PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33768439-5	2021	Many researchers have voiced concerns that the use of ACEIs and ARBs may increase tissue ACE2 levels.	aceis	54-59	angiotensin converting enzyme 2	Homo sapiens	89-93	
33768439-10	2021	Further studies are required to investigate the effect of ACEIs and ARBs on ACE2 expression and COVID-19.	aceis	58-63	angiotensin converting enzyme 2	Homo sapiens	76-80	
33475077-3	2021	OBJECTIVE: The purpose of this review is to discuss the existing evidence on the interaction between COVID-19 infection, ACE2 and ACEIs or ARBs and to examine the main implications for clinical practice.	aceis	130-135	angiotensin converting enzyme 2	Homo sapiens	121-125	
32665962-4	2020	The concern is that the use of ACEIs and ARBs will increase the expression of ACE2 and increase patient susceptibility to viral host cell entry and propagation.	aceis	31-36	angiotensin converting enzyme 2	Homo sapiens	78-82	
33426364-5	2021	The CVD drugs ACEIs and ARBs, as well as the T2D drugs GLP-1R agonists, were shown to activate angiotensin-converting enzyme 2 (ACE2) expression in experimental animals.	aceis	14-19	angiotensin converting enzyme 2	Homo sapiens	95-126	
33426364-5	2021	The CVD drugs ACEIs and ARBs, as well as the T2D drugs GLP-1R agonists, were shown to activate angiotensin-converting enzyme 2 (ACE2) expression in experimental animals.	aceis	14-19	angiotensin converting enzyme 2	Homo sapiens	128-132	
33290594-6	2021	ACEIs and ARBs may increase the amount of ACE-2 formation and, theoretically, increase the risk of SARS-CoV-2 entry into cells, thus inducing inflammation [2].	aceis	0-5	angiotensin converting enzyme 2	Homo sapiens	42-47	
32712300-3	2020	The use of ACEIs/ARBs (RAAS inhibitors) regulates the renin-angiotensin-aldosterone system (RAAS) and may increase ACE2 expression.	aceis	11-16	angiotensin converting enzyme 2	Homo sapiens	115-119	
32712300-5	2020	In this review, we summarize preclinical and clinical studies to investigate whether the use of ACEIs/ARBs increases ACE2 expression in animals or patients.	aceis	96-101	angiotensin converting enzyme 2	Homo sapiens	117-121	
32611305-6	2020	Intravenous infusions of ACEIs and ARBs in experimental animals increase the number of ACE2 receptors.	aceis	25-30	angiotensin converting enzyme 2	Homo sapiens	87-91	
32311651-5	2020	ACEIs and ARBs lead to a reduction in angiotensin II level by increasing the ACE2 level, thus they cause a low cytosolic pH.	aceis	0-5	angiotensin converting enzyme 2	Homo sapiens	77-81	
32311651-6	2020	Increased cardiac ACE2 levels due to ACEIs and ARBs can trigger cardiac arrhythmias and myocarditis by causing the virus to easily enter the heart tissue.	aceis	37-42	angiotensin converting enzyme 2	Homo sapiens	18-22