PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25124340-5 2014 Paracetamol, NSAIDs, COX-2 antagonists, and gabapentin reduced 24 h post-operative morphine requirements with 6.3 (95% confidence interval: 3.7 to 9.0) mg, 10.2 (8.7, 11.7) mg, 10.9 (9.1, 12.8) mg, and >= 13 mg, respectively, when administered as monotherapy. Morphine 83-91 mitochondrially encoded cytochrome c oxidase II Homo sapiens 21-26 24928142-0 2014 Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway. Morphine 29-37 mitochondrially encoded cytochrome c oxidase II Homo sapiens 115-120 24928142-11 2014 Conversely, cyclooxygenase (COX)-2, primarily produced from peripheral macrophages in acute inflammation states, was up-regulated in the early phase at morphine-injected sites. Morphine 152-160 mitochondrially encoded cytochrome c oxidase II Homo sapiens 12-34 24928142-14 2014 A morphine-induced shift in macrophage phenotype may be mediated by a COX-2-dependent mechanism. Morphine 2-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 70-75 20346263-3 2010 REVIEW METHODS: Randomised controlled trials comparing paracetamol, NSAIDs or COX-2 inhibitors to each other or placebo, in adults receiving patient-controlled analgesia (PCA) with morphine following major surgery, were included. Morphine 181-189 mitochondrially encoded cytochrome c oxidase II Homo sapiens 78-83 21163799-0 2011 Only a small reduction in morphine use with adding NSAIDs, paracetamol or COX-2 inhibitors to patient controlled morphine in the 24 h after major surgery. Morphine 26-34 mitochondrially encoded cytochrome c oxidase II Homo sapiens 74-79 20346263-18 2010 CONCLUSIONS: 24-hour morphine consumption decreased by 6.3 mg to 10.9 mg, compared to placebo, when paracetamol, NSAID or COX-2 inhibitors were added to PCA morphine following surgery. Morphine 21-29 mitochondrially encoded cytochrome c oxidase II Homo sapiens 122-127 20346263-15 2010 When paracetamol, NSAIDs or COX-2 inhibitors were added to PCA morphine, there was a statistically significant reduction in morphine consumption: paracetamol (MD -6.34 mg; 95% CrI -9.02 to -3.65); NSAIDs (MD -10.18; 95% CrI -11.65 to -8.72); and COX-2 inhibitors (MD -10.92; 95% CrI -12.77 to -9.08). Morphine 63-71 mitochondrially encoded cytochrome c oxidase II Homo sapiens 28-33 20346263-15 2010 When paracetamol, NSAIDs or COX-2 inhibitors were added to PCA morphine, there was a statistically significant reduction in morphine consumption: paracetamol (MD -6.34 mg; 95% CrI -9.02 to -3.65); NSAIDs (MD -10.18; 95% CrI -11.65 to -8.72); and COX-2 inhibitors (MD -10.92; 95% CrI -12.77 to -9.08). Morphine 124-132 mitochondrially encoded cytochrome c oxidase II Homo sapiens 28-33 10593169-0 1999 Biochemical changes in prostanoids and cerebral expression of cyclooxygenase (COX)-1 and COX-2 during morphine sulfate infusion in the newborn piglet . Morphine 102-118 mitochondrially encoded cytochrome c oxidase II Homo sapiens 89-94 16113982-3 1999 From these we have selected excitability blockers acting on sodium and calcium channels, progress in drugs acting at glutamate receptors, cannabinoid receptors, capsaicin analogs, novel opioids acting at receptors other than the mu receptor for morphine, substance P antagonists and cyclooxygenase (COX)-2 inhibitors as being of particular interest. Morphine 245-253 mitochondrially encoded cytochrome c oxidase II Homo sapiens 283-305 28039239-9 2017 For AOM used alone, morphine consumption reduction was greatest with alpha-2 agonists, NSAIDs, and COX-2 inhibitors. Morphine 20-28 mitochondrially encoded cytochrome c oxidase II Homo sapiens 99-104 28474563-7 2017 Recent studies uncover two mechanisms by which morphine may up-regulate P-gp and BCRP at the BBB: 1) via a glutamate, NMDA-receptor and COX-2 signaling cascade, and 2) via TLR4 activation, subsequent development of neuroinflammation, and activation of NF-kB, presumably via glial cells. Morphine 47-55 mitochondrially encoded cytochrome c oxidase II Homo sapiens 136-141