were suppressed by the application of SB-334867 (as a selective Orx1 antagonist) in morphine-dependent rats. Morphine 135-143 cAMP responsive element binding protein 1 Rattus norvegicus 26-30 32404265-6 2020 Our results unraveled that Orx1 blockade is involved in the development of morphine dependency through diminution of a variety of intracellular events including the cAMP, CREB and PLCbeta3 levels in morphine-dependent rats. Morphine 75-83 cAMP responsive element binding protein 1 Rattus norvegicus 171-175 32404265-6 2020 Our results unraveled that Orx1 blockade is involved in the development of morphine dependency through diminution of a variety of intracellular events including the cAMP, CREB and PLCbeta3 levels in morphine-dependent rats. Morphine 199-207 cAMP responsive element binding protein 1 Rattus norvegicus 171-175 32428531-0 2020 Impairment of cost-benefit decision making in morphine-dependent rats is partly mediated via the alteration of BDNF and p-CREB levels in the nucleus accumbens. Morphine 46-54 cAMP responsive element binding protein 1 Rattus norvegicus 122-126 31616243-12 2019 oligodeoxynucleotide (ODN) antisense to cAMP-responsive element binding protein (CREB) attenuated morphine-induced hyperalgesia. Morphine 98-106 cAMP responsive element binding protein 1 Rattus norvegicus 40-79 31838222-6 2020 In morphine-treated rats, level of BDNF and p-CREB/CREB ratio reduced during both forms of decision making while p-GSK3beta/GSK3beta ratio increased during delay-based and did not have a significant difference with the control group during effort-based decision making. Morphine 3-11 cAMP responsive element binding protein 1 Rattus norvegicus 46-50 31838222-6 2020 In morphine-treated rats, level of BDNF and p-CREB/CREB ratio reduced during both forms of decision making while p-GSK3beta/GSK3beta ratio increased during delay-based and did not have a significant difference with the control group during effort-based decision making. Morphine 3-11 cAMP responsive element binding protein 1 Rattus norvegicus 51-55 31838222-9 2020 In conclusion, our data revealed that subchronic exposure to morphine interferes with the cost-benefit decision making may be via changes in level of BDNF, p-CREB/CREB and p-GSK3beta/GSK3beta ratio in the amygdala. Morphine 61-69 cAMP responsive element binding protein 1 Rattus norvegicus 158-162 31838222-9 2020 In conclusion, our data revealed that subchronic exposure to morphine interferes with the cost-benefit decision making may be via changes in level of BDNF, p-CREB/CREB and p-GSK3beta/GSK3beta ratio in the amygdala. Morphine 61-69 cAMP responsive element binding protein 1 Rattus norvegicus 163-167 31639423-7 2020 Taken together, the results suggest that D1R antagonist decreased the withdrawal response in morphine-exposed rats by downregulating the downstream factors, CaMKII, p-ERK and CREB. Morphine 93-101 cAMP responsive element binding protein 1 Rattus norvegicus 175-179 31616243-13 2019 Real-time polymerase chain reaction (RT-PCR) analysis showed that CREB downstream genes expressions were significantly up-regulated 96 h after morphine injection in spinal cord. Morphine 143-151 cAMP responsive element binding protein 1 Rattus norvegicus 66-70 31616243-14 2019 Together, our data suggest that central ERK is involved in the analgesic and hyperalgesic effects of morphine while JNK, p38, and CREB are involved in the morphine-induced delayed hyperalgesia. Morphine 155-163 cAMP responsive element binding protein 1 Rattus norvegicus 130-134 31616243-12 2019 oligodeoxynucleotide (ODN) antisense to cAMP-responsive element binding protein (CREB) attenuated morphine-induced hyperalgesia. Morphine 98-106 cAMP responsive element binding protein 1 Rattus norvegicus 81-85 30292787-3 2018 We found that treatment with a selective TRPV1 antagonist, SB366791, significantly decreased the morphine SA-induced activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII), Akt and the cAMP response element binding protein (CREB) in the nucleus accumbens (NAc). Morphine 97-105 cAMP responsive element binding protein 1 Rattus norvegicus 197-234 31253357-7 2019 RESULTS: Spinal morphine tolerance was associated with an increased expression of neuronal MCU, phospho-CREB (pCREB), and CPEB1 in the spinal cord dorsal horn. Morphine 16-24 cAMP responsive element binding protein 1 Rattus norvegicus 104-108 31253357-9 2019 Intrathecal antisense oligodeoxynucleotide against CREB or CPEB1 restored the anti-nociceptive effects of morphine compared with mismatch oligodeoxynucleotide in von Frey test and hotplate test. Morphine 106-114 cAMP responsive element binding protein 1 Rattus norvegicus 51-55 30707953-0 2019 Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway. Morphine 66-74 cAMP responsive element binding protein 1 Rattus norvegicus 137-141 30707953-8 2019 Our results showed that neuropathic pain increased the pCREB/CREB ratio in the amygdala, and this ratio was decreased after morphine-induced anti-allodynia. Morphine 124-132 cAMP responsive element binding protein 1 Rattus norvegicus 56-60 30707953-9 2019 The potentiative effect of the coadministration of D-AP5/L-NAME on an ineffective dose of morphine also decreased the amygdala pCREB/CREB levels. Morphine 90-98 cAMP responsive element binding protein 1 Rattus norvegicus 128-132 30292787-0 2018 TRPV1 modulates morphine self-administration via activation of the CaMKII-CREB pathway in the nucleus accumbens. Morphine 16-24 cAMP responsive element binding protein 1 Rattus norvegicus 74-78 30292787-3 2018 We found that treatment with a selective TRPV1 antagonist, SB366791, significantly decreased the morphine SA-induced activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII), Akt and the cAMP response element binding protein (CREB) in the nucleus accumbens (NAc). Morphine 97-105 cAMP responsive element binding protein 1 Rattus norvegicus 236-240 30292787-6 2018 Taken together, our findings highlight that TRPV1 plays an important role in morphine addiction, likely via activation of the CaMKII-CREB pathway in the NAc. Morphine 77-85 cAMP responsive element binding protein 1 Rattus norvegicus 133-137 29054430-0 2018 NMDA receptor dependent changes in c-fos and p-CREB signaling following extinction and reinstatement of morphine place preference. Morphine 104-112 cAMP responsive element binding protein 1 Rattus norvegicus 47-51 30170186-5 2018 Intra-accumbal administration of the CB1 agonist during the extinction period of morphine-induced CPP reduced the pCREB/CREB ratio in the NAc. Morphine 81-89 cAMP responsive element binding protein 1 Rattus norvegicus 115-119 29031903-10 2018 In conclusion, we found that agmatine abolished chronic morphine-induced decrease in proliferation of hippocampal progenitors in vivo and in vitro, which may be due to the increase in cAMP-CREB-BDNF signaling. Morphine 56-64 cAMP responsive element binding protein 1 Rattus norvegicus 189-193 29415719-0 2018 MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting beta-arrestin2. Morphine 24-32 cAMP responsive element binding protein 1 Rattus norvegicus 85-89 29415719-7 2018 RESULTS: The results obtained showed that when compared with the morphine tolerance group, there was an increase in miR-365 expression and a decrease in the beta-arrestin2, ERK, CREB protein expressions, contents of IL-1beta, TNF-alpha, IL-18 and GFAP expression in the miR-365 mimic group, while the miR-365 inhibitor group displayed an opposite trend. Morphine 65-73 cAMP responsive element binding protein 1 Rattus norvegicus 178-182 29054430-7 2018 Therefore, it can be assumed that consolidation and reconsolidation of morphine memory via intra-PFC, -NAc and -HIP NMDA glutamate receptors are in accordance with changes in p-CREB/CREB ratio and c-fos levels. Morphine 71-79 cAMP responsive element binding protein 1 Rattus norvegicus 177-181 29054430-7 2018 Therefore, it can be assumed that consolidation and reconsolidation of morphine memory via intra-PFC, -NAc and -HIP NMDA glutamate receptors are in accordance with changes in p-CREB/CREB ratio and c-fos levels. Morphine 71-79 cAMP responsive element binding protein 1 Rattus norvegicus 182-186 24597568-0 2015 Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone-precipitated conditioned place aversion in acute morphine-treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala. Morphine 122-130 cAMP responsive element binding protein 1 Rattus norvegicus 167-171 25746394-0 2015 NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required. Morphine 57-65 cAMP responsive element binding protein 1 Rattus norvegicus 140-144 26598419-0 2017 Glucocorticoid receptor but not mineralocorticoid receptor mediates the activation of ERK pathway and CREB during morphine withdrawal. Morphine 114-122 cAMP responsive element binding protein 1 Rattus norvegicus 102-106 27053349-2 2017 In addition, several lines of study have indicated that cAMP response element-binding protein (CREB) and c-fos have important role in morphine-induced conditioned place preference (CPP) induced by drugs of abuse, such as morphine, cocaine, nicotine, and alcohol. Morphine 134-142 cAMP responsive element binding protein 1 Rattus norvegicus 56-93 27053349-2 2017 In addition, several lines of study have indicated that cAMP response element-binding protein (CREB) and c-fos have important role in morphine-induced conditioned place preference (CPP) induced by drugs of abuse, such as morphine, cocaine, nicotine, and alcohol. Morphine 134-142 cAMP responsive element binding protein 1 Rattus norvegicus 95-99 27053349-2 2017 In addition, several lines of study have indicated that cAMP response element-binding protein (CREB) and c-fos have important role in morphine-induced conditioned place preference (CPP) induced by drugs of abuse, such as morphine, cocaine, nicotine, and alcohol. Morphine 221-229 cAMP responsive element binding protein 1 Rattus norvegicus 56-93 27053349-2 2017 In addition, several lines of study have indicated that cAMP response element-binding protein (CREB) and c-fos have important role in morphine-induced conditioned place preference (CPP) induced by drugs of abuse, such as morphine, cocaine, nicotine, and alcohol. Morphine 221-229 cAMP responsive element binding protein 1 Rattus norvegicus 95-99 26708494-3 2016 Our findings indicated that post-training or pre-test administration of morphine (2 and 6 mg/kg) or DM (10-30 mg/kg) impaired memory consolidation and retrieval which was associated with the attenuation of the levels of phosphorylated Ca(2+)/calmodulin-dependent protein kinase II (p-CAMKII) and cAMP responsive element-binding protein (p-CREB) in the targeted sites. Morphine 72-80 cAMP responsive element binding protein 1 Rattus norvegicus 339-343 26708494-6 2016 In addition, DM administration potentiated morphine-induced SDL which was related to the enhanced levels of hippocampal and PFC CAMKII-CREB signaling pathways. Morphine 43-51 cAMP responsive element binding protein 1 Rattus norvegicus 135-139 25746394-9 2015 CONCLUSIONS: Arc/Arg3.1 in the NAc shell mediates the reconsolidation of morphine-associated context memory via up-regulating the level of membrane of GluR1, for which the local activation of the ERK-CREB signal pathway, as an upstream mechanism of Arc/Arg3.1, is required. Morphine 73-81 cAMP responsive element binding protein 1 Rattus norvegicus 200-204 25481016-8 2014 Our findings revealed that in saline- or morphine-treated animals, acute and subcronic stress increased the p-ERK/ERK ratio, p-CREB/CREB ratio and c-fos level in the hypothalamus and hippocampus and this enhancement in morphine-treated animals, was more considerable than that in saline-treated animals. Morphine 41-49 cAMP responsive element binding protein 1 Rattus norvegicus 127-131 25481016-3 2014 In the current study, effects of acute and subchronic stress on the alteration of p-ERK, p-CREB and c-fos levels in the hypothalamus and hippocampus of saline- or morphine-treated animals during morphine-induced conditioned place preference (CPP) procedure were investigated. Morphine 163-171 cAMP responsive element binding protein 1 Rattus norvegicus 91-95 25481016-7 2014 The results indicated that in saline- or morphine-treated animals, p-ERK/ERK ratio, p-CREB/CREB ratio and c-fos level increased after application of acute and subchronic stress (except for p-ERK/ERK ratio in morphine-control group). Morphine 41-49 cAMP responsive element binding protein 1 Rattus norvegicus 86-90 25481016-7 2014 The results indicated that in saline- or morphine-treated animals, p-ERK/ERK ratio, p-CREB/CREB ratio and c-fos level increased after application of acute and subchronic stress (except for p-ERK/ERK ratio in morphine-control group). Morphine 41-49 cAMP responsive element binding protein 1 Rattus norvegicus 91-95 25481016-8 2014 Our findings revealed that in saline- or morphine-treated animals, acute and subcronic stress increased the p-ERK/ERK ratio, p-CREB/CREB ratio and c-fos level in the hypothalamus and hippocampus and this enhancement in morphine-treated animals, was more considerable than that in saline-treated animals. Morphine 41-49 cAMP responsive element binding protein 1 Rattus norvegicus 132-136 24704371-7 2014 These results suggested that CREB-mediated epigenetic upregulation of PSD-95 critically contributed to the enhanced glutamatergic transmission and rewarding behavior induced by morphine conditioning. Morphine 177-185 cAMP responsive element binding protein 1 Rattus norvegicus 29-33 25302800-8 2014 Chronic morphine treatment suppressed desensitization of cAMP and MAPK signaling, increased CREB phosphorylation through a MAPK/ERK pathway and induced delays of gastrointestinal transit, which was prevented by MAPK/ERK blockade. Morphine 8-16 cAMP responsive element binding protein 1 Rattus norvegicus 92-96 25302800-9 2014 This study showed that opioids induce endocytosis- and dynamin-dependent MAPK/ERK activation in enteric neurons and that chronic morphine treatment triggers changes at the receptor level and downstream signaling resulting in MAPK/ERK-dependent CREB activation. Morphine 129-137 cAMP responsive element binding protein 1 Rattus norvegicus 244-248 24292370-12 2014 Our findings suggest that in saline- or morphine-treated animals, acute and subchronic stress increases p-ERK, p-CREB, and c-fos levels in the mesocorticolimbic system. Morphine 40-48 cAMP responsive element binding protein 1 Rattus norvegicus 113-117 24038231-6 2013 The immunohistochemistry studies showed that morphine administration also increased striatal mu opioid receptor immunoreactivity but reduced P-CREB expression, effects that were blocked by the PD168,077-induced activation of D4 receptors. Morphine 45-53 cAMP responsive element binding protein 1 Rattus norvegicus 143-147 23035088-7 2012 We conclude that extinction of aversive memory of morphine withdrawal requires epigenetic regulation of BDNF gene transcription in the vmPFC through activation of the ERK-CREB signaling pathway perhaps in a NMDA receptor-dependent manner. Morphine 50-58 cAMP responsive element binding protein 1 Rattus norvegicus 171-175 22715022-0 2012 Hydrocodone and morphine possess similar rewarding effects and reduce ERK and CREB phosphorylation in the nucleus accumbens. Morphine 16-24 cAMP responsive element binding protein 1 Rattus norvegicus 78-82 22715022-6 2012 Moreover, hydrocodone and morphine equally reduced phosphorylation levels of ERK and CREB proteins in the nucleus accumbens, suggesting that both drugs exert their effects through signal transduction pathways known to be involved in drug reward and reinforcement. Morphine 26-34 cAMP responsive element binding protein 1 Rattus norvegicus 85-89 22355339-2 2012 The present study tested the hypothesis that changes in CREB activation and phosphorylated TORC1 levels in the hypothalamic paraventricular nucleus (PVN) after naloxone-precipitated morphine withdrawal as well as the HPA axis activity arises from alpha(1)- and/or beta-adrenoceptor activation. Morphine 182-190 cAMP responsive element binding protein 1 Rattus norvegicus 56-60 22580231-6 2012 In cells treated with chronic morphine, the expression of CREB, adenylyl cyclase (AC) and protein kinase A (PKA) were increased, while in cells infected with LV-CREB3, treated with chronic morphine treatment failed to increase the expressions of CREB and AC. Morphine 30-38 cAMP responsive element binding protein 1 Rattus norvegicus 58-62 22580231-6 2012 In cells treated with chronic morphine, the expression of CREB, adenylyl cyclase (AC) and protein kinase A (PKA) were increased, while in cells infected with LV-CREB3, treated with chronic morphine treatment failed to increase the expressions of CREB and AC. Morphine 30-38 cAMP responsive element binding protein 1 Rattus norvegicus 161-165 22580231-6 2012 In cells treated with chronic morphine, the expression of CREB, adenylyl cyclase (AC) and protein kinase A (PKA) were increased, while in cells infected with LV-CREB3, treated with chronic morphine treatment failed to increase the expressions of CREB and AC. Morphine 189-197 cAMP responsive element binding protein 1 Rattus norvegicus 58-62 22580231-6 2012 In cells treated with chronic morphine, the expression of CREB, adenylyl cyclase (AC) and protein kinase A (PKA) were increased, while in cells infected with LV-CREB3, treated with chronic morphine treatment failed to increase the expressions of CREB and AC. Morphine 189-197 cAMP responsive element binding protein 1 Rattus norvegicus 161-165 22580231-7 2012 Consistently, in the rat model for chronic morphine treatment, morphine increased the expression of CREB, AC and PKA in LC neurons. Morphine 43-51 cAMP responsive element binding protein 1 Rattus norvegicus 100-104 22580231-7 2012 Consistently, in the rat model for chronic morphine treatment, morphine increased the expression of CREB, AC and PKA in LC neurons. Morphine 63-71 cAMP responsive element binding protein 1 Rattus norvegicus 100-104 22580231-10 2012 In conclusion, the lentiviral vectors expressing CREB shRNA inhibited the increase of CREB and AC expression induced by chronic morphine treatment both in vivo and in vitro. Morphine 128-136 cAMP responsive element binding protein 1 Rattus norvegicus 49-53 22580231-10 2012 In conclusion, the lentiviral vectors expressing CREB shRNA inhibited the increase of CREB and AC expression induced by chronic morphine treatment both in vivo and in vitro. Morphine 128-136 cAMP responsive element binding protein 1 Rattus norvegicus 86-90 22355339-9 2012 Present results suggest that, during acute morphine withdrawal, NA may control the HPA axis activity through CREB activation at the PVN level. Morphine 43-51 cAMP responsive element binding protein 1 Rattus norvegicus 109-113 22355339-10 2012 We concluded that the combined increase in CREB phosphorylation and decrease in pTORC1 levels might represent, in part, two of the mechanisms of CREB activation at the PVN during morphine withdrawal. Morphine 179-187 cAMP responsive element binding protein 1 Rattus norvegicus 43-47 22355339-10 2012 We concluded that the combined increase in CREB phosphorylation and decrease in pTORC1 levels might represent, in part, two of the mechanisms of CREB activation at the PVN during morphine withdrawal. Morphine 179-187 cAMP responsive element binding protein 1 Rattus norvegicus 145-149 21782156-7 2011 Interestingly, at some time-points, combined treatment with morphine and PD168,077 substantially increased c-Fos, FosB/DeltaFosB and P-CREB expression. Morphine 60-68 cAMP responsive element binding protein 1 Rattus norvegicus 135-139 20731628-9 2010 The levels of phosphorylated DARPP32 (Thr34) and phosphorylated CREB (Ser133) were increased in the ACG of rats that had maintained the morphine-induced place preference, whereas the increases of these levels induced by morphine were blocked by pre-treatment of a selective dopamine D1 receptor antagonist SCH23390. Morphine 136-144 cAMP responsive element binding protein 1 Rattus norvegicus 64-68 21615389-3 2011 Here, we investigated changes in activation of the transcription factor, cAMP-response element binding protein (CREB), in the hypothalamic paraventricular nucleus (PVN) and the kinases that may mediate the morphine withdrawal-triggered activation of CREB and the response of the hypothalamic-pituitary-adrenocortical (HPA) axis after naloxone-induced morphine withdrawal. Morphine 206-214 cAMP responsive element binding protein 1 Rattus norvegicus 73-110 21615389-3 2011 Here, we investigated changes in activation of the transcription factor, cAMP-response element binding protein (CREB), in the hypothalamic paraventricular nucleus (PVN) and the kinases that may mediate the morphine withdrawal-triggered activation of CREB and the response of the hypothalamic-pituitary-adrenocortical (HPA) axis after naloxone-induced morphine withdrawal. Morphine 206-214 cAMP responsive element binding protein 1 Rattus norvegicus 112-116 21615389-3 2011 Here, we investigated changes in activation of the transcription factor, cAMP-response element binding protein (CREB), in the hypothalamic paraventricular nucleus (PVN) and the kinases that may mediate the morphine withdrawal-triggered activation of CREB and the response of the hypothalamic-pituitary-adrenocortical (HPA) axis after naloxone-induced morphine withdrawal. Morphine 206-214 cAMP responsive element binding protein 1 Rattus norvegicus 250-254 21295078-2 2011 Several lines of evidence have shown that cAMP-response element binding protein (CREB), extracellular signal-regulated kinase (ERK), and c-fos have pivotal role in CPP induced by drugs of abuse, such as morphine, cocaine, nicotine, and alcohol. Morphine 203-211 cAMP responsive element binding protein 1 Rattus norvegicus 42-79 21295078-2 2011 Several lines of evidence have shown that cAMP-response element binding protein (CREB), extracellular signal-regulated kinase (ERK), and c-fos have pivotal role in CPP induced by drugs of abuse, such as morphine, cocaine, nicotine, and alcohol. Morphine 203-211 cAMP responsive element binding protein 1 Rattus norvegicus 81-85 21615389-3 2011 Here, we investigated changes in activation of the transcription factor, cAMP-response element binding protein (CREB), in the hypothalamic paraventricular nucleus (PVN) and the kinases that may mediate the morphine withdrawal-triggered activation of CREB and the response of the hypothalamic-pituitary-adrenocortical (HPA) axis after naloxone-induced morphine withdrawal. Morphine 351-359 cAMP responsive element binding protein 1 Rattus norvegicus 73-110 21615389-3 2011 Here, we investigated changes in activation of the transcription factor, cAMP-response element binding protein (CREB), in the hypothalamic paraventricular nucleus (PVN) and the kinases that may mediate the morphine withdrawal-triggered activation of CREB and the response of the hypothalamic-pituitary-adrenocortical (HPA) axis after naloxone-induced morphine withdrawal. Morphine 351-359 cAMP responsive element binding protein 1 Rattus norvegicus 112-116 21171355-0 2007 [Effects of intrathecal injection of U0126 on the expression of phospho-CREB in spinal cord of morphine-induced withdrawal rats]. Morphine 95-103 cAMP responsive element binding protein 1 Rattus norvegicus 72-76 19108758-0 2009 Effects of morphine-dependent and withdrawal on activation of the distal cerebrospinal fluid contacting neurons" phosphorylation CREB in rat brain. Morphine 11-19 cAMP responsive element binding protein 1 Rattus norvegicus 129-133 19108758-8 2009 CONCLUSION: Morphine-dependent and withdrawal can activate the distal cerebrospinal fluid contacting neurons phosphorylation CREB in rat brain. Morphine 12-20 cAMP responsive element binding protein 1 Rattus norvegicus 125-129 20818076-9 2010 Intraperitoneal injection of morphine prevented the increased phosphorylation of CREB in the spinal cord and inhibited the mechanical allodynia induced by the incision (P>0.05). Morphine 29-37 cAMP responsive element binding protein 1 Rattus norvegicus 81-85 22110916-7 2010 The upregulation of p-CREB was inhibited by morphine and gabapentin. Morphine 44-52 cAMP responsive element binding protein 1 Rattus norvegicus 22-26 19545278-0 2009 Morphine withdrawal regulates phosphorylation of cAMP response element binding protein (CREB) through PKC in the nucleus tractus solitarius-A2 catecholaminergic neurons. Morphine 0-8 cAMP responsive element binding protein 1 Rattus norvegicus 49-86 19545278-0 2009 Morphine withdrawal regulates phosphorylation of cAMP response element binding protein (CREB) through PKC in the nucleus tractus solitarius-A2 catecholaminergic neurons. Morphine 0-8 cAMP responsive element binding protein 1 Rattus norvegicus 88-92 19545278-4 2009 In the current study we used immunoblotting and immunohistochemistry to investigate changes in CREB phosphorylation in the NTS and kinases that may mediate the morphine withdrawal-triggered activation of CREB and hypothalamo-pituitary-adrenocortical (HPA) axis (another stress system circuit) response after naloxone-induced morphine withdrawal. Morphine 160-168 cAMP responsive element binding protein 1 Rattus norvegicus 95-99 19545278-4 2009 In the current study we used immunoblotting and immunohistochemistry to investigate changes in CREB phosphorylation in the NTS and kinases that may mediate the morphine withdrawal-triggered activation of CREB and hypothalamo-pituitary-adrenocortical (HPA) axis (another stress system circuit) response after naloxone-induced morphine withdrawal. Morphine 160-168 cAMP responsive element binding protein 1 Rattus norvegicus 204-208 19545278-4 2009 In the current study we used immunoblotting and immunohistochemistry to investigate changes in CREB phosphorylation in the NTS and kinases that may mediate the morphine withdrawal-triggered activation of CREB and hypothalamo-pituitary-adrenocortical (HPA) axis (another stress system circuit) response after naloxone-induced morphine withdrawal. Morphine 325-333 cAMP responsive element binding protein 1 Rattus norvegicus 95-99 19545278-4 2009 In the current study we used immunoblotting and immunohistochemistry to investigate changes in CREB phosphorylation in the NTS and kinases that may mediate the morphine withdrawal-triggered activation of CREB and hypothalamo-pituitary-adrenocortical (HPA) axis (another stress system circuit) response after naloxone-induced morphine withdrawal. Morphine 325-333 cAMP responsive element binding protein 1 Rattus norvegicus 204-208 19545278-5 2009 We found an increased phosphorylation of CREB (pCREB) selectively within tyrosine hydroxylase (TH) immunoreactive neurons in the NTS from morphine-withdrawn rats, which parallel elevated corticosterone levels. Morphine 138-146 cAMP responsive element binding protein 1 Rattus norvegicus 41-45 19545278-9 2009 The results indicate that PKC mediates both CREB activation and HPA response by morphine withdrawal and might suggest that CREB activation in the NTS is related to TH expression associated with morphine withdrawal. Morphine 194-202 cAMP responsive element binding protein 1 Rattus norvegicus 123-127 19052216-5 2008 The progressive increase in low-dose (3 mg/kg) morphine CPP was associated with increased ERK phosphorylation (a measure of ERK activity) and CREB (a downstream target of ERK) phosphorylation in central but not basolateral amygdala. Morphine 47-55 cAMP responsive element binding protein 1 Rattus norvegicus 142-146 18616461-9 2008 Silencing of CREB or Elk-1 significantly increased ERK activation observed after 5 min of morphine stimulation. Morphine 90-98 cAMP responsive element binding protein 1 Rattus norvegicus 13-17 18616461-12 2008 These differences suggest that both CREB-dependent and Elk-1-dependent transcription contribute to the expression of proteins regulating morphine-induced ERK activity (particular phosphatases, upstream kinases or their activatory proteins). Morphine 137-145 cAMP responsive element binding protein 1 Rattus norvegicus 36-40 21171355-1 2007 AIM: To explore effects of intrathecal injection of U0126 on morphine withdrawal response and the spinal Phospho-CREB expression in morphine-induced withdrawal rats. Morphine 132-140 cAMP responsive element binding protein 1 Rattus norvegicus 113-117 16641242-1 2006 The transcription factor cAMP response element-binding protein (CREB) is implicated in mediating the actions of chronic morphine in the locus ceruleus (LC), but direct evidence to support such a role is limited. Morphine 120-128 cAMP responsive element binding protein 1 Rattus norvegicus 25-62 16775132-5 2006 Here, we show that somatic signs of naloxone-precipitated withdrawal were associated with increased P-CREB, but not P-GluR1, in the NAc of morphine-dependent rats. Morphine 139-147 cAMP responsive element binding protein 1 Rattus norvegicus 102-106 16641242-1 2006 The transcription factor cAMP response element-binding protein (CREB) is implicated in mediating the actions of chronic morphine in the locus ceruleus (LC), but direct evidence to support such a role is limited. Morphine 120-128 cAMP responsive element binding protein 1 Rattus norvegicus 64-68 16641242-7 2006 Together, these data provide direct evidence that CREB plays an important role in controlling the electrical excitability of LC neurons and that morphine-induced increases in CREB activity contribute to the behavioral and neural adaptations associated with opiate dependence and withdrawal. Morphine 145-153 cAMP responsive element binding protein 1 Rattus norvegicus 175-179 16421965-0 2006 Changes of CREB in rat hippocampus, prefrontal cortex and nucleus accumbens during three phases of morphine induced conditioned place preference in rats. Morphine 99-107 cAMP responsive element binding protein 1 Rattus norvegicus 11-15 16421965-1 2006 OBJECTIVE: To investigate the changes in CREB (cAMP response element binding protein) in hippocampus, PFC (prefrontal cortex) and NAc (nucleus accumbens) during three phases of morphine induced CPP (conditioned place preference) in rats, and to elucidate the role of CREB during the progress of conditioned place preference. Morphine 177-185 cAMP responsive element binding protein 1 Rattus norvegicus 41-45 16421965-1 2006 OBJECTIVE: To investigate the changes in CREB (cAMP response element binding protein) in hippocampus, PFC (prefrontal cortex) and NAc (nucleus accumbens) during three phases of morphine induced CPP (conditioned place preference) in rats, and to elucidate the role of CREB during the progress of conditioned place preference. Morphine 177-185 cAMP responsive element binding protein 1 Rattus norvegicus 47-84 16421965-1 2006 OBJECTIVE: To investigate the changes in CREB (cAMP response element binding protein) in hippocampus, PFC (prefrontal cortex) and NAc (nucleus accumbens) during three phases of morphine induced CPP (conditioned place preference) in rats, and to elucidate the role of CREB during the progress of conditioned place preference. Morphine 177-185 cAMP responsive element binding protein 1 Rattus norvegicus 267-271 16421965-6 2006 CONCLUSION: It was proved that CPP model can be used as an effective tool to investigate the mechanisms underlying drug-induced reinstatement of drug seeking after extinction, and that morphine induced CPP and drug primed reinstatement may involve activation of the transcription factor CREB in several brain areas, suggesting that the CREB and its target gene regulation pathway may mediate the basic mechanism underlying opioid dependence and its drug seeking behavior. Morphine 185-193 cAMP responsive element binding protein 1 Rattus norvegicus 287-291 16421965-6 2006 CONCLUSION: It was proved that CPP model can be used as an effective tool to investigate the mechanisms underlying drug-induced reinstatement of drug seeking after extinction, and that morphine induced CPP and drug primed reinstatement may involve activation of the transcription factor CREB in several brain areas, suggesting that the CREB and its target gene regulation pathway may mediate the basic mechanism underlying opioid dependence and its drug seeking behavior. Morphine 185-193 cAMP responsive element binding protein 1 Rattus norvegicus 336-340 16598705-6 2006 In addition, prenatal morphine exposure reduced not only the expression of nNOS and the phosphorylation of cAMP responsive element-binding protein at serine 133 (CREB(Serine-133)), but also the magnitude of long-term depression (LTD) at P14. Morphine 22-30 cAMP responsive element binding protein 1 Rattus norvegicus 162-166 16598705-9 2006 Collectively, the study demonstrates that maternal exposure to morphine decreases the magnitude of PSD-95, nNOS, the phosphorylation of CREB(Serine-133), and LTD expression in hippocampal CA1 subregion of young offspring (e.g., P14). Morphine 63-71 cAMP responsive element binding protein 1 Rattus norvegicus 136-140 16289800-6 2005 The spinal ERK inhibition or knockdown also reduced morphine withdrawal-induced phosphorylation of cAMP response element binding protein (CREB), which is one of the important downstream substrates of ERK pathway, and Fos expression. Morphine 52-60 cAMP responsive element binding protein 1 Rattus norvegicus 99-136 16289800-6 2005 The spinal ERK inhibition or knockdown also reduced morphine withdrawal-induced phosphorylation of cAMP response element binding protein (CREB), which is one of the important downstream substrates of ERK pathway, and Fos expression. Morphine 52-60 cAMP responsive element binding protein 1 Rattus norvegicus 138-142 16319314-2 2005 Here we show that the expression of spinal NMDAR and PKCgamma after chronic morphine is regulated by spinal GR through a cAMP response element-binding protein (CREB)-dependent pathway. Morphine 76-84 cAMP responsive element binding protein 1 Rattus norvegicus 121-158 16319314-2 2005 Here we show that the expression of spinal NMDAR and PKCgamma after chronic morphine is regulated by spinal GR through a cAMP response element-binding protein (CREB)-dependent pathway. Morphine 76-84 cAMP responsive element binding protein 1 Rattus norvegicus 160-164 16319314-7 2005 Moreover, the expression of phosphorylated CREB was upregulated within the spinal cord dorsal horn after chronic morphine, and a CREB antisense oligodeoxynucleotide coadministered intrathecally with morphine prevented the upregulation of GR, NR1, and PKCgamma. Morphine 113-121 cAMP responsive element binding protein 1 Rattus norvegicus 43-47 16319314-7 2005 Moreover, the expression of phosphorylated CREB was upregulated within the spinal cord dorsal horn after chronic morphine, and a CREB antisense oligodeoxynucleotide coadministered intrathecally with morphine prevented the upregulation of GR, NR1, and PKCgamma. Morphine 199-207 cAMP responsive element binding protein 1 Rattus norvegicus 43-47 16319314-7 2005 Moreover, the expression of phosphorylated CREB was upregulated within the spinal cord dorsal horn after chronic morphine, and a CREB antisense oligodeoxynucleotide coadministered intrathecally with morphine prevented the upregulation of GR, NR1, and PKCgamma. Morphine 199-207 cAMP responsive element binding protein 1 Rattus norvegicus 129-133 16319314-8 2005 These results indicate that spinal GR through the cAMP-CREB pathway played a significant role in NMDAR and PKCgamma expression after chronic morphine exposure. Morphine 141-149 cAMP responsive element binding protein 1 Rattus norvegicus 55-59 16095816-6 2005 In addition, the effect of morphine on the phosphorylation of the transcription factors, cyclic AMP responsive element-binding protein (CREB) was investigated. Morphine 27-35 cAMP responsive element binding protein 1 Rattus norvegicus 89-134 16095816-6 2005 In addition, the effect of morphine on the phosphorylation of the transcription factors, cyclic AMP responsive element-binding protein (CREB) was investigated. Morphine 27-35 cAMP responsive element binding protein 1 Rattus norvegicus 136-140 16095816-7 2005 Western blot analysis showed that morphine significantly increased phosphorylation of CREB. Morphine 34-42 cAMP responsive element binding protein 1 Rattus norvegicus 86-90 12969258-0 2003 Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum. Morphine 116-124 cAMP responsive element binding protein 1 Rattus norvegicus 51-88 12969258-0 2003 Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum. Morphine 116-124 cAMP responsive element binding protein 1 Rattus norvegicus 90-94 12969258-2 2003 One potential consequence of up-regulated cAMP signaling is increased phosphorylation of cAMP response element binding protein (CREB), a transcription factor that may regulate neuroadaptations related to morphine dependence. Morphine 204-212 cAMP responsive element binding protein 1 Rattus norvegicus 89-126 12969258-2 2003 One potential consequence of up-regulated cAMP signaling is increased phosphorylation of cAMP response element binding protein (CREB), a transcription factor that may regulate neuroadaptations related to morphine dependence. Morphine 204-212 cAMP responsive element binding protein 1 Rattus norvegicus 128-132 12969258-4 2003 To determine if morphine withdrawal leads to increased CREB phosphorylation in striatal tissues, we examined the effects of naloxone-precipitated morphine withdrawal on CREB phosphorylation in primary cultures of rat striatal neurons. Morphine 16-24 cAMP responsive element binding protein 1 Rattus norvegicus 55-59 12969258-5 2003 Precipitated morphine withdrawal was associated with enhanced dopamine-, SKF 82958 (D1 receptor agonist)-, and forskolin-induced CREB phosphorylation. Morphine 13-21 cAMP responsive element binding protein 1 Rattus norvegicus 129-133 15183518-6 2004 Caspace 1, D2 dopamine receptor, GABA-A alpha1 subunit, GRIA 1/3/4, Galphai2, PSD-95 and CREB were down-regulated in the NAc shell with morphine administration. Morphine 136-144 cAMP responsive element binding protein 1 Rattus norvegicus 89-93 11683901-0 2001 Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study. Morphine 8-16 cAMP responsive element binding protein 1 Rattus norvegicus 100-104 11683901-10 2001 Naloxone effectively blocked these actions of morphine, whereas a selective MEK1 inhibitor, PD98059, inhibited the morphine-induced increase in the phosphorylation of ERK and CREB, and the expression of CGRP and SP. Morphine 46-54 cAMP responsive element binding protein 1 Rattus norvegicus 175-179 11683901-10 2001 Naloxone effectively blocked these actions of morphine, whereas a selective MEK1 inhibitor, PD98059, inhibited the morphine-induced increase in the phosphorylation of ERK and CREB, and the expression of CGRP and SP. Morphine 115-123 cAMP responsive element binding protein 1 Rattus norvegicus 175-179 11683901-12 2001 These in vitro and in vivo data suggest that the phosphorylation of MAP kinases and CREB plays a role in the morphine-induced increase in spinal CGRP and SP levels in primary sensory afferents, contributing to the development of tolerance to opioid-induced analgesia. Morphine 109-117 cAMP responsive element binding protein 1 Rattus norvegicus 84-88