PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28039239-9	2017	For AOM used alone, morphine consumption reduction was greatest with alpha-2 agonists, NSAIDs, and COX-2 inhibitors.	Morphine	20-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104	
28474563-7	2017	Recent studies uncover two mechanisms by which morphine may up-regulate P-gp and BCRP at the BBB: 1) via a glutamate, NMDA-receptor and COX-2 signaling cascade, and 2) via TLR4 activation, subsequent development of neuroinflammation, and activation of NF-kB, presumably via glial cells.	Morphine	47-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141	
25124340-5	2014	Paracetamol, NSAIDs, COX-2 antagonists, and gabapentin reduced 24 h post-operative morphine requirements with 6.3 (95% confidence interval: 3.7 to 9.0) mg, 10.2 (8.7, 11.7) mg, 10.9 (9.1, 12.8) mg, and >= 13 mg, respectively, when administered as monotherapy.	Morphine	83-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26	
20346263-3	2010	REVIEW METHODS: Randomised controlled trials comparing paracetamol, NSAIDs or COX-2 inhibitors to each other or placebo, in adults receiving patient-controlled analgesia (PCA) with morphine following major surgery, were included.	Morphine	181-189	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83	
21163799-0	2011	Only a small reduction in morphine use with adding NSAIDs, paracetamol or COX-2 inhibitors to patient controlled morphine in the 24 h after major surgery.	Morphine	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79	
20346263-18	2010	CONCLUSIONS: 24-hour morphine consumption decreased by 6.3 mg to 10.9 mg, compared to placebo, when paracetamol, NSAID or COX-2 inhibitors were added to PCA morphine following surgery.	Morphine	21-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127	
24928142-0	2014	Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway.	Morphine	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120	
24928142-11	2014	Conversely, cyclooxygenase (COX)-2, primarily produced from peripheral macrophages in acute inflammation states, was up-regulated in the early phase at morphine-injected sites.	Morphine	152-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-34	
24928142-14	2014	A morphine-induced shift in macrophage phenotype may be mediated by a COX-2-dependent mechanism.	Morphine	2-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75	
20346263-15	2010	When paracetamol, NSAIDs or COX-2 inhibitors were added to PCA morphine, there was a statistically significant reduction in morphine consumption: paracetamol (MD -6.34 mg; 95% CrI -9.02 to -3.65); NSAIDs (MD -10.18; 95% CrI -11.65 to -8.72); and COX-2 inhibitors (MD -10.92; 95% CrI -12.77 to -9.08).	Morphine	63-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33	
20346263-15	2010	When paracetamol, NSAIDs or COX-2 inhibitors were added to PCA morphine, there was a statistically significant reduction in morphine consumption: paracetamol (MD -6.34 mg; 95% CrI -9.02 to -3.65); NSAIDs (MD -10.18; 95% CrI -11.65 to -8.72); and COX-2 inhibitors (MD -10.92; 95% CrI -12.77 to -9.08).	Morphine	124-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33	
10593169-0	1999	Biochemical changes in prostanoids and cerebral expression of cyclooxygenase (COX)-1 and COX-2 during morphine sulfate infusion in the newborn piglet .	Morphine	102-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94	
16113982-3	1999	From these we have selected excitability blockers acting on sodium and calcium channels, progress in drugs acting at glutamate receptors, cannabinoid receptors, capsaicin analogs, novel opioids acting at receptors other than the mu receptor for morphine, substance P antagonists and cyclooxygenase (COX)-2 inhibitors as being of particular interest.	Morphine	245-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	283-305